| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Alpelisib perturbation in SNU-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Alpelisib_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.189823 |
| FOXP1 | forkhead box P1 | 0.181896 |
| PKM | pyruvate kinase, muscle | 0.125624 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.124325 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.123617 |
| VCL | vinculin | 0.118923 |
| GLI3 | GLI family zinc finger 3 | 0.112724 |
| HDAC9 | histone deacetylase 9 | 0.111443 |
| TJP1 | tight junction protein 1 | 0.111433 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.108837 |
| EGFR | epidermal growth factor receptor | 0.0973952 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0948978 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0889726 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0708464 |
| ZNF608 | zinc finger protein 608 | 0.0703012 |
| MYO5C | myosin VC | 0.065512 |
| PTMA | prothymosin, alpha | 0.0647847 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0645722 |
| TRERF1 | transcriptional regulating factor 1 | 0.0629624 |
| GLI2 | GLI family zinc finger 2 | 0.0618265 |
| GSE1 | Gse1 coiled-coil protein | 0.0605434 |
| SOX6 | SRY (sex determining region Y)-box 6 | 0.056965 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0563989 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0561519 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0540061 |
| PDGFC | platelet derived growth factor C | 0.0537949 |
| EFNA5 | ephrin-A5 | 0.0508927 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0507834 |
| EZR | ezrin | 0.0502745 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.049232 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0485838 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0474426 |
| SEPTIN9 | septin 9 | 0.0471328 |
| TACC2 | transforming, acidic coiled-coil containing protein 2 | 0.04696 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0468685 |
| MACROD2 | MACRO domain containing 2 | 0.0464513 |
| NBEA | neurobeachin | 0.0456999 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0434513 |
| FER1L6 | fer-1-like family member 6 | 0.0434245 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0432915 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0426772 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0421901 |
| JMJD1C | jumonji domain containing 1C | 0.0419915 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0405106 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0404328 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0402965 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.039111 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.038976 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0389613 |
| ANXA1 | annexin A1 | 0.0389548 |
| AHNAK | AHNAK nucleoprotein | 0.0388135 |
| NPAS2 | neuronal PAS domain protein 2 | 0.038772 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | 0.0371162 |
| MED13L | mediator complex subunit 13-like | 0.0351386 |
| USP34 | ubiquitin specific peptidase 34 | 0.0347949 |
| CENPF | centromere protein F, 350/400kDa | 0.0346509 |
| BPTF | bromodomain PHD finger transcription factor | 0.0345924 |
| PYGB | phosphorylase, glycogen; brain | 0.034488 |
| RRM2 | ribonucleotide reductase M2 | 0.0341189 |
| SGMS2 | sphingomyelin synthase 2 | 0.0338234 |
| BMP10 | bone morphogenetic protein 10 | 0.0331606 |
| DUSP4 | dual specificity phosphatase 4 | 0.0329894 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.0328486 |
| PCBP2 | poly(rC) binding protein 2 | 0.032716 |
| POTEF | POTE ankyrin domain family, member F | 0.0318253 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0316483 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0315136 |
| MED13 | mediator complex subunit 13 | 0.0312358 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0311104 |
| RBM6 | RNA binding motif protein 6 | 0.0308342 |
| EXT1 | exostosin glycosyltransferase 1 | 0.030826 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0304862 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0303011 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0302901 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0302405 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0299115 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 0.0299067 |
| ENO1 | enolase 1, (alpha) | 0.0298676 |
| PTK2 | protein tyrosine kinase 2 | 0.0297672 |
| FAM91A1 | family with sequence similarity 91, member A1 | 0.0295386 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0295335 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0293224 |
| CREBBP | CREB binding protein | 0.0291938 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.029132 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0287732 |
| KANK1 | KN motif and ankyrin repeat domains 1 | 0.0285746 |
| SMYD3 | SET and MYND domain containing 3 | 0.0283783 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.0283557 |
| GCNT1 | glucosaminyl (N-acetyl) transferase 1, core 2 | 0.0282891 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0280387 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0279894 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0278851 |
| NFIA | nuclear factor I/A | 0.0278324 |
| YBX1 | Y box binding protein 1 | 0.0276324 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0276122 |
| USP8 | ubiquitin specific peptidase 8 | 0.0273658 |
| AHCYL2 | adenosylhomocysteinase-like 2 | 0.0273637 |
