| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Amsacrine perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Amsacrine_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.164637 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0599969 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0543078 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0503898 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0486808 |
| FLNB | filamin B, beta | 0.0424574 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0400972 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0380145 |
| AHNAK | AHNAK nucleoprotein | 0.03706 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0368355 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0359656 |
| KYNU | kynureninase | 0.0353642 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.033841 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.033347 |
| PLEC | plectin | 0.0332501 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0320679 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0320441 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0315978 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0312135 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0305072 |
| FLNA | filamin A, alpha | 0.0296029 |
| FMNL2 | formin-like 2 | 0.0292902 |
| CMIP | c-Maf inducing protein | 0.0287825 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0272008 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0264898 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0260354 |
| BRD2 | bromodomain containing 2 | 0.0256494 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0256461 |
| USP36 | ubiquitin specific peptidase 36 | 0.0242717 |
| MCL1 | myeloid cell leukemia 1 | 0.023683 |
| SFTPA2 | surfactant protein A2 | 0.0235611 |
| STC1 | stanniocalcin 1 | 0.0232044 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0228083 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.022673 |
| COPA | coatomer protein complex, subunit alpha | 0.0226069 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0219549 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.021937 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0219207 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0218643 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0207925 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0206673 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0206206 |
| MAP7 | microtubule-associated protein 7 | 0.020535 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0204605 |
| NDRG1 | N-myc downstream regulated 1 | 0.0203319 |
| EGFR | epidermal growth factor receptor | 0.0202817 |
| UTRN | utrophin | 0.0201779 |
| ATXN1 | ataxin 1 | 0.0196899 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0196719 |
| FGA | fibrinogen alpha chain | 0.0195313 |
| RRM2 | ribonucleotide reductase M2 | 0.0193661 |
| RIGI | RNA sensor RIG-I | 0.0193402 |
| MYO1E | myosin IE | 0.0190109 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0189535 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0189087 |
| HLA-E | major histocompatibility complex, class I, E | 0.018773 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0187081 |
| MSN | moesin | 0.0186422 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0179397 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0177276 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.01727 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0170574 |
| PRELID2 | PRELI domain containing 2 | 0.0168057 |
| EXT1 | exostosin glycosyltransferase 1 | 0.016805 |
| TPM3 | tropomyosin 3 | 0.0166344 |
| NEBL | nebulette | 0.0165964 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0163323 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.016264 |
| YLPM1 | YLP motif containing 1 | 0.0161694 |
| HLA-A | major histocompatibility complex, class I, A | 0.015912 |
| PRKCA | protein kinase C, alpha | 0.015888 |
| PSEN1 | presenilin 1 | 0.0158603 |
| KIF1B | kinesin family member 1B | 0.0158418 |
| SEPTIN9 | septin 9 | 0.0153556 |
| SETX | senataxin | 0.0153352 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0152477 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.0151573 |
| GDI2 | GDP dissociation inhibitor 2 | 0.0150319 |
| HMGA2 | high mobility group AT-hook 2 | 0.0149535 |
| YTHDC1 | YTH domain containing 1 | 0.0148598 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | 0.014834 |
| INTS6 | integrator complex subunit 6 | 0.0148125 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.014755 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0147489 |
| TRIP11 | thyroid hormone receptor interactor 11 | 0.0146957 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0146885 |
| CYTH1 | cytohesin 1 | 0.0146389 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | 0.0145877 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 0.014507 |
| TMF1 | TATA element modulatory factor 1 | 0.0143499 |
| ANO6 | anoctamin 6 | 0.0143115 |
| GPATCH2L | G patch domain containing 2-like | 0.0142007 |
| SNX14 | sorting nexin 14 | 0.0140579 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0137788 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | 0.0135882 |
| NUMB | numb homolog (Drosophila) | 0.0135427 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0134802 |
