Alpelisib_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Alpelisib perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Alpelisib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.219227
MT2A metallothionein 2A 0.111531
FAM107B family with sequence similarity 107, member B 0.0994912
PM20D1 peptidase M20 domain containing 1 0.0835578
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0754267
SOD2 superoxide dismutase 2, mitochondrial 0.0749736
WWOX WW domain containing oxidoreductase 0.0722062
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.065694
TM4SF1 transmembrane 4 L six family member 1 0.0656192
FTH1 ferritin, heavy polypeptide 1 0.0617354
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0591587
HSPA8 heat shock 70kDa protein 8 0.0565784
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0556825
ASPH aspartate beta-hydroxylase 0.0543669
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0542636
RICTOR RPTOR independent companion of MTOR, complex 2 0.0504825
TFPI2 tissue factor pathway inhibitor 2 0.0502298
UBASH3B ubiquitin associated and SH3 domain containing B 0.0499881
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0484807
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0482506
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0466522
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0461383
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0452509
FNDC3B fibronectin type III domain containing 3B 0.044528
MACF1 microtubule-actin crosslinking factor 1 0.0423099
MCL1 myeloid cell leukemia 1 0.0421918
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0419459
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0400229
SMOC1 SPARC related modular calcium binding 1 0.0398086
PDE10A phosphodiesterase 10A 0.0396302
ARHGAP26 Rho GTPase activating protein 26 0.038048
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0371655
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0371494
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0370365
BMP6 bone morphogenetic protein 6 0.0365311
LDHA lactate dehydrogenase A 0.0359465
EXOC6B exocyst complex component 6B 0.0357998
SVIL supervillin 0.0354851
APLP2 amyloid beta (A4) precursor-like protein 2 0.035033
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0347787
DOCK5 dedicator of cytokinesis 5 0.0341178
ATXN1 ataxin 1 0.033277
KYNU kynureninase 0.032862
ATP11A ATPase, class VI, type 11A 0.0324483
PARD3B par-3 family cell polarity regulator beta 0.0324083
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0318153
LGALS12 lectin, galactoside-binding, soluble, 12 0.0313127
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0306664
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0303835
CEMIP cell migration inducing protein, hyaluronan binding 0.0302747
NRG1 neuregulin 1 0.0301541
GPHN gephyrin 0.0300863
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0300062
MYOF myoferlin 0.0291757
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0284569
WAC WW domain containing adaptor with coiled-coil 0.0276611
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.02706
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0266075
SMAD2 SMAD family member 2 0.0262022
NCKAP1 NCK-associated protein 1 0.0261971
PCBP2 poly(rC) binding protein 2 0.025986
RPL7 ribosomal protein L7 0.0255271
RPLP0 ribosomal protein, large, P0 0.0249667
RPL19 ribosomal protein L19 0.02488
RPL23 ribosomal protein L23 0.0244153
AHR aryl hydrocarbon receptor 0.0243254
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0241458
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0241298
SFTPA2 surfactant protein A2 0.0239461
CANX calnexin 0.0235068
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0234868
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0234006
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.02329
RPL30 ribosomal protein L30 0.0232504
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.022972
PRKCE protein kinase C, epsilon 0.0228373
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0227853
PRKN parkin RBR E3 ubiquitin protein ligase 0.0227107
YAP1 Yes-associated protein 1 0.0226653
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0219799
MAML3 mastermind-like 3 (Drosophila) 0.0217734
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0217192
SFPQ splicing factor proline/glutamine-rich 0.0216591
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0216586
NCOA2 nuclear receptor coactivator 2 0.0216356
SMAD3 SMAD family member 3 0.0214253
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 0.0213297
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0212986
PRKD1 protein kinase D1 0.0211197
ZSWIM6 zinc finger, SWIM-type containing 6 0.0209981
RPS18 ribosomal protein S18 0.0209869
ZFAND3 zinc finger, AN1-type domain 3 0.0209508
EIF1 eukaryotic translation initiation factor 1 0.0209422
KIAA0319 KIAA0319 0.0209234
