| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Altretamine perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Altretamine_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.14722 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.141011 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.134575 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.10867 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0929534 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0862633 |
| LDHA | lactate dehydrogenase A | 0.0805401 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0792849 |
| CALR | calreticulin | 0.0678139 |
| ENO1 | enolase 1, (alpha) | 0.0608974 |
| CCNL1 | cyclin L1 | 0.0535697 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0528246 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0503168 |
| ECT2 | epithelial cell transforming 2 | 0.0463418 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0453229 |
| RRM2 | ribonucleotide reductase M2 | 0.0424946 |
| TPM3 | tropomyosin 3 | 0.0413017 |
| ANXA5 | annexin A5 | 0.0365129 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0358307 |
| IGF2 | insulin-like growth factor 2 | 0.0342225 |
| HYOU1 | hypoxia up-regulated 1 | 0.0337337 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0335389 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0332616 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0318232 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0312963 |
| APP | amyloid beta (A4) precursor protein | 0.0311961 |
| TFG | TRK-fused gene | 0.0309907 |
| NUP58 | nucleoporin 58 | 0.0308588 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0308368 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0299838 |
| VMP1 | vacuole membrane protein 1 | 0.0293275 |
| UBC | ubiquitin C | 0.0289117 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0284718 |
| COPA | coatomer protein complex, subunit alpha | 0.0281483 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0278654 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0278482 |
| TMEM123 | transmembrane protein 123 | 0.0273432 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0272865 |
| NRG1 | neuregulin 1 | 0.0272334 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0271683 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 0.0268524 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0266734 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.026645 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0264164 |
| FNBP1L | formin binding protein 1-like | 0.0262625 |
| RPLP0 | ribosomal protein, large, P0 | 0.0259938 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | 0.0258911 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0258727 |
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | 0.0258188 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | 0.0256702 |
| PCBP2 | poly(rC) binding protein 2 | 0.0252448 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0243019 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0242776 |
| MYOF | myoferlin | 0.0239568 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0237087 |
| COTL1 | coactosin-like F-actin binding protein 1 | 0.0236143 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0233388 |
| CD109 | CD109 molecule | 0.023257 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.022964 |
| ANXA1 | annexin A1 | 0.0226734 |
| CHN1 | chimerin 1 | 0.0225024 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0222614 |
| UIMC1 | ubiquitin interaction motif containing 1 | 0.022033 |
| PGK1 | phosphoglycerate kinase 1 | 0.0219714 |
| ZNF292 | zinc finger protein 292 | 0.0217397 |
| PKM | pyruvate kinase, muscle | 0.021632 |
| CALU | calumenin | 0.0213335 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0211528 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0211459 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0208766 |
| DDB1 | damage-specific DNA binding protein 1, 127kDa | 0.0205964 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.020568 |
| TPD52 | tumor protein D52 | 0.0205409 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0203499 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.020075 |
| THBS1 | thrombospondin 1 | 0.0198926 |
| HMGB1 | high mobility group box 1 | 0.0196041 |
| TPM4 | tropomyosin 4 | 0.0195649 |
| PRR16 | proline rich 16 | 0.019529 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0194433 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0194409 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0193912 |
| EIF4A3 | eukaryotic translation initiation factor 4A3 | 0.0192964 |
| TMED10 | transmembrane emp24-like trafficking protein 10 (yeast) | 0.0191378 |
| S100A10 | S100 calcium binding protein A10 | 0.0191139 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.0190697 |
| PTK2 | protein tyrosine kinase 2 | 0.0188843 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | 0.0188652 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.0186088 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0185379 |
| AK1 | adenylate kinase 1 | 0.0184965 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0182276 |
| WDR43 | WD repeat domain 43 | 0.0181766 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0181686 |
| IST1 | increased sodium tolerance 1 homolog (yeast) | 0.0178067 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0177771 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.017769 |
