Alpelisib_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Alpelisib perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Alpelisib_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.153969
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.137504
HDAC9 histone deacetylase 9 0.11406
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.106269
SOD2 superoxide dismutase 2, mitochondrial 0.0976886
CD44 CD44 molecule (Indian blood group) 0.0796867
MYH9 myosin, heavy chain 9, non-muscle 0.0637216
EXT1 exostosin glycosyltransferase 1 0.0605118
VCL vinculin 0.0595065
SFTPA2 surfactant protein A2 0.0583442
GLIS3 GLIS family zinc finger 3 0.057694
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0565112
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0556427
SMAD3 SMAD family member 3 0.0554815
APLP2 amyloid beta (A4) precursor-like protein 2 0.0549548
ANXA2 annexin A2 0.053011
ZSWIM6 zinc finger, SWIM-type containing 6 0.0521479
LDHA lactate dehydrogenase A 0.051912
COL6A3 collagen, type VI, alpha 3 0.0513907
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0498313
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0487317
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0486656
VCAN versican 0.0476712
ATXN1 ataxin 1 0.0447867
TNS3 tensin 3 0.0431033
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0423321
VMP1 vacuole membrane protein 1 0.0418434
ASPH aspartate beta-hydroxylase 0.0398526
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0379065
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0360099
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0360034
FNDC3B fibronectin type III domain containing 3B 0.0356245
ICAM1 intercellular adhesion molecule 1 0.0351709
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0341632
SQSTM1 sequestosome 1 0.0341021
AHNAK AHNAK nucleoprotein 0.033995
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0337164
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0332072
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0331225
RIGI RNA sensor RIG-I 0.0331222
ZBTB38 zinc finger and BTB domain containing 38 0.0330173
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0327544
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0326705
HMGA2 high mobility group AT-hook 2 0.0324787
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.031719
PCBP2 poly(rC) binding protein 2 0.0315999
SVIL supervillin 0.0314143
KYNU kynureninase 0.0313137
BICC1 BicC family RNA binding protein 1 0.0310025
RNF213 ring finger protein 213 0.0307728
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.030743
DUSP10 dual specificity phosphatase 10 0.0305922
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.030292
LPP LIM domain containing preferred translocation partner in lipoma 0.0302745
TENT5A terminal nucleotidyltransferase 5A 0.029875
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.029743
EEF2 eukaryotic translation elongation factor 2 0.0294092
AKAP13 A kinase (PRKA) anchor protein 13 0.0285838
MACF1 microtubule-actin crosslinking factor 1 0.0276862
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0276645
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0275283
USP9X ubiquitin specific peptidase 9, X-linked 0.0274094
INTS6 integrator complex subunit 6 0.0272685
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0270638
RND3 Rho family GTPase 3 0.0269933
MSN moesin 0.0269186
CANX calnexin 0.026665
MBNL1 muscleblind-like splicing regulator 1 0.0265723
TNIP1 TNFAIP3 interacting protein 1 0.0265152
APP amyloid beta (A4) precursor protein 0.0262726
RAB7A RAB7A, member RAS oncogene family 0.0259389
FLNA filamin A, alpha 0.02561
EEF1G eukaryotic translation elongation factor 1 gamma 0.0255922
TRIO trio Rho guanine nucleotide exchange factor 0.0254262
TRIP12 thyroid hormone receptor interactor 12 0.0249422
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0246746
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0245435
TXNIP thioredoxin interacting protein 0.0245233
WWTR1 WW domain containing transcription regulator 1 0.0243968
GOLGB1 golgin B1 0.0243311
SEPTIN9 septin 9 0.0241894
AHR aryl hydrocarbon receptor 0.0241356
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0238961
COL1A2 collagen, type I, alpha 2 0.0237188
NABP1 nucleic acid binding protein 1 0.0236838
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0236685
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0235765
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0235345
THBS1 thrombospondin 1 0.0233738
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0233248
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0232396
STC1 stanniocalcin 1 0.0230656
IQGAP1 IQ motif containing GTPase activating protein 1 0.0228576
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0227146
TLE4 transducin-like enhancer of split 4 0.0224421
JMJD1C jumonji domain containing 1C 0.0223055
PPARD peroxisome proliferator-activated receptor delta 0.0222224
