Altretamine_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Altretamine perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Altretamine_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 0.115816
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0932563
NAMPT nicotinamide phosphoribosyltransferase 0.0909772
TRIO trio Rho guanine nucleotide exchange factor 0.0735252
COL6A3 collagen, type VI, alpha 3 0.0672771
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0668559
ARRDC3 arrestin domain containing 3 0.060529
ATP13A3 ATPase type 13A3 0.056462
EEF2 eukaryotic translation elongation factor 2 0.0559221
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0522386
ELL2 elongation factor, RNA polymerase II, 2 0.0491218
SMAD3 SMAD family member 3 0.0472938
VEGFA vascular endothelial growth factor A 0.0464354
B2M beta-2-microglobulin 0.0464212
EGFR epidermal growth factor receptor 0.0429318
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0424627
IL6 interleukin 6 0.0399121
IGF2 insulin-like growth factor 2 0.0391403
TPM3 tropomyosin 3 0.0372927
RNF145 ring finger protein 145 0.0362034
DSCAM Down syndrome cell adhesion molecule 0.0356916
MSN moesin 0.0351428
YEATS2 YEATS domain containing 2 0.034984
SHB Src homology 2 domain containing adaptor protein B 0.0349667
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.034919
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0343305
SMYD3 SET and MYND domain containing 3 0.0342397
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0338212
ABLIM3 actin binding LIM protein family, member 3 0.0317484
EPS8 epidermal growth factor receptor pathway substrate 8 0.0313062
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0311472
ZMIZ1 zinc finger, MIZ-type containing 1 0.0309635
SNX13 sorting nexin 13 0.030799
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0306722
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0304704
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0301905
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0298722
YME1L1 YME1-like 1 ATPase 0.0295988
ANXA5 annexin A5 0.0293539
AKAP9 A kinase (PRKA) anchor protein 9 0.0282634
ZNF148 zinc finger protein 148 0.0281144
NUB1 negative regulator of ubiquitin-like proteins 1 0.0280724
TENT2 terminal nucleotidyltransferase 2 0.0278214
FLNB filamin B, beta 0.0277684
SKAP2 src kinase associated phosphoprotein 2 0.0273985
SLMAP sarcolemma associated protein 0.0272641
PSD3 pleckstrin and Sec7 domain containing 3 0.0272179
CCNL1 cyclin L1 0.0270904
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0268384
GARS1 glycyl-tRNA synthetase 1 0.0266589
RB1CC1 RB1-inducible coiled-coil 1 0.026619
MMP12 matrix metallopeptidase 12 0.0264552
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0260986
MAP4 microtubule-associated protein 4 0.0259598
EIF4H eukaryotic translation initiation factor 4H 0.0256955
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0256415
P3H1 prolyl 3-hydroxylase 1 0.0255373
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0254798
ZNF292 zinc finger protein 292 0.0254718
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0254376
TNPO1 transportin 1 0.0252348
CSNK1A1 casein kinase 1, alpha 1 0.0252011
COPA coatomer protein complex, subunit alpha 0.0250775
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0249542
NRP1 neuropilin 1 0.0248917
TRRAP transformation/transcription domain-associated protein 0.0248817
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0248649
ANKRD11 ankyrin repeat domain 11 0.0248589
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0246452
ARHGAP32 Rho GTPase activating protein 32 0.0246279
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0244255
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0243416
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0241979
BCLAF1 BCL2-associated transcription factor 1 0.0239378
RBBP6 retinoblastoma binding protein 6 0.0237109
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) 0.0236178
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0235192
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0234506
MBNL1 muscleblind-like splicing regulator 1 0.0233616
TMEM165 transmembrane protein 165 0.02328
CUL3 cullin 3 0.0232561
PRRC2C proline-rich coiled-coil 2C 0.0232415
ARMH3 armadillo like helical domain containing 3 0.0230162
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase 0.023007
SPRED1 sprouty-related, EVH1 domain containing 1 0.0226423
ITPRID2 ITPR interacting domain containing 2 0.0225869
GPC6 glypican 6 0.0224412
MGLL monoglyceride lipase 0.0223763
TXNRD1 thioredoxin reductase 1 0.0223606
RBM25 RNA binding motif protein 25 0.0223219
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0222491
WNT5A wingless-type MMTV integration site family, member 5A 0.0221476
FTH1 ferritin, heavy polypeptide 1 0.0221413
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0220459
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0219458
