| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/2179 |
| Similar Terms | |
| Downloads & Tools |
197 proteins with high or low expression in Amsacrine relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PAH | phenylalanine hydroxylase | 4.24 |
| TMEM59 | transmembrane protein 59 | 3.69 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | 3.65 |
| APOB | apolipoprotein B | 3.53 |
| ITM2B | integral membrane protein 2B | 3.32 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 3.27 |
| NDFIP1 | Nedd4 family interacting protein 1 | 3.26 |
| NDFIP2 | Nedd4 family interacting protein 2 | 2.97 |
| ITM2C | integral membrane protein 2C | 2.93 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 2.85 |
| APOE | apolipoprotein E | 2.74 |
| LRP10 | low density lipoprotein receptor-related protein 10 | 2.72 |
| TMEM248 | transmembrane protein 248 | 2.61 |
| GINM1 | glycoprotein integral membrane 1 | 2.49 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 2.38 |
| NCOA4 | nuclear receptor coactivator 4 | 2.31 |
| NPDC1 | neural proliferation, differentiation and control, 1 | 2.3 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | 2.29 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 2.23 |
| TP53I3 | tumor protein p53 inducible protein 3 | 2.23 |
| AREG | amphiregulin | 2.2 |
| IFNGR1 | interferon gamma receptor 1 | 2.19 |
| MFAP3L | microfibrillar-associated protein 3-like | 2.1 |
| HAS3 | hyaluronan synthase 3 | 2.09 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 2.08 |
| NBR1 | neighbor of BRCA1 gene 1 | 2.06 |
| ADGRG1 | adhesion G protein-coupled receptor G1 | 2.02 |
| RNF19B | ring finger protein 19B | 2.0 |
| IL13RA1 | interleukin 13 receptor, alpha 1 | 2.0 |
| FGFBP1 | fibroblast growth factor binding protein 1 | 1.98 |
| MAP1LC3B2 | microtubule-associated protein 1 light chain 3 beta 2 | 1.94 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 1.93 |
| IL10RB | interleukin 10 receptor, beta | 1.91 |
| SULF2 | sulfatase 2 | 1.9 |
| SDC4 | syndecan 4 | 1.9 |
| ZDHHC9 | zinc finger, DHHC-type containing 9 | 1.85 |
| PSAP | prosaposin | 1.85 |
| FAS | Fas cell surface death receptor | 1.84 |
| APP | amyloid beta (A4) precursor protein | 1.84 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 1.8 |
| TP53 | tumor protein p53 | 1.79 |
| GDF15 | growth differentiation factor 15 | 1.78 |
| RNF149 | ring finger protein 149 | 1.78 |
| IL6ST | interleukin 6 signal transducer | 1.73 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 1.73 |
| SLC16A6 | solute carrier family 16, member 6 | 1.69 |
| OSMR | oncostatin M receptor | 1.68 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | 1.68 |
| HGFAC | HGF activator | 1.67 |
| SMTN | smoothelin | 1.64 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 1.63 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 1.57 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | 1.56 |
| HLA-B | major histocompatibility complex, class I, B | 1.53 |
| MFGE8 | milk fat globule-EGF factor 8 protein | 1.5 |
| SERINC3 | serine incorporator 3 | 1.49 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 1.48 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 1.47 |
| JAG1 | jagged 1 | 1.45 |
| F5 | coagulation factor V (proaccelerin, labile factor) | 1.44 |
| CTSL | cathepsin L | 1.43 |
| CCNE1 | cyclin E1 | 1.42 |
| SERINC1 | serine incorporator 1 | 1.41 |
| FGFR2 | fibroblast growth factor receptor 2 | 1.4 |
| EREG | epiregulin | 1.39 |
