Alzheimer's disease Gene Set

Dataset PhosphoSitePlus Phosphosite-Disease Associations
Category disease or phenotype associations
Type disease
Description A dementia that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting in late middle age and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. It is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability.|A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.|A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)|A dementia which is an incurable disease of unknown cause, starting in late middle age or in old age, that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood, that leads in advanced cases to a profound decline in cognitive and physical functioning, and that is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. (Experimental Factor Ontology, EFO_0000249)
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Genes

17 proteins associated with the disease Alzheimer's disease from the curated PhosphoSitePlus Phosphosite-Disease Associations dataset.

Symbol Name
APLP2 amyloid beta (A4) precursor-like protein 2
APP amyloid beta (A4) precursor protein
DNM1L dynamin 1-like
DPYSL2 dihydropyrimidinase-like 2
GSK3B glycogen synthase kinase 3 beta
MAP1B microtubule-associated protein 1B
MAP2 microtubule-associated protein 2
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAPT microtubule-associated protein tau
NEFH neurofilament, heavy polypeptide
NEFM neurofilament, medium polypeptide
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SQSTM1 sequestosome 1