| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Amsacrine perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Amsacrine_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.23271 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.15278 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.151463 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.141608 |
| COL5A1 | collagen, type V, alpha 1 | 0.138414 |
| CDH13 | cadherin 13 | 0.0984055 |
| AHNAK | AHNAK nucleoprotein | 0.097596 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0968496 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0928764 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0863675 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0822755 |
| PLAT | plasminogen activator, tissue | 0.0772182 |
| CALR | calreticulin | 0.0705564 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0663552 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0659017 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0648404 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0617883 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0605962 |
| CANX | calnexin | 0.0584442 |
| FN1 | fibronectin 1 | 0.0583298 |
| PLEC | plectin | 0.0581543 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0556115 |
| RUNX1 | runt-related transcription factor 1 | 0.0555467 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0544687 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.053046 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0529963 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0527593 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0485804 |
| GOLGA4 | golgin A4 | 0.0483297 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0477345 |
| COPA | coatomer protein complex, subunit alpha | 0.0474075 |
| SEPTIN9 | septin 9 | 0.0465632 |
| EGFR | epidermal growth factor receptor | 0.0462601 |
| CCND1 | cyclin D1 | 0.0452799 |
| LOX | lysyl oxidase | 0.0434706 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0419694 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0404622 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 0.0404135 |
| MSI2 | musashi RNA-binding protein 2 | 0.0392848 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0375463 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0361774 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0360446 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0359091 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0355517 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0351356 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0348432 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0346699 |
| MAP1B | microtubule-associated protein 1B | 0.0332784 |
| PLXNA2 | plexin A2 | 0.0326619 |
| COL5A2 | collagen, type V, alpha 2 | 0.0323365 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0320051 |
| CD109 | CD109 molecule | 0.0319273 |
| XPC | xeroderma pigmentosum, complementation group C | 0.031756 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0315692 |
| GDF15 | growth differentiation factor 15 | 0.0315079 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0311466 |
| TPM3 | tropomyosin 3 | 0.0310731 |
| SLFN5 | schlafen family member 5 | 0.0299889 |
| IL7R | interleukin 7 receptor | 0.0293059 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | 0.02921 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0287891 |
| HDAC9 | histone deacetylase 9 | 0.0286357 |
| CEP170 | centrosomal protein 170kDa | 0.0278638 |
| DSPP | dentin sialophosphoprotein | 0.0278525 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0275529 |
| DST | dystonin | 0.0275196 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0274706 |
| BCL2L1 | BCL2-like 1 | 0.0269359 |
| VEGFC | vascular endothelial growth factor C | 0.0268877 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.0267471 |
| RND3 | Rho family GTPase 3 | 0.0262243 |
| FMN2 | formin 2 | 0.0261576 |
| FLNA | filamin A, alpha | 0.0259031 |
| S100A6 | S100 calcium binding protein A6 | 0.0258948 |
| KRT18 | keratin 18, type I | 0.0257808 |
| MSANTD3 | Myb/SANT-like DNA-binding domain containing 3 | 0.0257331 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0256796 |
| MSN | moesin | 0.025367 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0253621 |
| HYOU1 | hypoxia up-regulated 1 | 0.0249716 |
| HELZ | helicase with zinc finger | 0.0249095 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0248341 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0246147 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0244798 |
| DGKG | diacylglycerol kinase, gamma 90kDa | 0.0244494 |
| NSD1 | nuclear receptor binding SET domain protein 1 | 0.024417 |
| SPDL1 | spindle apparatus coiled-coil protein 1 | 0.0243824 |
| PLEKHA2 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 | 0.0243803 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0241279 |
| APP | amyloid beta (A4) precursor protein | 0.0241053 |
| TPM1 | tropomyosin 1 (alpha) | 0.0240864 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0239843 |
| UBXN4 | UBX domain protein 4 | 0.0238388 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 0.0237244 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 0.02371 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0236648 |
| DENND1A | DENN/MADD domain containing 1A | 0.0236143 |
| TPM4 | tropomyosin 4 | 0.0236129 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0235303 |
