Alpelisib_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Alpelisib perturbation in SW 1088 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Alpelisib_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.139487
TGFBI transforming growth factor, beta-induced, 68kDa 0.138326
FNDC3B fibronectin type III domain containing 3B 0.084152
NRXN3 neurexin 3 0.0746897
CANX calnexin 0.0671423
FN1 fibronectin 1 0.06422
MYH9 myosin, heavy chain 9, non-muscle 0.0631346
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0608937
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0607395
KYNU kynureninase 0.0598828
EXT1 exostosin glycosyltransferase 1 0.0595642
PRELID2 PRELI domain containing 2 0.057887
ATXN1 ataxin 1 0.0488654
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0484448
EGFR epidermal growth factor receptor 0.047807
HIP1 huntingtin interacting protein 1 0.0475908
SOD2 superoxide dismutase 2, mitochondrial 0.0475235
COL5A1 collagen, type V, alpha 1 0.0455254
ERRFI1 ERBB receptor feedback inhibitor 1 0.0455081
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0452753
SMAD3 SMAD family member 3 0.0440198
EXOC4 exocyst complex component 4 0.0439052
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0433186
ZBTB20 zinc finger and BTB domain containing 20 0.0431274
TRIO trio Rho guanine nucleotide exchange factor 0.0417452
HOOK2 hook microtubule-tethering protein 2 0.0412122
CALR calreticulin 0.0386511
GLIS3 GLIS family zinc finger 3 0.037881
ZSWIM6 zinc finger, SWIM-type containing 6 0.0377694
ECE1 endothelin converting enzyme 1 0.0374409
GOLGB1 golgin B1 0.0361255
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0354748
TIMP3 TIMP metallopeptidase inhibitor 3 0.0351311
ARRDC3 arrestin domain containing 3 0.0347166
HMGA2 high mobility group AT-hook 2 0.0337667
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0330101
LDHA lactate dehydrogenase A 0.032905
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.032827
GSE1 Gse1 coiled-coil protein 0.0328143
SEPTIN9 septin 9 0.0327247
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0323718
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0321245
MACF1 microtubule-actin crosslinking factor 1 0.0319939
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0319345
PTK2 protein tyrosine kinase 2 0.0316115
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0316026
RUNX1 runt-related transcription factor 1 0.0311475
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0308948
ALK anaplastic lymphoma receptor tyrosine kinase 0.0306197
APLP2 amyloid beta (A4) precursor-like protein 2 0.0305581
SETBP1 SET binding protein 1 0.0300972
AHNAK AHNAK nucleoprotein 0.0300941
DPYD dihydropyrimidine dehydrogenase 0.0299807
MEF2A myocyte enhancer factor 2A 0.0293904
ARB2A ARB2 cotranscriptional regulator A 0.0292382
VEGFC vascular endothelial growth factor C 0.0291291
WNT5A wingless-type MMTV integration site family, member 5A 0.0290831
ZMIZ1 zinc finger, MIZ-type containing 1 0.0288126
FBXL7 F-box and leucine-rich repeat protein 7 0.0288095
FLNA filamin A, alpha 0.0282764
ANXA2 annexin A2 0.0282727
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0275991
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0275882
CD44 CD44 molecule (Indian blood group) 0.0274083
TENT2 terminal nucleotidyltransferase 2 0.0272556
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0272182
NCOR2 nuclear receptor corepressor 2 0.0270861
DNAH11 dynein, axonemal, heavy chain 11 0.0269066
MBD5 methyl-CpG binding domain protein 5 0.026742
BBS9 Bardet-Biedl syndrome 9 0.0265187
MYO9A myosin IXA 0.026422
ANO6 anoctamin 6 0.0262539
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0259653
IL6ST interleukin 6 signal transducer 0.0257063
PSD3 pleckstrin and Sec7 domain containing 3 0.0254155
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0251811
STARD13 StAR-related lipid transfer (START) domain containing 13 0.0251003
MBNL2 muscleblind-like splicing regulator 2 0.0250599
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.024658
EXOC6B exocyst complex component 6B 0.0245476
IQGAP1 IQ motif containing GTPase activating protein 1 0.0243417
FAT1 FAT atypical cadherin 1 0.0243397
ABLIM3 actin binding LIM protein family, member 3 0.0242004
SYNGAP1 synaptic Ras GTPase activating protein 1 0.0237622
DSCAM Down syndrome cell adhesion molecule 0.023536
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0232587
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.023244
FNIP1 folliculin interacting protein 1 0.0232233
ZNF638 zinc finger protein 638 0.0231212
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0230384
MYO10 myosin X 0.0229476
TNIP1 TNFAIP3 interacting protein 1 0.0227678
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0225876
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0225175
PTPRM protein tyrosine phosphatase, receptor type, M 0.0224688
