Altretamine_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Altretamine perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Altretamine_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DSCAM Down syndrome cell adhesion molecule 0.0882744
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.082146
MBNL2 muscleblind-like splicing regulator 2 0.0654338
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0576639
PHF3 PHD finger protein 3 0.0557613
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0545199
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0541338
BTBD9 BTB (POZ) domain containing 9 0.0539477
LMO7 LIM domain 7 0.0518593
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0481036
ERRFI1 ERBB receptor feedback inhibitor 1 0.0444988
FNDC3A fibronectin type III domain containing 3A 0.0442295
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0401081
LPP LIM domain containing preferred translocation partner in lipoma 0.038791
N4BP2L2 NEDD4 binding protein 2-like 2 0.0383283
ARHGAP26 Rho GTPase activating protein 26 0.0372783
ATXN1 ataxin 1 0.0369598
ERBIN erbb2 interacting protein 0.0367371
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.036709
ASPH aspartate beta-hydroxylase 0.0364361
UBAC2 UBA domain containing 2 0.0363013
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0362354
DSPP dentin sialophosphoprotein 0.0356872
CCNL1 cyclin L1 0.0354898
ARGLU1 arginine and glutamate rich 1 0.0352727
NEBL nebulette 0.0348023
CTNND1 catenin (cadherin-associated protein), delta 1 0.0336127
IGF1R insulin-like growth factor 1 receptor 0.0326379
TSC22D2 TSC22 domain family, member 2 0.0323016
FNIP1 folliculin interacting protein 1 0.0322484
COG6 component of oligomeric golgi complex 6 0.031378
PTK2 protein tyrosine kinase 2 0.0311998
TENT2 terminal nucleotidyltransferase 2 0.0311761
TMED2 transmembrane emp24 domain trafficking protein 2 0.0309618
VMP1 vacuole membrane protein 1 0.0306542
KMT2C lysine (K)-specific methyltransferase 2C 0.0302752
AFF1 AF4/FMR2 family, member 1 0.0301313
FAT1 FAT atypical cadherin 1 0.0293394
MYO5B myosin VB 0.0290469
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0287756
MLPH melanophilin 0.0286589
TRIO trio Rho guanine nucleotide exchange factor 0.0286283
HELZ helicase with zinc finger 0.0286088
KDM4C lysine (K)-specific demethylase 4C 0.027905
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.02787
ARRDC3 arrestin domain containing 3 0.027778
SMAD3 SMAD family member 3 0.027718
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0276939
MYH9 myosin, heavy chain 9, non-muscle 0.026925
ZBTB20 zinc finger and BTB domain containing 20 0.0268177
DST dystonin 0.0267838
TSC22D1 TSC22 domain family, member 1 0.0264707
TUFT1 tuftelin 1 0.0264686
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0261657
KIF16B kinesin family member 16B 0.0261341
MCTP2 multiple C2 domains, transmembrane 2 0.0260697
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0259803
LRRC1 leucine rich repeat containing 1 0.0256546
BICRAL BICRA like chromatin remodeling complex associated protein 0.025533
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0255227
ANO6 anoctamin 6 0.0254818
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0251122
VEGFA vascular endothelial growth factor A 0.0250749
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0246672
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.024528
KDM6A lysine (K)-specific demethylase 6A 0.0245192
EHF ets homologous factor 0.0244227
RNF43 ring finger protein 43 0.0240684
SPRED1 sprouty-related, EVH1 domain containing 1 0.0239413
ARHGAP32 Rho GTPase activating protein 32 0.0238358
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0237978
SBF2 SET binding factor 2 0.0234012
BCLAF1 BCL2-associated transcription factor 1 0.0232816
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0231415
GRK3 G protein-coupled receptor kinase 3 0.0229158
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0224241
SUCO SUN domain containing ossification factor 0.0221533
MON2 MON2 homolog (S. cerevisiae) 0.0220185
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0219321
ESRP1 epithelial splicing regulatory protein 1 0.0216183
XRN1 5'-3' exoribonuclease 1 0.0214414
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0212722
FNDC3B fibronectin type III domain containing 3B 0.0212703
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0211795
ERCC5 excision repair cross-complementation group 5 0.0211175
UBL3 ubiquitin-like 3 0.021094
COPA coatomer protein complex, subunit alpha 0.0210574
PADI1 peptidyl arginine deiminase, type I 0.0208419
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.020725
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0207001
EFNB2 ephrin-B2 0.0206691
CEMIP2 cell migration inducing hyaluronidase 2 0.0206343
RABGAP1 RAB GTPase activating protein 1 0.0205642
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0205404
