Alpha DNA polymerase:primase complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025
Category structural or functional annotations
Type cellular component
Description A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which catalyzes the synthesis of an RNA primer on the lagging strand of replicating DNA; the smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis. (Gene Ontology, GO_0005658)
External Link http://amigo.geneontology.org/amigo/term/GO:0005658
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Genes

248 proteins co-occuring with the Alpha DNA polymerase:primase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

Symbol Name Standardized Value
PRIM2 primase, DNA, polypeptide 2 (58kDa) 2.462
CTC1 CTS telomere maintenance complex component 1 2.414
MCM10 minichromosome maintenance complex component 10 2.376
WDHD1 WD repeat and HMG-box DNA binding protein 1 2.346
PRIM1 primase, DNA, polypeptide 1 (49kDa) 2.272
TEN1 TEN1 CST complex subunit 2.27
STN1 STN1 subunit of CST complex 2.22
CDC45 cell division cycle 45 2.179
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 2.155
POLR1A polymerase (RNA) I polypeptide A, 194kDa 2.123
POLA2 polymerase (DNA directed), alpha 2, accessory subunit 2.064
PRIMPOL primase and polymerase (DNA-directed) 2.035
PCNA proliferating cell nuclear antigen 1.999
POLR1B polymerase (RNA) I polypeptide B, 128kDa 1.981
RPA3 replication protein A3, 14kDa 1.967
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 1.908
DNA2 DNA replication helicase/nuclease 2 1.877
TIPIN TIMELESS interacting protein 1.849
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 1.841
RTEL1 regulator of telomere elongation helicase 1 1.836
MCM7 minichromosome maintenance complex component 7 1.8
GINS4 GINS complex subunit 4 (Sld5 homolog) 1.787
FEN1 flap structure-specific endonuclease 1 1.785
PIF1 PIF1 5'-to-3' DNA helicase 1.739
MCM5 minichromosome maintenance complex component 5 1.732
CDC6 cell division cycle 6 1.731
HELB helicase (DNA) B 1.674
ANXA6 annexin A6 1.655
DBF4 DBF4 zinc finger 1.654
CDT1 chromatin licensing and DNA replication factor 1 1.65
MCM3 minichromosome maintenance complex component 3 1.626
RAD52 RAD52 homolog (S. cerevisiae) 1.612
POLE4 polymerase (DNA-directed), epsilon 4, accessory subunit 1.608
MCM4 minichromosome maintenance complex component 4 1.567
MCM6 minichromosome maintenance complex component 6 1.538
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit 1.537
POT1 protection of telomeres 1 1.536
LRIF1 ligand dependent nuclear receptor interacting factor 1 1.523
GINS3 GINS complex subunit 3 (Psf3 homolog) 1.517
TOPBP1 topoisomerase (DNA) II binding protein 1 1.493
ACD adrenocortical dysplasia homolog (mouse) 1.479
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 1.475
EXO1 exonuclease 1 1.47
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 1.447
POLE polymerase (DNA directed), epsilon, catalytic subunit 1.434
ATAD5 ATPase family, AAA domain containing 5 1.419
SSBP1 single-stranded DNA binding protein 1, mitochondrial 1.419
TP53BP1 tumor protein p53 binding protein 1 1.405
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 1.404
IZUMO1 izumo sperm-egg fusion 1 1.396
CLSPN claspin 1.39
POLL polymerase (DNA directed), lambda 1.367
CCNA1 cyclin A1 1.365
CCNA2 cyclin A2 1.365
TENT4A terminal nucleotidyltransferase 4A 1.364
TOP1MT topoisomerase (DNA) I, mitochondrial 1.363
WRN Werner syndrome, RecQ helicase-like 1.347
RAD51 RAD51 recombinase 1.341
TIMELESS timeless circadian clock 1.335
ERCC2 excision repair cross-complementation group 2 1.327
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 1.286
RAD50 RAD50 homolog (S. cerevisiae) 1.286
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 1.267
CDK2 cyclin-dependent kinase 2 1.265
MTBP MDM2 binding protein 1.242
CHEK1 checkpoint kinase 1 1.236
CCDC93 coiled-coil domain containing 93 1.231
ATM ATM serine/threonine kinase 1.22
TOP1 topoisomerase (DNA) I 1.203
GINS1 GINS complex subunit 1 (Psf1 homolog) 1.196
TICRR TOPBP1-interacting checkpoint and replication regulator 1.19
BRIP1 BRCA1 interacting protein C-terminal helicase 1 1.189
