| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Altretamine perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Altretamine_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.238688 |
| LAMC2 | laminin, gamma 2 | 0.0835743 |
| CCNL1 | cyclin L1 | 0.0831412 |
| SLTM | SAFB-like, transcription modulator | 0.0783148 |
| GRAMD1B | GRAM domain containing 1B | 0.075815 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0750912 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.06686 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0648524 |
| RUNX1 | runt-related transcription factor 1 | 0.0646417 |
| MCL1 | myeloid cell leukemia 1 | 0.062333 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0614237 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0569242 |
| MKI67 | marker of proliferation Ki-67 | 0.0562458 |
| NDRG1 | N-myc downstream regulated 1 | 0.0562437 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0556328 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0548664 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0539165 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0506941 |
| MT2A | metallothionein 2A | 0.0505844 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0504311 |
| TXNRD1 | thioredoxin reductase 1 | 0.0499995 |
| CES1 | carboxylesterase 1 | 0.0492847 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0484187 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0481371 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.047961 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0475451 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0465127 |
| ANXA5 | annexin A5 | 0.0457137 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0448916 |
| PCBP2 | poly(rC) binding protein 2 | 0.0445609 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0439983 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0434087 |
| TOP1 | topoisomerase (DNA) I | 0.0427605 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0416458 |
| USP34 | ubiquitin specific peptidase 34 | 0.0367805 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0366882 |
| UBC | ubiquitin C | 0.0365612 |
| ZNF292 | zinc finger protein 292 | 0.0360225 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.035988 |
| ZNF638 | zinc finger protein 638 | 0.0358675 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0357992 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0352022 |
| CDCP1 | CUB domain containing protein 1 | 0.0350181 |
| LAMA4 | laminin, alpha 4 | 0.0348536 |
| HYOU1 | hypoxia up-regulated 1 | 0.0347219 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0344939 |
| VMP1 | vacuole membrane protein 1 | 0.0344418 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0344263 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0341612 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 0.0341011 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0340768 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0338231 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0329159 |
| ATP11A | ATPase, class VI, type 11A | 0.0328915 |
| TMEM165 | transmembrane protein 165 | 0.0314821 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0308794 |
| ARRDC3 | arrestin domain containing 3 | 0.0308025 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0297661 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0295135 |
| GPATCH2L | G patch domain containing 2-like | 0.0292466 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0292407 |
| DTNA | dystrobrevin, alpha | 0.0290032 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0288547 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0287339 |
| NPTN | neuroplastin | 0.0285099 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0280181 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0278658 |
| SMYD3 | SET and MYND domain containing 3 | 0.0277525 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0276968 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0273609 |
| OSMR | oncostatin M receptor | 0.0271789 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0271747 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0269848 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0267622 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0267555 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.026653 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0266464 |
| PKM | pyruvate kinase, muscle | 0.0265858 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0263973 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0260633 |
| STK24 | serine/threonine kinase 24 | 0.0259994 |
| RAD51B | RAD51 paralog B | 0.0259816 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0256945 |
| JMJD1C | jumonji domain containing 1C | 0.0255177 |
| ASPH | aspartate beta-hydroxylase | 0.0247186 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.024448 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0244088 |
| ZNF207 | zinc finger protein 207 | 0.0243564 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0242829 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0242684 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0241615 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0238885 |
| BLZF1 | basic leucine zipper nuclear factor 1 | 0.0237171 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0236643 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0234686 |
| TPM3 | tropomyosin 3 | 0.0234145 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0228639 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | 0.0224597 |
