Amnesia Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A cognitive disorder where the memory is disturbed or lost and involves the loss of memories previously established, loss of the ability to create new memories, or loss of the ability to learn new information. (Human Disease Ontology, DOID_10914)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D000647
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Genes

323 genes/proteins associated with the disease Amnesia from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
APP amyloid beta (A4) precursor protein 2.88009
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 2.88009
PDYN prodynorphin 2.88009
IL6 interleukin 6 2.88009
TRH thyrotropin-releasing hormone 2.88009
SIGMAR1 sigma non-opioid intracellular receptor 1 2.88009
NGF nerve growth factor (beta polypeptide) 2.88009
IL1A interleukin 1, alpha 2.88009
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 2.88009
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.88009
TAC1 tachykinin, precursor 1 2.88009
AVP arginine vasopressin 2.88009
PREP prolyl endopeptidase 2.88009
GRP gastrin-releasing peptide 2.88009
POMC proopiomelanocortin 2.88009
IL2 interleukin 2 2.88009
HRH3 histamine receptor H3 2.88009
FOS FBJ murine osteosarcoma viral oncogene homolog 2.52347
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.42186
ACHE acetylcholinesterase (Yt blood group) 2.39425
MAPK1 mitogen-activated protein kinase 1 2.38592
TNF tumor necrosis factor 2.38409
MAPK3 mitogen-activated protein kinase 3 2.3655
IL1B interleukin 1, beta 2.33796
BCL2 B-cell CLL/lymphoma 2 2.2874
CAT catalase 2.28346
CREB1 cAMP responsive element binding protein 1 2.27709
NOS2 nitric oxide synthase 2, inducible 2.27505
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.26478
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 2.23623
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 2.23421
JUN jun proto-oncogene 2.2031
BDNF brain-derived neurotrophic factor 2.19389
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.15145
TH tyrosine hydroxylase 2.13878
MAPK8 mitogen-activated protein kinase 8 2.13137
BAX BCL2-associated X protein 2.12842
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.11729
DRD2 dopamine receptor D2 2.10609
EGR1 early growth response 1 2.09345
CRH corticotropin releasing hormone 2.09001
TP53 tumor protein p53 2.08669
PRL prolactin 2.07314
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.05105
NPY neuropeptide Y 2.0274
AKT1 v-akt murine thymoma viral oncogene homolog 1 2.02585
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.99733
HMOX1 heme oxygenase 1 1.98525
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.98025
PENK proenkephalin 1.95995
CCL2 chemokine (C-C motif) ligand 2 1.91468
DRD1 dopamine receptor D1 1.91267
MMP2 matrix metallopeptidase 2 1.90935
GFAP glial fibrillary acidic protein 1.90525
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.90509
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 1.90192
BCL2L1 BCL2-like 1 1.88917
CCND1 cyclin D1 1.88109
GSK3B glycogen synthase kinase 3 beta 1.86722
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.8566
JUNB jun B proto-oncogene 1.85046
TGFB1 transforming growth factor, beta 1 1.84323
SOD1 superoxide dismutase 1, soluble 1.83841
REN renin 1.83824
ICAM1 intercellular adhesion molecule 1 1.81556
ELK1 ELK1, member of ETS oncogene family 1.79273
LHB luteinizing hormone beta polypeptide 1.78568
IFNG interferon, gamma 1.7834
ARC activity-regulated cytoskeleton-associated protein 1.78129
DRD3 dopamine receptor D3 1.77686
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.7759
CXCL8 chemokine (C-X-C motif) ligand 8 1.7757
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.77004
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.76405
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.75797
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.75221
CALCA calcitonin-related polypeptide alpha 1.74822
VEGFA vascular endothelial growth factor A 1.74782
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.74621
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 1.73999
SOD2 superoxide dismutase 2, mitochondrial 1.7315
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.72863
PRKCD protein kinase C, delta 1.72199
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 1.71606
ACTA2 actin, alpha 2, smooth muscle, aorta 1.71399
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.7105
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.71009
NPPA natriuretic peptide A 1.70533
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 1.68889
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 1.68868
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 1.68761
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 1.68422
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.68379
MAPK14 mitogen-activated protein kinase 14 1.6774
IGF1 insulin-like growth factor 1 (somatomedin C) 1.67675
OXT oxytocin/neurophysin I prepropeptide 1.67159
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.66964
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 1.66727
MAPK9 mitogen-activated protein kinase 9 1.64056
EDN1 endothelin 1 1.62691