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0220289
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0219778
MED13L mediator complex subunit 13-like 0.0219768

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.11885
IGFBP3 insulin-like growth factor binding protein 3 -0.0826221
TPT1 tumor protein, translationally-controlled 1 -0.0709979
IER3 immediate early response 3 -0.0697875
HLA-B major histocompatibility complex, class I, B -0.0649264
TMSB10 thymosin beta 10 -0.0516873
NDRG1 N-myc downstream regulated 1 -0.0502962
PLIN2 perilipin 2 -0.0500354
RPL9 ribosomal protein L9 -0.0467489
RPL37A ribosomal protein L37a -0.0446389
CADM1 cell adhesion molecule 1 -0.0444363
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0439204
UGCG UDP-glucose ceramide glucosyltransferase -0.0436086
MT2A metallothionein 2A -0.041596
EIF1 eukaryotic translation initiation factor 1 -0.0393629
FTL ferritin, light polypeptide -0.0392454
PTMA prothymosin, alpha -0.0384706
NAMPT nicotinamide phosphoribosyltransferase -0.0381537
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0377531
ZMYND8 zinc finger, MYND-type containing 8 -0.0354931
RPL35A ribosomal protein L35a -0.0349167
WSB1 WD repeat and SOCS box containing 1 -0.0339276
RPS3 ribosomal protein S3 -0.0312602
RPS23 ribosomal protein S23 -0.0311767
RPLP2 ribosomal protein, large, P2 -0.029784
RPS24 ribosomal protein S24 -0.0286131
RPS6 ribosomal protein S6 -0.0284167
RPL36 ribosomal protein L36 -0.028181
SDK1 sidekick cell adhesion molecule 1 -0.0278064
RPL36A ribosomal protein L36a -0.0275176
MXI1 MAX interactor 1, dimerization protein -0.0273733
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0258895
NPEPPS aminopeptidase puromycin sensitive -0.0241998
RPS13 ribosomal protein S13 -0.0236495
ACTG1 actin gamma 1 -0.0234822
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0232659
RPL31 ribosomal protein L31 -0.0229721
RPS21 ribosomal protein S21 -0.022696
AFF3 AF4/FMR2 family, member 3 -0.0222228
RPL26 ribosomal protein L26 -0.0222161
ADM adrenomedullin -0.0220218
RPS27A ribosomal protein S27a -0.0217635
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0216671
RPS29 ribosomal protein S29 -0.0212109
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0208448
ABI3BP ABI family, member 3 (NESH) binding protein -0.0201579
RPS8 ribosomal protein S8 -0.0200898
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0198789
BTG1 B-cell translocation gene 1, anti-proliferative -0.0195527
ATP13A3 ATPase type 13A3 -0.0190217
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0188663
GNAS GNAS complex locus -0.0187061
KDM3A lysine (K)-specific demethylase 3A -0.0181329
ENO2 enolase 2 (gamma, neuronal) -0.0181274
RPL12 ribosomal protein L12 -0.0180974
RPS10 ribosomal protein S10 -0.017654
RPS12 ribosomal protein S12 -0.0175351
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0173329
MMP12 matrix metallopeptidase 12 -0.0172292
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.017105
GOLGA4 golgin A4 -0.016938
KMT2C lysine (K)-specific methyltransferase 2C -0.0167804
RPS25 ribosomal protein S25 -0.016668
KDM5B lysine (K)-specific demethylase 5B -0.0164205
HILPDA hypoxia inducible lipid droplet-associated -0.0162992
LCORL ligand dependent nuclear receptor corepressor-like -0.0157101
FAM162A family with sequence similarity 162, member A -0.0156422
ENO1 enolase 1, (alpha) -0.0155995
RPL38 ribosomal protein L38 -0.0155047
VDAC1 voltage-dependent anion channel 1 -0.0155002
CD109 CD109 molecule -0.0152672
RAI14 retinoic acid induced 14 -0.0151606
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0151577
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0149927
ESYT2 extended synaptotagmin-like protein 2 -0.0148848
IFITM3 interferon induced transmembrane protein 3 -0.0144696
S100A9 S100 calcium binding protein A9 -0.014438
CD63 CD63 molecule -0.0143963
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0143002
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0142773
DLG1 discs, large homolog 1 (Drosophila) -0.0142251
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 -0.0141839
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0141525
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0140847
ZNF292 zinc finger protein 292 -0.0140193
RPL13A ribosomal protein L13a -0.0138815
CTSD cathepsin D -0.0138172
RPL27 ribosomal protein L27 -0.0137758
TPM4 tropomyosin 4 -0.0135246
GARS1 glycyl-tRNA synthetase 1 -0.0133911
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0132896
KPNB1 karyopherin (importin) beta 1 -0.0132142
SORBS2 sorbin and SH3 domain containing 2 -0.0130622
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0129786
RPL37 ribosomal protein L37 -0.0129417
RPS27 ribosomal protein S27 -0.0126334
CDC27 cell division cycle 27 -0.0123102
RAB6A RAB6A, member RAS oncogene family -0.0122967
RPL7A ribosomal protein L7a -0.0119856
ITSN2 intersectin 2 -0.0119485