Altretamine_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Altretamine perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Altretamine_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.103422
TRIO trio Rho guanine nucleotide exchange factor 0.0974919
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0974238
CDH13 cadherin 13 0.0609312
NAV1 neuron navigator 1 0.0576008
COL5A1 collagen, type V, alpha 1 0.0447207
DST dystonin 0.0440304
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0373602
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0339875
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0323656
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0314334
EGFR epidermal growth factor receptor 0.0302338
MYOF myoferlin 0.0299226
RUNX1 runt-related transcription factor 1 0.0291302
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0290621
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0249572
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0248494
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0245831
ATP13A3 ATPase type 13A3 0.0243533
MACF1 microtubule-actin crosslinking factor 1 0.0240301
SLC39A11 solute carrier family 39, member 11 0.0238808
PLAT plasminogen activator, tissue 0.0238067
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0232399
SP3 Sp3 transcription factor 0.0224837
COL8A1 collagen, type VIII, alpha 1 0.0223139
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0218947
PDE4D phosphodiesterase 4D, cAMP-specific 0.0213671
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0212359
ADAM9 ADAM metallopeptidase domain 9 0.0211563
THBS2 thrombospondin 2 0.0209839
USP34 ubiquitin specific peptidase 34 0.0206178
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0203653
NAV2 neuron navigator 2 0.0203597
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0200539
PBX3 pre-B-cell leukemia homeobox 3 0.01985
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0194183
GLS2 glutaminase 2 (liver, mitochondrial) 0.0191012
AUTS2 autism susceptibility candidate 2 0.0189083
RAD51B RAD51 paralog B 0.0180666
PODXL podocalyxin-like 0.0179217
USP9X ubiquitin specific peptidase 9, X-linked 0.0179044
MYH9 myosin, heavy chain 9, non-muscle 0.0175915
ANO6 anoctamin 6 0.0170998
ANKRD36C ankyrin repeat domain 36C 0.0169579
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0168862
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0168203
ASPH aspartate beta-hydroxylase 0.0165104
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0163369
YEATS2 YEATS domain containing 2 0.0161759
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0161744
MSN moesin 0.016049
RAI14 retinoic acid induced 14 0.0159923
AFDN afadin, adherens junction formation factor 0.0159698
NCOR2 nuclear receptor corepressor 2 0.0157167
SAMD9 sterile alpha motif domain containing 9 0.0156282
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0154863
SEPTIN9 septin 9 0.0154548
ANKRD36 ankyrin repeat domain 36 0.0153996
ITPRID2 ITPR interacting domain containing 2 0.0148885
FN1 fibronectin 1 0.0147397
EFNA5 ephrin-A5 0.0146032
SDK1 sidekick cell adhesion molecule 1 0.014441
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0143621
NCKAP1 NCK-associated protein 1 0.0142718
DIRAS3 DIRAS family, GTP-binding RAS-like 3 0.0142017
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0141733
MMP12 matrix metallopeptidase 12 0.0141281
TPM1 tropomyosin 1 (alpha) 0.0138053
MBNL1 muscleblind-like splicing regulator 1 0.0136732
ABI3BP ABI family, member 3 (NESH) binding protein 0.0136458
KDM6A lysine (K)-specific demethylase 6A 0.0135716
PRELID2 PRELI domain containing 2 0.0135096
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0134133
ELL2 elongation factor, RNA polymerase II, 2 0.0133761
TENM3 teneurin transmembrane protein 3 0.0133467
PTK2 protein tyrosine kinase 2 0.0133465
PSD3 pleckstrin and Sec7 domain containing 3 0.0132843
RNF213 ring finger protein 213 0.0132789
MTCL1 microtubule crosslinking factor 1 0.0130651
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.0130074
SUCNR1 succinate receptor 1 0.0129499
AHNAK2 AHNAK nucleoprotein 2 0.0129366
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0128928
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0128427
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 0.0127762
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0126851
DCLK2 doublecortin-like kinase 2 0.0126792
LDLRAD4 low density lipoprotein receptor class A domain containing 4 0.0123519
DSPP dentin sialophosphoprotein 0.0123185
TNS3 tensin 3 0.0120993
NBAS neuroblastoma amplified sequence 0.0120405
VEGFC vascular endothelial growth factor C 0.0120303
RNF145 ring finger protein 145 0.0118815
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0118603
E2F7 E2F transcription factor 7 0.0118425