RFC3 replication factor C (activator 1) 3, 38kDa 1.163
CIAPIN1 cytokine induced apoptosis inhibitor 1 1.161
ORC5 origin recognition complex, subunit 5 1.146
BRCA1 breast cancer 1, early onset 1.134
CIAO3 cytosolic iron-sulfur assembly component 3 1.123
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) 1.117
CCDC22 coiled-coil domain containing 22 1.111
NTHL1 nth endonuclease III-like 1 (E. coli) 1.101
CHEK2 checkpoint kinase 2 1.098
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 1.094
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 1.092
TP53 tumor protein p53 1.089
BUB1 BUB1 mitotic checkpoint serine/threonine kinase 1.085
RFC4 replication factor C (activator 1) 4, 37kDa 1.082
DONSON downstream neighbor of SON 1.075
SEM1 SEM1 26S proteasome subunit 1.066
RECQL4 RecQ protein-like 4 1.062
SCAI suppressor of cancer cell invasion 1.06
PDK3 pyruvate dehydrogenase kinase, isozyme 3 1.06
BRCA2 breast cancer 2, early onset 1.059
DCLRE1B DNA cross-link repair 1B 1.056
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) 1.043
SHLD3 shieldin complex subunit 3 1.038
CDCA5 cell division cycle associated 5 1.027
REV1 REV1, polymerase (DNA directed) 1.022
POLH polymerase (DNA directed), eta 1.017
CCDC169-SOHLH2 CCDC169-SOHLH2 readthrough 0.997
RAD18 RAD18 E3 ubiquitin protein ligase 0.992
CDC7 cell division cycle 7 0.979
PDHX pyruvate dehydrogenase complex, component X 0.967
RECQL RecQ helicase-like 0.961
ASTE1 asteroid homolog 1 (Drosophila) 0.96
POLDIP3 polymerase (DNA-directed), delta interacting protein 3 0.957
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) 0.946
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 0.946
SEPTIN7 septin 7 0.944
MSMB microseminoprotein, beta- 0.937
XPA xeroderma pigmentosum, complementation group A 0.933
POLD2 polymerase (DNA directed), delta 2, accessory subunit 0.929
MRC1 mannose receptor, C type 1 0.909
CIAO2A cytosolic iron-sulfur assembly component 2A 0.905
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.901
MUS81 MUS81 structure-specific endonuclease subunit 0.892
ERCC1 excision repair cross-complementation group 1 0.889
CRCT1 cysteine-rich C-terminal 1 0.884
CLCC1 chloride channel CLIC-like 1 0.867
SDE2 SDE2 telomere maintenance homolog (S. pombe) 0.858
SLX4 SLX4 structure-specific endonuclease subunit 0.856
TCHP trichoplein, keratin filament binding 0.855
RAD54B RAD54 homolog B (S. cerevisiae) 0.85
TPTE2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 0.843
CNFN cornifelin 0.84
FANCM Fanconi anemia, complementation group M 0.832
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase 0.831
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.83
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 0.821
TTK TTK protein kinase 0.82
ORC6 origin recognition complex, subunit 6 0.805
PXMP4 peroxisomal membrane protein 4, 24kDa 0.801
RBBP8 retinoblastoma binding protein 8 0.798
SHF Src homology 2 domain containing F 0.794
GANAB glucosidase, alpha; neutral AB 0.792
RFC2 replication factor C (activator 1) 2, 40kDa 0.789
SMC3 structural maintenance of chromosomes 3 0.788
CDK1 cyclin-dependent kinase 1 0.782
ABHD11 abhydrolase domain containing 11 0.781
NEK2 NIMA-related kinase 2 0.781
RNF168 ring finger protein 168, E3 ubiquitin protein ligase 0.781
CNTN2 contactin 2 (axonal) 0.776
ZRANB3 zinc finger, RAN-binding domain containing 3 0.774
GEN1 GEN1 Holliday junction 5' flap endonuclease 0.772
UNG uracil-DNA glycosylase 0.769
TERT telomerase reverse transcriptase 0.768
TERB2 telomere repeat binding bouquet formation protein 2 0.758
SDSL serine dehydratase-like 0.749
UBR1 ubiquitin protein ligase E3 component n-recognin 1 0.739
WEE1 WEE1 G2 checkpoint kinase 0.737
USP51 ubiquitin specific peptidase 51 0.731
ANKHD1 ankyrin repeat and KH domain containing 1 0.73
ANKRD17 ankyrin repeat domain 17 0.728
POLM polymerase (DNA directed), mu 0.716
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 0.711
HLTF helicase-like transcription factor 0.71
MUTYH mutY homolog 0.707
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1 0.706
TMEM107 transmembrane protein 107 0.705
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 0.703