UBE3A ubiquitin protein ligase E3A 0.0218031
BIRC6 baculoviral IAP repeat containing 6 0.021772
NF1 neurofibromin 1 0.0216955
PPP4R3B protein phosphatase 4 regulatory subunit 3B 0.0216929
RSAD2 radical S-adenosyl methionine domain containing 2 0.0216013

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.290569
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.232418
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.211186
TMSB10 thymosin beta 10 -0.151382
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.129285
AHNAK AHNAK nucleoprotein -0.100704
CANX calnexin -0.0907374
TGFBI transforming growth factor, beta-induced, 68kDa -0.0811301
FN1 fibronectin 1 -0.0788146
HLA-C major histocompatibility complex, class I, C -0.0783548
HMGA2 high mobility group AT-hook 2 -0.0764438
SDC4 syndecan 4 -0.0761426
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0752557
VIM vimentin -0.0721413
NRXN3 neurexin 3 -0.0694368
CALU calumenin -0.0677287
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0673153
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0643975
PTMA prothymosin, alpha -0.0626457
HDLBP high density lipoprotein binding protein -0.0609111
MT2A metallothionein 2A -0.0586888
COL1A1 collagen, type I, alpha 1 -0.0560467
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0559789
HLA-A major histocompatibility complex, class I, A -0.0556826
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0553
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0552211
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0542376
HLA-B major histocompatibility complex, class I, B -0.0526619
CAVIN1 caveolae associated protein 1 -0.0503113
PDLIM5 PDZ and LIM domain 5 -0.0495993
SEC24D SEC24 family member D -0.0493549
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0468948
PRSS23 protease, serine, 23 -0.046534
CAV1 caveolin 1, caveolae protein, 22kDa -0.0462132
LMAN1 lectin, mannose-binding, 1 -0.0452702
SQSTM1 sequestosome 1 -0.0452499
SOD2 superoxide dismutase 2, mitochondrial -0.0449559
LOX lysyl oxidase -0.0444835
PRRC1 proline-rich coiled-coil 1 -0.0443971
ANXA2 annexin A2 -0.0439868
EIF1 eukaryotic translation initiation factor 1 -0.0439762
RAD51B RAD51 paralog B -0.0437482
PTGES2 prostaglandin E synthase 2 -0.0432626
RAB1A RAB1A, member RAS oncogene family -0.0417061
CALR calreticulin -0.041184
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.039995
LOC112694756 uncharaterized LOC112694756 -0.0397077
ACTG1 actin gamma 1 -0.0391774
NABP1 nucleic acid binding protein 1 -0.039038
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0390335
INTS6 integrator complex subunit 6 -0.0386419
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.038421
SEC31A SEC31 homolog A (S. cerevisiae) -0.0381492
SAR1A secretion associated, Ras related GTPase 1A -0.0381489
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0362617
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.035936
TUBB tubulin, beta class I -0.0357954
RPL28 ribosomal protein L28 -0.0356169
SEPTIN7 septin 7 -0.0354619
THY1 Thy-1 cell surface antigen -0.0345176
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0337694
POTEF POTE ankyrin domain family, member F -0.0336173
FUS FUS RNA binding protein -0.0333322
VCL vinculin -0.0330404
MARCHF6 membrane associated ring-CH-type finger 6 -0.0325831
WSB1 WD repeat and SOCS box containing 1 -0.0322743
GLG1 golgi glycoprotein 1 -0.0321041
MT1X metallothionein 1X -0.0319081
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -0.0318555
MORF4L2 mortality factor 4 like 2 -0.0318187
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0317768
LDHA lactate dehydrogenase A -0.0310237
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0305214
CMIP c-Maf inducing protein -0.0305024
STC1 stanniocalcin 1 -0.0303514
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.030243
SPDYA speedy/RINGO cell cycle regulator family member A -0.0301784
COL6A1 collagen, type VI, alpha 1 -0.0300854
HM13 histocompatibility (minor) 13 -0.0296665
HMGB1 high mobility group box 1 -0.0296491
CST3 cystatin C -0.0296451
COL1A2 collagen, type I, alpha 2 -0.0290885
ARF1 ADP-ribosylation factor 1 -0.0288151
FNIP1 folliculin interacting protein 1 -0.0287914
DIAPH3 diaphanous-related formin 3 -0.0287333
MAP1B microtubule-associated protein 1B -0.0286923
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0284375
FBXL7 F-box and leucine-rich repeat protein 7 -0.0283996
SETD5 SET domain containing 5 -0.0281205
HDAC9 histone deacetylase 9 -0.0280003
RND3 Rho family GTPase 3 -0.0279811
MBD5 methyl-CpG binding domain protein 5 -0.0279458
PTN pleiotrophin -0.0277381
FRMD4A FERM domain containing 4A -0.0277297
CCNI cyclin I -0.0274166
TNS3 tensin 3 -0.0273416
EIF5B eukaryotic translation initiation factor 5B -0.0269367
TPX2 TPX2, microtubule-associated -0.0267949
IGFBP5 insulin-like growth factor binding protein 5 -0.0266782
MACF1 microtubule-actin crosslinking factor 1 -0.0266092