| B2M | beta-2-microglobulin | 0.0224463 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0222993 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.166106 |
| TMSB10 | thymosin beta 10 | -0.153381 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.131789 |
| PTMA | prothymosin, alpha | -0.130071 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0993595 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0953786 |
| H1-0 | H1.0 linker histone | -0.0946254 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0859242 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0676372 |
| FTL | ferritin, light polypeptide | -0.0628693 |
| S100A10 | S100 calcium binding protein A10 | -0.057761 |
| RPS24 | ribosomal protein S24 | -0.0492729 |
| RPL35A | ribosomal protein L35a | -0.0482095 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0398667 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0398219 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0388292 |
| IER3 | immediate early response 3 | -0.0379536 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0379043 |
| PDE8A | phosphodiesterase 8A | -0.0378919 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0368093 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0364487 |
| CANX | calnexin | -0.0339725 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0337744 |
| RPL34 | ribosomal protein L34 | -0.0319367 |
| RPL12 | ribosomal protein L12 | -0.0311478 |
| GM2A | GM2 ganglioside activator | -0.0310251 |
| AHNAK | AHNAK nucleoprotein | -0.0305264 |
| RPS27A | ribosomal protein S27a | -0.0299277 |
| HDLBP | high density lipoprotein binding protein | -0.0294471 |
| RPLP1 | ribosomal protein, large, P1 | -0.0294146 |
| HBP1 | HMG-box transcription factor 1 | -0.0282546 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0279392 |
| CSTB | cystatin B (stefin B) | -0.0278214 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0277754 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0270818 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0266471 |
| GNAS | GNAS complex locus | -0.0266434 |
| RPS8 | ribosomal protein S8 | -0.0257918 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.025278 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0251407 |
| S100P | S100 calcium binding protein P | -0.0246059 |
| HMGA1 | high mobility group AT-hook 1 | -0.0245904 |
| EMP1 | epithelial membrane protein 1 | -0.0242673 |
| S100A6 | S100 calcium binding protein A6 | -0.0242103 |
| UVRAG | UV radiation resistance associated | -0.0241819 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0236932 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0236096 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0234999 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0227317 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0222999 |
| ANKLE2 | ankyrin repeat and LEM domain containing 2 | -0.0219187 |
| BBX | bobby sox homolog (Drosophila) | -0.0214719 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.021339 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.021244 |
| RPLP0 | ribosomal protein, large, P0 | -0.0211261 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0206692 |
| RPS25 | ribosomal protein S25 | -0.0200309 |
| PERP | PERP, TP53 apoptosis effector | -0.0200202 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0199887 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0196225 |
| RPL31 | ribosomal protein L31 | -0.0192036 |
| HLA-B | major histocompatibility complex, class I, B | -0.0189901 |
| RPL6 | ribosomal protein L6 | -0.0183605 |
| ACTG1 | actin gamma 1 | -0.0182273 |
| RPL19 | ribosomal protein L19 | -0.0181317 |
| RPL36A | ribosomal protein L36a | -0.0180859 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.017874 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0177203 |
| RPL26 | ribosomal protein L26 | -0.017171 |
| SDC4 | syndecan 4 | -0.0169087 |
| ZNF267 | zinc finger protein 267 | -0.0168258 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0166247 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0164768 |
| RPLP2 | ribosomal protein, large, P2 | -0.0163996 |
| RPS21 | ribosomal protein S21 | -0.0162423 |
| TRIM56 | tripartite motif containing 56 | -0.0161541 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0159164 |
| RRBP1 | ribosome binding protein 1 | -0.0159057 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0158419 |
| BMP7 | bone morphogenetic protein 7 | -0.0157824 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0157491 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0156719 |
| RPS19 | ribosomal protein S19 | -0.0156715 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0156672 |
| ZFR | zinc finger RNA binding protein | -0.0155243 |
| RPL8 | ribosomal protein L8 | -0.0153734 |
| SEC61G | Sec61 gamma subunit | -0.0153425 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0150356 |
| TLK1 | tousled-like kinase 1 | -0.0148972 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0147767 |
| AGR2 | anterior gradient 2 | -0.0147323 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0145034 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0143965 |
| RNF213 | ring finger protein 213 | -0.0142858 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0141522 |
| SRP72 | signal recognition particle 72kDa | -0.0140961 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0139956 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0136715 |
| RPS29 | ribosomal protein S29 | -0.0136333 |
| GLG1 | golgi glycoprotein 1 | -0.0135911 |