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 1.62512
CDK2 cyclin-dependent kinase 2 1.61851
PARP1 poly (ADP-ribose) polymerase 1 1.61805
HOMER1 homer scaffolding protein 1 1.60105
PCNA proliferating cell nuclear antigen 1.59826
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.58889
INS insulin 1.58561
FAS Fas cell surface death receptor 1.58255
NOS3 nitric oxide synthase 3 (endothelial cell) 1.58113
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.57018
OPRM1 opioid receptor, mu 1 1.56509
FGF2 fibroblast growth factor 2 (basic) 1.56117
NOS1 nitric oxide synthase 1 (neuronal) 1.55698
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.55574
SREBF1 sterol regulatory element binding transcription factor 1 1.55157
TIMP1 TIMP metallopeptidase inhibitor 1 1.54499
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 1.53844
PRKCB protein kinase C, beta 1.53283
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.53258
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.52667
EGFR epidermal growth factor receptor 1.51657
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.51155
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 1.50827
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.50498
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.49635
FOSB FBJ murine osteosarcoma viral oncogene homolog B 1.49558
TLR4 toll-like receptor 4 1.49457
MMP9 matrix metallopeptidase 9 1.48967
MPO myeloperoxidase 1.4871
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 1.48454
MAOA monoamine oxidase A 1.4766
S100A9 S100 calcium binding protein A9 1.47426
DDIT3 DNA-damage-inducible transcript 3 1.47322
CNR1 cannabinoid receptor 1 (brain) 1.46883
ODC1 ornithine decarboxylase 1 1.46172
DUSP1 dual specificity phosphatase 1 1.45989
PRKCA protein kinase C, alpha 1.45141
NFE2L2 nuclear factor, erythroid 2-like 2 1.45115
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 1.45089
FASN fatty acid synthase 1.44653
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 1.44219
CCL5 chemokine (C-C motif) ligand 5 1.43239
TIMP2 TIMP metallopeptidase inhibitor 2 1.42967
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 1.42616
IL10 interleukin 10 1.42183
ALB albumin 1.42101
STAT1 signal transducer and activator of transcription 1, 91kDa 1.41008
VIM vimentin 1.40623
CYCS cytochrome c, somatic 1.40064
BCHE butyrylcholinesterase 1.40008
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 1.39591
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.39422
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 1.38835
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1.38469
STAR steroidogenic acute regulatory protein 1.37902
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.3759
CD40 CD40 molecule, TNF receptor superfamily member 5 1.35792
AHR aryl hydrocarbon receptor 1.35502
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 1.35098
COL1A1 collagen, type I, alpha 1 1.3484
EPO erythropoietin 1.34664
CHAT choline O-acetyltransferase 1.34576
VCAM1 vascular cell adhesion molecule 1 1.34547
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.34401
PPARG peroxisome proliferator-activated receptor gamma 1.3388
DUSP6 dual specificity phosphatase 6 1.33257
GAL galanin/GMAP prepropeptide 1.32905
CXCL2 chemokine (C-X-C motif) ligand 2 1.32607
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 1.32399
TYR tyrosinase 1.31776
MCL1 myeloid cell leukemia 1 1.31178
FN1 fibronectin 1 1.30881
NR4A1 nuclear receptor subfamily 4, group A, member 1 1.30238
ADCY5 adenylate cyclase 5 1.30147
SOCS3 suppressor of cytokine signaling 3 1.29256
ADORA1 adenosine A1 receptor 1.28919
COMT catechol-O-methyltransferase 1.28889
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 1.28579
GPX1 glutathione peroxidase 1 1.27813
HSPB1 heat shock 27kDa protein 1 1.2772
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 1.26052
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.24843
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.2475
PLAT plasminogen activator, tissue 1.24718
CKB creatine kinase, brain 1.24687
CTSD cathepsin D 1.2437
CREM cAMP responsive element modulator 1.24338
PER1 period circadian clock 1 1.24307
ADRB1 adrenoceptor beta 1 1.24275
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.23993
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.23899
GJA1 gap junction protein, alpha 1, 43kDa 1.23712
COL1A2 collagen, type I, alpha 2 1.2368
PVALB parvalbumin 1.23552
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 1.23011
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.22948
IL12B interleukin 12B 1.22566
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 1.21823
NTS neurotensin 1.21402
INSR insulin receptor 1.2137
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9 1.21304
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.21271
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.21043
CYP3A cytochrome P450, family 3, subfamily A 1.21011
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 1.20946
GSR glutathione reductase 1.20719
ADRB2 adrenoceptor beta 2, surface 1.20295
CCK cholecystokinin 1.20229
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic 1.19999
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 1.19835