RBM26 RNA binding motif protein 26 0.0205159
SNX13 sorting nexin 13 0.0203155
USP49 ubiquitin specific peptidase 49 0.0202244
HYOU1 hypoxia up-regulated 1 0.0201822
NDRG1 N-myc downstream regulated 1 0.0200985
ERP44 endoplasmic reticulum protein 44 0.0200535

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.173303
PTMA prothymosin, alpha -0.159786
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.132737
B2M beta-2-microglobulin -0.130841
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.10136
HLA-B major histocompatibility complex, class I, B -0.100274
LCN2 lipocalin 2 -0.0872325
TMSB10 thymosin beta 10 -0.0827854
FTL ferritin, light polypeptide -0.07718
EPSTI1 epithelial stromal interaction 1 (breast) -0.0736399
IFI27 interferon, alpha-inducible protein 27 -0.0715495
LYZ lysozyme -0.0673146
MT2A metallothionein 2A -0.065248
RPL35A ribosomal protein L35a -0.0648861
RPL23 ribosomal protein L23 -0.0606267
RPS6 ribosomal protein S6 -0.0581896
IFI6 interferon, alpha-inducible protein 6 -0.0577973
EGR1 early growth response 1 -0.0547865
RPS8 ribosomal protein S8 -0.0540626
RPL34 ribosomal protein L34 -0.0537445
JUN jun proto-oncogene -0.053576
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0506898
RNF213 ring finger protein 213 -0.0499309
HLA-C major histocompatibility complex, class I, C -0.0454978
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.044993
HLA-E major histocompatibility complex, class I, E -0.044914
SLC38A1 solute carrier family 38, member 1 -0.0446505
LOC112694756 uncharaterized LOC112694756 -0.0438845
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.043347
GNAS GNAS complex locus -0.0429992
RPS24 ribosomal protein S24 -0.0421206
RPLP1 ribosomal protein, large, P1 -0.042007
LOC102724023 ES1 protein homolog, mitochondrial -0.0402056
RPL19 ribosomal protein L19 -0.0400561
HLA-A major histocompatibility complex, class I, A -0.0400429
CANX calnexin -0.0393768
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.038841
RPL26 ribosomal protein L26 -0.0387897
RPL7L1 ribosomal protein L7-like 1 -0.0383953
H1-0 H1.0 linker histone -0.0381803
XAF1 XIAP associated factor 1 -0.0378621
RPL37A ribosomal protein L37a -0.0373051
GCLC glutamate-cysteine ligase, catalytic subunit -0.0369064
RPS19 ribosomal protein S19 -0.0366572
EPCAM epithelial cell adhesion molecule -0.0365835
RAB7A RAB7A, member RAS oncogene family -0.0360289
RPL31 ribosomal protein L31 -0.035683
EIF1 eukaryotic translation initiation factor 1 -0.0356493
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0347754
SPATA13 spermatogenesis associated 13 -0.0341761
VDAC1 voltage-dependent anion channel 1 -0.0341002
KRT19 keratin 19, type I -0.0337801
MUC20 mucin 20, cell surface associated -0.0337759
RPL11 ribosomal protein L11 -0.0333857
RIGI RNA sensor RIG-I -0.0333097
RPS29 ribosomal protein S29 -0.033255
S100A6 S100 calcium binding protein A6 -0.0330807
IFITM3 interferon induced transmembrane protein 3 -0.0330348
RPL12 ribosomal protein L12 -0.032707
S100A9 S100 calcium binding protein A9 -0.0326209
WSB1 WD repeat and SOCS box containing 1 -0.0324529
RACK1 receptor for activated C kinase 1 -0.0324169
VIM vimentin -0.0323245
MT1X metallothionein 1X -0.0323177
CSTB cystatin B (stefin B) -0.0322975
RPS27 ribosomal protein S27 -0.0322186
TPI1 triosephosphate isomerase 1 -0.0321537
C6ORF132 chromosome 6 open reading frame 132 -0.0312091
TM4SF1 transmembrane 4 L six family member 1 -0.0308725
AREG amphiregulin -0.0307986
MX2 MX dynamin-like GTPase 2 -0.0292451
SERF2 small EDRK-rich factor 2 -0.0289585
PDIA3 protein disulfide isomerase family A, member 3 -0.028761
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0283865
BPTF bromodomain PHD finger transcription factor -0.0283153
LY6E lymphocyte antigen 6 complex, locus E -0.0280793
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0280791
H3-3B H3.3 histone B -0.0278801
RPL37 ribosomal protein L37 -0.027795
SP100 SP100 nuclear antigen -0.0276437
RPS13 ribosomal protein S13 -0.0271494
PERP PERP, TP53 apoptosis effector -0.0268861
RPS27A ribosomal protein S27a -0.0265729
RPL30 ribosomal protein L30 -0.026535
ANXA2 annexin A2 -0.0262655
PRRC2C proline-rich coiled-coil 2C -0.0262061
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0260106
RPL18 ribosomal protein L18 -0.0260016
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0259609
RPL9 ribosomal protein L9 -0.0257114
S100P S100 calcium binding protein P -0.025681
CBX3 chromobox homolog 3 -0.025666
RPL36A ribosomal protein L36a -0.0255557
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0253108
ZNF609 zinc finger protein 609 -0.0253057
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0252528
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0251456
POMP proteasome maturation protein -0.0251087
RPLP2 ribosomal protein, large, P2 -0.0250807
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0250654