| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Alpelisib perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Alpelisib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.299046 |
| FN1 | fibronectin 1 | 0.199166 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.187893 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.177911 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.15714 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.134796 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.131137 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.115029 |
| PDE10A | phosphodiesterase 10A | 0.111275 |
| MCL1 | myeloid cell leukemia 1 | 0.102243 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0985852 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0944607 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0872064 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0826163 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0749257 |
| CDH13 | cadherin 13 | 0.0740412 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0721069 |
| VIM | vimentin | 0.0719742 |
| PDLIM5 | PDZ and LIM domain 5 | 0.071098 |
| KYNU | kynureninase | 0.0710469 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0703712 |
| LDHA | lactate dehydrogenase A | 0.0703703 |
| CANX | calnexin | 0.0700131 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0696952 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0694435 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.0689095 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0663219 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.06419 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0631985 |
| SMAD2 | SMAD family member 2 | 0.0611799 |
| FNDC3A | fibronectin type III domain containing 3A | 0.061125 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0610369 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0609309 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0607691 |
| STC1 | stanniocalcin 1 | 0.0598125 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.059411 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0590883 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0590007 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0584872 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0564709 |
| GRAMD1B | GRAM domain containing 1B | 0.055987 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0555469 |
| SQSTM1 | sequestosome 1 | 0.0551867 |
| PKM | pyruvate kinase, muscle | 0.0546268 |
| ENO1 | enolase 1, (alpha) | 0.0542184 |
| CTSL | cathepsin L | 0.0540761 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0524039 |
| PCBP2 | poly(rC) binding protein 2 | 0.0508104 |
| B2M | beta-2-microglobulin | 0.0507214 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0503099 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0502728 |
| RAB3B | RAB3B, member RAS oncogene family | 0.0494935 |
| PTMA | prothymosin, alpha | 0.0493698 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0492042 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0488409 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0483232 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0478921 |
| ANXA2 | annexin A2 | 0.0478649 |
| MYOF | myoferlin | 0.0476549 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0475926 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0463458 |
| SFTPA2 | surfactant protein A2 | 0.0463305 |
| INHBA | inhibin, beta A | 0.0435831 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0426493 |
| HLA-A | major histocompatibility complex, class I, A | 0.0426408 |
| PYGL | phosphorylase, glycogen, liver | 0.0421892 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0420806 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0420196 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0419629 |
| AUTS2 | autism susceptibility candidate 2 | 0.0419606 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0411215 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0410923 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 0.0405584 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.039743 |
| MAP7 | microtubule-associated protein 7 | 0.0394254 |
| RPS6 | ribosomal protein S6 | 0.0392133 |
| RPS8 | ribosomal protein S8 | 0.0380056 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0378882 |
| FAM107B | family with sequence similarity 107, member B | 0.0374175 |
| KRT19 | keratin 19, type I | 0.0373332 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0364825 |
| RAD51B | RAD51 paralog B | 0.0361925 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0361497 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0361313 |
| CTBP2 | C-terminal binding protein 2 | 0.0360209 |
| ANTXR1 | anthrax toxin receptor 1 | 0.0351814 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0351789 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0350173 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0349438 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | 0.0348981 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0347968 |
| TPM3 | tropomyosin 3 | 0.0346619 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | 0.0341241 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0339362 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0338436 |
| SET | SET nuclear proto-oncogene | 0.0333341 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0331855 |
| PGK1 | phosphoglycerate kinase 1 | 0.0331113 |
| MT2A | metallothionein 2A | 0.0328672 |
| PRKAA2 | protein kinase, AMP-activated, alpha 2 catalytic subunit | 0.0324939 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0777174 |
