| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Alpelisib perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Alpelisib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.28124 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.174896 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.161704 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.152466 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.139477 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.123121 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.116317 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.102772 |
| ASPH | aspartate beta-hydroxylase | 0.096607 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0918048 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0816748 |
| ANXA2 | annexin A2 | 0.0806402 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0792714 |
| CANX | calnexin | 0.0773397 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0749123 |
| PTK2 | protein tyrosine kinase 2 | 0.0729778 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0714734 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0679293 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0675181 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.066684 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0640138 |
| LMO7 | LIM domain 7 | 0.0635377 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0609651 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0601398 |
| DSPP | dentin sialophosphoprotein | 0.0594096 |
| FN1 | fibronectin 1 | 0.0589892 |
| PLEC | plectin | 0.0580691 |
| SMAD3 | SMAD family member 3 | 0.0570709 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0550693 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0549366 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0548601 |
| SGMS2 | sphingomyelin synthase 2 | 0.0544624 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0544152 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0541788 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.053659 |
| SQSTM1 | sequestosome 1 | 0.0528399 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.052074 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0519662 |
| ARRDC3 | arrestin domain containing 3 | 0.0518091 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.051025 |
| MYO5B | myosin VB | 0.0506273 |
| LDHA | lactate dehydrogenase A | 0.0503602 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0498462 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0494331 |
| NAV2 | neuron navigator 2 | 0.049347 |
| G0S2 | G0/G1 switch 2 | 0.0493244 |
| ERBIN | erbb2 interacting protein | 0.0489879 |
| LAMC2 | laminin, gamma 2 | 0.047172 |
| HDAC9 | histone deacetylase 9 | 0.0470981 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0455279 |
| DTNA | dystrobrevin, alpha | 0.0452977 |
| TJP1 | tight junction protein 1 | 0.0448345 |
| EFNA5 | ephrin-A5 | 0.0440426 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0439349 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0438698 |
| VGLL3 | vestigial-like family member 3 | 0.0435629 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | 0.0435121 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0432321 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0428327 |
| POTEF | POTE ankyrin domain family, member F | 0.0427704 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0419565 |
| KIAA1217 | KIAA1217 | 0.0418098 |
| DIAPH1 | diaphanous-related formin 1 | 0.0410137 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0407547 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0405799 |
| EGFR | epidermal growth factor receptor | 0.0403362 |
| MYO10 | myosin X | 0.0401998 |
| NR3C2 | nuclear receptor subfamily 3, group C, member 2 | 0.0399447 |
| CALR | calreticulin | 0.0399216 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0397889 |
| MCL1 | myeloid cell leukemia 1 | 0.038514 |
| TOP1 | topoisomerase (DNA) I | 0.0384197 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 0.0381334 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0380954 |
| ANO6 | anoctamin 6 | 0.0375933 |
| PCBP2 | poly(rC) binding protein 2 | 0.0375284 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0371892 |
| EZR | ezrin | 0.0371153 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0365862 |
| EGR1 | early growth response 1 | 0.0363842 |
| BRD2 | bromodomain containing 2 | 0.0362348 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0357432 |
| MX1 | MX dynamin-like GTPase 1 | 0.0356714 |
| HMGA1 | high mobility group AT-hook 1 | 0.0351248 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0351137 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0348063 |
| MSN | moesin | 0.034737 |
| UBC | ubiquitin C | 0.0346778 |
| TPM3 | tropomyosin 3 | 0.0345365 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0344755 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0339092 |
| KRT19 | keratin 19, type I | 0.0337669 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0336714 |
| KRT7 | keratin 7, type II | 0.0332912 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0331198 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0326219 |
| CD44 | CD44 molecule (Indian blood group) | 0.0325795 |
| MAP1B | microtubule-associated protein 1B | 0.0324938 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0322683 |
