Amebiasis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A parasitic protozoa infectious disease that involves infection caused by the amoeba Entamoeba histolytica. Amebic invasion of the intestinal lining causes dysentery, colitis or diarrhea. The infection can also spread through the blood to the liver and, rarely, to the lungs, brain or other organs. (Human Disease Ontology, DOID_9181)
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Genes

253 genes co-occuring with the disease Amebiasis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
CPA5 carboxypeptidase A5 2.434
AIG1 androgen-induced 1 2.273
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 2.234
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 2.228
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 2.227
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 2.221
IL17A interleukin 17A 2.102
TNF tumor necrosis factor 2.05
CABP5 calcium binding protein 5 2.013
MYO1C myosin IC 2.01
IFNG interferon, gamma 2.008
IL1B interleukin 1, beta 1.96
FN1 fibronectin 1 1.901
COL1A2 collagen, type I, alpha 2 1.888
LMLN leishmanolysin-like (metallopeptidase M8 family) 1.839
IL6 interleukin 6 1.83
REG1B regenerating islet-derived 1 beta 1.82
CXCL8 chemokine (C-X-C motif) ligand 8 1.81
COL1A1 collagen, type I, alpha 1 1.808
CD4 CD4 molecule 1.803
IGLL5 immunoglobulin lambda-like polypeptide 5 1.793
ALB albumin 1.768
COL3A1 collagen, type III, alpha 1 1.762
MUC2 mucin 2, oligomeric mucus/gel-forming 1.749
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.739
IL10 interleukin 10 1.731
TLR2 toll-like receptor 2 1.727
COL5A2 collagen, type V, alpha 2 1.725
COL4A1 collagen, type IV, alpha 1 1.713
IL4 interleukin 4 1.69
PRAMEF18 PRAME family member 18 1.67
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.665
TLR4 toll-like receptor 4 1.66
COL4A2 collagen, type IV, alpha 2 1.648
LTF lactotransferrin 1.641
MYO1B myosin IB 1.638
CD8A CD8a molecule 1.63
TXN thioredoxin 1.625
ACE2 angiotensin I converting enzyme 2 1.611
COL5A1 collagen, type V, alpha 1 1.606
COL6A3 collagen, type VI, alpha 3 1.605
IGLL1 immunoglobulin lambda-like polypeptide 1 1.6
CRP C-reactive protein, pentraxin-related 1.559
ERVW-1 endogenous retrovirus group W, member 1 1.548
IL1A interleukin 1, alpha 1.548
HSPA4 heat shock 70kDa protein 4 1.546
LAMA4 laminin, alpha 4 1.543
ERVFRD-1 endogenous retrovirus group FRD, member 1 1.532
ERV3-1 endogenous retrovirus group 3, member 1 1.532
PXDN peroxidasin 1.527
PXDNL peroxidasin-like 1.524
TGFB1 transforming growth factor, beta 1 1.523
CTSL cathepsin L 1.502
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 1.499
LEPR leptin receptor 1.479
LAMC1 laminin, gamma 1 (formerly LAMB2) 1.476
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.475
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.466
PRKG1 protein kinase, cGMP-dependent, type I 1.464
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.464
ACTB actin, beta 1.456
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) 1.45
IL18 interleukin 18 1.445
LAMB3 laminin, beta 3 1.444
CALR calreticulin 1.441
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.432
METAP2 methionyl aminopeptidase 2 1.417
TPI1 triosephosphate isomerase 1 1.409
IL2 interleukin 2 1.409
ADCY10 adenylate cyclase 10 (soluble) 1.399
CTSB cathepsin B 1.388
IL13 interleukin 13 1.385
IL5 interleukin 5 1.377
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21 1.376
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.373
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.372
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 1.367
TP53 tumor protein p53 1.365
CCL2 chemokine (C-C motif) ligand 2 1.363
TBL1X transducin (beta)-like 1X-linked 1.361
LUM lumican 1.359