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0221826
BTBD9 BTB (POZ) domain containing 9 0.0220357
MPRIP myosin phosphatase Rho interacting protein 0.0216639
HIPK2 homeodomain interacting protein kinase 2 0.0216266
METTL15 methyltransferase like 15 0.0215849

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.31272
MT2A metallothionein 2A -0.212115
VIM vimentin -0.141013
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.140966
FTL ferritin, light polypeptide -0.0978819
HLA-B major histocompatibility complex, class I, B -0.0954906
MT1X metallothionein 1X -0.0828695
PTMA prothymosin, alpha -0.078928
COL1A1 collagen, type I, alpha 1 -0.077528
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0695183
EIF1 eukaryotic translation initiation factor 1 -0.0578081
RPL35A ribosomal protein L35a -0.0526506
RPL28 ribosomal protein L28 -0.0471218
RPS6 ribosomal protein S6 -0.0469466
COL1A2 collagen, type I, alpha 2 -0.0463407
S100A9 S100 calcium binding protein A9 -0.0449323
HLA-C major histocompatibility complex, class I, C -0.0445641
POTEF POTE ankyrin domain family, member F -0.044455
S100A10 S100 calcium binding protein A10 -0.0444498
TPT1 tumor protein, translationally-controlled 1 -0.0444232
RPL34 ribosomal protein L34 -0.0429536
LOC112694756 uncharaterized LOC112694756 -0.041816
RPLP1 ribosomal protein, large, P1 -0.0416379
S100A6 S100 calcium binding protein A6 -0.0395239
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0395145
GARS1 glycyl-tRNA synthetase 1 -0.0387888
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0386981
IGFBP7 insulin-like growth factor binding protein 7 -0.0380816
GNAS GNAS complex locus -0.0362832
COL6A2 collagen, type VI, alpha 2 -0.0359115
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0353343
HLA-A major histocompatibility complex, class I, A -0.0349037
KMT2E lysine (K)-specific methyltransferase 2E -0.0325734
CST3 cystatin C -0.0323767
B2M beta-2-microglobulin -0.0322282
CAVIN1 caveolae associated protein 1 -0.0322187
ELL2 elongation factor, RNA polymerase II, 2 -0.031902
PDIA3 protein disulfide isomerase family A, member 3 -0.0310193
HILPDA hypoxia inducible lipid droplet-associated -0.0307396
RPS23 ribosomal protein S23 -0.0299824
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0290852
RHEB Ras homolog enriched in brain -0.0289533
ARF1 ADP-ribosylation factor 1 -0.0285331
ACTG1 actin gamma 1 -0.0281259
PRSS23 protease, serine, 23 -0.0277587
H3-3B H3.3 histone B -0.0274239
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0268483
RPL36A ribosomal protein L36a -0.0267876
RPS19 ribosomal protein S19 -0.0258989
RPLP2 ribosomal protein, large, P2 -0.0257514
RPL11 ribosomal protein L11 -0.0253762
RPL31 ribosomal protein L31 -0.0253082
AKAP12 A kinase (PRKA) anchor protein 12 -0.0251443
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0249091
TENT5A terminal nucleotidyltransferase 5A -0.024722
RTN4 reticulon 4 -0.0242387
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0236889
CD63 CD63 molecule -0.0236068
CCNI cyclin I -0.0232772
WSB1 WD repeat and SOCS box containing 1 -0.0232571
BSG basigin (Ok blood group) -0.0226196
MATR3 matrin 3 -0.0225731
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0225301
UGCG UDP-glucose ceramide glucosyltransferase -0.0225082
PDE4D phosphodiesterase 4D, cAMP-specific -0.0224718
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0224439
PKM pyruvate kinase, muscle -0.0222962
COL6A1 collagen, type VI, alpha 1 -0.0217758
SEC61G Sec61 gamma subunit -0.0216326
HMGB1 high mobility group box 1 -0.0214091
EGR1 early growth response 1 -0.0213908
RPS21 ribosomal protein S21 -0.0213068
RPL7A ribosomal protein L7a -0.0212534
RPL37A ribosomal protein L37a -0.0212272
EHD2 EH-domain containing 2 -0.021114
RPS24 ribosomal protein S24 -0.0208661
RPS5 ribosomal protein S5 -0.0206809
RPL36 ribosomal protein L36 -0.0205884
SERF2 small EDRK-rich factor 2 -0.0205344
CBX3 chromobox homolog 3 -0.0205329
RSRC2 arginine/serine-rich coiled-coil 2 -0.0204733
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0203418
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0198926
RPL8 ribosomal protein L8 -0.0197328
SDC4 syndecan 4 -0.0197177
MYL12B myosin, light chain 12B, regulatory -0.019643
INHBA inhibin, beta A -0.0196419
SCFD2 sec1 family domain containing 2 -0.0195364
RPS12 ribosomal protein S12 -0.0195287
TMEM165 transmembrane protein 165 -0.0193588
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0193164
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0193086
TBCA tubulin folding cofactor A -0.0192685
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0192193
TMSB4X thymosin beta 4, X-linked -0.0190961
RBM39 RNA binding motif protein 39 -0.0187652
RPL12 ribosomal protein L12 -0.0186587
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0183758
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0182791
UBC ubiquitin C -0.018217