Altretamine_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Altretamine perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Altretamine_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.0770013
FN1 fibronectin 1 0.067644
TSC22D2 TSC22 domain family, member 2 0.0648355
CCNL1 cyclin L1 0.057366
FNDC3B fibronectin type III domain containing 3B 0.0553742
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0455108
RNF145 ring finger protein 145 0.043874
FAM13A family with sequence similarity 13, member A 0.0425819
NDRG1 N-myc downstream regulated 1 0.0415491
TFG TRK-fused gene 0.0410997
FXR1 fragile X mental retardation, autosomal homolog 1 0.0405158
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0382255
ASPH aspartate beta-hydroxylase 0.0356194
UBA6 ubiquitin-like modifier activating enzyme 6 0.0350613
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0332723
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0330339
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0329379
USP3 ubiquitin specific peptidase 3 0.0323606
MARCHF6 membrane associated ring-CH-type finger 6 0.032248
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0321339
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0320915
ADAM9 ADAM metallopeptidase domain 9 0.0307982
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0303987
RYBP RING1 and YY1 binding protein 0.0303719
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.030298
ANXA5 annexin A5 0.0290494
NCKAP1 NCK-associated protein 1 0.0271847
ZNF292 zinc finger protein 292 0.0270503
GARS1 glycyl-tRNA synthetase 1 0.0269073
NUP58 nucleoporin 58 0.0268681
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0263241
EEF2 eukaryotic translation elongation factor 2 0.0258409
MSMO1 methylsterol monooxygenase 1 0.025577
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0248285
MATR3 matrin 3 0.0243939
QKI QKI, KH domain containing, RNA binding 0.0226322
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0225119
ARRDC3 arrestin domain containing 3 0.0224643
PCBP2 poly(rC) binding protein 2 0.022381
BHLHE40 basic helix-loop-helix family, member e40 0.0223632
ECT2 epithelial cell transforming 2 0.0221117
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0220286
TNIP1 TNFAIP3 interacting protein 1 0.0216844
PAPOLA poly(A) polymerase alpha 0.0215797
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0215047
PTK2 protein tyrosine kinase 2 0.0213993
ELL2 elongation factor, RNA polymerase II, 2 0.0210685
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0208998
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0207945
RLF rearranged L-myc fusion 0.0202851
CPNE8 copine VIII 0.0202817
SSBP2 single-stranded DNA binding protein 2 0.019689
MYH9 myosin, heavy chain 9, non-muscle 0.0192209
RAD23B RAD23 homolog B (S. cerevisiae) 0.019184
CDK17 cyclin-dependent kinase 17 0.0189345
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0187745
HSPA8 heat shock 70kDa protein 8 0.0187128
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0186414
MEF2A myocyte enhancer factor 2A 0.01863
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0185849
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0185147
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0183886
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0183212
ATP13A3 ATPase type 13A3 0.0180754
EPS8 epidermal growth factor receptor pathway substrate 8 0.017912
RYK receptor-like tyrosine kinase 0.0178745
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0177789
TRA2B transformer 2 beta homolog (Drosophila) 0.0176425
CLINT1 clathrin interactor 1 0.0175688
YTHDC1 YTH domain containing 1 0.0174408
NPTN neuroplastin 0.0172195
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0171486
MSN moesin 0.016997
CDC73 cell division cycle 73 0.0168592
CD83 CD83 molecule 0.0168321
KDM1A lysine (K)-specific demethylase 1A 0.0167703
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0166682
GRB10 growth factor receptor-bound protein 10 0.0166347
LRRC1 leucine rich repeat containing 1 0.0165544
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.016301
CD46 CD46 molecule, complement regulatory protein 0.0162756
UBQLN1 ubiquilin 1 0.0162715
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0162511
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0160866
NEK7 NIMA-related kinase 7 0.0160292
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0160248
MTMR3 myotubularin related protein 3 0.0158479
IRF6 interferon regulatory factor 6 0.0157024
SLMAP sarcolemma associated protein 0.0156447
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0156333
KDM6A lysine (K)-specific demethylase 6A 0.0154988
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0153324
RHEB Ras homolog enriched in brain 0.01518
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0151702
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0151684
