| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Alpelisib perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Alpelisib_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.139365 |
| FNDC3B | fibronectin type III domain containing 3B | 0.133393 |
| LDHA | lactate dehydrogenase A | 0.127482 |
| SQSTM1 | sequestosome 1 | 0.107768 |
| PRKCA | protein kinase C, alpha | 0.0998644 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0888321 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.085776 |
| DST | dystonin | 0.0840141 |
| SMAD3 | SMAD family member 3 | 0.0803167 |
| SVIL | supervillin | 0.0789412 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0731814 |
| ANXA2 | annexin A2 | 0.0719658 |
| CD44 | CD44 molecule (Indian blood group) | 0.0714117 |
| ATXN1 | ataxin 1 | 0.0650926 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0631771 |
| AHNAK | AHNAK nucleoprotein | 0.0614658 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0605459 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0592476 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0580367 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0577081 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0576955 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0561588 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0551053 |
| PKM | pyruvate kinase, muscle | 0.0537643 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0535275 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0523747 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0515916 |
| ENO1 | enolase 1, (alpha) | 0.0509597 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0502759 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.0495324 |
| PTK2 | protein tyrosine kinase 2 | 0.0483863 |
| MAP1B | microtubule-associated protein 1B | 0.0479864 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.047698 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.047231 |
| CALR | calreticulin | 0.0464896 |
| TPI1 | triosephosphate isomerase 1 | 0.0460223 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0452633 |
| ANXA1 | annexin A1 | 0.0436568 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0430947 |
| INTS6 | integrator complex subunit 6 | 0.0430054 |
| MYOF | myoferlin | 0.0425192 |
| CANX | calnexin | 0.0422685 |
| SEPTIN9 | septin 9 | 0.0408808 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0403644 |
| RUNX1 | runt-related transcription factor 1 | 0.0400044 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0394237 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0394151 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0393694 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0382432 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0381789 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0377243 |
| PRSS23 | protease, serine, 23 | 0.0377201 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.0376933 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0367437 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0362793 |
| ITGA6 | integrin, alpha 6 | 0.0361341 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0361249 |
| PCBP2 | poly(rC) binding protein 2 | 0.0360596 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0354132 |
| ANO6 | anoctamin 6 | 0.0352651 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.034629 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.034628 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0345992 |
| ABR | active BCR-related | 0.0339787 |
| EMP1 | epithelial membrane protein 1 | 0.0338264 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.033558 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.0331523 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0328867 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0323999 |
| ANGPTL4 | angiopoietin-like 4 | 0.0315966 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0315322 |
| EZR | ezrin | 0.031457 |
| WWOX | WW domain containing oxidoreductase | 0.0314138 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.031303 |
| FMNL2 | formin-like 2 | 0.0311052 |
| SKIL | SKI-like proto-oncogene | 0.0310113 |
| CEP250 | centrosomal protein 250kDa | 0.0308986 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.030884 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0308065 |
| USO1 | USO1 vesicle transport factor | 0.0306171 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.030578 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0305315 |
| ADM | adrenomedullin | 0.030495 |
| RAI14 | retinoic acid induced 14 | 0.0298791 |
| PLEC | plectin | 0.029829 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0296927 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0293994 |
| UTRN | utrophin | 0.0293421 |
| SCAPER | S-phase cyclin A-associated protein in the ER | 0.0292393 |
| RAD51B | RAD51 paralog B | 0.0292055 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0287082 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0284021 |
| BRD2 | bromodomain containing 2 | 0.0282658 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0280647 |
| HLA-A | major histocompatibility complex, class I, A | 0.0276198 |
| NAV2 | neuron navigator 2 | 0.0272397 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0271929 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0269404 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0267806 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0266844 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0831631 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.076845 |