| TXNRD1 | thioredoxin reductase 1 | -0.0727914 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0638921 |
| NEK7 | NIMA-related kinase 7 | -0.0634988 |
| RTN4 | reticulon 4 | -0.0383733 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0332793 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0307971 |
| TNPO1 | transportin 1 | -0.0273226 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0270426 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0267684 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.026566 |
| RPS24 | ribosomal protein S24 | -0.0264192 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0261617 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0250761 |
| OGA | O-GlcNAcase | -0.0245892 |
| RBM39 | RNA binding motif protein 39 | -0.024475 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0241159 |
| ENAH | enabled homolog (Drosophila) | -0.0225069 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | -0.0212047 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.020384 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.020295 |
| USP3 | ubiquitin specific peptidase 3 | -0.0200138 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.0199004 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.019514 |
| NTN4 | netrin 4 | -0.0192721 |
| RPS27A | ribosomal protein S27a | -0.0191651 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0191512 |
| CTSC | cathepsin C | -0.0191173 |
| RPL9 | ribosomal protein L9 | -0.0185146 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0185014 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0177518 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0175967 |
| RPL35A | ribosomal protein L35a | -0.0175104 |
| TMSB10 | thymosin beta 10 | -0.0170951 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.016477 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.0158952 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.0150633 |
| GDA | guanine deaminase | -0.0147011 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0146225 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0145457 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0142892 |
| GPRIN3 | GPRIN family member 3 | -0.0142206 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0141223 |
| HYCC2 | hyccin PI4KA lipid kinase complex subunit 2 | -0.0139325 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0138374 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | -0.0137118 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0135406 |
| MFF | mitochondrial fission factor | -0.0134899 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.0134723 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | -0.0133709 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0131372 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0131167 |
| SAR1A | secretion associated, Ras related GTPase 1A | -0.0130733 |
| POU2F1 | POU class 2 homeobox 1 | -0.0130016 |
| CEP95 | centrosomal protein 95kDa | -0.012928 |
| ZNF292 | zinc finger protein 292 | -0.012848 |
| USP15 | ubiquitin specific peptidase 15 | -0.0128347 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0128249 |
| WDR43 | WD repeat domain 43 | -0.0127587 |
| CDK17 | cyclin-dependent kinase 17 | -0.0127572 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.012615 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | -0.0126107 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0124174 |
| ATP13A3 | ATPase type 13A3 | -0.0123632 |
| PALLD | palladin, cytoskeletal associated protein | -0.0121409 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0120296 |
| PHIP | pleckstrin homology domain interacting protein | -0.0119863 |
| CRYAB | crystallin, alpha B | -0.0119859 |
| RFX7 | regulatory factor X, 7 | -0.0116948 |
| MFSD12 | major facilitator superfamily domain containing 12 | -0.0115863 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.011528 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | -0.0115147 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0115083 |
| MYPN | myopalladin | -0.0114401 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0114054 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0113404 |
| ADGRA3 | adhesion G protein-coupled receptor A3 | -0.0113381 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0112447 |
| SBF2 | SET binding factor 2 | -0.0112011 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | -0.011157 |
| LYPLAL1 | lysophospholipase-like 1 | -0.0111141 |
| PID1 | phosphotyrosine interaction domain containing 1 | -0.0108147 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0107531 |
| AOPEP | aminopeptidase O (putative) | -0.0107354 |
| SCCPDH | saccharopine dehydrogenase (putative) | -0.0106916 |
| DLGAP1 | discs, large (Drosophila) homolog-associated protein 1 | -0.0106862 |
| FOXJ3 | forkhead box J3 | -0.0106756 |
| ITGAV | integrin, alpha V | -0.0106408 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0105746 |
| PTBP2 | polypyrimidine tract binding protein 2 | -0.0105724 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0105713 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0104537 |
| UCK2 | uridine-cytidine kinase 2 | -0.0103945 |
| RPL13A | ribosomal protein L13a | -0.0103866 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0103279 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0103072 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.0102854 |
| PHF21A | PHD finger protein 21A | -0.010278 |
| CHML | choroideremia-like (Rab escort protein 2) | -0.0102529 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0102448 |