FMN1 formin 1 1.357
TRDMT1 tRNA aspartic acid methyltransferase 1 1.35
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 1.347
COL6A2 collagen, type VI, alpha 2 1.341
THBS2 thrombospondin 2 1.334
REG1A regenerating islet-derived 1 alpha 1.332
DRICH1 aspartate-rich 1 1.332
CHIT1 chitinase 1 (chitotriosidase) 1.329
COL12A1 collagen, type XII, alpha 1 1.327
MMP9 matrix metallopeptidase 9 1.326
GOLGA6L7 golgin A6 family like 7 1.325
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.321
TMPRSS2 transmembrane protease, serine 2 1.32
RNF24 ring finger protein 24 1.319
LEP leptin 1.318
CXCL2 chemokine (C-X-C motif) ligand 2 1.317
THBS1 thrombospondin 1 1.312
CNGB1 cyclic nucleotide gated channel beta 1 1.299
IFNB1 interferon, beta 1, fibroblast 1.296
ANXA5 annexin A5 1.29
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 1.284
ENDOU endonuclease, polyU-specific 1.282
SHANK3 SH3 and multiple ankyrin repeat domains 3 1.279
REN renin 1.277
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.268
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.262
MPO myeloperoxidase 1.262
CLDN4 claudin 4 1.261
LMAN1L lectin, mannose-binding, 1 like 1.261
STAT1 signal transducer and activator of transcription 1, 91kDa 1.26
CTSS cathepsin S 1.256
FOS FBJ murine osteosarcoma viral oncogene homolog 1.256
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.254
QTRT1 queuine tRNA-ribosyltransferase 1 1.254
PSAPL1 prosaposin-like 1 (gene/pseudogene) 1.25
TLR9 toll-like receptor 9 1.249
LAMC2 laminin, gamma 2 1.248
MYH14 myosin, heavy chain 14, non-muscle 1.248
EGFR epidermal growth factor receptor 1.248
CD59 CD59 molecule, complement regulatory protein 1.247
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 1.245
CXCL10 chemokine (C-X-C motif) ligand 10 1.241
ADCY4 adenylate cyclase 4 1.241
CCL3 chemokine (C-C motif) ligand 3 1.239
IFNA1 interferon, alpha 1 1.238
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 1.235
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.234
INS insulin 1.233
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 1.229
PTPN11 protein tyrosine phosphatase, non-receptor type 11 1.228
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.227
VAMP8 vesicle-associated membrane protein 8 1.224
CHIA chitinase, acidic 1.223
FLNA filamin A, alpha 1.221
CPA1 carboxypeptidase A1 (pancreatic) 1.22
LAMB1 laminin, beta 1 1.216
CD1D CD1d molecule 1.211
LAMA3 laminin, alpha 3 1.207
GNPDA1 glucosamine-6-phosphate deaminase 1 1.203
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.202
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.201
RAB7B RAB7B, member RAS oncogene family 1.2
BCL2 B-cell CLL/lymphoma 2 1.2
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 1.197
GABARAPL2 GABA(A) receptor-associated protein-like 2 1.193
COL10A1 collagen, type X, alpha 1 1.192
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.191
CABP1 calcium binding protein 1 1.19
RAB7A RAB7A, member RAS oncogene family 1.189
COLGALT1 collagen beta(1-O)galactosyltransferase 1 1.188
NID2 nidogen 2 (osteonidogen) 1.187
JUN jun proto-oncogene 1.185
CTRL chymotrypsin-like 1.181
ICAM1 intercellular adhesion molecule 1 1.181
ZNF70 zinc finger protein 70 1.179
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 1.177
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 1.175
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.174
TLR7 toll-like receptor 7 1.172
C8A complement component 8, alpha polypeptide 1.169
MYB v-myb avian myeloblastosis viral oncogene homolog 1.168
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.165
GABARAPL1 GABA(A) receptor-associated protein like 1 1.164
COL11A1 collagen, type XI, alpha 1 1.161
CALM3 calmodulin 3 (phosphorylase kinase, delta) 1.157