| TMSB10 | thymosin beta 10 | -0.0717274 |
| GOLGA4 | golgin A4 | -0.0676468 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0580041 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0533003 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | -0.0508404 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0477105 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.047635 |
| RPL4 | ribosomal protein L4 | -0.0467733 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0464107 |
| SMC5 | structural maintenance of chromosomes 5 | -0.0427983 |
| NDRG1 | N-myc downstream regulated 1 | -0.0426976 |
| DIAPH3 | diaphanous-related formin 3 | -0.0423316 |
| ZNF292 | zinc finger protein 292 | -0.0415877 |
| TMEM263 | transmembrane protein 263 | -0.0394045 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0388776 |
| ACTG1 | actin gamma 1 | -0.0386784 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0385087 |
| NKTR | natural killer cell triggering receptor | -0.0384568 |
| OSMR | oncostatin M receptor | -0.0383461 |
| RBM39 | RNA binding motif protein 39 | -0.0376592 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.037552 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0365635 |
| RPLP2 | ribosomal protein, large, P2 | -0.0359493 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0357438 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | -0.0354186 |
| KIAA1958 | KIAA1958 | -0.0352132 |
| TPX2 | TPX2, microtubule-associated | -0.0347676 |
| RPS6 | ribosomal protein S6 | -0.0345917 |
| USP34 | ubiquitin specific peptidase 34 | -0.0343462 |
| RPL35A | ribosomal protein L35a | -0.0327384 |
| RPL32 | ribosomal protein L32 | -0.0326131 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0323328 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0323088 |
| SGO2 | shugoshin 2 | -0.0322081 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | -0.0318634 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0318183 |
| RPL37A | ribosomal protein L37a | -0.031785 |
| ATM | ATM serine/threonine kinase | -0.0316712 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0316535 |
| GPC6 | glypican 6 | -0.0311434 |
| SEC24A | SEC24 family member A | -0.0308473 |
| PIAS1 | protein inhibitor of activated STAT, 1 | -0.030644 |
| CEP295 | centrosomal protein 295kDa | -0.0306278 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0304573 |
| BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide | -0.0300114 |
| COG5 | component of oligomeric golgi complex 5 | -0.0296496 |
| NUP214 | nucleoporin 214kDa | -0.0292888 |
| UBAC2 | UBA domain containing 2 | -0.0292146 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0292036 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0291753 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0289906 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0288728 |
| GOLGA3 | golgin A3 | -0.0288613 |
| PSMD5 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 | -0.0284833 |
| RBM33 | RNA binding motif protein 33 | -0.0283971 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0282244 |
| MED13L | mediator complex subunit 13-like | -0.0280926 |
| EXOC6B | exocyst complex component 6B | -0.0276784 |
| CKAP2 | cytoskeleton associated protein 2 | -0.0273962 |
| NALCN | sodium leak channel, non selective | -0.0273961 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0273806 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -0.0270763 |
| ANO10 | anoctamin 10 | -0.027032 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.026816 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0267634 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0266136 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0264227 |
| CD2AP | CD2-associated protein | -0.0263939 |
| CEP95 | centrosomal protein 95kDa | -0.0259609 |
| RPS25 | ribosomal protein S25 | -0.0258981 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0258349 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | -0.0258194 |
| PHIP | pleckstrin homology domain interacting protein | -0.0258078 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0256863 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0255931 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0254851 |
| CFDP1 | craniofacial development protein 1 | -0.0254719 |
| CALU | calumenin | -0.0253607 |
| RRBP1 | ribosome binding protein 1 | -0.0253325 |
| HELZ | helicase with zinc finger | -0.0252394 |
| ARF1 | ADP-ribosylation factor 1 | -0.0251123 |
| SCAF8 | SR-related CTD-associated factor 8 | -0.0250913 |
| RFX7 | regulatory factor X, 7 | -0.0250764 |
| YBX3 | Y box binding protein 3 | -0.0249332 |
| TUT4 | terminal uridylyl transferase 4 | -0.0248942 |
| MKI67 | marker of proliferation Ki-67 | -0.0248531 |
| SKIC3 | SKI3 subunit of superkiller complex | -0.0248485 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0247882 |
| KIAA1328 | KIAA1328 | -0.0245279 |
| PHF14 | PHD finger protein 14 | -0.0244953 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0243942 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0243876 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0243525 |
| PCNX4 | pecanex 4 | -0.0243154 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0242667 |
| TTK | TTK protein kinase | -0.0242472 |
| NEMF | nuclear export mediator factor | -0.0241074 |
| H3-3B | H3.3 histone B | -0.0240126 |