| DGKA | diacylglycerol kinase, alpha 80kDa | 1.39 |
| LDLR | low density lipoprotein receptor | 1.38 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 1.37 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 1.37 |
| CLDND1 | claudin domain containing 1 | 1.37 |
| PTPRU | protein tyrosine phosphatase, receptor type, U | 1.37 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 1.36 |
| CCND3 | cyclin D3 | 1.35 |
| GRN | granulin | 1.34 |
| TMEM185B | transmembrane protein 185B | 1.34 |
| UNC5B | unc-5 homolog B (C. elegans) | 1.33 |
| UBL3 | ubiquitin-like 3 | 1.33 |
| SQSTM1 | sequestosome 1 | 1.32 |
| ACVR1B | activin A receptor, type IB | 1.31 |
| PTPRS | protein tyrosine phosphatase, receptor type, S | 1.31 |
| RHOD | ras homolog family member D | 1.3 |
| ADIPOR1 | adiponectin receptor 1 | 1.29 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 1.27 |
| RRM2B | ribonucleotide reductase M2 B (TP53 inducible) | 1.27 |
| GJC1 | gap junction protein, gamma 1, 45kDa | 1.26 |
| CALCOCO2 | calcium binding and coiled-coil domain 2 | 1.25 |
| RHOB | ras homolog family member B | 1.25 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 1.24 |
| CCNE2 | cyclin E2 | 1.24 |
| RINL | Ras and Rab interactor-like | 1.23 |
| LRP11 | low density lipoprotein receptor-related protein 11 | 1.22 |
| LAMA3 | laminin, alpha 3 | 1.22 |
| MSMO1 | methylsterol monooxygenase 1 | 1.21 |
| MPZL2 | myelin protein zero-like 2 | 1.21 |
| RAET1G | retinoic acid early transcript 1G | 1.2 |
| PCDH1 | protocadherin 1 | 1.2 |
| EPS8L2 | EPS8-like 2 | 1.18 |
| FBXO41 | F-box protein 41 | 1.18 |
| FAT1 | FAT atypical cadherin 1 | 1.18 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGAM | integrin, alpha M (complement component 3 receptor 3 subunit) | -1.93 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -1.49 |
| LMOD1 | leiomodin 1 (smooth muscle) | -1.47 |
| CDT1 | chromatin licensing and DNA replication factor 1 | -1.37 |
| H1-2 | H1.2 linker histone, cluster member | -1.35 |
| LMO4 | LIM domain only 4 | -1.32 |
| FNIP1 | folliculin interacting protein 1 | -1.28 |
| E2F2 | E2F transcription factor 2 | -1.24 |
| GGH | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) | -1.23 |
| KMT5A | lysine methyltransferase 5A | -1.17 |
| CCDC170 | coiled-coil domain containing 170 | -1.16 |
| CPVL | carboxypeptidase, vitellogenic-like | -1.12 |
| NAGA | N-acetylgalactosaminidase, alpha- | -1.1 |
| CTBS | chitobiase, di-N-acetyl- | -1.09 |
| IKZF5 | IKAROS family zinc finger 5 (Pegasus) | -1.07 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | -1.07 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | -1.06 |
| MCTS2P | malignant T cell amplified sequence 2, pseudogene | -1.04 |
| ODC1 | ornithine decarboxylase 1 | -1.04 |
| WRN | Werner syndrome, RecQ helicase-like | -1.02 |
| NOVA2 | neuro-oncological ventral antigen 2 | -1.0 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | -0.99 |
| ARSK | arylsulfatase family, member K | -0.96 |
| NAGLU | N-acetylglucosaminidase, alpha | -0.94 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.94 |
| ZNF165 | zinc finger protein 165 | -0.91 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.91 |
| SAPCD2 | suppressor APC domain containing 2 | -0.9 |
| BICRAL | BICRA like chromatin remodeling complex associated protein | -0.9 |
| NTHL1 | nth endonuclease III-like 1 (E. coli) | -0.89 |
| DEPDC1 | DEP domain containing 1 | -0.89 |
| TMEM231 | transmembrane protein 231 | -0.89 |
