Altretamine_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Altretamine perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Altretamine_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LPIN1 lipin 1 0.0976778
MEIS2 Meis homeobox 2 0.0775971
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0675466
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0603713
FAM13A family with sequence similarity 13, member A 0.059536
DST dystonin 0.0513586
DSCAM Down syndrome cell adhesion molecule 0.0502424
HMBOX1 homeobox containing 1 0.0477184
OGA O-GlcNAcase 0.046558
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0447667
MED13 mediator complex subunit 13 0.0416072
KMT2C lysine (K)-specific methyltransferase 2C 0.0415569
KDM3A lysine (K)-specific demethylase 3A 0.041512
CDH10 cadherin 10, type 2 (T2-cadherin) 0.041266
FNDC3B fibronectin type III domain containing 3B 0.0408906
HELZ helicase with zinc finger 0.0407569
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0398065
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.03977
NRIP1 nuclear receptor interacting protein 1 0.0383413
AOPEP aminopeptidase O (putative) 0.0381903
MSI2 musashi RNA-binding protein 2 0.0369517
BIRC6 baculoviral IAP repeat containing 6 0.0369137
NAMPT nicotinamide phosphoribosyltransferase 0.0367013
MBNL2 muscleblind-like splicing regulator 2 0.0352252
TLE4 transducin-like enhancer of split 4 0.0351786
DTNA dystrobrevin, alpha 0.0348783
TENT5A terminal nucleotidyltransferase 5A 0.0347453
ADGRG6 adhesion G protein-coupled receptor G6 0.0342942
SOS1 son of sevenless homolog 1 (Drosophila) 0.0339089
PCM1 pericentriolar material 1 0.0332446
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.0326295
WAC WW domain containing adaptor with coiled-coil 0.0317925
ZCCHC7 zinc finger, CCHC domain containing 7 0.0316663
APP amyloid beta (A4) precursor protein 0.0315502
RNF213 ring finger protein 213 0.0311365
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0303669
PICALM phosphatidylinositol binding clathrin assembly protein 0.0302723
CCNL1 cyclin L1 0.0301789
CASC3 cancer susceptibility candidate 3 0.0297643
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0295997
SNX13 sorting nexin 13 0.0287622
MBD5 methyl-CpG binding domain protein 5 0.0284382
ANTXR1 anthrax toxin receptor 1 0.0281731
COPA coatomer protein complex, subunit alpha 0.0276563
CCNY cyclin Y 0.0276435
ZMIZ1 zinc finger, MIZ-type containing 1 0.0269754
ZBTB20 zinc finger and BTB domain containing 20 0.0267121
ZNF292 zinc finger protein 292 0.0265405
KLHL13 kelch-like family member 13 0.0264174
LSAMP limbic system-associated membrane protein 0.0260924
AUTS2 autism susceptibility candidate 2 0.0259558
PUM2 pumilio RNA-binding family member 2 0.0256241
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0253701
CLTC clathrin, heavy chain (Hc) 0.0253448
CD36 CD36 molecule (thrombospondin receptor) 0.0252643
AFF4 AF4/FMR2 family, member 4 0.0248899
VEGFA vascular endothelial growth factor A 0.0247452
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0244991
CLASP2 cytoplasmic linker associated protein 2 0.0244647
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) 0.0242541
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.024002
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0239975
VMP1 vacuole membrane protein 1 0.0235455
DENND1A DENN/MADD domain containing 1A 0.0234582
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0231489
NBAS neuroblastoma amplified sequence 0.0231152
WDR26 WD repeat domain 26 0.0230705
HSPA8 heat shock 70kDa protein 8 0.0229618
CDC73 cell division cycle 73 0.0226286
XPO1 exportin 1 0.0226056
ADAR adenosine deaminase, RNA-specific 0.0225959
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0224853
RBM20 RNA binding motif protein 20 0.0224575
WDFY3 WD repeat and FYVE domain containing 3 0.0224191
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0224088
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.0223295
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0222898
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0222815
TBC1D22A TBC1 domain family, member 22A 0.0222379
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0220341
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0220233
SETD5 SET domain containing 5 0.0218942
HOOK2 hook microtubule-tethering protein 2 0.0218804
RBM26 RNA binding motif protein 26 0.0218299
ACSL3 acyl-CoA synthetase long-chain family member 3 0.021757
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.0216925
EIF4B eukaryotic translation initiation factor 4B 0.0215999
PSD3 pleckstrin and Sec7 domain containing 3 0.0215678
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0215407
ZFAND3 zinc finger, AN1-type domain 3 0.0215226
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0214146
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0212673