TOMM70 translocase of outer mitochondrial membrane 70 0.698
CIAO2B cytosolic iron-sulfur assembly component 2B 0.691
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 0.689
MRGBP MRG/MORF4L binding protein 0.687
MAJIN membrane anchored junction protein 0.682
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 0.68
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 0.674
SHLD2 shieldin complex subunit 2 0.674
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 0.669
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.668
SH2D3A SH2 domain containing 3A 0.66
EPC1 enhancer of polycomb homolog 1 (Drosophila) 0.658
USP26 ubiquitin specific peptidase 26 0.657
WAPL WAPL cohesin release factor 0.653
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 0.652
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase 0.649
AGXT2 alanine--glyoxylate aminotransferase 2 0.648
MED29 mediator complex subunit 29 0.646
MYB v-myb avian myeloblastosis viral oncogene homolog 0.638
PGA4 pepsinogen 4, group I (pepsinogen A) 0.637
ERCC6 excision repair cross-complementation group 6 0.636
DNAH8 dynein, axonemal, heavy chain 8 0.635
EME1 essential meiotic structure-specific endonuclease 1 0.633
PPP2R5B protein phosphatase 2, regulatory subunit B', beta 0.629
CIAO1 cytosolic iron-sulfur assembly component 1 0.627
FHIT fragile histidine triad 0.627
WWOX WW domain containing oxidoreductase 0.627
FXN frataxin 0.625
TERB1 telomere repeat binding bouquet formation protein 1 0.625
PGA3 pepsinogen 3, group I (pepsinogen A) 0.623
WRNIP1 Werner helicase interacting protein 1 0.615
USP1 ubiquitin specific peptidase 1 0.615
SOX12 SRY (sex determining region Y)-box 12 0.607
EXOG endo/exonuclease (5'-3'), endonuclease G-like 0.607
STARD7 StAR-related lipid transfer (START) domain containing 7 0.606
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.606
RNF4 ring finger protein 4 0.605
CDC27 cell division cycle 27 0.604
CCNE1 cyclin E1 0.602
SBDS Shwachman-Bodian-Diamond syndrome 0.592
MCM9 minichromosome maintenance complex component 9 0.589
SHLD1 shieldin complex subunit 1 0.586
PARP1 poly (ADP-ribose) polymerase 1 0.58
ANAPC1 anaphase promoting complex subunit 1 0.58
FBXO4 F-box protein 4 0.58
NUP43 nucleoporin 43kDa 0.577
RAD17 RAD17 homolog (S. pombe) 0.572
ZFR zinc finger RNA binding protein 0.571
ATRIP ATR interacting protein 0.57
CCNY cyclin Y 0.569
NUBP2 nucleotide binding protein 2 0.569
NUP58 nucleoporin 58 0.568
USP46 ubiquitin specific peptidase 46 0.568
PPP4R3B protein phosphatase 4 regulatory subunit 3B 0.566
CLYBL citrate lyase beta like 0.564
FSBP fibrinogen silencer binding protein 0.563
SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 0.559
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 0.552
USP12 ubiquitin specific peptidase 12 0.547
GTSE1 G-2 and S-phase expressed 1 0.547
ERCC3 excision repair cross-complementation group 3 0.546
BABAM1 BRISC and BRCA1 A complex member 1 0.546
MKRN1 makorin ring finger protein 1 0.545
MOAP1 modulator of apoptosis 1 0.544
ZBED1 zinc finger, BED-type containing 1 0.544
MEAF6 MYST/Esa1-associated factor 6 0.544
KANSL1 KAT8 regulatory NSL complex subunit 1 0.543
AMT aminomethyltransferase 0.542
NFYA nuclear transcription factor Y, alpha 0.541
NTPCR nucleoside-triphosphatase, cancer-related 0.539
H2AC20 H2A clustered histone 20 0.538
H2AC19 H2A clustered histone 19 0.537
RLIM ring finger protein, LIM domain interacting 0.535
AOC2 amine oxidase, copper containing 2 (retina-specific) 0.535
TM7SF2 transmembrane 7 superfamily member 2 0.533
FBXO3 F-box protein 3 0.525
NUP37 nucleoporin 37kDa 0.524
ORC3 origin recognition complex, subunit 3 0.523
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.522
ZNF410 zinc finger protein 410 0.52
FBXO8 F-box protein 8 0.518
SPRTN SprT-like N-terminal domain 0.518
DERL3 derlin 3 0.514
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 0.51
RFC5 replication factor C (activator 1) 5, 36.5kDa 0.509
RNF8 ring finger protein 8, E3 ubiquitin protein ligase 0.507
MSH3 mutS homolog 3 0.504
MAPK1 mitogen-activated protein kinase 1 0.502
GMNN geminin, DNA replication inhibitor 0.502