Altretamine_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Altretamine perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Altretamine_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RAD51B RAD51 paralog B 0.0718447
TPM3 tropomyosin 3 0.0666355
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.061734
EEF2 eukaryotic translation elongation factor 2 0.0581956
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0519518
CSDE1 cold shock domain containing E1, RNA-binding 0.0433899
CCNL1 cyclin L1 0.0403577
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0403499
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0394803
TRIO trio Rho guanine nucleotide exchange factor 0.038506
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0359443
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.034747
MARCHF4 membrane associated ring-CH-type finger 4 0.0346548
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0340668
PTK2 protein tyrosine kinase 2 0.0335509
COPA coatomer protein complex, subunit alpha 0.0331818
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0324712
ANO6 anoctamin 6 0.0324249
SFPQ splicing factor proline/glutamine-rich 0.030686
TBC1D5 TBC1 domain family, member 5 0.0301491
WNK1 WNK lysine deficient protein kinase 1 0.028814
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0281456
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0279295
PDE4D phosphodiesterase 4D, cAMP-specific 0.0276928
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0266504
EIF4B eukaryotic translation initiation factor 4B 0.0264881
ANXA5 annexin A5 0.0263857
NUP153 nucleoporin 153kDa 0.026241
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0261883
WDR43 WD repeat domain 43 0.0258925
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0257777
UBQLN1 ubiquilin 1 0.0254959
NCKAP1 NCK-associated protein 1 0.0251202
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.024927
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0244765
NUP58 nucleoporin 58 0.0244603
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0233853
NCAPG2 non-SMC condensin II complex, subunit G2 0.0230026
DENND1A DENN/MADD domain containing 1A 0.022905
DOCK5 dedicator of cytokinesis 5 0.0224734
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0224621
PNN pinin, desmosome associated protein 0.0223547
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0222655
BRD2 bromodomain containing 2 0.0221815
PTEN phosphatase and tensin homolog 0.0215409
FAF1 Fas (TNFRSF6) associated factor 1 0.021538
RNGTT RNA guanylyltransferase and 5'-phosphatase 0.0212531
CAMTA1 calmodulin binding transcription activator 1 0.0209022
ZFC3H1 zinc finger, C3H1-type containing 0.0208195
ERRFI1 ERBB receptor feedback inhibitor 1 0.0206438
FKBP4 FK506 binding protein 4, 59kDa 0.0206186
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0204396
BCLAF1 BCL2-associated transcription factor 1 0.0203691
UBAP2L ubiquitin associated protein 2-like 0.020268
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0199582
SUCO SUN domain containing ossification factor 0.0197229
DIAPH1 diaphanous-related formin 1 0.0196573
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0196038
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0195091
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.0193574
HSPA8 heat shock 70kDa protein 8 0.0190431
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0186696
CHD7 chromodomain helicase DNA binding protein 7 0.0185006
GRAMD1B GRAM domain containing 1B 0.0184977
IGF2 insulin-like growth factor 2 0.0184628
NUP155 nucleoporin 155kDa 0.0184406
SAMD4A sterile alpha motif domain containing 4A 0.0184402
PUM2 pumilio RNA-binding family member 2 0.0184006
ANKRD11 ankyrin repeat domain 11 0.0183967
ATAD2 ATPase family, AAA domain containing 2 0.0183409
RUNX1 runt-related transcription factor 1 0.0183005
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0182769
RPL3 ribosomal protein L3 0.017945
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.0178612
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.017858
CEP192 centrosomal protein 192kDa 0.0176891
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0176734
RASAL2 RAS protein activator like 2 0.01738
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0173246
LRRC59 leucine rich repeat containing 59 0.0172938
HELZ helicase with zinc finger 0.0172406
ATP13A3 ATPase type 13A3 0.0171839
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa 0.0171342
SPIDR scaffolding protein involved in DNA repair 0.0171223
PCBP2 poly(rC) binding protein 2 0.0171099
ZZZ3 zinc finger, ZZ-type containing 3 0.0170577
SPAG5 sperm associated antigen 5 0.0170491
EWSR1 EWS RNA-binding protein 1 0.0170398
CDK19 cyclin-dependent kinase 19 0.0169451
GMDS GDP-mannose 4,6-dehydratase 0.0169269
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0167869
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0165931
CNOT1 CCR4-NOT transcription complex, subunit 1 0.016539
