| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Amsacrine perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Amsacrine_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.182396 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.150893 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.100639 |
| YAP1 | Yes-associated protein 1 | 0.0723074 |
| HMGA2 | high mobility group AT-hook 2 | 0.0718541 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0690053 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0596894 |
| FTL | ferritin, light polypeptide | 0.0577857 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0564625 |
| INTS6 | integrator complex subunit 6 | 0.0560697 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0556035 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0533125 |
| ZNF638 | zinc finger protein 638 | 0.0529926 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0510696 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0509286 |
| TMSB10 | thymosin beta 10 | 0.0486631 |
| WWOX | WW domain containing oxidoreductase | 0.0484032 |
| RRM2 | ribonucleotide reductase M2 | 0.0471312 |
| ASPH | aspartate beta-hydroxylase | 0.0453178 |
| PRELID2 | PRELI domain containing 2 | 0.0452492 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0430902 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0415426 |
| MYO1D | myosin ID | 0.041484 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0412093 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.04071 |
| NHSL1 | NHS-like 1 | 0.0406725 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0388499 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0386091 |
| RNF213 | ring finger protein 213 | 0.0380712 |
| RPL35A | ribosomal protein L35a | 0.0380524 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | 0.0376882 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0376131 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0374926 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.037331 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.037157 |
| LRRC23 | leucine rich repeat containing 23 | 0.0369975 |
| PRKCE | protein kinase C, epsilon | 0.0368305 |
| DENND5A | DENN/MADD domain containing 5A | 0.0365426 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.036277 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0360895 |
| PHF21A | PHD finger protein 21A | 0.0360564 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0360245 |
| EXOC4 | exocyst complex component 4 | 0.0359246 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.035598 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0355922 |
| H1-0 | H1.0 linker histone | 0.0355354 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | 0.0353668 |
| AHNAK | AHNAK nucleoprotein | 0.0353053 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0348198 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0340195 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0339729 |
| SMYD3 | SET and MYND domain containing 3 | 0.0336941 |
| R3HDM2 | R3H domain containing 2 | 0.0333706 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0332665 |
| TPM3 | tropomyosin 3 | 0.0321018 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0320217 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0317414 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0316062 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0312018 |
| FAM168A | family with sequence similarity 168, member A | 0.0308292 |
| PCDH7 | protocadherin 7 | 0.0306518 |
| CPOX | coproporphyrinogen oxidase | 0.0304281 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0303368 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0299855 |
| NEBL | nebulette | 0.0298884 |
| SERTAD2 | SERTA domain containing 2 | 0.0295825 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0290212 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0289841 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.028973 |
| SFTPA2 | surfactant protein A2 | 0.0288753 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0287759 |
| TNRC18 | trinucleotide repeat containing 18 | 0.0287264 |
| STIP1 | stress-induced phosphoprotein 1 | 0.0285034 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0281198 |
| MGAT4C | MGAT4 family, member C | 0.0281091 |
| RPLP1 | ribosomal protein, large, P1 | 0.0279169 |
| RPL23 | ribosomal protein L23 | 0.0277134 |
| ZNF292 | zinc finger protein 292 | 0.0276425 |
| FLNA | filamin A, alpha | 0.027578 |
| RPS29 | ribosomal protein S29 | 0.0275459 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0274893 |
| HELZ | helicase with zinc finger | 0.0271544 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0270242 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0263284 |
| YEATS2 | YEATS domain containing 2 | 0.0262511 |
| ENO1 | enolase 1, (alpha) | 0.0260942 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.026075 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0258392 |
| PKM | pyruvate kinase, muscle | 0.0258227 |
| BRD2 | bromodomain containing 2 | 0.025762 |
| MTCL1 | microtubule crosslinking factor 1 | 0.0253928 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0252351 |
| FBXO11 | F-box protein 11 | 0.0251293 |
| ANK2 | ankyrin 2, neuronal | 0.02505 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.024805 |
| JMJD1C | jumonji domain containing 1C | 0.0246656 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0244647 |
| RPLP2 | ribosomal protein, large, P2 | 0.0244487 |
| CAMKMT | calmodulin-lysine N-methyltransferase | 0.024243 |
