| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Altretamine perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Altretamine_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.21743 |
| NDRG1 | N-myc downstream regulated 1 | 0.153832 |
| IGF2 | insulin-like growth factor 2 | 0.132516 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.122206 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.102983 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0778765 |
| PRELID2 | PRELI domain containing 2 | 0.073939 |
| RNF149 | ring finger protein 149 | 0.0706484 |
| UBA2 | ubiquitin-like modifier activating enzyme 2 | 0.066997 |
| RPS8 | ribosomal protein S8 | 0.0658958 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0652784 |
| METTL15 | methyltransferase like 15 | 0.0645783 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0644872 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0642629 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0637088 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0631833 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0629715 |
| NFIB | nuclear factor I/B | 0.0628343 |
| B2M | beta-2-microglobulin | 0.0621097 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0619353 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0611596 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0603306 |
| SBF2 | SET binding factor 2 | 0.0600187 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0586186 |
| NPTN | neuroplastin | 0.0567718 |
| PCGF5 | polycomb group ring finger 5 | 0.0552108 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0545414 |
| YEATS2 | YEATS domain containing 2 | 0.0540735 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0538414 |
| RIGI | RNA sensor RIG-I | 0.0537341 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.053118 |
| DST | dystonin | 0.0531179 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0528457 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0526362 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0526091 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0525493 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0512139 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0507108 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0505126 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0502529 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0490992 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0489068 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0483101 |
| DICER1 | dicer 1, ribonuclease type III | 0.0476169 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0476046 |
| CXXC1 | CXXC finger protein 1 | 0.0471032 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0467382 |
| LAMB3 | laminin, beta 3 | 0.0465221 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0464715 |
| KRT18 | keratin 18, type I | 0.0457521 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0453445 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.045238 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0450577 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0441747 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | 0.0433705 |
| GOLGA4 | golgin A4 | 0.0426468 |
| MT2A | metallothionein 2A | 0.0421329 |
| RNF24 | ring finger protein 24 | 0.0419816 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0416955 |
| MAP1B | microtubule-associated protein 1B | 0.0410451 |
| ACAP2 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 | 0.0406548 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0403306 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0397392 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0383487 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0382048 |
| NBAS | neuroblastoma amplified sequence | 0.0380919 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0379646 |
| PCBP2 | poly(rC) binding protein 2 | 0.0378737 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0377427 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0377352 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.03718 |
| WDPCP | WD repeat containing planar cell polarity effector | 0.0370719 |
| DSPP | dentin sialophosphoprotein | 0.0370188 |
| GHITM | growth hormone inducible transmembrane protein | 0.0369188 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0368366 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0368227 |
| COG5 | component of oligomeric golgi complex 5 | 0.0367706 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0367436 |
| HDAC8 | histone deacetylase 8 | 0.0366491 |
| RBM39 | RNA binding motif protein 39 | 0.0364593 |
| PRKG1 | protein kinase, cGMP-dependent, type I | 0.0364395 |
| RPS12 | ribosomal protein S12 | 0.0360451 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | 0.0359098 |
| PDE8A | phosphodiesterase 8A | 0.0358038 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0357267 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0356886 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0354936 |
| FLNB | filamin B, beta | 0.0353008 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.034942 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0348252 |
| ZNF148 | zinc finger protein 148 | 0.0346149 |
| RPS17 | ribosomal protein S17 | 0.0346067 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0343666 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0342021 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.0338187 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0336261 |
| RORA | RAR-related orphan receptor A | 0.0334434 |
| ADNP | activity-dependent neuroprotector homeobox | 0.0333148 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0331372 |
| RPS27A | ribosomal protein S27a | 0.0330716 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | -0.211296 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.122342 |
| VIM | vimentin | -0.117033 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.111658 |
| ATOSA | atos homolog A | -0.103964 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.103253 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0953285 |
| PTMA | prothymosin, alpha | -0.0932218 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0931174 |
| AHNAK | AHNAK nucleoprotein | -0.0896894 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0841325 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0815038 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0812631 |
| SRPK2 | SRSF protein kinase 2 | -0.0795038 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0748739 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0730838 |
| RPS6 | ribosomal protein S6 | -0.0725307 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0723575 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0715444 |
| TMSB10 | thymosin beta 10 | -0.0649388 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0648313 |
| SNX9 | sorting nexin 9 | -0.064325 |
| MUC16 | mucin 16, cell surface associated | -0.0639207 |
| SLMAP | sarcolemma associated protein | -0.0632277 |
| RPL19 | ribosomal protein L19 | -0.0626483 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0619423 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.059242 |
| EGFR | epidermal growth factor receptor | -0.0584157 |
| TNPO1 | transportin 1 | -0.0579196 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0574133 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0559917 |
| FTL | ferritin, light polypeptide | -0.0555553 |
| KRT17 | keratin 17, type I | -0.0553348 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.0541987 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0541792 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0535832 |
| JMJD1C | jumonji domain containing 1C | -0.0533837 |
| MYO1E | myosin IE | -0.0530094 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0526633 |
| TXNIP | thioredoxin interacting protein | -0.0526259 |
| H3-3B | H3.3 histone B | -0.0526059 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0522427 |
| TJP1 | tight junction protein 1 | -0.0522381 |
| S100A6 | S100 calcium binding protein A6 | -0.0517747 |
| SVIL | supervillin | -0.0515794 |
| EZR | ezrin | -0.0514942 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0514917 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0497381 |
| RBM47 | RNA binding motif protein 47 | -0.0494413 |
| ANXA1 | annexin A1 | -0.0489522 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0483386 |
| CUX1 | cut-like homeobox 1 | -0.0462697 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0456684 |
| RPL35A | ribosomal protein L35a | -0.0453678 |
| CDK13 | cyclin-dependent kinase 13 | -0.0453024 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0444887 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0431521 |
| KATNBL1 | katanin p80 subunit B-like 1 | -0.042862 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0422757 |
| SQSTM1 | sequestosome 1 | -0.0422717 |
| S100A9 | S100 calcium binding protein A9 | -0.0416655 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0415974 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | -0.0414988 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.041455 |
| HMGA1 | high mobility group AT-hook 1 | -0.0413714 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.041304 |
| CD2AP | CD2-associated protein | -0.0410973 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0410655 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0410224 |
| MPRIP | myosin phosphatase Rho interacting protein | -0.0403438 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0398014 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0390131 |
| TPR | translocated promoter region, nuclear basket protein | -0.0387308 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0383606 |
| ACTG1 | actin gamma 1 | -0.0380318 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0377372 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0376323 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0376242 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0373419 |
| ATXN1 | ataxin 1 | -0.0371501 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0369992 |
| SLC12A6 | solute carrier family 12 (potassium/chloride transporter), member 6 | -0.0369599 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0359194 |
| POTEF | POTE ankyrin domain family, member F | -0.0358128 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0357208 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0356209 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0355972 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0355788 |
| NHSL1 | NHS-like 1 | -0.0354759 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0350252 |
| JUN | jun proto-oncogene | -0.0347828 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0341868 |
| TMEM123 | transmembrane protein 123 | -0.0339119 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0338035 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0337193 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | -0.033647 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0331911 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0326763 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0323738 |
| ABLIM1 | actin binding LIM protein 1 | -0.0320076 |