ADRA2A adrenoceptor alpha 2A 1.19835
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 1.19509
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 1.19179
LPL lipoprotein lipase 1.1908
CRYAB crystallin, alpha B 1.18718
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.18554
MMP13 matrix metallopeptidase 13 1.18489
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 1.18391
NPPC natriuretic peptide C 1.17926
IL12A interleukin 12A 1.17728
ERN1 endoplasmic reticulum to nucleus signaling 1 1.17596
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 1.17596
FSHB follicle stimulating hormone, beta polypeptide 1.17497
CES2 carboxylesterase 2 1.17399
MAP2K1 mitogen-activated protein kinase kinase 1 1.173
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 1.17101
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.16833
PNPLA2 patatin-like phospholipase domain containing 2 1.165
MMP1 matrix metallopeptidase 1 1.16467
EGF epidermal growth factor 1.16368
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 1.16269
MYH7 myosin, heavy chain 7, cardiac muscle, beta 1.16137
CCNA2 cyclin A2 1.16035
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7 1.15933
CD14 CD14 molecule 1.15797
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 1.15661
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 1.15458
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 1.15391
PRKCE protein kinase C, epsilon 1.15391
S100A8 S100 calcium binding protein A8 1.15089
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.14989
SOX11 SRY (sex determining region Y)-box 11 1.14816
OPRK1 opioid receptor, kappa 1 1.14404
CLU clusterin 1.14064
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 1.14064
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 1.13724
HNF4A hepatocyte nuclear factor 4, alpha 1.13724
ACACA acetyl-CoA carboxylase alpha 1.13143
NQO1 NAD(P)H dehydrogenase, quinone 1 1.12805
ATF2 activating transcription factor 2 1.12703
CDC6 cell division cycle 6 1.12703
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 1.12323
HRH1 histamine receptor H1 1.12082
IRS1 insulin receptor substrate 1 1.11843
RGS4 regulator of G-protein signaling 4 1.11325
CCND3 cyclin D3 1.11325
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 1.10872
SDC4 syndecan 4 1.10527
KDR kinase insert domain receptor 1.10388
CAMK4 calcium/calmodulin-dependent protein kinase IV 1.10317
CHEK2 checkpoint kinase 2 1.10282
CDK4 cyclin-dependent kinase 4 1.10282
HSPA1A heat shock 70kDa protein 1A 1.09892
MAP2 microtubule-associated protein 2 1.09716
CASP4 caspase 4, apoptosis-related cysteine peptidase 1.09541
RB1 retinoblastoma 1 1.09541
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 1.09506
PPARA peroxisome proliferator-activated receptor alpha 1.09332
NTF3 neurotrophin 3 1.0894
ADRB3 adrenoceptor beta 3 1.08549
SGK1 serum/glucocorticoid regulated kinase 1 1.08513
CCKBR cholecystokinin B receptor 1.08266
PLCG1 phospholipase C, gamma 1 1.08196
ADRA1A adrenoceptor alpha 1A 1.08196
F3 coagulation factor III (thromboplastin, tissue factor) 1.08019
CES1 carboxylesterase 1 1.08019
EGR2 early growth response 2 1.07732
MKI67 marker of proliferation Ki-67 1.07447
NR0B2 nuclear receptor subfamily 0, group B, member 2 1.07411
TRIB3 tribbles pseudokinase 3 1.07305
CALB1 calbindin 1, 28kDa 1.07269
IL4 interleukin 4 1.07093
CCL3 chemokine (C-C motif) ligand 3 1.07057
GATA3 GATA binding protein 3 1.07057
CTSB cathepsin B 1.07057
MAPT microtubule-associated protein tau 1.06808
S100B S100 calcium binding protein B 1.05972
BAD BCL2-associated agonist of cell death 1.05648
G6PD glucose-6-phosphate dehydrogenase 1.05648
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.05423
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 1.05386
HSPA4 heat shock 70kDa protein 4 1.05237
IGF1R insulin-like growth factor 1 receptor 1.05163
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 1.05126
ACE angiotensin I converting enzyme 1.04904
VIP vasoactive intestinal peptide 1.04868
RGS2 regulator of G-protein signaling 2 1.04831
MMP3 matrix metallopeptidase 3 1.04684
GADD45A growth arrest and DNA-damage-inducible, alpha 1.04574
CASP6 caspase 6, apoptosis-related cysteine peptidase 1.04538
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.04465
MAOB monoamine oxidase B 1.04276
PKM pyruvate kinase, muscle 1.04276
FOSL1 FOS-like antigen 1 1.04201
FASLG Fas ligand (TNF superfamily, member 6) 1.04051
GPX2 glutathione peroxidase 2 1.03715
NTNG1 netrin G1 1.03641
RHOA ras homolog family member A 1.03419
RARA retinoic acid receptor, alpha 1.03419
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3 1.03159
TGFB3 transforming growth factor, beta 3 1.03122
CYBB cytochrome b-245, beta polypeptide 1.02896
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.02151
NEFH neurofilament, heavy polypeptide 1.02114
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 1.01966
ADORA2A adenosine A2a receptor 1.01814
PLCD4 phospholipase C, delta 4 1.01776
ESR1 estrogen receptor 1 1.01625
GH1 growth hormone 1 1.01549
FOXO1 forkhead box O1 1.01474
SULT1A3 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 1.01137
PRKCG protein kinase C, gamma 1.01137
CYR61 cysteine-rich, angiogenic inducer, 61 1.01025