Amsacrine_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Amsacrine perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Amsacrine_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.106928
PLEC plectin 0.0900572
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0837452
SLC35F3 solute carrier family 35, member F3 0.0813104
PDE4D phosphodiesterase 4D, cAMP-specific 0.0728931
AHNAK AHNAK nucleoprotein 0.072876
PDLIM5 PDZ and LIM domain 5 0.0723731
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0647917
INTS6 integrator complex subunit 6 0.0604629
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0576274
DST dystonin 0.0519098
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0513562
MACF1 microtubule-actin crosslinking factor 1 0.047701
HMGA2 high mobility group AT-hook 2 0.0450904
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.042097
ANO1 anoctamin 1, calcium activated chloride channel 0.0398128
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0397402
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0385812
PTK2 protein tyrosine kinase 2 0.0371923
BCAR3 breast cancer anti-estrogen resistance 3 0.0369414
RABGAP1L RAB GTPase activating protein 1-like 0.0365095
HSPG2 heparan sulfate proteoglycan 2 0.0348608
EFNA5 ephrin-A5 0.0348344
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0345869
RNF217 ring finger protein 217 0.0328802
SULF2 sulfatase 2 0.0328342
EXOC4 exocyst complex component 4 0.0314412
RASAL2 RAS protein activator like 2 0.0311662
MEGF6 multiple EGF-like-domains 6 0.0310764
DPYD dihydropyrimidine dehydrogenase 0.031031
EGFR epidermal growth factor receptor 0.0308033
AMOTL1 angiomotin like 1 0.0298748
FTH1 ferritin, heavy polypeptide 1 0.0291319
PALLD palladin, cytoskeletal associated protein 0.0289991
PSD3 pleckstrin and Sec7 domain containing 3 0.0288369
MECOM MDS1 and EVI1 complex locus 0.0288173
TGM2 transglutaminase 2 0.0283929
UTRN utrophin 0.0282523
AKAP13 A kinase (PRKA) anchor protein 13 0.0274739
SOD2 superoxide dismutase 2, mitochondrial 0.0266669
DGKH diacylglycerol kinase, eta 0.0265507
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0264437
TNS3 tensin 3 0.0262167
RAD51B RAD51 paralog B 0.025893
AOPEP aminopeptidase O (putative) 0.025508
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0252162
TRIO trio Rho guanine nucleotide exchange factor 0.024794
ITGB4 integrin, beta 4 0.0235899
DOCK5 dedicator of cytokinesis 5 0.0232221
THSD4 thrombospondin, type I, domain containing 4 0.0231803
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0230347
CSMD2 CUB and Sushi multiple domains 2 0.0230097
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0228799
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.022812
ATXN1 ataxin 1 0.0223709
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0222747
KLF5 Kruppel-like factor 5 (intestinal) 0.0218421
AHNAK2 AHNAK nucleoprotein 2 0.0217129
MTAP methylthioadenosine phosphorylase 0.0217025
TSC22D1 TSC22 domain family, member 1 0.0215995
CUX1 cut-like homeobox 1 0.0211354
ASPH aspartate beta-hydroxylase 0.0210883
ITGB8 integrin, beta 8 0.0210641
PLXNA2 plexin A2 0.0209064
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0208646
ZSWIM6 zinc finger, SWIM-type containing 6 0.0207155
PEAK1 pseudopodium-enriched atypical kinase 1 0.0203973
EXT1 exostosin glycosyltransferase 1 0.0203902
CTBP2 C-terminal binding protein 2 0.0202353
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0202268
SMAD3 SMAD family member 3 0.0201426
FLNA filamin A, alpha 0.0200593
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0197212
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0193231
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0192351
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0190863
PRSS23 protease, serine, 23 0.0189947
MAML3 mastermind-like 3 (Drosophila) 0.0188237
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0187138
SVIL supervillin 0.0186687
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0183861
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0182685
TRAPPC9 trafficking protein particle complex 9 0.0181026
ZMIZ1 zinc finger, MIZ-type containing 1 0.0180933
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0178722
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.017818
NCOR2 nuclear receptor corepressor 2 0.0176685
SMYD3 SET and MYND domain containing 3 0.0176038
DPYSL2 dihydropyrimidinase-like 2 0.0175212
CNTNAP3 contactin associated protein-like 3 0.0173607
ZC3H12C zinc finger CCCH-type containing 12C 0.0172709
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0171257
GRAMD1B GRAM domain containing 1B 0.0171009
LRRC8C leucine rich repeat containing 8 family, member C 0.0169567
