Altretamine_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Altretamine perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Altretamine_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.190511
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.164126
EFNA5 ephrin-A5 0.112248
PDE10A phosphodiesterase 10A 0.108126
ASPH aspartate beta-hydroxylase 0.0944576
PSD3 pleckstrin and Sec7 domain containing 3 0.0913965
NAMPT nicotinamide phosphoribosyltransferase 0.0797116
GDA guanine deaminase 0.0764437
FN1 fibronectin 1 0.0732955
COL5A2 collagen, type V, alpha 2 0.0670087
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0641179
TRIO trio Rho guanine nucleotide exchange factor 0.0621501
NRCAM neuronal cell adhesion molecule 0.0594375
PCBP3 poly(rC) binding protein 3 0.0583336
DST dystonin 0.0543626
FNDC3B fibronectin type III domain containing 3B 0.0532134
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0484488
CDH13 cadherin 13 0.0432985
DOCK4 dedicator of cytokinesis 4 0.0427322
GRAMD1B GRAM domain containing 1B 0.0422564
MYOF myoferlin 0.0421491
NALF1 NALCN channel auxiliary factor 1 0.0417405
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.041325
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0406758
PDLIM5 PDZ and LIM domain 5 0.0388175
PM20D1 peptidase M20 domain containing 1 0.038094
NEK7 NIMA-related kinase 7 0.0367936
SMYD3 SET and MYND domain containing 3 0.0362345
COL8A1 collagen, type VIII, alpha 1 0.035806
LIMCH1 LIM and calponin homology domains 1 0.0347768
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0347399
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0344922
KYNU kynureninase 0.0338762
COL4A5 collagen, type IV, alpha 5 0.0338752
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0336186
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0333483
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0330198
TXNRD1 thioredoxin reductase 1 0.0313779
CD109 CD109 molecule 0.0312512
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0305654
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0297001
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0277907
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0275562
ZEB2 zinc finger E-box binding homeobox 2 0.0272329
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0264103
DGKD diacylglycerol kinase, delta 130kDa 0.0259866
COL4A6 collagen, type IV, alpha 6 0.0252293
ELL2 elongation factor, RNA polymerase II, 2 0.0250615
NPAS2 neuronal PAS domain protein 2 0.0240471
SAMD4A sterile alpha motif domain containing 4A 0.023679
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0236584
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0234175
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0233667
P3H2 prolyl 3-hydroxylase 2 0.0230688
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0229861
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0227937
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0226711
CTSC cathepsin C 0.0217316
ITPRID2 ITPR interacting domain containing 2 0.0216349
ADGRD1 adhesion G protein-coupled receptor D1 0.021038
BCAR3 breast cancer anti-estrogen resistance 3 0.0208395
MAML3 mastermind-like 3 (Drosophila) 0.0198248
PTPRM protein tyrosine phosphatase, receptor type, M 0.0192342
GLIS3 GLIS family zinc finger 3 0.0190543
TGFBR1 transforming growth factor, beta receptor 1 0.018805
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0184787
RPH3AL rabphilin 3A-like (without C2 domains) 0.0184201
RTN1 reticulon 1 0.0183223
AGFG1 ArfGAP with FG repeats 1 0.0183083
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.018183
ALPK2 alpha-kinase 2 0.0179383
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.017767
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0172017
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0171226
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0170948
USP9X ubiquitin specific peptidase 9, X-linked 0.0170224
TMX4 thioredoxin-related transmembrane protein 4 0.0167448
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0161784
PBX1 pre-B-cell leukemia homeobox 1 0.0161604
DNER delta/notch-like EGF repeat containing 0.0160463
NBAS neuroblastoma amplified sequence 0.0159021
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0155187
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.015512
GPRIN3 GPRIN family member 3 0.0154764
PALLD palladin, cytoskeletal associated protein 0.0154385
PDE4B phosphodiesterase 4B, cAMP-specific 0.0153969
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0153778
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0153407
FNDC3A fibronectin type III domain containing 3A 0.0149192
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 0.014813
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0147953
BDNF brain-derived neurotrophic factor 0.014705
TNPO1 transportin 1 0.0146008
