Alpelisib_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Alpelisib perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Alpelisib_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.14001
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.117302
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.113201
FAM20C family with sequence similarity 20, member C 0.108089
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.10465
SOD2 superoxide dismutase 2, mitochondrial 0.0893365
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0884162
FNDC3B fibronectin type III domain containing 3B 0.0800708
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0759514
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0744257
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0724395
CD44 CD44 molecule (Indian blood group) 0.0715806
NTN4 netrin 4 0.0715792
HMGA2 high mobility group AT-hook 2 0.0706725
LRMDA leucine rich melanocyte differentiation associated 0.0696863
EXT1 exostosin glycosyltransferase 1 0.0680619
RAD51B RAD51 paralog B 0.0634242
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0606675
GLCCI1 glucocorticoid induced 1 0.0578697
PDE4D phosphodiesterase 4D, cAMP-specific 0.0572122
VIM vimentin 0.0568483
NRG1 neuregulin 1 0.0556843
AHNAK AHNAK nucleoprotein 0.0553228
GRB10 growth factor receptor-bound protein 10 0.0539431
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0537289
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0528435
PCBP2 poly(rC) binding protein 2 0.0527872
PSD3 pleckstrin and Sec7 domain containing 3 0.0521049
LOX lysyl oxidase 0.0515595
SEPTIN9 septin 9 0.0514205
INTS6 integrator complex subunit 6 0.0505575
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0500898
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0493886
SAMD9 sterile alpha motif domain containing 9 0.0493743
SMAD3 SMAD family member 3 0.0490889
KYNU kynureninase 0.0489365
IFI44L interferon-induced protein 44-like 0.0486014
SP100 SP100 nuclear antigen 0.0478923
DST dystonin 0.0474705
SQSTM1 sequestosome 1 0.0472915
MECOM MDS1 and EVI1 complex locus 0.0472027
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0471942
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0470815
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.0449105
ZNF804A zinc finger protein 804A 0.0442064
ZSWIM6 zinc finger, SWIM-type containing 6 0.0439338
LDHA lactate dehydrogenase A 0.0438286
APLP2 amyloid beta (A4) precursor-like protein 2 0.0435947
ATXN1 ataxin 1 0.0435414
PRKCA protein kinase C, alpha 0.0431578
LOXL2 lysyl oxidase-like 2 0.0426585
B2M beta-2-microglobulin 0.0419202
ENO1 enolase 1, (alpha) 0.0417413
ASPH aspartate beta-hydroxylase 0.0406182
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0401002
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0399902
GLIS3 GLIS family zinc finger 3 0.039978
SFTPA2 surfactant protein A2 0.0392026
SYT1 synaptotagmin I 0.0381013
AADAC arylacetamide deacetylase 0.0378446
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0376465
ANXA2 annexin A2 0.0372883
SVIL supervillin 0.0371754
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0365441
MSRB3 methionine sulfoxide reductase B3 0.0365038
TGFB1 transforming growth factor, beta 1 0.0364755
RNF213 ring finger protein 213 0.0358173
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0357295
IFI6 interferon, alpha-inducible protein 6 0.0356776
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0356047
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0351034
MAML3 mastermind-like 3 (Drosophila) 0.034462
RPLP0 ribosomal protein, large, P0 0.03349
EHBP1 EH domain binding protein 1 0.0332774
CANX calnexin 0.0328668
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0326688
GRIK5 glutamate receptor, ionotropic, kainate 5 0.0324916
CUX1 cut-like homeobox 1 0.0324046
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0321412
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0321307
MX1 MX dynamin-like GTPase 1 0.031612
NAV1 neuron navigator 1 0.0316083
DPYD dihydropyrimidine dehydrogenase 0.0315789
ECE1 endothelin converting enzyme 1 0.0314787
VCL vinculin 0.0313351
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0307842
MBNL1 muscleblind-like splicing regulator 1 0.0302044
MAML2 mastermind-like 2 (Drosophila) 0.0300836
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0299785
LRP1B low density lipoprotein receptor-related protein 1B 0.0299774
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0298188
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0296994
EXOC4 exocyst complex component 4 0.0294276
MX2 MX dynamin-like GTPase 2 0.0294204
KCTD16 potassium channel tetramerization domain containing 16 0.0288445
FTH1 ferritin, heavy polypeptide 1 0.0286542
MYO10 myosin X 0.0281196
PCDH7 protocadherin 7 0.0281096
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0278078
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0277229

decreased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase -0.162181
GOLGA4 golgin A4 -0.126599
NDRG1 N-myc downstream regulated 1 -0.0748467
