Alpelisib_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Alpelisib perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Alpelisib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.376666
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.219642
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.147317
YBX3 Y box binding protein 3 0.124526
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.121768
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.10939
MCL1 myeloid cell leukemia 1 0.100914
GRAMD1B GRAM domain containing 1B 0.0912283
THSD4 thrombospondin, type I, domain containing 4 0.0798999
PDE4D phosphodiesterase 4D, cAMP-specific 0.0779382
KTN1 kinectin 1 (kinesin receptor) 0.0761253
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0728953
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0694011
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0692564
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0673684
TPI1 triosephosphate isomerase 1 0.0667254
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0661903
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0651364
TPM3 tropomyosin 3 0.0632262
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0628095
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0623504
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0580289
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0539075
DOCK5 dedicator of cytokinesis 5 0.0536698
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.053339
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.053046
FMNL2 formin-like 2 0.0513595
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0500042
WWOX WW domain containing oxidoreductase 0.0499422
IGF1R insulin-like growth factor 1 receptor 0.0493881
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0493756
PCBP2 poly(rC) binding protein 2 0.049319
PDE10A phosphodiesterase 10A 0.0492619
KRT18 keratin 18, type I 0.0487575
PRKCE protein kinase C, epsilon 0.0479055
FNDC3B fibronectin type III domain containing 3B 0.0475556
ENO1 enolase 1, (alpha) 0.0474186
TPM2 tropomyosin 2 (beta) 0.0472539
MACF1 microtubule-actin crosslinking factor 1 0.0465931
CANX calnexin 0.046203
IFI6 interferon, alpha-inducible protein 6 0.0460563
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0445467
ZSWIM6 zinc finger, SWIM-type containing 6 0.0435991
HSPA8 heat shock 70kDa protein 8 0.043508
EXOC4 exocyst complex component 4 0.0433873
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0431878
BRD2 bromodomain containing 2 0.0427427
PTMA prothymosin, alpha 0.042662
SVIL supervillin 0.0419429
RIMS2 regulating synaptic membrane exocytosis 2 0.0413673
RPS8 ribosomal protein S8 0.0411462
GOLGB1 golgin B1 0.0410152
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0402787
ZCCHC7 zinc finger, CCHC domain containing 7 0.0400908
VIM vimentin 0.0399563
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0399399
AFF3 AF4/FMR2 family, member 3 0.0391865
APLP2 amyloid beta (A4) precursor-like protein 2 0.0391244
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0385297
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0382395
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0368224
RPS3 ribosomal protein S3 0.0366909
SERBP1 SERPINE1 mRNA binding protein 1 0.0365246
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0363221
ATP11A ATPase, class VI, type 11A 0.036205
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0354596
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.035303
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0352555
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0349506
YBX1 Y box binding protein 1 0.034883
PDLIM5 PDZ and LIM domain 5 0.0347364
EXT1 exostosin glycosyltransferase 1 0.0345314
DST dystonin 0.0342158
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0341581
TLN1 talin 1 0.0341
ATXN1 ataxin 1 0.034011
EEF1G eukaryotic translation elongation factor 1 gamma 0.0338526
AEBP2 AE binding protein 2 0.033785
HOMER1 homer scaffolding protein 1 0.0328624
USP34 ubiquitin specific peptidase 34 0.0328555
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0327948
ADAR adenosine deaminase, RNA-specific 0.0322836
AHNAK AHNAK nucleoprotein 0.0321127
TPM4 tropomyosin 4 0.0319811
CUX1 cut-like homeobox 1 0.0316618
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0315294
ERRFI1 ERBB receptor feedback inhibitor 1 0.0312935
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0312336
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0310851
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0308817
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0306906
LDHA lactate dehydrogenase A 0.0305796
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0305403
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0302762
DSPP dentin sialophosphoprotein 0.030262
ZFAND3 zinc finger, AN1-type domain 3 0.0299615
HMGA2 high mobility group AT-hook 2 0.02983
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.029699
