Alpelisib_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Alpelisib perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Alpelisib_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.11937
EXT1 exostosin glycosyltransferase 1 0.103962
ZSWIM6 zinc finger, SWIM-type containing 6 0.0782177
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0739358
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0729814
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0717667
FNDC3B fibronectin type III domain containing 3B 0.0708923
CANX calnexin 0.0697803
ASPH aspartate beta-hydroxylase 0.069112
ANKRD28 ankyrin repeat domain 28 0.0643752
APLP2 amyloid beta (A4) precursor-like protein 2 0.0597664
SVIL supervillin 0.0580199
SMAD3 SMAD family member 3 0.0574206
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.054517
SEPTIN9 septin 9 0.0528767
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0524972
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0513553
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0457652
TXNIP thioredoxin interacting protein 0.0455142
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0452
RICTOR RPTOR independent companion of MTOR, complex 2 0.0443227
MBNL1 muscleblind-like splicing regulator 1 0.0435543
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0433419
FAT1 FAT atypical cadherin 1 0.0414866
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0412701
DSCAM Down syndrome cell adhesion molecule 0.040387
PTK2 protein tyrosine kinase 2 0.0402775
EMP1 epithelial membrane protein 1 0.0392592
NPAS2 neuronal PAS domain protein 2 0.0390197
LTBP1 latent transforming growth factor beta binding protein 1 0.0381432
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0380525
SFTPA2 surfactant protein A2 0.0373989
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0345764
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0345468
ATXN1 ataxin 1 0.0339998
ATF6 activating transcription factor 6 0.0339475
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.032977
SIK3 SIK family kinase 3 0.0325023
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 0.0323215
ELL2 elongation factor, RNA polymerase II, 2 0.0320791
INTS6 integrator complex subunit 6 0.0320003
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0317625
NAMPT nicotinamide phosphoribosyltransferase 0.031454
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0314533
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0302478
SMYD3 SET and MYND domain containing 3 0.0301038
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0300007
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0299892
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0298567
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0294362
YBX3 Y box binding protein 3 0.0293204
GPATCH2L G patch domain containing 2-like 0.02927
MT2A metallothionein 2A 0.0291594
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0288746
WAC WW domain containing adaptor with coiled-coil 0.0288742
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0287093
AFF1 AF4/FMR2 family, member 1 0.0286282
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0285761
PCBP2 poly(rC) binding protein 2 0.0283775
TOP1 topoisomerase (DNA) I 0.0278004
SHB Src homology 2 domain containing adaptor protein B 0.0277997
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0267536
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0265519
RNF145 ring finger protein 145 0.0265114
SUCO SUN domain containing ossification factor 0.0264128
COPA coatomer protein complex, subunit alpha 0.0261129
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0261051
ABLIM1 actin binding LIM protein 1 0.0259356
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0252194
CTBP2 C-terminal binding protein 2 0.0241166
IL6ST interleukin 6 signal transducer 0.0240198
HELZ helicase with zinc finger 0.0238898
SIRT1 sirtuin 1 0.0237707
EPS8 epidermal growth factor receptor pathway substrate 8 0.0235532
SGMS2 sphingomyelin synthase 2 0.0234479
CXCL8 chemokine (C-X-C motif) ligand 8 0.0234134
FNDC3A fibronectin type III domain containing 3A 0.0226742
CLIP2 CAP-GLY domain containing linker protein 2 0.0225847
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0225659
ADAM17 ADAM metallopeptidase domain 17 0.022349
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0220759
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0220349
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0220107
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0218608
NXN nucleoredoxin 0.0217981
AHR aryl hydrocarbon receptor 0.0217823
AGO2 argonaute RISC catalytic component 2 0.0217588
AKAP13 A kinase (PRKA) anchor protein 13 0.0214563
EREG epiregulin 0.0210205
HSPA8 heat shock 70kDa protein 8 0.0208321
TENT2 terminal nucleotidyltransferase 2 0.0207926
PDLIM5 PDZ and LIM domain 5 0.020742
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.020461
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.0203857
