| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Amsacrine perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Amsacrine_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GRAMD1B | GRAM domain containing 1B | 0.133699 |
| CES1 | carboxylesterase 1 | 0.112977 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.10138 |
| FAM13A | family with sequence similarity 13, member A | 0.0885282 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0871495 |
| PLEC | plectin | 0.0842353 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0735148 |
| MCL1 | myeloid cell leukemia 1 | 0.0722211 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0709886 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0703049 |
| SPAG9 | sperm associated antigen 9 | 0.0697133 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.066961 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.066926 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0647326 |
| SLTM | SAFB-like, transcription modulator | 0.0643901 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0641806 |
| TOP1 | topoisomerase (DNA) I | 0.0616448 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0609122 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0582808 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0580264 |
| GSK3B | glycogen synthase kinase 3 beta | 0.056626 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0536658 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0534079 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0529466 |
| SMAD3 | SMAD family member 3 | 0.0522451 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0518852 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0516779 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0492267 |
| EGFR | epidermal growth factor receptor | 0.0477557 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0475732 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.047346 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0471492 |
| DTNA | dystrobrevin, alpha | 0.0470338 |
| RUNX1 | runt-related transcription factor 1 | 0.046073 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0459313 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0452704 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0451728 |
| RNF145 | ring finger protein 145 | 0.0441883 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0441852 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0437321 |
| ATP13A3 | ATPase type 13A3 | 0.0436562 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0429791 |
| ATP11A | ATPase, class VI, type 11A | 0.0421482 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0413551 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0412764 |
| MYOF | myoferlin | 0.0410266 |
| HYOU1 | hypoxia up-regulated 1 | 0.0407723 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0405523 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0400219 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0392247 |
| HELZ | helicase with zinc finger | 0.0383277 |
| MSN | moesin | 0.0377821 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0364563 |
| BRD2 | bromodomain containing 2 | 0.03642 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0360977 |
| INTS6 | integrator complex subunit 6 | 0.0357246 |
| ANKRD37 | ankyrin repeat domain 37 | 0.0355662 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0343709 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0343148 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0338849 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.033437 |
| FAT1 | FAT atypical cadherin 1 | 0.033269 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0331422 |
| PCBP2 | poly(rC) binding protein 2 | 0.0330467 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0328824 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0326537 |
| CSNK1E | casein kinase 1, epsilon | 0.032249 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0321016 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0318874 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0315043 |
| PTK2 | protein tyrosine kinase 2 | 0.0313805 |
| VEGFC | vascular endothelial growth factor C | 0.0313784 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0310899 |
| PDE8A | phosphodiesterase 8A | 0.0308969 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0308189 |
| SON | SON DNA binding protein | 0.030814 |
| HMGA2 | high mobility group AT-hook 2 | 0.0306228 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.030267 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0299445 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0299154 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0299052 |
| SCEL | sciellin | 0.0295807 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0295253 |
| NPTN | neuroplastin | 0.0294117 |
| JMJD1C | jumonji domain containing 1C | 0.0293617 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0292642 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0291962 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0291354 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0288645 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0287851 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0287371 |
| YAP1 | Yes-associated protein 1 | 0.0284299 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0284258 |
| SVIL | supervillin | 0.0283 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.028276 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0281064 |
| FLNA | filamin A, alpha | 0.0280751 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.027957 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.027279 |
| MED13L | mediator complex subunit 13-like | 0.0272097 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.182366 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.147229 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.133266 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.115704 |
| TXNRD1 | thioredoxin reductase 1 | -0.0985329 |
| LAMC2 | laminin, gamma 2 | -0.0943422 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0876255 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0812692 |
| ASPH | aspartate beta-hydroxylase | -0.0756756 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0748992 |
| B2M | beta-2-microglobulin | -0.0745717 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0724547 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0721826 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0712581 |
| RPL35A | ribosomal protein L35a | -0.0684698 |
| LMO7 | LIM domain 7 | -0.0671989 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0662277 |
| RPS24 | ribosomal protein S24 | -0.0650797 |
| S100A10 | S100 calcium binding protein A10 | -0.0633574 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0631357 |
| EFNA5 | ephrin-A5 | -0.0629907 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0627169 |
| RPL34 | ribosomal protein L34 | -0.0592351 |
| ACTG1 | actin gamma 1 | -0.0557833 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0537247 |
| RPS3 | ribosomal protein S3 | -0.0535297 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0533999 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0529182 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0526102 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0522524 |
| PTMA | prothymosin, alpha | -0.0511726 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0506094 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0497094 |
| RPS25 | ribosomal protein S25 | -0.0473766 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0472835 |
| RPS8 | ribosomal protein S8 | -0.0472449 |
| HLA-B | major histocompatibility complex, class I, B | -0.0467331 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0465665 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0464175 |
| TRIM56 | tripartite motif containing 56 | -0.046163 |
| CST3 | cystatin C | -0.045821 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0446317 |
| GM2A | GM2 ganglioside activator | -0.0421604 |
| LAMB3 | laminin, beta 3 | -0.0419731 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0412659 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0410618 |
| EGR1 | early growth response 1 | -0.0405473 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0393068 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0383757 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0377041 |
| FTL | ferritin, light polypeptide | -0.0373622 |
| RPL31 | ribosomal protein L31 | -0.0364738 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0338005 |
| KRT7 | keratin 7, type II | -0.0327628 |
| SPTSSA | serine palmitoyltransferase, small subunit A | -0.0318524 |
| ANKLE2 | ankyrin repeat and LEM domain containing 2 | -0.0313427 |
| RPS27A | ribosomal protein S27a | -0.030993 |
| S100A6 | S100 calcium binding protein A6 | -0.0309284 |
| RPL37 | ribosomal protein L37 | -0.0309057 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0303856 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.030385 |
| AGR2 | anterior gradient 2 | -0.0302555 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0301077 |
| GNAS | GNAS complex locus | -0.0293044 |
| S100A11 | S100 calcium binding protein A11 | -0.0287985 |
| LDHA | lactate dehydrogenase A | -0.0282706 |
| RPS29 | ribosomal protein S29 | -0.0281524 |
| RAB27B | RAB27B, member RAS oncogene family | -0.028035 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0280329 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0279948 |
| NSUN6 | NOP2/Sun domain family, member 6 | -0.0279529 |
| AREG | amphiregulin | -0.0279414 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0278974 |
| S100A9 | S100 calcium binding protein A9 | -0.0276301 |
| RPLP1 | ribosomal protein, large, P1 | -0.0275056 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | -0.0270434 |
| RPL26 | ribosomal protein L26 | -0.0269294 |
| IER3 | immediate early response 3 | -0.0266918 |
| RPL37A | ribosomal protein L37a | -0.0265875 |
| RPL11 | ribosomal protein L11 | -0.0264565 |
| RAB1A | RAB1A, member RAS oncogene family | -0.026305 |
| RPL30 | ribosomal protein L30 | -0.0262071 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0261303 |
| TKT | transketolase | -0.0261091 |
| RPL19 | ribosomal protein L19 | -0.0252277 |
| SMIM31 | small integral membrane protein 31 | -0.0251996 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0251976 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0244358 |
| RPS27 | ribosomal protein S27 | -0.024271 |
| RPL36A | ribosomal protein L36a | -0.0240208 |
| RIGI | RNA sensor RIG-I | -0.0240095 |
| PLSCR1 | phospholipid scramblase 1 | -0.0236705 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0235563 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0230995 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.022743 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0227272 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0226396 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0223271 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0223035 |
| PGK1 | phosphoglycerate kinase 1 | -0.022181 |
