Altretamine_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Altretamine perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Altretamine_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZFAND3 zinc finger, AN1-type domain 3 0.0458851
ADAM10 ADAM metallopeptidase domain 10 0.0449004
FLNB filamin B, beta 0.0431526
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0411814
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0394124
NBAS neuroblastoma amplified sequence 0.0359538
EXT1 exostosin glycosyltransferase 1 0.0356987
CAMTA1 calmodulin binding transcription activator 1 0.0349874
ANK2 ankyrin 2, neuronal 0.0343849
GOLGA4 golgin A4 0.0341637
RBM39 RNA binding motif protein 39 0.0328986
ZNF292 zinc finger protein 292 0.0324186
CCNL1 cyclin L1 0.0316537
PICALM phosphatidylinositol binding clathrin assembly protein 0.029447
ECT2 epithelial cell transforming 2 0.028411
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0283208
PTBP2 polypyrimidine tract binding protein 2 0.028121
NCKAP1 NCK-associated protein 1 0.0280455
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0279397
EIF4A2 eukaryotic translation initiation factor 4A2 0.0275127
PDGFC platelet derived growth factor C 0.0271413
PRELID2 PRELI domain containing 2 0.0269559
NUP58 nucleoporin 58 0.0258781
GSK3B glycogen synthase kinase 3 beta 0.025351
CD47 CD47 molecule 0.0252845
ADAM9 ADAM metallopeptidase domain 9 0.0249707
EML4 echinoderm microtubule associated protein like 4 0.0248942
ANKRD11 ankyrin repeat domain 11 0.0244716
NAMPT nicotinamide phosphoribosyltransferase 0.0244162
TXNRD1 thioredoxin reductase 1 0.0240006
GARS1 glycyl-tRNA synthetase 1 0.0236946
RTN4 reticulon 4 0.0235193
ELOVL5 ELOVL fatty acid elongase 5 0.0234224
VMP1 vacuole membrane protein 1 0.0230354
PARD3 par-3 family cell polarity regulator 0.0228711
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0228078
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.0224003
AKAP9 A kinase (PRKA) anchor protein 9 0.02231
LPP LIM domain containing preferred translocation partner in lipoma 0.0221118
KMT2C lysine (K)-specific methyltransferase 2C 0.0220584
JMJD1C jumonji domain containing 1C 0.0220246
TFG TRK-fused gene 0.0219612
ZNF608 zinc finger protein 608 0.021765
KMT2E lysine (K)-specific methyltransferase 2E 0.0215813
COG5 component of oligomeric golgi complex 5 0.0215183
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0214167
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0213081
TMEM65 transmembrane protein 65 0.0208181
ZFC3H1 zinc finger, C3H1-type containing 0.0206404
SMYD3 SET and MYND domain containing 3 0.0203926
BIRC6 baculoviral IAP repeat containing 6 0.0203314
DSCAM Down syndrome cell adhesion molecule 0.0202821
HDAC9 histone deacetylase 9 0.0202206
KDM4C lysine (K)-specific demethylase 4C 0.0198398
TBC1D5 TBC1 domain family, member 5 0.0197987
SBF2 SET binding factor 2 0.01972
KDM3A lysine (K)-specific demethylase 3A 0.019621
EEF2 eukaryotic translation elongation factor 2 0.0194943
MON2 MON2 homolog (S. cerevisiae) 0.0193295
GLS2 glutaminase 2 (liver, mitochondrial) 0.0192429
ZEB1 zinc finger E-box binding homeobox 1 0.0192335
SAMD4A sterile alpha motif domain containing 4A 0.0191453
CASC3 cancer susceptibility candidate 3 0.0189128
PUM2 pumilio RNA-binding family member 2 0.0188933
YEATS2 YEATS domain containing 2 0.0187322
COPA coatomer protein complex, subunit alpha 0.0187028
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0185133
USP24 ubiquitin specific peptidase 24 0.0184359
ANKRD36 ankyrin repeat domain 36 0.018222
QKI QKI, KH domain containing, RNA binding 0.018214
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0182113
CDC73 cell division cycle 73 0.0180271
PLXNA1 plexin A1 0.017689
KDM6A lysine (K)-specific demethylase 6A 0.0175101
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0173064
NCEH1 neutral cholesterol ester hydrolase 1 0.0172366
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0171877
EIF4B eukaryotic translation initiation factor 4B 0.0171511
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0170951
TMEM39A transmembrane protein 39A 0.0170061
PGK1 phosphoglycerate kinase 1 0.0169845
PYGB phosphorylase, glycogen; brain 0.0166985
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0165758
RHBDD1 rhomboid domain containing 1 0.0165355
RUSC2 RUN and SH3 domain containing 2 0.016474
TTC3 tetratricopeptide repeat domain 3 0.0164375
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0162869
RNF145 ring finger protein 145 0.0162485
ATOSA atos homolog A 0.016201
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0161882
BRWD1 bromodomain and WD repeat domain containing 1 0.0160844
MTMR3 myotubularin related protein 3 0.0160519
HELZ helicase with zinc finger 0.0160316
