| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Alpelisib perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Alpelisib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.284555 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.103271 |
| RNF213 | ring finger protein 213 | 0.0776688 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0746749 |
| MYOF | myoferlin | 0.0737356 |
| LMO7 | LIM domain 7 | 0.0693876 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0587492 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0539584 |
| GRAMD1B | GRAM domain containing 1B | 0.0536421 |
| DSPP | dentin sialophosphoprotein | 0.0509396 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0507692 |
| INTS6 | integrator complex subunit 6 | 0.0443284 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0409332 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0387737 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0381387 |
| ANXA2 | annexin A2 | 0.0378048 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0365627 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0362855 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0356993 |
| HOMER1 | homer scaffolding protein 1 | 0.0351201 |
| RAD51B | RAD51 paralog B | 0.0339812 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0338078 |
| NTN4 | netrin 4 | 0.0333565 |
| S100P | S100 calcium binding protein P | 0.0315984 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.030791 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0295726 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0294945 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0293614 |
| DOCK5 | dedicator of cytokinesis 5 | 0.029145 |
| CP | ceruloplasmin (ferroxidase) | 0.02797 |
| AHR | aryl hydrocarbon receptor | 0.0279017 |
| SIK3 | SIK family kinase 3 | 0.0278417 |
| SVIL | supervillin | 0.0277068 |
| IRS2 | insulin receptor substrate 2 | 0.0269977 |
| GOLGB1 | golgin B1 | 0.0269807 |
| MYO1E | myosin IE | 0.02692 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0268901 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0268187 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0267309 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0265408 |
| RPS2 | ribosomal protein S2 | 0.0265305 |
| UGDH | UDP-glucose 6-dehydrogenase | 0.0256884 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.025419 |
| MAP7 | microtubule-associated protein 7 | 0.0254155 |
| CTBP2 | C-terminal binding protein 2 | 0.0253656 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0252668 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0252624 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0250344 |
| WWOX | WW domain containing oxidoreductase | 0.0247076 |
| CUX1 | cut-like homeobox 1 | 0.0244503 |
| MX1 | MX dynamin-like GTPase 1 | 0.0243238 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0240659 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0236718 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.023612 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0227998 |
| KYNU | kynureninase | 0.0227517 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0227234 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0226265 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0224612 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0224487 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0223599 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0221401 |
| B2M | beta-2-microglobulin | 0.0220239 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0215902 |
| RPL7 | ribosomal protein L7 | 0.0215045 |
| CPE | carboxypeptidase E | 0.0214078 |
| ATF6 | activating transcription factor 6 | 0.0213007 |
| FAM107B | family with sequence similarity 107, member B | 0.0212385 |
| SLK | STE20-like kinase | 0.0211844 |
| SLTM | SAFB-like, transcription modulator | 0.0211613 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0210315 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0210125 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0200543 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.01986 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0198574 |
| CANX | calnexin | 0.0198054 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0197376 |
| DST | dystonin | 0.0191052 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0191043 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0189943 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0187574 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0187499 |
| FAT1 | FAT atypical cadherin 1 | 0.0185355 |
| PRDX1 | peroxiredoxin 1 | 0.0184289 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0183711 |
| SEPTIN9 | septin 9 | 0.0182195 |
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | 0.01795 |
| CAV2 | caveolin 2 | 0.0179105 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | 0.0177122 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0173875 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0170169 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0168696 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0168322 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0167662 |
| ATOSA | atos homolog A | 0.0167608 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0166691 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0166061 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0165696 |
| CES1 | carboxylesterase 1 | 0.016229 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0161746 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.202464 |
| UBC | ubiquitin C | -0.126644 |
| LAMC2 | laminin, gamma 2 | -0.116818 |
| NDRG1 | N-myc downstream regulated 1 | -0.112698 |
| MT2A | metallothionein 2A | -0.0923914 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0802561 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0773342 |
| SEC61G | Sec61 gamma subunit | -0.0696911 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0692642 |
| FTL | ferritin, light polypeptide | -0.0624528 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0624289 |
| PKM | pyruvate kinase, muscle | -0.0605519 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0594999 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0560693 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0531025 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0520584 |
| EGR1 | early growth response 1 | -0.0519613 |
| LAMB3 | laminin, beta 3 | -0.0505755 |
| LAMA4 | laminin, alpha 4 | -0.049423 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0469627 |
| TXNRD1 | thioredoxin reductase 1 | -0.0467052 |
| LOC112694756 | uncharaterized LOC112694756 | -0.046397 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0454543 |
| MCL1 | myeloid cell leukemia 1 | -0.0440596 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0439728 |
| RPS27A | ribosomal protein S27a | -0.0439579 |
| MT1X | metallothionein 1X | -0.041658 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0415574 |
| TMEM165 | transmembrane protein 165 | -0.0405014 |
| PTMA | prothymosin, alpha | -0.0404935 |
| ACTG1 | actin gamma 1 | -0.0401477 |
| S100A10 | S100 calcium binding protein A10 | -0.0389286 |
| RPL35A | ribosomal protein L35a | -0.038901 |
| OSMR | oncostatin M receptor | -0.0385367 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0369322 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0365931 |
| RPS24 | ribosomal protein S24 | -0.0363872 |
| ASPH | aspartate beta-hydroxylase | -0.0359109 |
| MKI67 | marker of proliferation Ki-67 | -0.0357969 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0356534 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0345569 |
| WDR45B | WD repeat domain 45B | -0.0343136 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0339222 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0336628 |
| H1-0 | H1.0 linker histone | -0.033474 |
| TOP1 | topoisomerase (DNA) I | -0.033219 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0332145 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0329055 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0328632 |
| RNMT | RNA (guanine-7-) methyltransferase | -0.0327698 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0325884 |
| RTN4 | reticulon 4 | -0.0320114 |
| NGLY1 | N-glycanase 1 | -0.0313127 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0308186 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0300468 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0297144 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0294969 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0287495 |
| STC1 | stanniocalcin 1 | -0.0286871 |
| RBM25 | RNA binding motif protein 25 | -0.0286531 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0286274 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0283074 |
| TES | testin LIM domain protein | -0.0277963 |
| ZNF292 | zinc finger protein 292 | -0.0274733 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0273994 |
| CDCP1 | CUB domain containing protein 1 | -0.0272675 |
| PGK1 | phosphoglycerate kinase 1 | -0.0272639 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0271196 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0266521 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0264785 |
| RASA2 | RAS p21 protein activator 2 | -0.0263456 |
| OGA | O-GlcNAcase | -0.0262499 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0261417 |
| SPAG9 | sperm associated antigen 9 | -0.026025 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0259121 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0258346 |
| IER3 | immediate early response 3 | -0.0256684 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0255955 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0254035 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.025388 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.0249117 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0247293 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0247251 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0247051 |
| CCNL1 | cyclin L1 | -0.0246267 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0245125 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.0244135 |
| RUNX1 | runt-related transcription factor 1 | -0.0243077 |
| RPS3 | ribosomal protein S3 | -0.0242767 |
| SEPTIN2 | septin 2 | -0.0242719 |
| ARRDC3 | arrestin domain containing 3 | -0.024175 |
| CCNI | cyclin I | -0.0241253 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0238032 |
| CST3 | cystatin C | -0.0236697 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | -0.0235165 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | -0.0234383 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0233286 |
| SEPTIN10 | septin 10 | -0.0233121 |
| MATR3 | matrin 3 | -0.0231991 |
| CSNK1E | casein kinase 1, epsilon | -0.023111 |