CD46 CD46 molecule, complement regulatory protein 0.0211487
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0210417
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0210269
PEAK1 pseudopodium-enriched atypical kinase 1 0.0210136
MED13L mediator complex subunit 13-like 0.0210122
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0208416
PRPF8 pre-mRNA processing factor 8 0.0207009
MEF2A myocyte enhancer factor 2A 0.020647

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.291044
PTMA prothymosin, alpha -0.152977
IGF2 insulin-like growth factor 2 -0.149294
VIM vimentin -0.140642
AKAP12 A kinase (PRKA) anchor protein 12 -0.130882
RPS6 ribosomal protein S6 -0.102996
RPL23 ribosomal protein L23 -0.0891287
RPLP1 ribosomal protein, large, P1 -0.0732133
RPL35A ribosomal protein L35a -0.0705619
RPL19 ribosomal protein L19 -0.0659259
TPT1 tumor protein, translationally-controlled 1 -0.0603938
RPS24 ribosomal protein S24 -0.0592669
TMSB10 thymosin beta 10 -0.0589883
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0585009
FTL ferritin, light polypeptide -0.0553032
RPL34 ribosomal protein L34 -0.0551701
ACTG1 actin gamma 1 -0.0532955
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0525213
NALF1 NALCN channel auxiliary factor 1 -0.0515069
NRG1 neuregulin 1 -0.0472499
RPL37A ribosomal protein L37a -0.0471611
RPLP0 ribosomal protein, large, P0 -0.0449424
RPS3 ribosomal protein S3 -0.0428664
RPL36 ribosomal protein L36 -0.0421781
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0413935
RPL12 ribosomal protein L12 -0.0410488
VCL vinculin -0.0410366
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0405936
RPS12 ribosomal protein S12 -0.039554
RPL31 ribosomal protein L31 -0.0393371
RPS19 ribosomal protein S19 -0.0391115
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0387771
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0386729
RPL32 ribosomal protein L32 -0.0382204
DPH6 diphthamine biosynthesis 6 -0.0379954
RPS8 ribosomal protein S8 -0.0373194
GPC5 glypican 5 -0.0372595
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0371601
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0367829
DCAF7 DDB1 and CUL4 associated factor 7 -0.0366395
CRH corticotropin releasing hormone -0.0358257
RPS25 ribosomal protein S25 -0.035821
IER3 immediate early response 3 -0.0352984
CADM2 cell adhesion molecule 2 -0.0349885
RPL38 ribosomal protein L38 -0.0347795
EIF1 eukaryotic translation initiation factor 1 -0.0345867
RPS27 ribosomal protein S27 -0.0342832
H3-3B H3.3 histone B -0.0340525
IGFBP3 insulin-like growth factor binding protein 3 -0.0334387
RPS14 ribosomal protein S14 -0.0331978
S100A9 S100 calcium binding protein A9 -0.033129
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0319651
B2M beta-2-microglobulin -0.0316285
S100A6 S100 calcium binding protein A6 -0.03118
RPS27A ribosomal protein S27a -0.0310359
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0310033
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0294207
RPS11 ribosomal protein S11 -0.0293899
TBX2 T-box 2 -0.0292285
RPL7A ribosomal protein L7a -0.0288835
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0285095
RPS5 ribosomal protein S5 -0.0283563
RPL37 ribosomal protein L37 -0.0280958
RPS15 ribosomal protein S15 -0.0280691
RPS21 ribosomal protein S21 -0.0279506
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0277667
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0276818
RPL28 ribosomal protein L28 -0.027614
RPL26 ribosomal protein L26 -0.0272573
RPS20 ribosomal protein S20 -0.027092
NAP1L1 nucleosome assembly protein 1-like 1 -0.0266062
RPL27 ribosomal protein L27 -0.0263818
MARCKS myristoylated alanine-rich protein kinase C substrate -0.026234
RPS23 ribosomal protein S23 -0.0259839
RPL30 ribosomal protein L30 -0.0256854
THSD4 thrombospondin, type I, domain containing 4 -0.0253019
RPS29 ribosomal protein S29 -0.0248728
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0248671
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0248292
RPS17 ribosomal protein S17 -0.024735
RPS2 ribosomal protein S2 -0.0245746
RPL7 ribosomal protein L7 -0.0245609
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0243892
CUX1 cut-like homeobox 1 -0.0241297
SOX4 SRY (sex determining region Y)-box 4 -0.0240626
RPL9 ribosomal protein L9 -0.0239872
TPI1 triosephosphate isomerase 1 -0.0238881
SYT1 synaptotagmin I -0.0238626
RPL35 ribosomal protein L35 -0.02364
RPL8 ribosomal protein L8 -0.0234572
COL1A1 collagen, type I, alpha 1 -0.0234366
GNAS GNAS complex locus -0.0233847
RPLP2 ribosomal protein, large, P2 -0.0233399
RPL5 ribosomal protein L5 -0.0233175
RHOBTB3 Rho-related BTB domain containing 3 -0.023312
BCAS3 breast carcinoma amplified sequence 3 -0.0231549
TPM4 tropomyosin 4 -0.022713
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0226893
VDAC1 voltage-dependent anion channel 1 -0.0222868
BICD1 bicaudal D homolog 1 (Drosophila) -0.0222007