| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Alpelisib perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Alpelisib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL5A2 | collagen, type V, alpha 2 | 0.260041 |
| COL11A1 | collagen, type XI, alpha 1 | 0.198729 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.165239 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | 0.158379 |
| CADM2 | cell adhesion molecule 2 | 0.154141 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.128078 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.12541 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.118121 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.112721 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0832034 |
| DST | dystonin | 0.0823747 |
| MKI67 | marker of proliferation Ki-67 | 0.0735056 |
| TENM3 | teneurin transmembrane protein 3 | 0.069321 |
| CANX | calnexin | 0.0691145 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0689894 |
| HDAC9 | histone deacetylase 9 | 0.0660321 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.0655993 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.065333 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.064387 |
| FOXP2 | forkhead box P2 | 0.0629614 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | 0.0606013 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0584235 |
| CSMD3 | CUB and Sushi multiple domains 3 | 0.0540219 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.0520239 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0477809 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0475321 |
| PCDH9 | protocadherin 9 | 0.0454505 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | 0.0427333 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0426194 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0417588 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | 0.0417476 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0414113 |
| ANK2 | ankyrin 2, neuronal | 0.0410144 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0408621 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0400641 |
| MEIS2 | Meis homeobox 2 | 0.039964 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0398884 |
| HMGA2 | high mobility group AT-hook 2 | 0.0396302 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0374377 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0371158 |
| ERBIN | erbb2 interacting protein | 0.0366913 |
| SHROOM3 | shroom family member 3 | 0.0361392 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0357629 |
| RBM25 | RNA binding motif protein 25 | 0.0354551 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0354167 |
| SIK3 | SIK family kinase 3 | 0.0350938 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0344561 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.034334 |
| CFL2 | cofilin 2 (muscle) | 0.0342008 |
| ZFHX4 | zinc finger homeobox 4 | 0.0341156 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0338639 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0335305 |
| TJP1 | tight junction protein 1 | 0.0334636 |
| MEF2C | myocyte enhancer factor 2C | 0.0329758 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0328262 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0323551 |
| BPTF | bromodomain PHD finger transcription factor | 0.0321203 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | 0.0319917 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0314331 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0313327 |
| PDGFC | platelet derived growth factor C | 0.0313015 |
| METAP2 | methionyl aminopeptidase 2 | 0.0311096 |
| WDR43 | WD repeat domain 43 | 0.0308871 |
| IGF2R | insulin-like growth factor 2 receptor | 0.0308577 |
| NCAM2 | neural cell adhesion molecule 2 | 0.0305948 |
| SMYD3 | SET and MYND domain containing 3 | 0.02996 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0298243 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0294935 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.0294408 |
| USP25 | ubiquitin specific peptidase 25 | 0.0293967 |
| SON | SON DNA binding protein | 0.0291372 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0290837 |
| SERTAD2 | SERTA domain containing 2 | 0.0289209 |
| TTC17 | tetratricopeptide repeat domain 17 | 0.02884 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0286507 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0284276 |
| NRDC | nardilysin convertase | 0.0279565 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0275479 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0275021 |
| ZNF608 | zinc finger protein 608 | 0.0274193 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0273427 |
| MPP2 | membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) | 0.0272913 |
| BRD2 | bromodomain containing 2 | 0.0271208 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0269332 |
| EVI5 | ecotropic viral integration site 5 | 0.0269189 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | 0.0269155 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0267876 |
| RBM33 | RNA binding motif protein 33 | 0.0265173 |
| EXOC6B | exocyst complex component 6B | 0.0264961 |
| NBEA | neurobeachin | 0.0264044 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.026386 |
| EIF5AL1 | eukaryotic translation initiation factor 5A-like 1 | 0.0262474 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0259806 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0258652 |
| PLEKHG1 | pleckstrin homology domain containing, family G (with RhoGef domain) member 1 | 0.0258473 |
| CCDC88A | coiled-coil domain containing 88A | 0.0257948 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0257508 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0256845 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0256402 |
