| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Amsacrine perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Amsacrine_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.210306 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.140222 |
| PLEC | plectin | 0.093656 |
| VEGFA | vascular endothelial growth factor A | 0.067807 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0529163 |
| STC1 | stanniocalcin 1 | 0.0510121 |
| RPS6 | ribosomal protein S6 | 0.0504199 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0469428 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.04576 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0429215 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0428997 |
| PTK2 | protein tyrosine kinase 2 | 0.0404167 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0403196 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0389423 |
| EFNA5 | ephrin-A5 | 0.0365218 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0363152 |
| EGFR | epidermal growth factor receptor | 0.033432 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0319044 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0304374 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | 0.0294342 |
| HLA-E | major histocompatibility complex, class I, E | 0.0292805 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0290915 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0288189 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0280653 |
| NAV2 | neuron navigator 2 | 0.0278862 |
| RUNX1 | runt-related transcription factor 1 | 0.026608 |
| HLA-C | major histocompatibility complex, class I, C | 0.0261044 |
| ZNF292 | zinc finger protein 292 | 0.0250397 |
| CLMP | CXADR-like membrane protein | 0.0242425 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0238992 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0238936 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0234791 |
| CDH13 | cadherin 13 | 0.0231443 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0229854 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.022788 |
| RPL13A | ribosomal protein L13a | 0.022711 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0225264 |
| MARCHF3 | membrane associated ring-CH-type finger 3 | 0.0220463 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0214802 |
| HYOU1 | hypoxia up-regulated 1 | 0.0212739 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | 0.0211096 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0211066 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0210656 |
| MRTFA | myocardin related transcription factor A | 0.0209822 |
| COL5A1 | collagen, type V, alpha 1 | 0.0206694 |
| HLA-B | major histocompatibility complex, class I, B | 0.0202969 |
| FAM13A | family with sequence similarity 13, member A | 0.0199843 |
| KIF13A | kinesin family member 13A | 0.0197993 |
| CFB | complement factor B | 0.0194789 |
| YEATS2 | YEATS domain containing 2 | 0.0188977 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0185858 |
| OSMR | oncostatin M receptor | 0.018409 |
| MMP3 | matrix metallopeptidase 3 | 0.0179965 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0178196 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0177159 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.0176551 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0174611 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.0174251 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0173943 |
| DHFR | dihydrofolate reductase | 0.0172492 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | 0.0170104 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0169036 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0167973 |
| RPL3 | ribosomal protein L3 | 0.0166715 |
| SRSF4 | serine/arginine-rich splicing factor 4 | 0.0165086 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0164035 |
| PDE10A | phosphodiesterase 10A | 0.0163989 |
| SEPTIN9 | septin 9 | 0.0163511 |
| RLF | rearranged L-myc fusion | 0.0163267 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0163026 |
| PID1 | phosphotyrosine interaction domain containing 1 | 0.0158993 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0158792 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | 0.0158338 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0157986 |
| GPHN | gephyrin | 0.015701 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0156438 |
| CADM1 | cell adhesion molecule 1 | 0.0153454 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0152097 |
| SH3PXD2B | SH3 and PX domains 2B | 0.0151577 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0151289 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0151181 |
| HAS2 | hyaluronan synthase 2 | 0.0150853 |
| NAV3 | neuron navigator 3 | 0.0149895 |
| CA12 | carbonic anhydrase XII | 0.0149854 |
| RNF24 | ring finger protein 24 | 0.0149424 |
| OXR1 | oxidation resistance 1 | 0.0149331 |
| NUCB1 | nucleobindin 1 | 0.0149306 |
| USP3 | ubiquitin specific peptidase 3 | 0.0148708 |
| ZFR | zinc finger RNA binding protein | 0.0148364 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0146097 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0145908 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.0145795 |
| JMJD1C | jumonji domain containing 1C | 0.0145435 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0141392 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0140461 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0139869 |