VPS36 vacuolar protein sorting 36 homolog (S. cerevisiae) 1.153
CD14 CD14 molecule 1.147
FLNB filamin B, beta 1.147
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 1.146
CYSTM1 cysteine-rich transmembrane module containing 1 1.145
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 1.144
CLDN7 claudin 7 1.14
MMP1 matrix metallopeptidase 1 1.14
MYD88 myeloid differentiation primary response 88 1.137
COL5A3 collagen, type V, alpha 3 1.134
GPKOW G patch domain and KOW motifs 1.133
FLNC filamin C, gamma 1.132
C3 complement component 3 1.129
CLDN1 claudin 1 1.129
COL8A1 collagen, type VIII, alpha 1 1.128
CDK1 cyclin-dependent kinase 1 1.127
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.125
LAMA1 laminin, alpha 1 1.124
ITGB4 integrin, beta 4 1.122
FDX1 ferredoxin 1 1.121
QTRT2 queuine tRNA-ribosyltransferase accessory subunit 2 1.12
SOCS3 suppressor of cytokine signaling 3 1.118
COL6A1 collagen, type VI, alpha 1 1.118
LAMA2 laminin, alpha 2 1.117
CCL20 chemokine (C-C motif) ligand 20 1.117
CXCL3 chemokine (C-X-C motif) ligand 3 1.116
MAPK3 mitogen-activated protein kinase 3 1.112
OCLN occludin 1.112
REG4 regenerating islet-derived family, member 4 1.11
CYBB cytochrome b-245, beta polypeptide 1.107
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast) 1.098
COL2A1 collagen, type II, alpha 1 1.094
PI3 peptidase inhibitor 3, skin-derived 1.088
MS4A7 membrane-spanning 4-domains, subfamily A, member 7 1.084
GNPDA2 glucosamine-6-phosphate deaminase 2 1.084
IL1R2 interleukin 1 receptor, type II 1.083
MMP3 matrix metallopeptidase 3 1.082
PANK1 pantothenate kinase 1 1.079
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 1.076
GJB6 gap junction protein, beta 6, 30kDa 1.074
LY96 lymphocyte antigen 96 1.072
ARG2 arginase 2 1.072
FURIN furin (paired basic amino acid cleaving enzyme) 1.07
CXCR2 chemokine (C-X-C motif) receptor 2 1.068
CCL4 chemokine (C-C motif) ligand 4 1.063
MMP2 matrix metallopeptidase 2 1.061
SH3GL3 SH3-domain GRB2-like 3 1.061
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.06
TJP2 tight junction protein 2 1.055
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.051
POSTN periostin, osteoblast specific factor 1.051
ENPEP glutamyl aminopeptidase (aminopeptidase A) 1.05
TLN2 talin 2 1.05
FGG fibrinogen gamma chain 1.046
NLRP3 NLR family, pyrin domain containing 3 1.046
CYLC2 cylicin, basic protein of sperm head cytoskeleton 2 1.045
S100G S100 calcium binding protein G 1.043
OXT oxytocin/neurophysin I prepropeptide 1.042
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa 1.04
RAB5A RAB5A, member RAS oncogene family 1.039
ACE angiotensin I converting enzyme 1.038
SCPEP1 serine carboxypeptidase 1 1.037
INHBA inhibin, beta A 1.036
CNTNAP3B contactin associated protein-like 3B 1.032
VCL vinculin 1.029
PSAP prosaposin 1.027
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 1.026
MNDA myeloid cell nuclear differentiation antigen 1.026
CYCS cytochrome c, somatic 1.025
AAK1 AP2 associated kinase 1 1.024
CCK cholecystokinin 1.023
HKDC1 hexokinase domain containing 1 1.022
CALML3 calmodulin-like 3 1.017
CHMP6 charged multivesicular body protein 6 1.016
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa 1.015
CD274 CD274 molecule 1.014
CTRB1 chymotrypsinogen B1 1.008
TOP2A topoisomerase (DNA) II alpha 170kDa 1.007
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 1.006
COL14A1 collagen, type XIV, alpha 1 1.006
NQO1 NAD(P)H dehydrogenase, quinone 1 1.005
GIMAP2 GTPase, IMAP family member 2 1.004
ESR1 estrogen receptor 1 1.002
VPS25 vacuolar protein sorting 25 homolog (S. cerevisiae) 1.001
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 1.001
PPARG peroxisome proliferator-activated receptor gamma 1.001
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 1.0