| DCLK2 | doublecortin-like kinase 2 | 0.0235221 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.188113 |
| MT2A | metallothionein 2A | -0.156482 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0930609 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0854072 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0508179 |
| CD44 | CD44 molecule (Indian blood group) | -0.0446877 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0446424 |
| VIM | vimentin | -0.0443031 |
| COL1A2 | collagen, type I, alpha 2 | -0.0436048 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0435673 |
| FBN1 | fibrillin 1 | -0.0418383 |
| PTMA | prothymosin, alpha | -0.0395102 |
| VCL | vinculin | -0.0380361 |
| MT1X | metallothionein 1X | -0.0378471 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0349818 |
| NDRG1 | N-myc downstream regulated 1 | -0.0343003 |
| HLA-B | major histocompatibility complex, class I, B | -0.0341262 |
| STC1 | stanniocalcin 1 | -0.0336472 |
| GPC6 | glypican 6 | -0.0335661 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0333183 |
| MYADM | myeloid-associated differentiation marker | -0.0316643 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0311159 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0308991 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.02777 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0274794 |
| S100A4 | S100 calcium binding protein A4 | -0.0272943 |
| PRELID2 | PRELI domain containing 2 | -0.0270785 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0254447 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0238226 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0233647 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0229178 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0224393 |
| RBM25 | RNA binding motif protein 25 | -0.0220195 |
| ACTG1 | actin gamma 1 | -0.0220104 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0218142 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0216826 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0213244 |
| MYL12B | myosin, light chain 12B, regulatory | -0.02077 |
| CENPF | centromere protein F, 350/400kDa | -0.0206385 |
| RPL32 | ribosomal protein L32 | -0.0205575 |
| RPL35A | ribosomal protein L35a | -0.0202452 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0201795 |
| COL3A1 | collagen, type III, alpha 1 | -0.0200008 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0199934 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0199872 |
| CD81 | CD81 molecule | -0.0195199 |
| CSTB | cystatin B (stefin B) | -0.0192869 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0191086 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0187297 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0179779 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0174616 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0174529 |
| TXNIP | thioredoxin interacting protein | -0.0171764 |
| SDC4 | syndecan 4 | -0.0171519 |
| CAVIN1 | caveolae associated protein 1 | -0.0165391 |
| EGR1 | early growth response 1 | -0.0163894 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0163501 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0163317 |
| MPZL1 | myelin protein zero-like 1 | -0.0162445 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0160798 |
| SH3BP2 | SH3-domain binding protein 2 | -0.0160093 |
| PRSS23 | protease, serine, 23 | -0.0159178 |
| ACTN4 | actinin, alpha 4 | -0.0157553 |
| RPL23 | ribosomal protein L23 | -0.0156922 |
| NPR2 | natriuretic peptide receptor 2 | -0.0154077 |
| GNAI2 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | -0.0153167 |
| TUBB | tubulin, beta class I | -0.0151319 |
| RPL9 | ribosomal protein L9 | -0.0150261 |
| MRC2 | mannose receptor, C type 2 | -0.014862 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0148361 |
| TMOD1 | tropomodulin 1 | -0.0147872 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0145062 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0144648 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0141794 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0139889 |
| TUBA1B | tubulin, alpha 1b | -0.0139028 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0137078 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | -0.0136961 |
| TMEM263 | transmembrane protein 263 | -0.0136949 |
| RASA2 | RAS p21 protein activator 2 | -0.0135975 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0133878 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | -0.0133088 |
| DEK | DEK proto-oncogene | -0.0129479 |
| B2M | beta-2-microglobulin | -0.0127887 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0126919 |
| UMAD1 | UBAP1-MVB12-associated (UMA) domain containing 1 | -0.0126246 |
| FTL | ferritin, light polypeptide | -0.0125799 |
| XPO7 | exportin 7 | -0.0124865 |
| SBF2 | SET binding factor 2 | -0.0124783 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | -0.0124714 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0123103 |
| SERF2 | small EDRK-rich factor 2 | -0.0123102 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0122808 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0122488 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | -0.0121506 |
| FUS | FUS RNA binding protein | -0.0121489 |
| CCNI | cyclin I | -0.0119264 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0118743 |
| MIDN | midnolin | -0.0118379 |
| SMIM3 | small integral membrane protein 3 | -0.011708 |