GLIS3 GLIS family zinc finger 3 0.0208842
PHIP pleckstrin homology domain interacting protein 0.0208147
SDCBP syndecan binding protein (syntenin) 0.0208051
CXCL2 chemokine (C-X-C motif) ligand 2 0.0207948
SERINC1 serine incorporator 1 0.020747
MOK MOK protein kinase 0.0207462

decreased expression

Symbol Name Standardized Value
ACTG1 actin gamma 1 -0.110711
IGF2 insulin-like growth factor 2 -0.100172
TMSB10 thymosin beta 10 -0.0914683
AKAP12 A kinase (PRKA) anchor protein 12 -0.0794411
VIM vimentin -0.0715623
TPM4 tropomyosin 4 -0.0663033
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0580087
PYGL phosphorylase, glycogen, liver -0.0573387
FTL ferritin, light polypeptide -0.0539904
ACTN1 actinin, alpha 1 -0.052404
FGB fibrinogen beta chain -0.0507559
BICC1 BicC family RNA binding protein 1 -0.0503667
POTEF POTE ankyrin domain family, member F -0.0490264
EGR1 early growth response 1 -0.0479302
IGFBP4 insulin-like growth factor binding protein 4 -0.0461989
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0456924
RBM25 RNA binding motif protein 25 -0.0451929
PLS3 plastin 3 -0.0445924
DGKD diacylglycerol kinase, delta 130kDa -0.042868
MAP1B microtubule-associated protein 1B -0.0419637
CMIP c-Maf inducing protein -0.0405625
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0394991
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0387877
PTMA prothymosin, alpha -0.0384933
DST dystonin -0.0380719
NPC1 Niemann-Pick disease, type C1 -0.0371004
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0369889
SOX4 SRY (sex determining region Y)-box 4 -0.0366252
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0366017
OSMR oncostatin M receptor -0.0350555
AK1 adenylate kinase 1 -0.0347227
COPA coatomer protein complex, subunit alpha -0.0341499
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0337525
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0333056
IGFBP3 insulin-like growth factor binding protein 3 -0.0326893
EGFR epidermal growth factor receptor -0.0321324
TMEM87A transmembrane protein 87A -0.0306684
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0304703
FLNB filamin B, beta -0.0300448
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0295426
PFN1 profilin 1 -0.0294748
PKM pyruvate kinase, muscle -0.0284584
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0281901
HSPB1 heat shock 27kDa protein 1 -0.0281124
CCNL1 cyclin L1 -0.0280886
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0273172
TPM1 tropomyosin 1 (alpha) -0.0270054
VCL vinculin -0.0264152
FBXO11 F-box protein 11 -0.0263096
HDAC9 histone deacetylase 9 -0.0261035
SLC35F3 solute carrier family 35, member F3 -0.0258657
PRR16 proline rich 16 -0.0258423
CALD1 caldesmon 1 -0.0254091
CAVIN1 caveolae associated protein 1 -0.0250975
SETD5 SET domain containing 5 -0.0249677
STRN3 striatin, calmodulin binding protein 3 -0.02496
LIMA1 LIM domain and actin binding 1 -0.0249228
BABAM2 BRISC and BRCA1 A complex member 2 -0.0247712
SRRM2 serine/arginine repetitive matrix 2 -0.0245599
WDR43 WD repeat domain 43 -0.0245068
MAP4 microtubule-associated protein 4 -0.0241886
FMNL2 formin-like 2 -0.0240901
LMNA lamin A/C -0.0240286
FERMT2 fermitin family member 2 -0.0239868
RAB7A RAB7A, member RAS oncogene family -0.0239056
KLF6 Kruppel-like factor 6 -0.0235815
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0230246
THBS1 thrombospondin 1 -0.0228603
ZNF644 zinc finger protein 644 -0.0221946
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0217445
GRAMD1B GRAM domain containing 1B -0.0215876
RHOA ras homolog family member A -0.021504
KTN1 kinectin 1 (kinesin receptor) -0.021466
CNRIP1 cannabinoid receptor interacting protein 1 -0.0211286
TCF25 transcription factor 25 (basic helix-loop-helix) -0.0208307
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0206604
NPEPPS aminopeptidase puromycin sensitive -0.0206234
WASF2 WAS protein family, member 2 -0.0204669
IER3 immediate early response 3 -0.0204441
BRD4 bromodomain containing 4 -0.0203587
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0202339
ANKRD11 ankyrin repeat domain 11 -0.0199654
CTNND1 catenin (cadherin-associated protein), delta 1 -0.019952
LAMC2 laminin, gamma 2 -0.0198561
P3H2 prolyl 3-hydroxylase 2 -0.0195773
KMT2E lysine (K)-specific methyltransferase 2E -0.0193888
THSD4 thrombospondin, type I, domain containing 4 -0.0193268
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0192741
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -0.0192217
ECT2 epithelial cell transforming 2 -0.0191877
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0191587
MGLL monoglyceride lipase -0.0190448
KLC1 kinesin light chain 1 -0.0190235
YME1L1 YME1-like 1 ATPase -0.0189802
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0189202
INHBA inhibin, beta A -0.0189027
HMGA1 high mobility group AT-hook 1 -0.0188593
AFF4 AF4/FMR2 family, member 4 -0.018835
TAGLN2 transgelin 2 -0.0187863
ZNF804A zinc finger protein 804A -0.0187237