| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Alpelisib perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Alpelisib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.260265 |
| KYNU | kynureninase | 0.243542 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.153379 |
| ASPH | aspartate beta-hydroxylase | 0.143108 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.135904 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.126637 |
| EGFR | epidermal growth factor receptor | 0.111319 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.110882 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.108422 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.10557 |
| DSCAM | Down syndrome cell adhesion molecule | 0.104843 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.102308 |
| VIM | vimentin | 0.097203 |
| FN1 | fibronectin 1 | 0.0855907 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0838097 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0835883 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0787877 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0728256 |
| EFNA5 | ephrin-A5 | 0.0711383 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0704456 |
| SMAD3 | SMAD family member 3 | 0.0684549 |
| TNPO1 | transportin 1 | 0.0667788 |
| TJP1 | tight junction protein 1 | 0.0661476 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0655089 |
| PRKCA | protein kinase C, alpha | 0.0638084 |
| TUSC3 | tumor suppressor candidate 3 | 0.0623206 |
| RSPO3 | R-spondin 3 | 0.0599026 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0595281 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0594909 |
| LMO7 | LIM domain 7 | 0.0587644 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.057975 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0578905 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0574775 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0574506 |
| RNF213 | ring finger protein 213 | 0.0546712 |
| B2M | beta-2-microglobulin | 0.0541454 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0536691 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0509493 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0497795 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0496702 |
| FAM107B | family with sequence similarity 107, member B | 0.0489847 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0487443 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0478668 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0477058 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0472759 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0451099 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | 0.0445474 |
| PTK2 | protein tyrosine kinase 2 | 0.0442104 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 0.0441269 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0433849 |
| OGA | O-GlcNAcase | 0.0433642 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0430771 |
| TMSB10 | thymosin beta 10 | 0.0425704 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0424238 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0422598 |
| HDLBP | high density lipoprotein binding protein | 0.0422339 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0418049 |
| GRAMD1B | GRAM domain containing 1B | 0.0411886 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0401165 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.039202 |
| HLA-B | major histocompatibility complex, class I, B | 0.0379353 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0373276 |
| MACC1 | metastasis associated in colon cancer 1 | 0.036735 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0363354 |
| SFTPA2 | surfactant protein A2 | 0.0363118 |
| MYOF | myoferlin | 0.0361517 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0358526 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0354856 |
| RAD51B | RAD51 paralog B | 0.0349897 |
| APP | amyloid beta (A4) precursor protein | 0.0347627 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0342906 |
| ENO1 | enolase 1, (alpha) | 0.0341704 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0331064 |
| USP34 | ubiquitin specific peptidase 34 | 0.032312 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0322405 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0320746 |
| ATXN1 | ataxin 1 | 0.0309417 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0309053 |
| RUNX1 | runt-related transcription factor 1 | 0.0307543 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0300155 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0299183 |
| PARD3 | par-3 family cell polarity regulator | 0.029803 |
| CALR | calreticulin | 0.0296392 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0288602 |
| TUFT1 | tuftelin 1 | 0.0285117 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.027817 |
| RPS8 | ribosomal protein S8 | 0.027754 |
| MT2A | metallothionein 2A | 0.0276413 |
| RPL35A | ribosomal protein L35a | 0.0275945 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0275231 |
| TXNIP | thioredoxin interacting protein | 0.0274014 |
| RGS6 | regulator of G-protein signaling 6 | 0.0273291 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0270687 |
| FUS | FUS RNA binding protein | 0.0264872 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0264818 |
| LCN2 | lipocalin 2 | 0.0256174 |
| RPL26 | ribosomal protein L26 | 0.0249094 |
| MYO1E | myosin IE | 0.0249025 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0247519 |
| TANK | TRAF family member-associated NFKB activator | 0.0246033 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GRB10 | growth factor receptor-bound protein 10 | -0.158777 |
| NDRG1 | N-myc downstream regulated 1 | -0.116516 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.113798 |
| LAMB3 | laminin, beta 3 | -0.0932375 |
| CMIP | c-Maf inducing protein | -0.0929164 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0877758 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0852863 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0825929 |
| NAV2 | neuron navigator 2 | -0.0807563 |
| LAMC2 | laminin, gamma 2 | -0.0805233 |
| IGF2 | insulin-like growth factor 2 | -0.0776969 |
| PDE10A | phosphodiesterase 10A | -0.0734373 |
| WDR26 | WD repeat domain 26 | -0.0704489 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0702365 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0698189 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0694429 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0641967 |
| MUC16 | mucin 16, cell surface associated | -0.0617615 |
| DENND1A | DENN/MADD domain containing 1A | -0.061183 |
| GOLGA4 | golgin A4 | -0.060301 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0596923 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.0582574 |
| FMNL2 | formin-like 2 | -0.0581134 |
| ZNF292 | zinc finger protein 292 | -0.0565539 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0562931 |
| FNIP1 | folliculin interacting protein 1 | -0.053321 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0521245 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0520619 |
| VCL | vinculin | -0.0516204 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0513187 |
| RCOR1 | REST corepressor 1 | -0.0507674 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0500564 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0490763 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0488994 |
| ZNF638 | zinc finger protein 638 | -0.0484397 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0484271 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0480692 |
| SVIL | supervillin | -0.0479108 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0475364 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.047323 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0467114 |
| MCL1 | myeloid cell leukemia 1 | -0.0459201 |
| MEF2A | myocyte enhancer factor 2A | -0.0458436 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0457803 |
| CDC73 | cell division cycle 73 | -0.0457789 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0440334 |
| XPO1 | exportin 1 | -0.0434161 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0431842 |
| NUMB | numb homolog (Drosophila) | -0.0431543 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0426917 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0425921 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.041598 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0413862 |
| ATOSA | atos homolog A | -0.0412871 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0411899 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0410846 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0409103 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0407423 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0401687 |
| FOXO1 | forkhead box O1 | -0.0391177 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.039033 |
| SETD2 | SET domain containing 2 | -0.038409 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0383465 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0381133 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.037528 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0370044 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0369632 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0369286 |
| TMEM41B | transmembrane protein 41B | -0.0366261 |
| RBM47 | RNA binding motif protein 47 | -0.0362487 |
| PRELID2 | PRELI domain containing 2 | -0.0354265 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0348129 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0344074 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0339675 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0339593 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0338349 |
| FTL | ferritin, light polypeptide | -0.0333306 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.032816 |
| ANXA2 | annexin A2 | -0.0324498 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0324104 |
| NBEA | neurobeachin | -0.0321628 |
| RPS6 | ribosomal protein S6 | -0.032104 |
| ANKRD11 | ankyrin repeat domain 11 | -0.031957 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.0314749 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0313737 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0311678 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0310094 |
| AFDN | afadin, adherens junction formation factor | -0.0309023 |
| ABHD17C | abhydrolase domain containing 17C | -0.0306016 |
| GPC6 | glypican 6 | -0.0305876 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0302309 |
| KIAA1217 | KIAA1217 | -0.0299732 |
| LNPEP | leucyl/cystinyl aminopeptidase | -0.0292806 |
| KIAA1671 | KIAA1671 | -0.0291058 |
| OXR1 | oxidation resistance 1 | -0.0290219 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0289925 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0289257 |
| JMJD1C | jumonji domain containing 1C | -0.0285443 |
| KRT17 | keratin 17, type I | -0.0283213 |
| NEBL | nebulette | -0.0282345 |
