Altretamine_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Altretamine perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Altretamine_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VEGFA vascular endothelial growth factor A 0.0618484
NDRG1 N-myc downstream regulated 1 0.0551092
LMO7 LIM domain 7 0.0544367
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0529021
FAM13A family with sequence similarity 13, member A 0.0524024
DSCAM Down syndrome cell adhesion molecule 0.0520185
GOLGA4 golgin A4 0.0495
ITGA6 integrin, alpha 6 0.0454841
FAT1 FAT atypical cadherin 1 0.0450257
EEF2 eukaryotic translation elongation factor 2 0.0445098
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0438655
PTEN phosphatase and tensin homolog 0.0429651
RNF145 ring finger protein 145 0.0418093
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0410455
MBNL2 muscleblind-like splicing regulator 2 0.0391676
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0388631
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0385213
ZFAND3 zinc finger, AN1-type domain 3 0.0377002
TXNIP thioredoxin interacting protein 0.0368206
ESYT2 extended synaptotagmin-like protein 2 0.0351362
ZNF292 zinc finger protein 292 0.0347018
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0344575
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0339849
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0334827
COPA coatomer protein complex, subunit alpha 0.032781
MED13L mediator complex subunit 13-like 0.0327749
MACF1 microtubule-actin crosslinking factor 1 0.0325406
CCNL1 cyclin L1 0.0321883
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0321017
CCNY cyclin Y 0.0320833
NBAS neuroblastoma amplified sequence 0.0318938
UBA6 ubiquitin-like modifier activating enzyme 6 0.0314667
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0308338
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.03001
SEC31A SEC31 homolog A (S. cerevisiae) 0.0286856
EPS8 epidermal growth factor receptor pathway substrate 8 0.0285613
NUP58 nucleoporin 58 0.0275273
ESRP1 epithelial splicing regulatory protein 1 0.026589
ANKRD11 ankyrin repeat domain 11 0.0261079
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0255742
SUCO SUN domain containing ossification factor 0.0255172
ERRFI1 ERBB receptor feedback inhibitor 1 0.0251747
ZFC3H1 zinc finger, C3H1-type containing 0.0250541
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0245771
EREG epiregulin 0.0245536
TTC3 tetratricopeptide repeat domain 3 0.0243002
TRIM2 tripartite motif containing 2 0.0242929
PCBP2 poly(rC) binding protein 2 0.0241954
PICALM phosphatidylinositol binding clathrin assembly protein 0.023621
GLS2 glutaminase 2 (liver, mitochondrial) 0.0234312
MON2 MON2 homolog (S. cerevisiae) 0.0233959
BTBD9 BTB (POZ) domain containing 9 0.0233629
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0232465
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0232057
VMP1 vacuole membrane protein 1 0.0230839
TMF1 TATA element modulatory factor 1 0.0227619
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0227432
MYH9 myosin, heavy chain 9, non-muscle 0.0222377
TFG TRK-fused gene 0.0221335
PUM2 pumilio RNA-binding family member 2 0.0219112
FNDC3B fibronectin type III domain containing 3B 0.0218193
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0217397
SCFD1 sec1 family domain containing 1 0.0211014
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0210884
LRRC1 leucine rich repeat containing 1 0.0207474
USP53 ubiquitin specific peptidase 53 0.0205725
BIRC6 baculoviral IAP repeat containing 6 0.0205605
CEMIP2 cell migration inducing hyaluronidase 2 0.0205536
KDM6A lysine (K)-specific demethylase 6A 0.0200833
KDM4C lysine (K)-specific demethylase 4C 0.0200533
ARF4 ADP-ribosylation factor 4 0.0199171
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0198553
ATXN1 ataxin 1 0.0197627
BCLAF1 BCL2-associated transcription factor 1 0.0196742
COG5 component of oligomeric golgi complex 5 0.0194353
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0193679
DERA deoxyribose-phosphate aldolase (putative) 0.0191186
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0191116
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0190342
DSPP dentin sialophosphoprotein 0.0189807
ZSWIM6 zinc finger, SWIM-type containing 6 0.0189281
RCOR1 REST corepressor 1 0.0188905
KMT2E lysine (K)-specific methyltransferase 2E 0.0187525
KRT8 keratin 8, type II 0.0186833
KDM4B lysine (K)-specific demethylase 4B 0.0184925
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0183169
SOS1 son of sevenless homolog 1 (Drosophila) 0.0182947
ADAM17 ADAM metallopeptidase domain 17 0.0182707
ITPRID2 ITPR interacting domain containing 2 0.0182256
RAB6A RAB6A, member RAS oncogene family 0.0180028
DNM2 dynamin 2 0.0179757
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.0178921
HELZ helicase with zinc finger 0.0178571