TXNRD1 thioredoxin reductase 1 0.0151462
OSBPL9 oxysterol binding protein-like 9 0.0151278
KMT2E lysine (K)-specific methyltransferase 2E 0.0149794
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0149363
UGCG UDP-glucose ceramide glucosyltransferase 0.0147537

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.213761
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.202726
TMSB10 thymosin beta 10 -0.18157
PTMA prothymosin, alpha -0.172015
ACTG1 actin gamma 1 -0.168053
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.143353
EXT1 exostosin glycosyltransferase 1 -0.0911476
FBXO32 F-box protein 32 -0.0906937
RPL35A ribosomal protein L35a -0.0891727
IFI27 interferon, alpha-inducible protein 27 -0.0885535
TPT1 tumor protein, translationally-controlled 1 -0.0860495
LAMB3 laminin, beta 3 -0.077422
EIF1 eukaryotic translation initiation factor 1 -0.0772196
S100A6 S100 calcium binding protein A6 -0.0762462
RPLP1 ribosomal protein, large, P1 -0.074843
RPL34 ribosomal protein L34 -0.0728179
SAMD4A sterile alpha motif domain containing 4A -0.0710271
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0686288
CSTB cystatin B (stefin B) -0.0679427
IFI6 interferon, alpha-inducible protein 6 -0.0671433
ISG15 ISG15 ubiquitin-like modifier -0.0643192
SOX4 SRY (sex determining region Y)-box 4 -0.0628065
RPS8 ribosomal protein S8 -0.0617912
POTEF POTE ankyrin domain family, member F -0.0606321
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0599816
S100A10 S100 calcium binding protein A10 -0.059052
LPP LIM domain containing preferred translocation partner in lipoma -0.0577867
LIMCH1 LIM and calponin homology domains 1 -0.056472
EFNA5 ephrin-A5 -0.0557208
TPM4 tropomyosin 4 -0.0551837
IFITM3 interferon induced transmembrane protein 3 -0.0539051
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0536073
TMSB4X thymosin beta 4, X-linked -0.0533127
RPLP2 ribosomal protein, large, P2 -0.0523621
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0514185
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0513143
IGFBP3 insulin-like growth factor binding protein 3 -0.0509299
HLA-B major histocompatibility complex, class I, B -0.0507633
RPS29 ribosomal protein S29 -0.050233
RPL23 ribosomal protein L23 -0.0499527
IFI16 interferon, gamma-inducible protein 16 -0.0494141
HLA-A major histocompatibility complex, class I, A -0.0489701
RPS13 ribosomal protein S13 -0.0481767
WSB1 WD repeat and SOCS box containing 1 -0.0479976
RPS19 ribosomal protein S19 -0.0474792
RPS23 ribosomal protein S23 -0.0468779
RPS6 ribosomal protein S6 -0.0463104
IFITM1 interferon induced transmembrane protein 1 -0.046096
RPL8 ribosomal protein L8 -0.0458567
AHNAK AHNAK nucleoprotein -0.0449223
LMO7 LIM domain 7 -0.0441177
TM4SF1 transmembrane 4 L six family member 1 -0.0436381
VIM vimentin -0.0428682
S100A9 S100 calcium binding protein A9 -0.042007
MYO1E myosin IE -0.0413914
KRT7 keratin 7, type II -0.0412803
MDK midkine (neurite growth-promoting factor 2) -0.0395147
BASP1 brain abundant, membrane attached signal protein 1 -0.0394861
RPL37A ribosomal protein L37a -0.0384493
ARHGAP5 Rho GTPase activating protein 5 -0.0382991
RPL9 ribosomal protein L9 -0.0382482
RPL19 ribosomal protein L19 -0.0378196
MT2A metallothionein 2A -0.0374368
RPL30 ribosomal protein L30 -0.0371029
RPL37 ribosomal protein L37 -0.0368528
RPL12 ribosomal protein L12 -0.0366261
GNAS GNAS complex locus -0.0363272
GOLGB1 golgin B1 -0.0362852
SH3KBP1 SH3-domain kinase binding protein 1 -0.0358252
RACK1 receptor for activated C kinase 1 -0.0353658
RPS27A ribosomal protein S27a -0.0353184
VCL vinculin -0.0351711
CCND1 cyclin D1 -0.0350953
RPS14 ribosomal protein S14 -0.0347676
LMNA lamin A/C -0.0341277
RPL31 ribosomal protein L31 -0.0339091
RPL32 ribosomal protein L32 -0.0336744
C15ORF48 chromosome 15 open reading frame 48 -0.0332594
UBE2H ubiquitin-conjugating enzyme E2H -0.0329752
RPS24 ribosomal protein S24 -0.0327217
MAP1B microtubule-associated protein 1B -0.0326711
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0321817
HSPB1 heat shock 27kDa protein 1 -0.0319425
RPS25 ribosomal protein S25 -0.0309415
RAI14 retinoic acid induced 14 -0.03086
RPS21 ribosomal protein S21 -0.030773
ZBTB20 zinc finger and BTB domain containing 20 -0.0307389
RPS16 ribosomal protein S16 -0.0307289
RAB7A RAB7A, member RAS oncogene family -0.0305715
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0304679
RRBP1 ribosome binding protein 1 -0.0304446
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0303812
RPL15 ribosomal protein L15 -0.0302982
RPL11 ribosomal protein L11 -0.0302281
ENO1 enolase 1, (alpha) -0.0300021
EPCAM epithelial cell adhesion molecule -0.0298848
RPS27 ribosomal protein S27 -0.0298391
RNF213 ring finger protein 213 -0.0297682
IFIH1 interferon induced with helicase C domain 1 -0.0295391
FNIP1 folliculin interacting protein 1 -0.0294115