Amsacrine_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Amsacrine perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Amsacrine_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
C3 complement component 3 0.208494
FN1 fibronectin 1 0.185686
IGF2 insulin-like growth factor 2 0.170521
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.138891
SVIL supervillin 0.127158
EEF2 eukaryotic translation elongation factor 2 0.106238
DSPP dentin sialophosphoprotein 0.0953248
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0949776
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0922008
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0793144
PTCHD4 patched domain containing 4 0.0779904
FOXP1 forkhead box P1 0.0682635
FBF1 Fas (TNFRSF6) binding factor 1 0.0656685
BCL2L1 BCL2-like 1 0.0625649
VEGFA vascular endothelial growth factor A 0.0605449
FAM107B family with sequence similarity 107, member B 0.0595557
PLEC plectin 0.0573937
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0571532
LOC112694756 uncharaterized LOC112694756 0.0568815
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0567677
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0553855
PEG3 paternally expressed 3 0.0505061
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0488233
NRIP1 nuclear receptor interacting protein 1 0.0483636
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0469183
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0459353
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.045157
MBNL2 muscleblind-like splicing regulator 2 0.0451129
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0448504
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0442951
AHSG alpha-2-HS-glycoprotein 0.0424716
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0408482
A2M alpha-2-macroglobulin 0.0405777
FLNA filamin A, alpha 0.0405029
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.040306
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0398697
OSBPL10 oxysterol binding protein-like 10 0.0397573
MYH9 myosin, heavy chain 9, non-muscle 0.0395899
SFTPA2 surfactant protein A2 0.0381707
AFF1 AF4/FMR2 family, member 1 0.0380139
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0369062
STAU1 staufen double-stranded RNA binding protein 1 0.0349287
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0345071
SEPTIN9 septin 9 0.0336246
RSRP1 arginine/serine-rich protein 1 0.0332829
ABTB3 ankyrin repeat and BTB domain containing 3 0.0330859
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0327915
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0325901
SOD2 superoxide dismutase 2, mitochondrial 0.0322917
EPS8 epidermal growth factor receptor pathway substrate 8 0.0318075
HP1BP3 heterochromatin protein 1, binding protein 3 0.0315297
PTPRM protein tyrosine phosphatase, receptor type, M 0.0313333
LYZ lysozyme 0.0302143
IGFBP1 insulin-like growth factor binding protein 1 0.02993
RICTOR RPTOR independent companion of MTOR, complex 2 0.0298879
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0298391
SHB Src homology 2 domain containing adaptor protein B 0.0294775
SAMD4A sterile alpha motif domain containing 4A 0.0293303
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.029192
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.028567
FAT1 FAT atypical cadherin 1 0.0285038
STC2 stanniocalcin 2 0.0284658
INTS6 integrator complex subunit 6 0.0281081
QKI QKI, KH domain containing, RNA binding 0.0280234
EPAS1 endothelial PAS domain protein 1 0.0278223
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0277595
ANKRD11 ankyrin repeat domain 11 0.02741
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0272263
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0270323
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0268538
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0266436
BIRC6 baculoviral IAP repeat containing 6 0.0265842
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0262527
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0262366
SRRM2 serine/arginine repetitive matrix 2 0.0261664
TLE4 transducin-like enhancer of split 4 0.0261207
KMT2E lysine (K)-specific methyltransferase 2E 0.0255221
SMAD3 SMAD family member 3 0.0255072
MACF1 microtubule-actin crosslinking factor 1 0.0254786
SESTD1 SEC14 and spectrin domains 1 0.0250508
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.024911
ASXL2 additional sex combs like transcriptional regulator 2 0.0249027
SH3PXD2A SH3 and PX domains 2A 0.0248469
DHFR dihydrofolate reductase 0.0246516
PDLIM5 PDZ and LIM domain 5 0.024514
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.024216
KIF1B kinesin family member 1B 0.0241537
ZBTB38 zinc finger and BTB domain containing 38 0.0236691
ABHD5 abhydrolase domain containing 5 0.0235878
WWTR1 WW domain containing transcription regulator 1 0.023413
APOB apolipoprotein B 0.023146
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0229628
MARF1 meiosis regulator and mRNA stability factor 1 0.0229394
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0228686