| CTSC | cathepsin C | -0.88 |
| PLK1 | polo-like kinase 1 | -0.87 |
| BLOC1S5 | biogenesis of lysosomal organelles complex-1, subunit 5, muted | -0.86 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | -0.85 |
| CCDC91 | coiled-coil domain containing 91 | -0.85 |
| CDC25B | cell division cycle 25B | -0.85 |
| AKNA | AT-hook transcription factor | -0.84 |
| OBI1 | ORC ubiquitin ligase 1 | -0.82 |
| SIAE | sialic acid acetylesterase | -0.82 |
| H1FX | H1 histone family, member X | -0.82 |
| GLA | galactosidase, alpha | -0.81 |
| EXO1 | exonuclease 1 | -0.8 |
| TMEM222 | transmembrane protein 222 | -0.8 |
| ZBTB14 | zinc finger and BTB domain containing 14 | -0.8 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.8 |
| TCF12 | transcription factor 12 | -0.79 |
| SELENOW | selenoprotein W | -0.79 |
| PRCP | prolylcarboxypeptidase (angiotensinase C) | -0.79 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.78 |
| MPND | MPN domain containing | -0.77 |
| CEP55 | centrosomal protein 55kDa | -0.76 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.76 |
| ZBTB9 | zinc finger and BTB domain containing 9 | -0.75 |
| H1-3 | H1.3 linker histone, cluster member | -0.75 |
| ZSWIM7 | zinc finger, SWIM-type containing 7 | -0.74 |
| HIST3H2A | histone cluster 3, H2a | -0.73 |
| UBXN2A | UBX domain protein 2A | -0.73 |
| THAP1 | THAP domain containing, apoptosis associated protein 1 | -0.73 |
| HIST2H3A | histone cluster 2, H3a | -0.72 |
| GM2A | GM2 ganglioside activator | -0.72 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | -0.7 |
| RNF216 | ring finger protein 216 | -0.69 |
| ZNF611 | zinc finger protein 611 | -0.69 |
| RGS3 | regulator of G-protein signaling 3 | -0.68 |
| JADE1 | jade family PHD finger 1 | -0.68 |
| DPP7 | dipeptidyl-peptidase 7 | -0.68 |
| AEBP2 | AE binding protein 2 | -0.68 |
| ZFHX2 | zinc finger homeobox 2 | -0.68 |
| TIPE1 | TNF alpha induced protein 8 like 1 | -0.68 |
| MMADHC | methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria | -0.67 |
| CDC20 | cell division cycle 20 | -0.67 |
| GTF2A1 | general transcription factor IIA, 1, 19/37kDa | -0.67 |
| TSEN15 | TSEN15 tRNA splicing endonuclease subunit | -0.67 |
| CHEK1 | checkpoint kinase 1 | -0.66 |
| SUN2 | Sad1 and UNC84 domain containing 2 | -0.65 |
| HIST2H2BC | histone cluster 2, H2bc (pseudogene) | -0.65 |
| COMMD5 | COMM domain containing 5 | -0.65 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.65 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.64 |
| GPT2 | glutamic pyruvate transaminase (alanine aminotransferase) 2 | -0.64 |
| GNS | glucosamine (N-acetyl)-6-sulfatase | -0.64 |
| ACTBL2 | actin, beta-like 2 | -0.64 |
| ZRANB3 | zinc finger, RAN-binding domain containing 3 | -0.64 |
| CENPE | centromere protein E, 312kDa | -0.63 |
| H3C1 | H3 clustered histone 1 | -0.62 |
| CIZ1 | CDKN1A interacting zinc finger protein 1 | -0.62 |
| CLN5 | ceroid-lipofuscinosis, neuronal 5 | -0.62 |
| MDC1 | mediator of DNA-damage checkpoint 1 | -0.62 |
| PHF19 | PHD finger protein 19 | -0.62 |
| CCDC57 | coiled-coil domain containing 57 | -0.62 |
| SMAD3 | SMAD family member 3 | -0.62 |
| MNT | MAX network transcriptional repressor | -0.62 |
| GLB1 | galactosidase, beta 1 | -0.61 |
| CCDC85B | coiled-coil domain containing 85B | -0.61 |
| MAZ | MYC-associated zinc finger protein (purine-binding transcription factor) | -0.61 |
| MTF1 | metal-regulatory transcription factor 1 | -0.61 |