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0165134
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0164838
LDLRAD3 low density lipoprotein receptor class A domain containing 3 0.0164552
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0164246
TRIP12 thyroid hormone receptor interactor 12 0.0164087
CEP250 centrosomal protein 250kDa 0.0164083
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0162921

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.418949
TMSB10 thymosin beta 10 -0.200908
AKAP12 A kinase (PRKA) anchor protein 12 -0.166742
PTMA prothymosin, alpha -0.130982
VIM vimentin -0.12531
YBX3 Y box binding protein 3 -0.102339
RPS8 ribosomal protein S8 -0.0920971
RPL35A ribosomal protein L35a -0.0854933
RPLP1 ribosomal protein, large, P1 -0.0800647
RPS21 ribosomal protein S21 -0.075553
MT2A metallothionein 2A -0.074236
RPL37 ribosomal protein L37 -0.0734445
TPT1 tumor protein, translationally-controlled 1 -0.0712646
NAP1L1 nucleosome assembly protein 1-like 1 -0.0684621
RPL12 ribosomal protein L12 -0.0681274
RPS3 ribosomal protein S3 -0.0673495
RPL26 ribosomal protein L26 -0.0608702
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0598238
RPL19 ribosomal protein L19 -0.0595215
TPI1 triosephosphate isomerase 1 -0.0595128
RPS27 ribosomal protein S27 -0.0590223
TFPI2 tissue factor pathway inhibitor 2 -0.058715
RPS27A ribosomal protein S27a -0.0586959
MYL12B myosin, light chain 12B, regulatory -0.0570091
RPLP0 ribosomal protein, large, P0 -0.0543188
RPL37A ribosomal protein L37a -0.0529479
RPS19 ribosomal protein S19 -0.0527079
RPL23 ribosomal protein L23 -0.0522983
RPL32 ribosomal protein L32 -0.0520878
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0520329
TPM2 tropomyosin 2 (beta) -0.0518725
RPL34 ribosomal protein L34 -0.0516587
WSB1 WD repeat and SOCS box containing 1 -0.0501939
RPS15 ribosomal protein S15 -0.0491755
RPL31 ribosomal protein L31 -0.0490479
PFN1 profilin 1 -0.0490433
RPS29 ribosomal protein S29 -0.0480246
FTL ferritin, light polypeptide -0.0461406
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0437854
GNAS GNAS complex locus -0.0435601
RPS4X ribosomal protein S4, X-linked -0.0424878
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0423353
RPL8 ribosomal protein L8 -0.0423214
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0421955
ACTG1 actin gamma 1 -0.0420492
RPL9 ribosomal protein L9 -0.0419153
RPLP2 ribosomal protein, large, P2 -0.0416517
VDAC1 voltage-dependent anion channel 1 -0.0412198
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0407452
RPS12 ribosomal protein S12 -0.0403743
RPS6 ribosomal protein S6 -0.0403346
CAVIN1 caveolae associated protein 1 -0.0398803
RPL35 ribosomal protein L35 -0.039363
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0384539
RPS24 ribosomal protein S24 -0.0383226
RPL36 ribosomal protein L36 -0.0382497
HLA-B major histocompatibility complex, class I, B -0.0373639
RACK1 receptor for activated C kinase 1 -0.0366042
AHNAK AHNAK nucleoprotein -0.0350894
IFI6 interferon, alpha-inducible protein 6 -0.0350838
EIF1 eukaryotic translation initiation factor 1 -0.0347551
RPL11 ribosomal protein L11 -0.0346808
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0339588
UBB ubiquitin B -0.0338187
RPS23 ribosomal protein S23 -0.0335501
STC1 stanniocalcin 1 -0.0328517
RPL13A ribosomal protein L13a -0.0323864
RPL5 ribosomal protein L5 -0.0319514
ATP5F1E ATP synthase F1 subunit epsilon -0.0312389
S100A10 S100 calcium binding protein A10 -0.0312162
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0310894
PHF20 PHD finger protein 20 -0.0310649
S100A6 S100 calcium binding protein A6 -0.0310434
PGK1 phosphoglycerate kinase 1 -0.0308166
NCOA7 nuclear receptor coactivator 7 -0.0306156
RPS10 ribosomal protein S10 -0.0305918
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0301305
KTN1 kinectin 1 (kinesin receptor) -0.0300353
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0300151
RPL28 ribosomal protein L28 -0.0295557
RPL38 ribosomal protein L38 -0.0289202
ZMYND8 zinc finger, MYND-type containing 8 -0.0285561
RPS16 ribosomal protein S16 -0.0279461
RPS14 ribosomal protein S14 -0.0274776
S100A11 S100 calcium binding protein A11 -0.0273778
KPNB1 karyopherin (importin) beta 1 -0.0273359
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0272685
H3-3B H3.3 histone B -0.0270722
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0269982
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0269411
RPL18 ribosomal protein L18 -0.0265638
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0264913
RAN RAN, member RAS oncogene family -0.0264863
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0262963
PHF21A PHD finger protein 21A -0.0258134
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0255764
EIF5B eukaryotic translation initiation factor 5B -0.0253724
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0253314
TRIM56 tripartite motif containing 56 -0.025327
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0253257