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.022789
TRIM24 tripartite motif containing 24 0.0227803
SYNJ2 synaptojanin 2 0.0225979
AKAP12 A kinase (PRKA) anchor protein 12 0.0225298
CADM1 cell adhesion molecule 1 0.0223635
JAK1 Janus kinase 1 0.0222829

decreased expression

Symbol Name Standardized Value
GPC6 glypican 6 -0.189343
MT2A metallothionein 2A -0.155981
ENO1 enolase 1, (alpha) -0.146251
TMSB10 thymosin beta 10 -0.125761
TPT1 tumor protein, translationally-controlled 1 -0.117294
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0973676
MAML2 mastermind-like 2 (Drosophila) -0.0939241
RPS27A ribosomal protein S27a -0.0935576
VCL vinculin -0.0900289
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0883591
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0869533
LRMDA leucine rich melanocyte differentiation associated -0.0803163
ASPH aspartate beta-hydroxylase -0.080047
RPL23 ribosomal protein L23 -0.0797574
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0743761
UBC ubiquitin C -0.0701117
RPS24 ribosomal protein S24 -0.070083
ZBTB20 zinc finger and BTB domain containing 20 -0.0663708
FNDC3B fibronectin type III domain containing 3B -0.0625578
RPS12 ribosomal protein S12 -0.0610184
RPL37A ribosomal protein L37a -0.0603301
EXT1 exostosin glycosyltransferase 1 -0.0584005
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0514529
NAP1L1 nucleosome assembly protein 1-like 1 -0.0513795
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.05085
RNF213 ring finger protein 213 -0.0501277
RPLP1 ribosomal protein, large, P1 -0.0500533
RIGI RNA sensor RIG-I -0.0483388
RPS8 ribosomal protein S8 -0.0479067
RPS19 ribosomal protein S19 -0.0474629
RPL26 ribosomal protein L26 -0.0474186
APOA2 apolipoprotein A-II -0.0467781
SLC38A2 solute carrier family 38, member 2 -0.0467257
NPAS2 neuronal PAS domain protein 2 -0.0462255
RPS21 ribosomal protein S21 -0.0455764
ZMYND8 zinc finger, MYND-type containing 8 -0.0442521
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0423369
SOX5 SRY (sex determining region Y)-box 5 -0.0421665
ATP10A ATPase, class V, type 10A -0.0416589
MX2 MX dynamin-like GTPase 2 -0.0411881
RPL9 ribosomal protein L9 -0.0411129
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0410918
RUNX1 runt-related transcription factor 1 -0.0410762
LPP LIM domain containing preferred translocation partner in lipoma -0.0409686
IFI6 interferon, alpha-inducible protein 6 -0.0407175
FRMD5 FERM domain containing 5 -0.0404946
ISG15 ISG15 ubiquitin-like modifier -0.0394544
NDRG1 N-myc downstream regulated 1 -0.0388177
RPS29 ribosomal protein S29 -0.0383575
RPL36A ribosomal protein L36a -0.0375892
ITGAV integrin, alpha V -0.0375755
RPS3 ribosomal protein S3 -0.0373279
DOCK4 dedicator of cytokinesis 4 -0.0370326
RPL34 ribosomal protein L34 -0.0366637
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0361049
IFITM1 interferon induced transmembrane protein 1 -0.0348563
DTNA dystrobrevin, alpha -0.034749
PTMA prothymosin, alpha -0.0347405
RPLP2 ribosomal protein, large, P2 -0.0345074
ITGA1 integrin, alpha 1 -0.0342748
RPL31 ribosomal protein L31 -0.0342296
RPS6 ribosomal protein S6 -0.0342083
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0334664
RACK1 receptor for activated C kinase 1 -0.0332411
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0330205
ELL2 elongation factor, RNA polymerase II, 2 -0.0330157
ACTG1 actin gamma 1 -0.0330091
HMGA1 high mobility group AT-hook 1 -0.0328789
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0324833
PLXDC2 plexin domain containing 2 -0.0321689
TM4SF1 transmembrane 4 L six family member 1 -0.0320994
ENAH enabled homolog (Drosophila) -0.0320612
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 -0.0319105
RPS25 ribosomal protein S25 -0.0311743
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0307549
RPL11 ribosomal protein L11 -0.030432
RPL38 ribosomal protein L38 -0.0304053
RPL12 ribosomal protein L12 -0.0296594
RPL37 ribosomal protein L37 -0.029178
RPL35A ribosomal protein L35a -0.0288824
RPL36 ribosomal protein L36 -0.028854
CSNK1A1 casein kinase 1, alpha 1 -0.0286497
EIF4A1 eukaryotic translation initiation factor 4A1 -0.028578
RPS13 ribosomal protein S13 -0.0283953
RBM39 RNA binding motif protein 39 -0.0283735
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -0.0279156
LDHA lactate dehydrogenase A -0.0277654
RPL35 ribosomal protein L35 -0.0270276
KDM7A lysine (K)-specific demethylase 7A -0.0260576
PRELID2 PRELI domain containing 2 -0.0259301
RPS27 ribosomal protein S27 -0.0257826
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0256606
TGFBI transforming growth factor, beta-induced, 68kDa -0.0255137
RPL30 ribosomal protein L30 -0.0253826
RNASET2 ribonuclease T2 -0.025375
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0246667
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0244087
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0242651
ETFB electron-transfer-flavoprotein, beta polypeptide -0.0240249
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0234415