| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Amsacrine perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Amsacrine_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.152493 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.11287 |
| CAPRIN2 | caprin family member 2 | 0.104235 |
| HLA-B | major histocompatibility complex, class I, B | 0.097377 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0743789 |
| FTL | ferritin, light polypeptide | 0.0638404 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0599937 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0590438 |
| POTEF | POTE ankyrin domain family, member F | 0.0553514 |
| FMNL2 | formin-like 2 | 0.0519037 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0496505 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | 0.04837 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0476535 |
| RPS12 | ribosomal protein S12 | 0.0443466 |
| PLEC | plectin | 0.0436603 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0433489 |
| VEGFA | vascular endothelial growth factor A | 0.0429589 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0422485 |
| SPAG9 | sperm associated antigen 9 | 0.0419963 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0418645 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.041385 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0413307 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0410063 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.040767 |
| HLA-A | major histocompatibility complex, class I, A | 0.0394308 |
| SFTPA2 | surfactant protein A2 | 0.0388981 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0386976 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0378832 |
| CADM2 | cell adhesion molecule 2 | 0.0376746 |
| TXNIP | thioredoxin interacting protein | 0.0376511 |
| CCNL1 | cyclin L1 | 0.036534 |
| H1-0 | H1.0 linker histone | 0.0364436 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0361803 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.035864 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0347505 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0343168 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0339385 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0335136 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0333177 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0328954 |
| BRD2 | bromodomain containing 2 | 0.0323283 |
| NDRG1 | N-myc downstream regulated 1 | 0.0317468 |
| RPS6 | ribosomal protein S6 | 0.0311927 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.031038 |
| B2M | beta-2-microglobulin | 0.0307317 |
| HELZ | helicase with zinc finger | 0.030727 |
| PLIN2 | perilipin 2 | 0.0304818 |
| GYS1 | glycogen synthase 1 (muscle) | 0.0301911 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0301749 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0292142 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0289833 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0284441 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0282905 |
| MT2A | metallothionein 2A | 0.027651 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0275235 |
| HLA-C | major histocompatibility complex, class I, C | 0.0272567 |
| SLK | STE20-like kinase | 0.0272511 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0271384 |
| SP100 | SP100 nuclear antigen | 0.0270895 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0270845 |
| KRT18 | keratin 18, type I | 0.0269444 |
| TGM2 | transglutaminase 2 | 0.0269382 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0269228 |
| DNER | delta/notch-like EGF repeat containing | 0.0268449 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | 0.0265736 |
| PFN1 | profilin 1 | 0.0265087 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0263492 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0259785 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0258559 |
| RPS19 | ribosomal protein S19 | 0.0258052 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.0255451 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0251998 |
| RNF213 | ring finger protein 213 | 0.0248739 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0247471 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0247364 |
| RPL19 | ribosomal protein L19 | 0.0246958 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0244689 |
| PCDH1 | protocadherin 1 | 0.0242662 |
| HLA-E | major histocompatibility complex, class I, E | 0.0242219 |
| RPL37A | ribosomal protein L37a | 0.0241814 |
| INTS6 | integrator complex subunit 6 | 0.0241058 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0240785 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0240384 |
| ECE1 | endothelin converting enzyme 1 | 0.0239708 |
| YAP1 | Yes-associated protein 1 | 0.0239532 |
| FNDC3B | fibronectin type III domain containing 3B | 0.023819 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0237817 |
| SDC4 | syndecan 4 | 0.0235098 |
| PRKCE | protein kinase C, epsilon | 0.0233811 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | 0.0233715 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0233668 |
| DDX41 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 | 0.0233307 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0230173 |
| RPL11 | ribosomal protein L11 | 0.0224584 |
| FOSL1 | FOS-like antigen 1 | 0.0223758 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0223014 |
| RPL36 | ribosomal protein L36 | 0.0220275 |
| RPS10 | ribosomal protein S10 | 0.0219372 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0216815 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0214275 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.279225 |
| TXNRD1 | thioredoxin reductase 1 | -0.231085 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.170763 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.129895 |
| AHNAK | AHNAK nucleoprotein | -0.118258 |
| RAI1 | retinoic acid induced 1 | -0.108796 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.103374 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.10083 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.100479 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0902334 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0856548 |
| CD44 | CD44 molecule (Indian blood group) | -0.08476 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.083891 |
| TMSB10 | thymosin beta 10 | -0.0838773 |
| UBC | ubiquitin C | -0.0813561 |
| TP63 | tumor protein p63 | -0.0792494 |
| USP34 | ubiquitin specific peptidase 34 | -0.0764764 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0759901 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0759827 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0754443 |
| CANX | calnexin | -0.0748505 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0695032 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0669937 |
| APP | amyloid beta (A4) precursor protein | -0.0648708 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0610071 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0595032 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.059074 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0577532 |
| RPS27A | ribosomal protein S27a | -0.05404 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0514449 |
| EHBP1 | EH domain binding protein 1 | -0.0488574 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0485462 |
| LDHA | lactate dehydrogenase A | -0.0484258 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0472237 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0446661 |
| ACTG1 | actin gamma 1 | -0.0423242 |
| RGS4 | regulator of G-protein signaling 4 | -0.0419617 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0410982 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | -0.0401919 |
| ZNF217 | zinc finger protein 217 | -0.0399635 |
| RTN4 | reticulon 4 | -0.039956 |
| JUN | jun proto-oncogene | -0.0395455 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0393983 |
| ENO1 | enolase 1, (alpha) | -0.0385841 |
| CENPF | centromere protein F, 350/400kDa | -0.038373 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.037187 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.03673 |
| RIGI | RNA sensor RIG-I | -0.0363191 |
| PGK1 | phosphoglycerate kinase 1 | -0.0353517 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0342467 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0341545 |
| FLNB | filamin B, beta | -0.0341454 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0339872 |
| BMERB1 | bMERB domain containing 1 | -0.0339767 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0336921 |
| DOCK11 | dedicator of cytokinesis 11 | -0.0336827 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | -0.0336791 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0333033 |
| UPP1 | uridine phosphorylase 1 | -0.03283 |
| CFAP299 | cilia and flagella associated protein 299 | -0.0324867 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | -0.0317721 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0315427 |
| TMEM41B | transmembrane protein 41B | -0.031508 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0313588 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0307294 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0306329 |
| HDLBP | high density lipoprotein binding protein | -0.0303892 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0293938 |
| RPL4 | ribosomal protein L4 | -0.0293775 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0288253 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0286652 |
| MKI67 | marker of proliferation Ki-67 | -0.0284208 |
| RASAL2 | RAS protein activator like 2 | -0.0280159 |
| EMP1 | epithelial membrane protein 1 | -0.0276179 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0273699 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0272982 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0272801 |
| MIB1 | mindbomb E3 ubiquitin protein ligase 1 | -0.0271132 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0270661 |
| EREG | epiregulin | -0.0270512 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0270455 |
| NAV2 | neuron navigator 2 | -0.0268747 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0267731 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0265209 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0261503 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0260538 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0259165 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0259101 |
| FERMT1 | fermitin family member 1 | -0.0256594 |
| CEP170 | centrosomal protein 170kDa | -0.0256148 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0256003 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0255062 |
| ERCC6L2 | excision repair cross-complementation group 6-like 2 | -0.0250924 |
| PUS7 | pseudouridylate synthase 7 (putative) | -0.0248388 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0246744 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.0241388 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0241203 |
| IPO7 | importin 7 | -0.0238458 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0237509 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | -0.0237405 |