NPC1 Niemann-Pick disease, type C1 -0.0707463
KDM2A lysine (K)-specific demethylase 2A -0.0704125
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0701812
ELL2 elongation factor, RNA polymerase II, 2 -0.0670976
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0576143
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0504133
USP34 ubiquitin specific peptidase 34 -0.0471859
RBM39 RNA binding motif protein 39 -0.0422645
KMT2C lysine (K)-specific methyltransferase 2C -0.0395705
PRRC2C proline-rich coiled-coil 2C -0.0381896
AKAP9 A kinase (PRKA) anchor protein 9 -0.0369933
ZNF292 zinc finger protein 292 -0.0363338
ZFC3H1 zinc finger, C3H1-type containing -0.0341297
SRP54 signal recognition particle 54kDa -0.0335463
TMEM165 transmembrane protein 165 -0.0335167
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0335084
SEC24A SEC24 family member A -0.0324421
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0320463
COG5 component of oligomeric golgi complex 5 -0.0318546
TTC3 tetratricopeptide repeat domain 3 -0.0316246
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.031217
SEC31A SEC31 homolog A (S. cerevisiae) -0.0302069
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0300877
KMT2E lysine (K)-specific methyltransferase 2E -0.0297813
DENND4A DENN/MADD domain containing 4A -0.0297582
SETD5 SET domain containing 5 -0.0293925
SS18 synovial sarcoma translocation, chromosome 18 -0.0291824
SBF2 SET binding factor 2 -0.0290973
PTEN phosphatase and tensin homolog -0.0289854
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0288404
ESYT2 extended synaptotagmin-like protein 2 -0.0285974
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0285748
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.0285261
ACBD3 acyl-CoA binding domain containing 3 -0.0284611
VEGFA vascular endothelial growth factor A -0.0284397
SPAG9 sperm associated antigen 9 -0.0282714
CHD1L chromodomain helicase DNA binding protein 1-like -0.0282075
SEC23A Sec23 homolog A (S. cerevisiae) -0.0281569
SEC24D SEC24 family member D -0.028073
JMJD1C jumonji domain containing 1C -0.0280493
MEF2A myocyte enhancer factor 2A -0.0279226
MTSS1 metastasis suppressor 1 -0.0275007
RPS2 ribosomal protein S2 -0.0273655
TAS2R14 taste receptor, type 2, member 14 -0.0272465
AKAP12 A kinase (PRKA) anchor protein 12 -0.0271293
OSMR oncostatin M receptor -0.0265844
KTN1 kinectin 1 (kinesin receptor) -0.0261863
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0260267
ITCH itchy E3 ubiquitin protein ligase -0.0259916
COPB1 coatomer protein complex, subunit beta 1 -0.0258724
ARHGAP5 Rho GTPase activating protein 5 -0.0254342
GPAT3 glycerol-3-phosphate acyltransferase 3 -0.025341
DTNA dystrobrevin, alpha -0.0252997
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0251791
STC1 stanniocalcin 1 -0.0251678
TBC1D15 TBC1 domain family, member 15 -0.0251067
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0248446
FAM3C family with sequence similarity 3, member C -0.0247288
RNF149 ring finger protein 149 -0.0245393
LRRC8C leucine rich repeat containing 8 family, member C -0.0242828
JARID2 jumonji, AT rich interactive domain 2 -0.0240988
RBM25 RNA binding motif protein 25 -0.0238061
RUNX1 runt-related transcription factor 1 -0.0237779
AKAP13 A kinase (PRKA) anchor protein 13 -0.0237388
MT2A metallothionein 2A -0.0237148
RAB5A RAB5A, member RAS oncogene family -0.0236027
SREBF2 sterol regulatory element binding transcription factor 2 -0.0235652
POM121 POM121 transmembrane nucleoporin -0.0235444
SOS2 son of sevenless homolog 2 (Drosophila) -0.0234357
LRRC49 leucine rich repeat containing 49 -0.0233645
SPRED1 sprouty-related, EVH1 domain containing 1 -0.0232939
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0232752
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0232502
CALU calumenin -0.0231961
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) -0.0230938
COPA coatomer protein complex, subunit alpha -0.0228364
NKTR natural killer cell triggering receptor -0.0227398
KDM7A lysine (K)-specific demethylase 7A -0.0227387
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0225933
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0224352
DUSP5 dual specificity phosphatase 5 -0.0222577
GNA12 guanine nucleotide binding protein (G protein) alpha 12 -0.0221689
MYO1B myosin IB -0.0219499
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0218773
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0216229
UGCG UDP-glucose ceramide glucosyltransferase -0.0215514
SUCO SUN domain containing ossification factor -0.0214961
CD109 CD109 molecule -0.0214887
EGFR epidermal growth factor receptor -0.0213415
DGKD diacylglycerol kinase, delta 130kDa -0.0210915
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0210132
MON2 MON2 homolog (S. cerevisiae) -0.020823
POM121C POM121 transmembrane nucleoporin C -0.020784
NBAS neuroblastoma amplified sequence -0.0207434
GOLT1B golgi transport 1B -0.0205386
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0204574
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.0204374