HDAC9 histone deacetylase 9 0.0169439
PLS3 plastin 3 0.0169283
BCR breakpoint cluster region 0.0168436
KIAA1671 KIAA1671 0.0166489
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0165734
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 0.0165537

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.18219
TIMP3 TIMP metallopeptidase inhibitor 3 -0.128872
B2M beta-2-microglobulin -0.119582
NDRG1 N-myc downstream regulated 1 -0.11528
CLU clusterin -0.11405
PTMA prothymosin, alpha -0.113274
MT2A metallothionein 2A -0.0957075
TMSB10 thymosin beta 10 -0.0930155
TPT1 tumor protein, translationally-controlled 1 -0.09205
RPS21 ribosomal protein S21 -0.0842427
RPS6 ribosomal protein S6 -0.0784572
ENO1 enolase 1, (alpha) -0.0764716
RPS8 ribosomal protein S8 -0.0704515
RPLP2 ribosomal protein, large, P2 -0.0699239
NAMPT nicotinamide phosphoribosyltransferase -0.0697558
TMSB4X thymosin beta 4, X-linked -0.0669913
S100A10 S100 calcium binding protein A10 -0.0656351
GOLGA4 golgin A4 -0.0638207
PGK1 phosphoglycerate kinase 1 -0.0629007
RPS13 ribosomal protein S13 -0.0620001
LMNA lamin A/C -0.0601316
RPL11 ribosomal protein L11 -0.0597874
HLA-B major histocompatibility complex, class I, B -0.0586045
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0583804
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0541483
FLNB filamin B, beta -0.0529483
EMP1 epithelial membrane protein 1 -0.0528657
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0523934
IFITM3 interferon induced transmembrane protein 3 -0.0518984
RPS19 ribosomal protein S19 -0.0514667
RPLP1 ribosomal protein, large, P1 -0.049391
RPS3 ribosomal protein S3 -0.049241
LDHA lactate dehydrogenase A -0.0469439
RPS24 ribosomal protein S24 -0.0463604
RPL23 ribosomal protein L23 -0.0453752
POTEF POTE ankyrin domain family, member F -0.0448955
S100A9 S100 calcium binding protein A9 -0.0444574
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0443036
DSTN destrin (actin depolymerizing factor) -0.044177
YBX3 Y box binding protein 3 -0.0441508
RPL12 ribosomal protein L12 -0.0431268
RPL37 ribosomal protein L37 -0.0428448
IFITM1 interferon induced transmembrane protein 1 -0.042601
RPS25 ribosomal protein S25 -0.0425174
RBM39 RNA binding motif protein 39 -0.0423213
KRT17 keratin 17, type I -0.0419464
ANLN anillin, actin binding protein -0.0408361
FTL ferritin, light polypeptide -0.0405572
RPL34 ribosomal protein L34 -0.0387233
EIF1 eukaryotic translation initiation factor 1 -0.0382758
NAP1L1 nucleosome assembly protein 1-like 1 -0.0382545
S100A6 S100 calcium binding protein A6 -0.0381436
RPS12 ribosomal protein S12 -0.0378452
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0374856
S100A2 S100 calcium binding protein A2 -0.0374159
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0373636
BCL2L1 BCL2-like 1 -0.0370032
RPL35A ribosomal protein L35a -0.0367673
RPL8 ribosomal protein L8 -0.0360378
RPL37A ribosomal protein L37a -0.0357283
GNAS GNAS complex locus -0.0349713
CUL4B cullin 4B -0.034956
RPL26 ribosomal protein L26 -0.034695
ITGA6 integrin, alpha 6 -0.0345805
CANX calnexin -0.0345766
MEF2A myocyte enhancer factor 2A -0.034296
CALU calumenin -0.0341628
PKM pyruvate kinase, muscle -0.0336401
RPL7A ribosomal protein L7a -0.0334319
RACK1 receptor for activated C kinase 1 -0.033194
SERINC3 serine incorporator 3 -0.0329115
RPS2 ribosomal protein S2 -0.0328668
RPLP0 ribosomal protein, large, P0 -0.0324781
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0323503
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0320618
MDK midkine (neurite growth-promoting factor 2) -0.0319918
RPL36A ribosomal protein L36a -0.0319696
RPL30 ribosomal protein L30 -0.0319364
PRRC2C proline-rich coiled-coil 2C -0.0317953
RPL19 ribosomal protein L19 -0.0317483
IFI6 interferon, alpha-inducible protein 6 -0.0317142
RPS23 ribosomal protein S23 -0.0316599
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0315716
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0313021
RPL32 ribosomal protein L32 -0.0311407
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0309857
S100A11 S100 calcium binding protein A11 -0.0308374
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.030622
RPL27A ribosomal protein L27a -0.0305219
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0304351
KMT2E lysine (K)-specific methyltransferase 2E -0.0303347
RPL5 ribosomal protein L5 -0.0301404
KTN1 kinectin 1 (kinesin receptor) -0.0300042
RPL31 ribosomal protein L31 -0.0298261
RPS27A ribosomal protein S27a -0.0294717
RPS14 ribosomal protein S14 -0.0292541
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0292199
CD99 CD99 molecule -0.0292032
SPAG9 sperm associated antigen 9 -0.0291166
WASF2 WAS protein family, member 2 -0.0290617