| APP | amyloid beta (A4) precursor protein | 0.0272585 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0272345 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0268521 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.102079 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0565896 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0547233 |
| S100A6 | S100 calcium binding protein A6 | -0.0518008 |
| RPL12 | ribosomal protein L12 | -0.0517231 |
| ACTG1 | actin gamma 1 | -0.0496931 |
| B2M | beta-2-microglobulin | -0.0467223 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0455791 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0416965 |
| RPL35A | ribosomal protein L35a | -0.0413572 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0404544 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0404156 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0399447 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0393227 |
| RPL13A | ribosomal protein L13a | -0.0377564 |
| RPL36 | ribosomal protein L36 | -0.0377231 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0375273 |
| RPL19 | ribosomal protein L19 | -0.0340677 |
| NEBL | nebulette | -0.033855 |
| RPS12 | ribosomal protein S12 | -0.0333841 |
| RPL4 | ribosomal protein L4 | -0.0327416 |
| RPS13 | ribosomal protein S13 | -0.032732 |
| RPL38 | ribosomal protein L38 | -0.0313137 |
| RPL26 | ribosomal protein L26 | -0.031262 |
| RPL28 | ribosomal protein L28 | -0.0310413 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0310079 |
| PHF3 | PHD finger protein 3 | -0.030043 |
| RPS27A | ribosomal protein S27a | -0.0292857 |
| MT2A | metallothionein 2A | -0.0291313 |
| GOLGA4 | golgin A4 | -0.0290072 |
| RPS24 | ribosomal protein S24 | -0.0288796 |
| RPLP1 | ribosomal protein, large, P1 | -0.0286071 |
| RPLP0 | ribosomal protein, large, P0 | -0.0284563 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0275782 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0268125 |
| TXNRD1 | thioredoxin reductase 1 | -0.0268042 |
| PRELID2 | PRELI domain containing 2 | -0.0264497 |
| SQSTM1 | sequestosome 1 | -0.0259816 |
| RPL8 | ribosomal protein L8 | -0.0259246 |
| RPS29 | ribosomal protein S29 | -0.0258692 |
| RACK1 | receptor for activated C kinase 1 | -0.0258255 |
| RPL32 | ribosomal protein L32 | -0.0258234 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0256245 |
| USP3 | ubiquitin specific peptidase 3 | -0.0256009 |
| RPS23 | ribosomal protein S23 | -0.0254629 |
| RPS11 | ribosomal protein S11 | -0.0253453 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0245334 |
| ATF4 | activating transcription factor 4 | -0.024476 |
| RPS5 | ribosomal protein S5 | -0.0242296 |
| ZNF292 | zinc finger protein 292 | -0.0233581 |
| RPS21 | ribosomal protein S21 | -0.0229594 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0228763 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0227063 |
| CCNI | cyclin I | -0.0226524 |
| CNOT6L | CCR4-NOT transcription complex, subunit 6-like | -0.0224176 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0222692 |
| RPL5 | ribosomal protein L5 | -0.0221958 |
| RPLP2 | ribosomal protein, large, P2 | -0.0221949 |
| RPL11 | ribosomal protein L11 | -0.0216841 |
| RAD18 | RAD18 E3 ubiquitin protein ligase | -0.0216068 |
| TMEM263 | transmembrane protein 263 | -0.0214226 |
| RPL37 | ribosomal protein L37 | -0.0211524 |
| RPS16 | ribosomal protein S16 | -0.0210084 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0208974 |
| BCOR | BCL6 corepressor | -0.0206408 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0206158 |
| TMEM123 | transmembrane protein 123 | -0.0202866 |
| HMGA1 | high mobility group AT-hook 1 | -0.0198558 |
| EPB41 | erythrocyte membrane protein band 4.1 | -0.0195971 |
| RPL34 | ribosomal protein L34 | -0.0193432 |
| BTG3 | BTG family, member 3 | -0.0192903 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0191962 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0188567 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0187767 |
| CENATAC | centrosomal AT-AC splicing factor | -0.0184467 |
| S100A4 | S100 calcium binding protein A4 | -0.0183836 |
| FOXO3 | forkhead box O3 | -0.0182802 |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit | -0.0180088 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.017881 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0178775 |
| CTIF | CBP80/20-dependent translation initiation factor | -0.0177956 |
| WASF2 | WAS protein family, member 2 | -0.0175905 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0175067 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.017431 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | -0.0173487 |
| RPS15 | ribosomal protein S15 | -0.0172739 |
| RPL30 | ribosomal protein L30 | -0.0169444 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0169099 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0167109 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0166113 |
| CDC73 | cell division cycle 73 | -0.0164316 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0163824 |
| DENND1A | DENN/MADD domain containing 1A | -0.0163821 |
| FHIT | fragile histidine triad | -0.0162388 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0162234 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.016166 |
| RHBDD1 | rhomboid domain containing 1 | -0.0161382 |
| RPS3 | ribosomal protein S3 | -0.0161033 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.016078 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.015998 |