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0116629
WDFY2 WD repeat and FYVE domain containing 2 0.0115839
FRMD4A FERM domain containing 4A 0.0115318
ZEB1 zinc finger E-box binding homeobox 1 0.0114917
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0114644

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.255949
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.255745
VIM vimentin -0.197601
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.176844
MT2A metallothionein 2A -0.142532
PTMA prothymosin, alpha -0.0886965
LMNA lamin A/C -0.0776375
CSTB cystatin B (stefin B) -0.0773882
S100A10 S100 calcium binding protein A10 -0.0746632
NDRG1 N-myc downstream regulated 1 -0.0720736
HLA-B major histocompatibility complex, class I, B -0.0653402
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0598386
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0588993
SQSTM1 sequestosome 1 -0.058644
AKAP12 A kinase (PRKA) anchor protein 12 -0.0576302
S100A6 S100 calcium binding protein A6 -0.0569138
B2M beta-2-microglobulin -0.053806
EIF1 eukaryotic translation initiation factor 1 -0.051068
LOC112694756 uncharaterized LOC112694756 -0.0483504
IFITM3 interferon induced transmembrane protein 3 -0.0465926
FTL ferritin, light polypeptide -0.0456408
UBC ubiquitin C -0.0446435
LOX lysyl oxidase -0.0439469
FTH1 ferritin, heavy polypeptide 1 -0.0410654
CD99 CD99 molecule -0.0409431
STC1 stanniocalcin 1 -0.0407848
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0388696
TPT1 tumor protein, translationally-controlled 1 -0.038705
HLA-E major histocompatibility complex, class I, E -0.0376
GNAS GNAS complex locus -0.0371976
RPL28 ribosomal protein L28 -0.0366268
CANX calnexin -0.036565
RPS8 ribosomal protein S8 -0.035483
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0346242
RPL23 ribosomal protein L23 -0.0345202
RPS19 ribosomal protein S19 -0.0344655
TAGLN2 transgelin 2 -0.0343806
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0340054
RPL12 ribosomal protein L12 -0.033529
HSPB1 heat shock 27kDa protein 1 -0.0331329
RPL34 ribosomal protein L34 -0.0322388
IFITM1 interferon induced transmembrane protein 1 -0.0320418
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0319454
ANXA2 annexin A2 -0.0318256
RPL19 ribosomal protein L19 -0.0314093
RPLP1 ribosomal protein, large, P1 -0.0310937
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0310913
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0309674
GOLGA4 golgin A4 -0.0308276
NAP1L1 nucleosome assembly protein 1-like 1 -0.0307026
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0305423
LDHA lactate dehydrogenase A -0.0304566
RPS3 ribosomal protein S3 -0.0302602
RPS6 ribosomal protein S6 -0.0298858
RPL35A ribosomal protein L35a -0.0297892
ADM adrenomedullin -0.0293847
RPL37A ribosomal protein L37a -0.0290262
HLA-C major histocompatibility complex, class I, C -0.0288143
VDAC1 voltage-dependent anion channel 1 -0.0285746
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0276364
GARS1 glycyl-tRNA synthetase 1 -0.0272064
PRRC2C proline-rich coiled-coil 2C -0.0270051
ACTG1 actin gamma 1 -0.0269461
RPL36 ribosomal protein L36 -0.026932
AHNAK AHNAK nucleoprotein -0.0263488
PFN1 profilin 1 -0.0262369
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0261373
TMSB4X thymosin beta 4, X-linked -0.0248336
RPL26 ribosomal protein L26 -0.0243738
SEC61G Sec61 gamma subunit -0.0243169
S100A4 S100 calcium binding protein A4 -0.0242734
MT1X metallothionein 1X -0.0237459
RPLP2 ribosomal protein, large, P2 -0.023659
CAVIN1 caveolae associated protein 1 -0.0235772
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0235211
RPS27A ribosomal protein S27a -0.0229212
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0228671
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0219812
HDLBP high density lipoprotein binding protein -0.0219008
HLA-A major histocompatibility complex, class I, A -0.0218005
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.021524
CALR calreticulin -0.0211863
RPL35 ribosomal protein L35 -0.0211318
RPS5 ribosomal protein S5 -0.0210424
RACK1 receptor for activated C kinase 1 -0.0207934
BSG basigin (Ok blood group) -0.0203502
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -0.0203336
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0202593
RPL32 ribosomal protein L32 -0.0199785
S100A11 S100 calcium binding protein A11 -0.0199408
JUN jun proto-oncogene -0.0198921
SLC38A1 solute carrier family 38, member 1 -0.0198848
H3-3B H3.3 histone B -0.0198188
S100A9 S100 calcium binding protein A9 -0.0197936
RAB1A RAB1A, member RAS oncogene family -0.0197083
INSIG1 insulin induced gene 1 -0.0193354
LMAN1 lectin, mannose-binding, 1 -0.019163
RRBP1 ribosome binding protein 1 -0.0191261
MYADM myeloid-associated differentiation marker -0.0189776
RPS24 ribosomal protein S24 -0.0188226