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0203068
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0202003
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0200995
PELI1 pellino E3 ubiquitin protein ligase 1 0.0200973
MYO10 myosin X 0.0199911
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0199671

decreased expression

Symbol Name Standardized Value
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.244454
TMSB10 thymosin beta 10 -0.0924739
HMGA2 high mobility group AT-hook 2 -0.0838476
NRG1 neuregulin 1 -0.0779496
HLA-B major histocompatibility complex, class I, B -0.0748784
PTMA prothymosin, alpha -0.0746553
TPT1 tumor protein, translationally-controlled 1 -0.0713742
SOX4 SRY (sex determining region Y)-box 4 -0.0702839
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0701919
FTL ferritin, light polypeptide -0.0638708
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0611696
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0547151
ACTG1 actin gamma 1 -0.0498032
TMSB4X thymosin beta 4, X-linked -0.0470812
SQSTM1 sequestosome 1 -0.0451867
NDRG1 N-myc downstream regulated 1 -0.0449843
S100A6 S100 calcium binding protein A6 -0.0437849
FN1 fibronectin 1 -0.0421002
PLIN2 perilipin 2 -0.0417547
RPL35A ribosomal protein L35a -0.0393313
IFI27 interferon, alpha-inducible protein 27 -0.0365946
TMEM165 transmembrane protein 165 -0.0356537
RAI14 retinoic acid induced 14 -0.0336133
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0329112
RPL31 ribosomal protein L31 -0.0320825
AKAP12 A kinase (PRKA) anchor protein 12 -0.0318132
ZMYND8 zinc finger, MYND-type containing 8 -0.0313889
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0307652
RPL37A ribosomal protein L37a -0.0296145
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0287459
MRPS6 mitochondrial ribosomal protein S6 -0.0277021
ITGA1 integrin, alpha 1 -0.0267907
RPS29 ribosomal protein S29 -0.0267089
IGFBP3 insulin-like growth factor binding protein 3 -0.0262934
FAM20C family with sequence similarity 20, member C -0.0253921
KLHL5 kelch-like family member 5 -0.0252746
HLA-A major histocompatibility complex, class I, A -0.0251255
SOS1 son of sevenless homolog 1 (Drosophila) -0.0245597
SYT1 synaptotagmin I -0.0244326
RPL38 ribosomal protein L38 -0.0243385
NPC1 Niemann-Pick disease, type C1 -0.024135
IER3 immediate early response 3 -0.024043
OSMR oncostatin M receptor -0.0237732
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0237057
GNAS GNAS complex locus -0.0235305
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0235135
DNAH5 dynein, axonemal, heavy chain 5 -0.0226963
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0219467
RPS27A ribosomal protein S27a -0.0217427
VIM vimentin -0.0213321
EIF1 eukaryotic translation initiation factor 1 -0.0210485
LAMB3 laminin, beta 3 -0.0210414
RPS21 ribosomal protein S21 -0.0207136
CTSD cathepsin D -0.0205515
RPL9 ribosomal protein L9 -0.0204761
RRBP1 ribosome binding protein 1 -0.0202681
RPS6 ribosomal protein S6 -0.019963
TAS2R14 taste receptor, type 2, member 14 -0.0199259
EFNA5 ephrin-A5 -0.0193659
RPS24 ribosomal protein S24 -0.0193643
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0192111
RPL26 ribosomal protein L26 -0.0191958
HPCAL1 hippocalcin-like 1 -0.0191674
SLC35F3 solute carrier family 35, member F3 -0.0191358
ENO1 enolase 1, (alpha) -0.0188678
FRMD4A FERM domain containing 4A -0.0188075
ENO2 enolase 2 (gamma, neuronal) -0.0186956
LOC102724023 ES1 protein homolog, mitochondrial -0.0181956
RPS8 ribosomal protein S8 -0.0177263
IGFBP5 insulin-like growth factor binding protein 5 -0.0173294
RPL37 ribosomal protein L37 -0.0172865
FAM114A1 family with sequence similarity 114, member A1 -0.0171914
CADM1 cell adhesion molecule 1 -0.0171541
S100A9 S100 calcium binding protein A9 -0.0171233
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.017094
GLIS3 GLIS family zinc finger 3 -0.0169953
SMOX spermine oxidase -0.0169869
AOPEP aminopeptidase O (putative) -0.0167982
CP ceruloplasmin (ferroxidase) -0.0167037
SFRP1 secreted frizzled-related protein 1 -0.0166489
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0163705
WSB1 WD repeat and SOCS box containing 1 -0.0161318
TM4SF1 transmembrane 4 L six family member 1 -0.0160339
NT5C2 5'-nucleotidase, cytosolic II -0.0159669
IFI16 interferon, gamma-inducible protein 16 -0.0157157
RPS3 ribosomal protein S3 -0.015621
RPL11 ribosomal protein L11 -0.0155899
RPL36 ribosomal protein L36 -0.0155527
RPL34 ribosomal protein L34 -0.0155352
RTN4 reticulon 4 -0.0154684
RUNX2 runt-related transcription factor 2 -0.0154001
S100A10 S100 calcium binding protein A10 -0.015367
RPS25 ribosomal protein S25 -0.015148
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0150978
NAV1 neuron navigator 1 -0.0149912
IL6 interleukin 6 -0.014989
SREBF2 sterol regulatory element binding transcription factor 2 -0.0149578
RPLP2 ribosomal protein, large, P2 -0.0148403
CD163L1 CD163 molecule-like 1 -0.0141738
GADD45A growth arrest and DNA-damage-inducible, alpha -0.0141529