FOXJ3 forkhead box J3 0.017811
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0176668
GSK3B glycogen synthase kinase 3 beta 0.0175776
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0175239
ATP13A3 ATPase type 13A3 0.0174428
ITCH itchy E3 ubiquitin protein ligase 0.0174408
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0174021

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.368876
TMSB10 thymosin beta 10 -0.188063
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.169118
TPT1 tumor protein, translationally-controlled 1 -0.12545
RPS6 ribosomal protein S6 -0.121448
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.112067
RPS8 ribosomal protein S8 -0.0861246
RPL35A ribosomal protein L35a -0.084427
RPL34 ribosomal protein L34 -0.0825294
RPLP1 ribosomal protein, large, P1 -0.0804276
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0765714
RPS19 ribosomal protein S19 -0.075373
RPL12 ribosomal protein L12 -0.0716301
NPSR1 neuropeptide S receptor 1 -0.0701419
RPL26 ribosomal protein L26 -0.0662595
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0649762
AHNAK AHNAK nucleoprotein -0.0648775
FTL ferritin, light polypeptide -0.0585717
RPS24 ribosomal protein S24 -0.0558592
RPLP2 ribosomal protein, large, P2 -0.0558458
RPL37A ribosomal protein L37a -0.0558205
RPL23 ribosomal protein L23 -0.053181
S100A6 S100 calcium binding protein A6 -0.0529264
RPL36 ribosomal protein L36 -0.0526089
RPL19 ribosomal protein L19 -0.0524933
ALCAM activated leukocyte cell adhesion molecule -0.0521664
RPS12 ribosomal protein S12 -0.0504883
RPS27A ribosomal protein S27a -0.0494248
RPL9 ribosomal protein L9 -0.0493562
ONECUT3 one cut homeobox 3 -0.0481054
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0480345
ACTG1 actin gamma 1 -0.0478979
RPL11 ribosomal protein L11 -0.0433205
RPS21 ribosomal protein S21 -0.0415455
RPS25 ribosomal protein S25 -0.0403893
EPCAM epithelial cell adhesion molecule -0.0397702
RPS3 ribosomal protein S3 -0.0392852
RPLP0 ribosomal protein, large, P0 -0.0381932
S100A9 S100 calcium binding protein A9 -0.0375621
RPL31 ribosomal protein L31 -0.0363525
RPL5 ribosomal protein L5 -0.0363161
RPS17 ribosomal protein S17 -0.0362661
RPS23 ribosomal protein S23 -0.0362658
RPS27 ribosomal protein S27 -0.0360211
NAP1L1 nucleosome assembly protein 1-like 1 -0.0358873
RPL18 ribosomal protein L18 -0.0355859
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.035427
IER3 immediate early response 3 -0.0352673
H1-0 H1.0 linker histone -0.0348041
RPL32 ribosomal protein L32 -0.0346794
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0340913
S100P S100 calcium binding protein P -0.0336403
RPS29 ribosomal protein S29 -0.0330629
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0326999
RPL8 ribosomal protein L8 -0.032111
RPS16 ribosomal protein S16 -0.03187
RPS14 ribosomal protein S14 -0.0317956
RPL35 ribosomal protein L35 -0.0315783
UQCRB ubiquinol-cytochrome c reductase binding protein -0.031566
RPL7A ribosomal protein L7a -0.0313219
HMGB1 high mobility group box 1 -0.0308444
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0302065
RPS11 ribosomal protein S11 -0.0301951
RPL27 ribosomal protein L27 -0.0295292
LOC112694756 uncharaterized LOC112694756 -0.0292665
RPL36A ribosomal protein L36a -0.0289222
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0287725
RPS13 ribosomal protein S13 -0.0286969
MT2A metallothionein 2A -0.0283504
NALF1 NALCN channel auxiliary factor 1 -0.028164
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0279141
S100A10 S100 calcium binding protein A10 -0.0278669
RPL30 ribosomal protein L30 -0.0272269
RACK1 receptor for activated C kinase 1 -0.026184
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.026176
RPL37 ribosomal protein L37 -0.026007
RPL7 ribosomal protein L7 -0.0259071
RPL38 ribosomal protein L38 -0.0258324
RPL13A ribosomal protein L13a -0.0253325
ISG15 ISG15 ubiquitin-like modifier -0.0252288
RPS5 ribosomal protein S5 -0.0251849
RPL27A ribosomal protein L27a -0.0245584
EIF5B eukaryotic translation initiation factor 5B -0.0242972
LMNA lamin A/C -0.0240402
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0239759
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0238193
GSTP1 glutathione S-transferase pi 1 -0.0232141
RPL28 ribosomal protein L28 -0.0232128
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0230627
TFF3 trefoil factor 3 (intestinal) -0.0229596
CCND1 cyclin D1 -0.022837
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0224435
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0223796
ENO1 enolase 1, (alpha) -0.0222657
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0222036
GNAS GNAS complex locus -0.0221875
MYL12B myosin, light chain 12B, regulatory -0.0218056
KRT18 keratin 18, type I -0.02178
SOX4 SRY (sex determining region Y)-box 4 -0.0215487
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0212217