| RPS27 | ribosomal protein S27 | 0.0138927 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0138362 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0138339 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0135912 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COL1A1 | collagen, type I, alpha 1 | -0.273393 |
| VIM | vimentin | -0.226245 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.195436 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.183108 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.14701 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.108971 |
| CD44 | CD44 molecule (Indian blood group) | -0.0929053 |
| TMSB10 | thymosin beta 10 | -0.0920113 |
| LDHA | lactate dehydrogenase A | -0.0893724 |
| UBC | ubiquitin C | -0.0884308 |
| COL1A2 | collagen, type I, alpha 2 | -0.0851765 |
| NDRG1 | N-myc downstream regulated 1 | -0.0833881 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0827368 |
| ENO1 | enolase 1, (alpha) | -0.0800917 |
| VCL | vinculin | -0.0780294 |
| CALD1 | caldesmon 1 | -0.0656402 |
| CLIC4 | chloride intracellular channel 4 | -0.061746 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0610238 |
| VCAN | versican | -0.0574107 |
| FBN1 | fibrillin 1 | -0.0557147 |
| TPM4 | tropomyosin 4 | -0.0531503 |
| CALU | calumenin | -0.0529421 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0520213 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0490631 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0468 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0454837 |
| MAP1B | microtubule-associated protein 1B | -0.0444738 |
| LOX | lysyl oxidase | -0.0428716 |
| INHBA | inhibin, beta A | -0.0417245 |
| MT2A | metallothionein 2A | -0.0402082 |
| ASPH | aspartate beta-hydroxylase | -0.0380776 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0373229 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0364718 |
| EGR1 | early growth response 1 | -0.0364602 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0347492 |
| HMGA2 | high mobility group AT-hook 2 | -0.0347123 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0346455 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0329244 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0327847 |
| PKM | pyruvate kinase, muscle | -0.0322607 |
| RIGI | RNA sensor RIG-I | -0.0311084 |
| ACTG1 | actin gamma 1 | -0.0303209 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0298756 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0293643 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0290298 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0288779 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0285663 |
| SDC2 | syndecan 2 | -0.0284913 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0273913 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0269243 |
| SLC38A2 | solute carrier family 38, member 2 | -0.026907 |
| POTEF | POTE ankyrin domain family, member F | -0.0266848 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0264824 |
| PALLD | palladin, cytoskeletal associated protein | -0.0264605 |
| NAV1 | neuron navigator 1 | -0.0259993 |
| MT1X | metallothionein 1X | -0.0252659 |
| FTL | ferritin, light polypeptide | -0.0251208 |
| PTMA | prothymosin, alpha | -0.0247266 |
| GLIS3 | GLIS family zinc finger 3 | -0.0246854 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0245609 |
| PDIA5 | protein disulfide isomerase family A, member 5 | -0.0242524 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0235895 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0234756 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0231257 |
| LIMA1 | LIM domain and actin binding 1 | -0.0218887 |
| RPS27A | ribosomal protein S27a | -0.0218845 |
| PRELID2 | PRELI domain containing 2 | -0.0218486 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0218014 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0217774 |
| TPM1 | tropomyosin 1 (alpha) | -0.0215305 |
| CENPF | centromere protein F, 350/400kDa | -0.0210412 |
| HMGA1 | high mobility group AT-hook 1 | -0.020995 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0207511 |
| ADAM12 | ADAM metallopeptidase domain 12 | -0.0201765 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0200501 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.0198955 |
| ZNF644 | zinc finger protein 644 | -0.0195606 |
| SERINC3 | serine incorporator 3 | -0.0194985 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0193585 |
| TMEM263 | transmembrane protein 263 | -0.0193419 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0191075 |
| B2M | beta-2-microglobulin | -0.0190968 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0189642 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0189631 |
| HMCN1 | hemicentin 1 | -0.0189259 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0188962 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0188564 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0187872 |
| ACTN1 | actinin, alpha 1 | -0.0184793 |
| RSU1 | Ras suppressor protein 1 | -0.0181857 |
| PRSS23 | protease, serine, 23 | -0.0181337 |
| ACTN4 | actinin, alpha 4 | -0.0181242 |
| TUBA1B | tubulin, alpha 1b | -0.018086 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0180756 |
| JUN | jun proto-oncogene | -0.0180508 |
| POSTN | periostin, osteoblast specific factor | -0.0180063 |
| VMP1 | vacuole membrane protein 1 | -0.0178195 |
| TUBB | tubulin, beta class I | -0.0177106 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.017544 |
| RACK1 | receptor for activated C kinase 1 | -0.0174276 |
