| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Alpelisib perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Alpelisib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYO1E | myosin IE | 0.250804 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.224081 |
| JMJD1C | jumonji domain containing 1C | 0.141457 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.125598 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.119031 |
| MED13L | mediator complex subunit 13-like | 0.117823 |
| FN1 | fibronectin 1 | 0.105537 |
| RPS3 | ribosomal protein S3 | 0.1045 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0937607 |
| MT2A | metallothionein 2A | 0.0934616 |
| ZNF644 | zinc finger protein 644 | 0.0893771 |
| LMO7 | LIM domain 7 | 0.088478 |
| TTC17 | tetratricopeptide repeat domain 17 | 0.0855454 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0837991 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0770705 |
| FAT1 | FAT atypical cadherin 1 | 0.0744298 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0737465 |
| ABHD2 | abhydrolase domain containing 2 | 0.0737347 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0715308 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0714215 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0697289 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.069723 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0686977 |
| RPS8 | ribosomal protein S8 | 0.0674745 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0660365 |
| B2M | beta-2-microglobulin | 0.0640282 |
| RAD51B | RAD51 paralog B | 0.063868 |
| MYO10 | myosin X | 0.0635583 |
| RPL26 | ribosomal protein L26 | 0.0631614 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.062975 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0619274 |
| EGFR | epidermal growth factor receptor | 0.0605613 |
| SPAG9 | sperm associated antigen 9 | 0.0597877 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0584314 |
| PARD3 | par-3 family cell polarity regulator | 0.0556245 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0552086 |
| SMYD3 | SET and MYND domain containing 3 | 0.0543878 |
| PTK2 | protein tyrosine kinase 2 | 0.0543261 |
| EZR | ezrin | 0.0539718 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0501199 |
| IGF1R | insulin-like growth factor 1 receptor | 0.050007 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0493305 |
| RPL11 | ribosomal protein L11 | 0.0478535 |
| RAB5A | RAB5A, member RAS oncogene family | 0.0478161 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0466945 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0459202 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0448868 |
| LDHA | lactate dehydrogenase A | 0.0444552 |
| CD44 | CD44 molecule (Indian blood group) | 0.0421419 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0419607 |
| NDRG1 | N-myc downstream regulated 1 | 0.0418809 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0417411 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0408784 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0398688 |
| VIM | vimentin | 0.0392608 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.036273 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0357129 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0350618 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.034349 |
| AHNAK | AHNAK nucleoprotein | 0.0342201 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0335982 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0315582 |
| CALR | calreticulin | 0.0299591 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0294059 |
| CAMKMT | calmodulin-lysine N-methyltransferase | 0.0287837 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0283963 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0271754 |
| MYH14 | myosin, heavy chain 14, non-muscle | 0.0269112 |
| RPS11 | ribosomal protein S11 | 0.0263659 |
| CCNI | cyclin I | 0.0252141 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0248866 |
| RPL15 | ribosomal protein L15 | 0.0247869 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0233016 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0219676 |
| GPHN | gephyrin | 0.0216552 |
| RPS29 | ribosomal protein S29 | 0.0200044 |
| VCL | vinculin | 0.0197264 |
| RPL12 | ribosomal protein L12 | 0.0176526 |
| RPS23 | ribosomal protein S23 | 0.0174169 |
| RTN4 | reticulon 4 | 0.0173857 |
| MTDH | metadherin | 0.0161219 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0155747 |
| RPS2 | ribosomal protein S2 | 0.0154085 |
| RPS6 | ribosomal protein S6 | 0.0151625 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0149342 |
| BRD2 | bromodomain containing 2 | 0.0141047 |
| CANX | calnexin | 0.0127785 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0121504 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0103342 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.00831141 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.00828799 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | 0.00790093 |
| NCOR1 | nuclear receptor corepressor 1 | 0.00680901 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.00645206 |
| SLC38A1 | solute carrier family 38, member 1 | 0.00572574 |
| SMAD3 | SMAD family member 3 | 0.00433048 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.00414663 |
| RPL9 | ribosomal protein L9 | 0.00347308 |
| H3-3B | H3.3 histone B | 0.0030571 |