| MCL1 | myeloid cell leukemia 1 | 0.0256011 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.108393 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0726207 |
| GPC3 | glypican 3 | -0.0674619 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0617033 |
| PEG10 | paternally expressed 10 | -0.0562596 |
| RFPL4B | ret finger protein-like 4B | -0.0521184 |
| PHIP | pleckstrin homology domain interacting protein | -0.0518866 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0516907 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.051273 |
| MAP4 | microtubule-associated protein 4 | -0.050827 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0396169 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0394203 |
| VIM | vimentin | -0.039356 |
| RPS8 | ribosomal protein S8 | -0.0393141 |
| MRPS30 | mitochondrial ribosomal protein S30 | -0.0374532 |
| TMSB10 | thymosin beta 10 | -0.0360343 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0345465 |
| ITGAV | integrin, alpha V | -0.0345347 |
| RPS12 | ribosomal protein S12 | -0.0344869 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0335149 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0332893 |
| RPL9 | ribosomal protein L9 | -0.0332236 |
| NTM | neurotrimin | -0.0331581 |
| RBM20 | RNA binding motif protein 20 | -0.0331332 |
| PPP4R1 | protein phosphatase 4, regulatory subunit 1 | -0.0329653 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0323358 |
| RPL35A | ribosomal protein L35a | -0.0318868 |
| THOC2 | THO complex 2 | -0.0315471 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0313003 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0310124 |
| UPP1 | uridine phosphorylase 1 | -0.0308898 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0302725 |
| RPL31 | ribosomal protein L31 | -0.0300378 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0298247 |
| ARHGEF4 | Rho guanine nucleotide exchange factor (GEF) 4 | -0.0291617 |
| TMEM165 | transmembrane protein 165 | -0.0290633 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0286014 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0284341 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0281805 |
| TXNRD1 | thioredoxin reductase 1 | -0.0280975 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.027863 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.027464 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | -0.0263884 |
| ARF1 | ADP-ribosylation factor 1 | -0.0263365 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.0263361 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.0261978 |
| ANKRD33B | ankyrin repeat domain 33B | -0.0259765 |
| TPX2 | TPX2, microtubule-associated | -0.0259188 |
| RPS6 | ribosomal protein S6 | -0.0255147 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0254605 |
| RPS16 | ribosomal protein S16 | -0.0253878 |
| EAPP | E2F-associated phosphoprotein | -0.0250399 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0249327 |
| CECR2 | cat eye syndrome chromosome region, candidate 2 | -0.0244403 |
| SLC30A8 | solute carrier family 30 (zinc transporter), member 8 | -0.024346 |
| PGAP1 | post-GPI attachment to proteins 1 | -0.02412 |
| NKTR | natural killer cell triggering receptor | -0.0238604 |
| PPM1B | protein phosphatase, Mg2+/Mn2+ dependent, 1B | -0.0238175 |
| GALNTL6 | polypeptide N-acetylgalactosaminyltransferase-like 6 | -0.0237215 |
| THOC1 | THO complex 1 | -0.0236766 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0232961 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0232182 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0230583 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0229052 |
| CNNM2 | cyclin and CBS domain divalent metal cation transport mediator 2 | -0.0228406 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0228139 |
| HMGB2 | high mobility group box 2 | -0.0228109 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0228068 |
| RPS25 | ribosomal protein S25 | -0.0226229 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0223855 |
| R3HDM1 | R3H domain containing 1 | -0.022379 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0222788 |
| TRERF1 | transcriptional regulating factor 1 | -0.0222156 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0221385 |
| SNX6 | sorting nexin 6 | -0.0221214 |
| RPL36A | ribosomal protein L36a | -0.022072 |
| YY1 | YY1 transcription factor | -0.0219769 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0216673 |
| RPS27A | ribosomal protein S27a | -0.0216386 |
| SGO2 | shugoshin 2 | -0.0214298 |
| PARD6B | par-6 family cell polarity regulator beta | -0.021368 |
| RPL37A | ribosomal protein L37a | -0.0212283 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0211899 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | -0.0211848 |
| GNAS | GNAS complex locus | -0.0210783 |
| CAVIN1 | caveolae associated protein 1 | -0.0210539 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0209161 |
| SYT1 | synaptotagmin I | -0.0208217 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0208054 |
| URI1 | URI1, prefoldin-like chaperone | -0.0207882 |
| CDH4 | cadherin 4, type 1, R-cadherin (retinal) | -0.0207819 |
| COL1A2 | collagen, type I, alpha 2 | -0.0207258 |
| ATXN2 | ataxin 2 | -0.0207147 |
| POGZ | pogo transposable element with ZNF domain | -0.0206485 |
| APOC1 | apolipoprotein C-I | -0.0205888 |
| USP3 | ubiquitin specific peptidase 3 | -0.0203581 |
| TFRC | transferrin receptor | -0.0203184 |
| SENP7 | SUMO1/sentrin specific peptidase 7 | -0.0202022 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0201116 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0198487 |