PYGL phosphorylase, glycogen, liver 0.0296821
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0296604

decreased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 -0.0467674
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0311284
TMSB10 thymosin beta 10 -0.0284762
RPL35A ribosomal protein L35a -0.0281908
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0263525
MKI67 marker of proliferation Ki-67 -0.0263498
EGR1 early growth response 1 -0.0263338
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0256269
KDM3A lysine (K)-specific demethylase 3A -0.0239613
PHIP pleckstrin homology domain interacting protein -0.022747
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0224665
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0221749
RTN4 reticulon 4 -0.0216205
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0195347
MIS18BP1 MIS18 binding protein 1 -0.0192286
CEP95 centrosomal protein 95kDa -0.0178352
SGO2 shugoshin 2 -0.0173346
TMEM165 transmembrane protein 165 -0.0172472
RBM25 RNA binding motif protein 25 -0.0169944
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0168207
IGF2 insulin-like growth factor 2 -0.0166306
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0164393
EIF1 eukaryotic translation initiation factor 1 -0.0160383
CDC27 cell division cycle 27 -0.015838
STIL SCL/TAL1 interrupting locus -0.0157597
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0156232
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0155126
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0153667
RUSC2 RUN and SH3 domain containing 2 -0.0152619
GPSM2 G-protein signaling modulator 2 -0.0148807
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0148384
ZNF292 zinc finger protein 292 -0.0147349
DIAPH3 diaphanous-related formin 3 -0.0145198
RNF169 ring finger protein 169 -0.0144696
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0144105
CIP2A cellular inhibitor of PP2A -0.014402
ANKRD12 ankyrin repeat domain 12 -0.0140897
MYL12B myosin, light chain 12B, regulatory -0.0140514
TIGAR TP53 induced glycolysis regulatory phosphatase -0.0139862
RNF38 ring finger protein 38 -0.013972
GATAD2B GATA zinc finger domain containing 2B -0.0139128
RPL4 ribosomal protein L4 -0.0138955
SINHCAF SIN3-HDAC complex associated factor -0.0137471
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0136374
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.013389
CBX3 chromobox homolog 3 -0.0131796
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0131055
WDR45B WD repeat domain 45B -0.0130802
PRR11 proline rich 11 -0.0130797
KIF18B kinesin family member 18B -0.0127488
NDC80 NDC80 kinetochore complex component -0.0126486
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -0.0124579
CEP135 centrosomal protein 135kDa -0.0122384
XPO1 exportin 1 -0.0122037
PNISR PNN-interacting serine/arginine-rich protein -0.0120858
TPX2 TPX2, microtubule-associated -0.0120105
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -0.0119529
TOPBP1 topoisomerase (DNA) II binding protein 1 -0.0119455
SMC4 structural maintenance of chromosomes 4 -0.0118985
MELK maternal embryonic leucine zipper kinase -0.0118147
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0117825
GARS1 glycyl-tRNA synthetase 1 -0.0117211
EPN2 epsin 2 -0.0117202
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha -0.0116695
CCNL1 cyclin L1 -0.0116509
CTTNBP2NL CTTNBP2 N-terminal like -0.0116429
KIF14 kinesin family member 14 -0.0114675
NUP153 nucleoporin 153kDa -0.0114082
CENPF centromere protein F, 350/400kDa -0.0113943
ZBTB35 zinc finger and BTB domain containing 35 -0.0113716
GOLGA4 golgin A4 -0.0112474
ANLN anillin, actin binding protein -0.0112267
MYSM1 Myb-like, SWIRM and MPN domains 1 -0.0111653
RFX7 regulatory factor X, 7 -0.01114
FBXO34 F-box protein 34 -0.0110777
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0109994
TMPO thymopoietin -0.0109387
BRWD3 bromodomain and WD repeat domain containing 3 -0.0108857
ZFAND6 zinc finger, AN1-type domain 6 -0.010826
ZC3H6 zinc finger CCCH-type containing 6 -0.0107625
FTL ferritin, light polypeptide -0.0107535
TUT4 terminal uridylyl transferase 4 -0.0107475
NPEPPS aminopeptidase puromycin sensitive -0.0107391
RBL1 retinoblastoma-like 1 -0.0107373
MT1X metallothionein 1X -0.0106553
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0106517
ATXN2 ataxin 2 -0.0106469
KIF4A kinesin family member 4A -0.0105907
ZFR zinc finger RNA binding protein -0.0105783
GAS2L3 growth arrest-specific 2 like 3 -0.010513
ACBD6 acyl-CoA binding domain containing 6 -0.0105123
CKAP2 cytoskeleton associated protein 2 -0.0103753
WSB1 WD repeat and SOCS box containing 1 -0.0103498
NABP1 nucleic acid binding protein 1 -0.0103386
KNL1 kinetochore scaffold 1 -0.0102588
RNF121 ring finger protein 121 -0.0101846
DLG1 discs, large homolog 1 (Drosophila) -0.0101723
SCLT1 sodium channel and clathrin linker 1 -0.0101643
XRN1 5'-3' exoribonuclease 1 -0.0101378
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0100426