| CUX1 | cut-like homeobox 1 | 0.0134357 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0133836 |
| KRT18 | keratin 18, type I | 0.0133562 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.394325 |
| TMSB10 | thymosin beta 10 | -0.21462 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.1875 |
| FTL | ferritin, light polypeptide | -0.158611 |
| GRAMD1B | GRAM domain containing 1B | -0.12309 |
| VIM | vimentin | -0.116053 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.114337 |
| TXNRD1 | thioredoxin reductase 1 | -0.106312 |
| RPL23 | ribosomal protein L23 | -0.0849292 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0753434 |
| PTMA | prothymosin, alpha | -0.0715551 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0664057 |
| RPS21 | ribosomal protein S21 | -0.0663012 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0620884 |
| RPLP1 | ribosomal protein, large, P1 | -0.0610041 |
| ACTG1 | actin gamma 1 | -0.0609791 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0559075 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0557602 |
| RPL35A | ribosomal protein L35a | -0.0539194 |
| RPS19 | ribosomal protein S19 | -0.0511381 |
| S100A6 | S100 calcium binding protein A6 | -0.0509581 |
| RPL19 | ribosomal protein L19 | -0.0490343 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0434393 |
| RPS8 | ribosomal protein S8 | -0.0433415 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0430921 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0429146 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0428045 |
| RPL36 | ribosomal protein L36 | -0.0426949 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.042338 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0416505 |
| RBM39 | RNA binding motif protein 39 | -0.0410656 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0410114 |
| RTN4 | reticulon 4 | -0.0404166 |
| RPS29 | ribosomal protein S29 | -0.0402328 |
| RPL7 | ribosomal protein L7 | -0.0402086 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0398244 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0391854 |
| RPS27A | ribosomal protein S27a | -0.037361 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0370138 |
| RPL26 | ribosomal protein L26 | -0.036295 |
| RPL4 | ribosomal protein L4 | -0.0347782 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0341709 |
| ZNF292 | zinc finger protein 292 | -0.0340718 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0340059 |
| RPS24 | ribosomal protein S24 | -0.0337084 |
| RPL8 | ribosomal protein L8 | -0.0326392 |
| RPS25 | ribosomal protein S25 | -0.032079 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0317859 |
| RPL30 | ribosomal protein L30 | -0.0317309 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0310949 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0310242 |
| S100A10 | S100 calcium binding protein A10 | -0.0308394 |
| RPL9 | ribosomal protein L9 | -0.030275 |
| RPS5 | ribosomal protein S5 | -0.0301694 |
| SERF2 | small EDRK-rich factor 2 | -0.0301252 |
| RPL34 | ribosomal protein L34 | -0.0296718 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0295533 |
| RPS23 | ribosomal protein S23 | -0.0292506 |
| IER3 | immediate early response 3 | -0.0292222 |
| RPL5 | ribosomal protein L5 | -0.0291477 |
| S100A11 | S100 calcium binding protein A11 | -0.0290862 |
| RPL31 | ribosomal protein L31 | -0.028843 |
| PFN1 | profilin 1 | -0.0286911 |
| RACK1 | receptor for activated C kinase 1 | -0.0286047 |
| PKM | pyruvate kinase, muscle | -0.0279231 |
| RPS27 | ribosomal protein S27 | -0.0278605 |
| YBX3 | Y box binding protein 3 | -0.027748 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0273276 |
| SRGN | serglycin | -0.0270275 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0270228 |
| RPS3 | ribosomal protein S3 | -0.0262463 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0253546 |
| QKI | QKI, KH domain containing, RNA binding | -0.025301 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0250408 |
| NNMT | nicotinamide N-methyltransferase | -0.0248928 |
| RPL36A | ribosomal protein L36a | -0.0243396 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0243361 |
| RPS14 | ribosomal protein S14 | -0.0239 |
| PSMC6 | proteasome (prosome, macropain) 26S subunit, ATPase, 6 | -0.023802 |
| MORF4L1 | mortality factor 4 like 1 | -0.0236185 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.0235974 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0235829 |
| RPL38 | ribosomal protein L38 | -0.0234708 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0233743 |
| RPS20 | ribosomal protein S20 | -0.0233353 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0227697 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0226069 |
| RPL37 | ribosomal protein L37 | -0.0225479 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0222801 |
| LMNA | lamin A/C | -0.0222616 |
| RPL28 | ribosomal protein L28 | -0.0221116 |
| RPS17 | ribosomal protein S17 | -0.0221074 |
| RPS16 | ribosomal protein S16 | -0.0221017 |
| RPLP0 | ribosomal protein, large, P0 | -0.0220925 |
| RPS12 | ribosomal protein S12 | -0.0220694 |
| PFDN2 | prefoldin subunit 2 | -0.0218511 |
| RPL32 | ribosomal protein L32 | -0.0217927 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0216744 |
| RPLP2 | ribosomal protein, large, P2 | -0.0214953 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0214314 |