| TPI1 | triosephosphate isomerase 1 | 0.0240945 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.252634 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.129348 |
| SLC38A2 | solute carrier family 38, member 2 | -0.106634 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0918317 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0824567 |
| ZNF804A | zinc finger protein 804A | -0.0607015 |
| MMP12 | matrix metallopeptidase 12 | -0.0603381 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0564358 |
| TMEM41B | transmembrane protein 41B | -0.0558811 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0533807 |
| YBX3 | Y box binding protein 3 | -0.0532677 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0525607 |
| EDARADD | EDAR-associated death domain | -0.0517167 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0503827 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0459462 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0454953 |
| ECT2 | epithelial cell transforming 2 | -0.0449869 |
| LMO7 | LIM domain 7 | -0.0442898 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0439844 |
| NEK7 | NIMA-related kinase 7 | -0.0410992 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0410126 |
| RASAL2 | RAS protein activator like 2 | -0.0397395 |
| CDK17 | cyclin-dependent kinase 17 | -0.0387287 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.037508 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0371765 |
| WDR43 | WD repeat domain 43 | -0.0369014 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.0363907 |
| CARD16 | caspase recruitment domain family, member 16 | -0.0349391 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0346746 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | -0.0339067 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0335787 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0332458 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0327202 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0325042 |
| PLK2 | polo-like kinase 2 | -0.0323765 |
| NLGN1 | neuroligin 1 | -0.0323632 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0317293 |
| OXR1 | oxidation resistance 1 | -0.0313806 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0310793 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0306439 |
| TMEM131 | transmembrane protein 131 | -0.0302905 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0297755 |
| RTN4 | reticulon 4 | -0.0292682 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0290293 |
| CLDN1 | claudin 1 | -0.0288989 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0288371 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0288332 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0287335 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0280826 |
| PDGFC | platelet derived growth factor C | -0.0273918 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0262314 |
| KLF6 | Kruppel-like factor 6 | -0.0260397 |
| SYT1 | synaptotagmin I | -0.0253896 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0252871 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0251109 |
| CENPF | centromere protein F, 350/400kDa | -0.0249456 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0249127 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0247909 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0246376 |
| DHX36 | DEAH (Asp-Glu-Ala-His) box polypeptide 36 | -0.0244083 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0242651 |
| YBX1 | Y box binding protein 1 | -0.0240133 |
| CDK6 | cyclin-dependent kinase 6 | -0.0240073 |
| DIAPH3 | diaphanous-related formin 3 | -0.0236508 |
| GASK1B | golgi associated kinase 1B | -0.0235791 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.023564 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0234889 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | -0.0231675 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0229434 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0227515 |
| AK1 | adenylate kinase 1 | -0.0226426 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.0223162 |
| AP3S1 | adaptor-related protein complex 3, sigma 1 subunit | -0.0221846 |
| CENPE | centromere protein E, 312kDa | -0.0221233 |
| RPLP0 | ribosomal protein, large, P0 | -0.0221219 |
| CALD1 | caldesmon 1 | -0.0219785 |
| CCNL1 | cyclin L1 | -0.021727 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0215422 |
| THOC2 | THO complex 2 | -0.0214852 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0208946 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | -0.0208268 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0208264 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0205269 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.020516 |
| CCNG1 | cyclin G1 | -0.0197517 |
| ZNF217 | zinc finger protein 217 | -0.0195577 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.019519 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0195175 |
| TUBA1B | tubulin, alpha 1b | -0.0194156 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0193381 |
| ZFP91 | ZFP91 zinc finger protein | -0.0191414 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0190916 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0185919 |
| CCT8 | chaperonin containing TCP1, subunit 8 (theta) | -0.0184759 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0184573 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0183701 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0179619 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0178514 |
| NDC80 | NDC80 kinetochore complex component | -0.0177593 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.0177355 |