| DST | dystonin | 0.0320084 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.0803838 |
| FTL | ferritin, light polypeptide | -0.0803186 |
| PTMA | prothymosin, alpha | -0.0790221 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0741176 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0681449 |
| RPL35A | ribosomal protein L35a | -0.0675513 |
| RPS29 | ribosomal protein S29 | -0.062614 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0587731 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0500837 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.049382 |
| RPS23 | ribosomal protein S23 | -0.0493361 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0486632 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0455954 |
| RPL37A | ribosomal protein L37a | -0.045448 |
| RPL9 | ribosomal protein L9 | -0.0446801 |
| HLA-B | major histocompatibility complex, class I, B | -0.0445363 |
| RPS27A | ribosomal protein S27a | -0.0424728 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.041187 |
| GNAS | GNAS complex locus | -0.0396181 |
| RPS3 | ribosomal protein S3 | -0.039548 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0384913 |
| RPLP2 | ribosomal protein, large, P2 | -0.0377682 |
| RPS13 | ribosomal protein S13 | -0.0360629 |
| RPS8 | ribosomal protein S8 | -0.0329779 |
| RPL31 | ribosomal protein L31 | -0.0302233 |
| RPL11 | ribosomal protein L11 | -0.0293938 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0293337 |
| RPL37 | ribosomal protein L37 | -0.0291639 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0291495 |
| RPL34 | ribosomal protein L34 | -0.0289384 |
| S100A10 | S100 calcium binding protein A10 | -0.0285746 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0283405 |
| RPL36 | ribosomal protein L36 | -0.0273074 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.027299 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0268066 |
| CSTB | cystatin B (stefin B) | -0.0256201 |
| RPLP1 | ribosomal protein, large, P1 | -0.0250822 |
| RPS6 | ribosomal protein S6 | -0.0250552 |
| RPS10 | ribosomal protein S10 | -0.0249769 |
| RPS27 | ribosomal protein S27 | -0.0248819 |
| RPL15 | ribosomal protein L15 | -0.0246815 |
| RPL38 | ribosomal protein L38 | -0.0245214 |
| HLA-E | major histocompatibility complex, class I, E | -0.0244381 |
| VCL | vinculin | -0.0236975 |
| ACTG1 | actin gamma 1 | -0.0235591 |
| RPS12 | ribosomal protein S12 | -0.0234112 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0232901 |
| CTSD | cathepsin D | -0.0227034 |
| EPCAM | epithelial cell adhesion molecule | -0.0225639 |
| HLA-A | major histocompatibility complex, class I, A | -0.0225439 |
| H3-3B | H3.3 histone B | -0.0224822 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0219644 |
| FBXO34 | F-box protein 34 | -0.021597 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0214603 |
| RPL28 | ribosomal protein L28 | -0.0213035 |
| RPS21 | ribosomal protein S21 | -0.0212697 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0211141 |
| COX7C | cytochrome c oxidase subunit VIIc | -0.0207616 |
| PSME1 | proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) | -0.0206268 |
| FBXO32 | F-box protein 32 | -0.0204462 |
| FAM162A | family with sequence similarity 162, member A | -0.0199323 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0194096 |
| WFDC2 | WAP four-disulfide core domain 2 | -0.0193102 |
| CAVIN1 | caveolae associated protein 1 | -0.0191855 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0190944 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0184185 |
| S100A9 | S100 calcium binding protein A9 | -0.0180144 |
| B2M | beta-2-microglobulin | -0.0179067 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | -0.0178794 |
| RPS25 | ribosomal protein S25 | -0.0176106 |
| RPS16 | ribosomal protein S16 | -0.0167229 |
| YY1 | YY1 transcription factor | -0.0165003 |
| TMSB4X | thymosin beta 4, X-linked | -0.0164938 |
| MUC20 | mucin 20, cell surface associated | -0.0163874 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0159236 |
| COX6C | cytochrome c oxidase subunit VIc | -0.0154473 |
| RPS15 | ribosomal protein S15 | -0.0153092 |
| RPL27 | ribosomal protein L27 | -0.0150582 |
| AOPEP | aminopeptidase O (putative) | -0.0148556 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0148274 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0146979 |
| RPL26 | ribosomal protein L26 | -0.0146309 |
| MUC1 | mucin 1, cell surface associated | -0.014537 |
| TMEM263 | transmembrane protein 263 | -0.014434 |
| PDXK | pyridoxal (pyridoxine, vitamin B6) kinase | -0.0144241 |
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | -0.0144181 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0143947 |
| NPC2 | Niemann-Pick disease, type C2 | -0.0141996 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0140898 |
| RPS11 | ribosomal protein S11 | -0.0140401 |
| TMEM165 | transmembrane protein 165 | -0.0140333 |
| RPL36A | ribosomal protein L36a | -0.0139139 |
| RPS20 | ribosomal protein S20 | -0.0139134 |
| ARF1 | ADP-ribosylation factor 1 | -0.0138993 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0138616 |
| NEBL | nebulette | -0.0138309 |
| RRBP1 | ribosome binding protein 1 | -0.0136682 |
| IFITM2 | interferon induced transmembrane protein 2 | -0.0134963 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0132283 |
| RPS24 | ribosomal protein S24 | -0.0131995 |