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0145899
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0145643
AOPEP aminopeptidase O (putative) 0.0137921
APP amyloid beta (A4) precursor protein 0.0137557
ATXN1 ataxin 1 0.0136883
ANTXR1 anthrax toxin receptor 1 0.0136822
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0136569

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.194164
VIM vimentin -0.11771
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.105514
TMSB10 thymosin beta 10 -0.101506
PTMA prothymosin, alpha -0.0938148
RPS6 ribosomal protein S6 -0.0851739
FTL ferritin, light polypeptide -0.0818636
RPLP1 ribosomal protein, large, P1 -0.0741661
TPT1 tumor protein, translationally-controlled 1 -0.0729025
RPS8 ribosomal protein S8 -0.0630752
RPL37A ribosomal protein L37a -0.0584791
RPL31 ribosomal protein L31 -0.054683
RPL35A ribosomal protein L35a -0.0538988
RPL26 ribosomal protein L26 -0.0522282
RPL12 ribosomal protein L12 -0.0510515
RPS12 ribosomal protein S12 -0.0491493
RPS23 ribosomal protein S23 -0.049108
RPS19 ribosomal protein S19 -0.0490279
RPS24 ribosomal protein S24 -0.0467505
RPL19 ribosomal protein L19 -0.0458644
RPLP0 ribosomal protein, large, P0 -0.0405066
RPL23 ribosomal protein L23 -0.0401593
EIF1 eukaryotic translation initiation factor 1 -0.0383663
RPL9 ribosomal protein L9 -0.0383608
NAP1L1 nucleosome assembly protein 1-like 1 -0.0381876
RPL34 ribosomal protein L34 -0.0373552
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0370251
RPL36A ribosomal protein L36a -0.0367047
RPS27A ribosomal protein S27a -0.0361016
RPLP2 ribosomal protein, large, P2 -0.0359798
RPS29 ribosomal protein S29 -0.0353901
MT2A metallothionein 2A -0.0353172
RPL11 ribosomal protein L11 -0.0346264
RPS27 ribosomal protein S27 -0.034008
RPL7A ribosomal protein L7a -0.0338868
RPS14 ribosomal protein S14 -0.0337954
RPS3 ribosomal protein S3 -0.0337438
NDRG1 N-myc downstream regulated 1 -0.032512
RPS25 ribosomal protein S25 -0.0323304
RPL36 ribosomal protein L36 -0.0318375
RPL37 ribosomal protein L37 -0.0315275
S100A6 S100 calcium binding protein A6 -0.0307773
RPS21 ribosomal protein S21 -0.0296451
RPS16 ribosomal protein S16 -0.0295626
RPS13 ribosomal protein S13 -0.0293759
S100A10 S100 calcium binding protein A10 -0.0293231
HLA-A major histocompatibility complex, class I, A -0.0287143
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.028427
GNAS GNAS complex locus -0.0280616
RPS17 ribosomal protein S17 -0.0274203
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0270145
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0261941
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.025549
RACK1 receptor for activated C kinase 1 -0.0255003
HLA-B major histocompatibility complex, class I, B -0.0254294
RPL13A ribosomal protein L13a -0.0251318
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0242601
RPL35 ribosomal protein L35 -0.0239025
RPL32 ribosomal protein L32 -0.0236161
B2M beta-2-microglobulin -0.0222343
VDAC1 voltage-dependent anion channel 1 -0.0221702
RPS5 ribosomal protein S5 -0.0221495
RPL28 ribosomal protein L28 -0.0220372
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0215771
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0215337
RPS4X ribosomal protein S4, X-linked -0.021435
RPL27 ribosomal protein L27 -0.0212261
ACTG1 actin gamma 1 -0.0211982
STC1 stanniocalcin 1 -0.0209808
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0207846
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0206989
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0203654
RPL8 ribosomal protein L8 -0.0200831
SRGN serglycin -0.0198061
FTH1 ferritin, heavy polypeptide 1 -0.019653
SOX4 SRY (sex determining region Y)-box 4 -0.019439
RPL5 ribosomal protein L5 -0.0194087
RPS11 ribosomal protein S11 -0.0188917
RPL30 ribosomal protein L30 -0.0187434
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0186742
RPL38 ribosomal protein L38 -0.0185868
RPL18 ribosomal protein L18 -0.0184274
POTEF POTE ankyrin domain family, member F -0.0182148
RPL27A ribosomal protein L27a -0.0181439
PFN1 profilin 1 -0.0180381
RPS15 ribosomal protein S15 -0.0179904
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0179858
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.017804
LMNA lamin A/C -0.0175349
TFPI2 tissue factor pathway inhibitor 2 -0.0171329
RPL10A ribosomal protein L10a -0.0168599
WSB1 WD repeat and SOCS box containing 1 -0.0168333
PKM pyruvate kinase, muscle -0.0158922
RPS20 ribosomal protein S20 -0.0158215
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0157545
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0157114
LOC112694756 uncharaterized LOC112694756 -0.0156638
PDIA3 protein disulfide isomerase family A, member 3 -0.015653
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0152747
ISG15 ISG15 ubiquitin-like modifier -0.0152455