| ANKRD17 | ankyrin repeat domain 17 | 0.00305529 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.142627 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.134957 |
| DOCK4 | dedicator of cytokinesis 4 | -0.12459 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.118006 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.11574 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.100411 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0960735 |
| PDE10A | phosphodiesterase 10A | -0.0936878 |
| PKM | pyruvate kinase, muscle | -0.0904302 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0851078 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0836219 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.083364 |
| RPS19 | ribosomal protein S19 | -0.0828166 |
| FAM13A | family with sequence similarity 13, member A | -0.0825576 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0783006 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0732489 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0711238 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0708899 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0684019 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0672358 |
| TXNRD1 | thioredoxin reductase 1 | -0.0667197 |
| MYOF | myoferlin | -0.0663944 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | -0.0643077 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0617522 |
| DST | dystonin | -0.0608961 |
| GOLGA4 | golgin A4 | -0.0592812 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0586039 |
| EFNA5 | ephrin-A5 | -0.0564016 |
| HELZ | helicase with zinc finger | -0.0563752 |
| SYAP1 | synapse associated protein 1 | -0.0559061 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0540716 |
| RORA | RAR-related orphan receptor A | -0.0536179 |
| FLNB | filamin B, beta | -0.0535654 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0506453 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0504399 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0503589 |
| FTL | ferritin, light polypeptide | -0.0496098 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.049172 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.047209 |
| ACTG1 | actin gamma 1 | -0.0471939 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0470597 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0462084 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.045461 |
| ASPH | aspartate beta-hydroxylase | -0.0443232 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0414606 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0407459 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0398771 |
| RPLP2 | ribosomal protein, large, P2 | -0.038913 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0376324 |
| SBF2 | SET binding factor 2 | -0.0356152 |
| TMSB10 | thymosin beta 10 | -0.0355459 |
| STC1 | stanniocalcin 1 | -0.0349712 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0346157 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.034578 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0345613 |
| RPS27A | ribosomal protein S27a | -0.0344248 |
| FBXO11 | F-box protein 11 | -0.03212 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0307834 |
| AFDN | afadin, adherens junction formation factor | -0.030512 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0301116 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0286094 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0277527 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0237135 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0236498 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.0234772 |
| RPL37A | ribosomal protein L37a | -0.02299 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0221448 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0216986 |
| RPS12 | ribosomal protein S12 | -0.0216629 |
| FNIP1 | folliculin interacting protein 1 | -0.0214669 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0209893 |
| TNS3 | tensin 3 | -0.0209272 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.020172 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0198639 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0194638 |
| JUN | jun proto-oncogene | -0.0190008 |
| PTMA | prothymosin, alpha | -0.0173596 |
| ZNF292 | zinc finger protein 292 | -0.0168667 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0159068 |
| RPL34 | ribosomal protein L34 | -0.0149146 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0146494 |
| RPL23 | ribosomal protein L23 | -0.0132994 |
| OGA | O-GlcNAcase | -0.0131788 |
| ANXA2 | annexin A2 | -0.0127322 |
| RPL35A | ribosomal protein L35a | -0.012275 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | -0.0121009 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.00994068 |
| PRKCA | protein kinase C, alpha | -0.00950945 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.00840241 |
| RPLP1 | ribosomal protein, large, P1 | -0.00807606 |
| MED13 | mediator complex subunit 13 | -0.00748213 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.00743151 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.00713858 |
| RRBP1 | ribosome binding protein 1 | -0.00541308 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.00482917 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.00364304 |
| TBC1D5 | TBC1 domain family, member 5 | -0.00342852 |
| ENO1 | enolase 1, (alpha) | -0.00342216 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.00323623 |
| NACA | nascent polypeptide-associated complex alpha subunit | -0.00299367 |