| RACGAP1 | Rac GTPase activating protein 1 | 0.0177492 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0176807 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0176243 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.280121 |
| PM20D1 | peptidase M20 domain containing 1 | -0.202071 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.129941 |
| GRAMD1B | GRAM domain containing 1B | -0.127046 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.116841 |
| TMSB10 | thymosin beta 10 | -0.105023 |
| RPS2 | ribosomal protein S2 | -0.0807112 |
| RPL19 | ribosomal protein L19 | -0.0789605 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.073719 |
| RPLP1 | ribosomal protein, large, P1 | -0.0667581 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0667097 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0653193 |
| RPL37A | ribosomal protein L37a | -0.0634545 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.0632941 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.061027 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0598751 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0583502 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0579195 |
| IER3 | immediate early response 3 | -0.0575696 |
| RPS6 | ribosomal protein S6 | -0.0533398 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0518481 |
| RPS8 | ribosomal protein S8 | -0.0509609 |
| RPS27A | ribosomal protein S27a | -0.0488501 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0463582 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0460715 |
| WWOX | WW domain containing oxidoreductase | -0.0455974 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0433021 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | -0.043273 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.043204 |
| SVIL | supervillin | -0.0428971 |
| GOLT1B | golgi transport 1B | -0.0418739 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0416142 |
| RPS21 | ribosomal protein S21 | -0.0410316 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0407019 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0401318 |
| RTN4 | reticulon 4 | -0.0395799 |
| RPL30 | ribosomal protein L30 | -0.0394818 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0394125 |
| ATXN1 | ataxin 1 | -0.0390798 |
| RPL26 | ribosomal protein L26 | -0.039026 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.038304 |
| EGFR | epidermal growth factor receptor | -0.0382926 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0378906 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0371895 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0369113 |
| DENND4A | DENN/MADD domain containing 4A | -0.0362513 |
| FAM107B | family with sequence similarity 107, member B | -0.0360006 |
| STC1 | stanniocalcin 1 | -0.0355577 |
| PFDN2 | prefoldin subunit 2 | -0.0355171 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0353259 |
| RPL5 | ribosomal protein L5 | -0.0352998 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0350867 |
| RPS12 | ribosomal protein S12 | -0.0349011 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0348657 |
| FTL | ferritin, light polypeptide | -0.0347686 |
| RPL9 | ribosomal protein L9 | -0.0332342 |
| KYNU | kynureninase | -0.0331205 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.0330792 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0330057 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0329044 |
| KANSL1L | KAT8 regulatory NSL complex subunit 1-like | -0.0328085 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0326639 |
| ZFHX3 | zinc finger homeobox 3 | -0.0326472 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0323237 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0322109 |
| USP34 | ubiquitin specific peptidase 34 | -0.0318235 |
| RPS23 | ribosomal protein S23 | -0.0314958 |
| PTMA | prothymosin, alpha | -0.0313595 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0305952 |
| RPL36 | ribosomal protein L36 | -0.0305653 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0303863 |
| PAPOLA | poly(A) polymerase alpha | -0.0303435 |
| EXOC6B | exocyst complex component 6B | -0.0302866 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0299616 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0296289 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0295898 |
| CCL5 | chemokine (C-C motif) ligand 5 | -0.029549 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.029447 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.029329 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0292295 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0292189 |
| RPL23 | ribosomal protein L23 | -0.0283456 |
| CMIP | c-Maf inducing protein | -0.0280512 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0279888 |
| NCOA1 | nuclear receptor coactivator 1 | -0.0279197 |
| RPL7 | ribosomal protein L7 | -0.0278933 |
| CCT3 | chaperonin containing TCP1, subunit 3 (gamma) | -0.0278158 |
| GOLGB1 | golgin B1 | -0.0277886 |
| RPS25 | ribosomal protein S25 | -0.0276307 |
| RPL28 | ribosomal protein L28 | -0.027073 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -0.0269816 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0268371 |
| S100A6 | S100 calcium binding protein A6 | -0.0266824 |
| BMP6 | bone morphogenetic protein 6 | -0.0266072 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.026468 |
| RPS19 | ribosomal protein S19 | -0.0263465 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0261708 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0261262 |
| SETD5 | SET domain containing 5 | -0.0258729 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0256745 |