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0159838
FOXJ3 forkhead box J3 0.0156957
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.0155719
RPL3 ribosomal protein L3 0.0155509
MBNL2 muscleblind-like splicing regulator 2 0.0155503
RB1CC1 RB1-inducible coiled-coil 1 0.0155361
ZCCHC7 zinc finger, CCHC domain containing 7 0.0155262

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.346592
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.305467
RPS6 ribosomal protein S6 -0.137191
TPT1 tumor protein, translationally-controlled 1 -0.131851
RPS8 ribosomal protein S8 -0.110982
RPL35A ribosomal protein L35a -0.100154
RPLP1 ribosomal protein, large, P1 -0.0800189
BMP10 bone morphogenetic protein 10 -0.0782133
RPL34 ribosomal protein L34 -0.0746188
RPL31 ribosomal protein L31 -0.0677677
RPLP0 ribosomal protein, large, P0 -0.0673741
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0645967
RPL12 ribosomal protein L12 -0.0631626
ACTG1 actin gamma 1 -0.0628061
RPL9 ribosomal protein L9 -0.0573309
RPS23 ribosomal protein S23 -0.0562022
RPLP2 ribosomal protein, large, P2 -0.0560259
RPL11 ribosomal protein L11 -0.0558989
S100A6 S100 calcium binding protein A6 -0.0551764
RPS13 ribosomal protein S13 -0.0548853
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.054668
RPS19 ribosomal protein S19 -0.0539423
RPL19 ribosomal protein L19 -0.0538244
RPL26 ribosomal protein L26 -0.0538093
HSPB1 heat shock 27kDa protein 1 -0.0509284
RPL23 ribosomal protein L23 -0.0487369
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0483168
RPL37A ribosomal protein L37a -0.0480988
RPL36 ribosomal protein L36 -0.047629
RPS21 ribosomal protein S21 -0.0454002
CCND1 cyclin D1 -0.0452354
S100A9 S100 calcium binding protein A9 -0.0447734
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0439505
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0433623
RPS27A ribosomal protein S27a -0.0433505
VCL vinculin -0.0418892
NAP1L1 nucleosome assembly protein 1-like 1 -0.0416362
S100A4 S100 calcium binding protein A4 -0.0409507
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.040627
RPS25 ribosomal protein S25 -0.0403909
KPNB1 karyopherin (importin) beta 1 -0.0400875
PFN1 profilin 1 -0.0396786
FOXP1 forkhead box P1 -0.0393454
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0372575
ARL4C ADP-ribosylation factor-like 4C -0.0371821
RPS14 ribosomal protein S14 -0.0368987
RPS24 ribosomal protein S24 -0.0366514
RPS3 ribosomal protein S3 -0.0362277
RPL8 ribosomal protein L8 -0.0360347
RPS12 ribosomal protein S12 -0.0356304
RPL32 ribosomal protein L32 -0.0353082
LOC102724023 ES1 protein homolog, mitochondrial -0.0350391
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0345863
MKI67 marker of proliferation Ki-67 -0.0345038
RPL27A ribosomal protein L27a -0.0341585
RPS11 ribosomal protein S11 -0.0341459
AHNAK AHNAK nucleoprotein -0.033652
CENPF centromere protein F, 350/400kDa -0.0331586
SMC4 structural maintenance of chromosomes 4 -0.0326545
RPS5 ribosomal protein S5 -0.0326153
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0320693
FTL ferritin, light polypeptide -0.0320168
MYL12B myosin, light chain 12B, regulatory -0.0316278
DIAPH3 diaphanous-related formin 3 -0.0310758
RPS29 ribosomal protein S29 -0.0309901
RACK1 receptor for activated C kinase 1 -0.0305148
TMSB10 thymosin beta 10 -0.0304654
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0303433
RPL7A ribosomal protein L7a -0.0298996
PRDX2 peroxiredoxin 2 -0.0298939
DLG1 discs, large homolog 1 (Drosophila) -0.0298392
RPL37 ribosomal protein L37 -0.0297459
ENO1 enolase 1, (alpha) -0.0290397
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.027839
RPL30 ribosomal protein L30 -0.02774
RPS17 ribosomal protein S17 -0.0276807
RPS16 ribosomal protein S16 -0.0274679
RPS27 ribosomal protein S27 -0.0273596
PKM pyruvate kinase, muscle -0.0270081
GNAS GNAS complex locus -0.0265046
MT2A metallothionein 2A -0.0261504
RPL7 ribosomal protein L7 -0.02592
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0258791
TPI1 triosephosphate isomerase 1 -0.025608
EIF1 eukaryotic translation initiation factor 1 -0.0255681
S100A10 S100 calcium binding protein A10 -0.025456
RPL18 ribosomal protein L18 -0.0252599
RPL5 ribosomal protein L5 -0.0251298
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.02496
RPL28 ribosomal protein L28 -0.0248874
TPX2 TPX2, microtubule-associated -0.0248624
TUBB4B tubulin, beta 4B class IVb -0.0244082
RPL36A ribosomal protein L36a -0.0244026
ZMYND8 zinc finger, MYND-type containing 8 -0.0242454
RPS4X ribosomal protein S4, X-linked -0.0242206
RPL10A ribosomal protein L10a -0.0236768
EBNA1BP2 EBNA1 binding protein 2 -0.0233907
TPM4 tropomyosin 4 -0.0231786
RPL13A ribosomal protein L13a -0.0230802
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0230044