| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Amsacrine perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Amsacrine_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.182268 |
| NDRG1 | N-myc downstream regulated 1 | 0.0877376 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0855226 |
| NAV2 | neuron navigator 2 | 0.0837312 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0833201 |
| RPS12 | ribosomal protein S12 | 0.0796927 |
| PDE10A | phosphodiesterase 10A | 0.0744397 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0674856 |
| EGFR | epidermal growth factor receptor | 0.0659904 |
| KRT17 | keratin 17, type I | 0.0645537 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0605351 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0603084 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0576117 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0547754 |
| COL5A2 | collagen, type V, alpha 2 | 0.0530674 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.052756 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0523816 |
| ANO6 | anoctamin 6 | 0.0513519 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | 0.0501469 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0481512 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.048142 |
| SMAD3 | SMAD family member 3 | 0.0480764 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.0472797 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0470928 |
| TSC22D2 | TSC22 domain family, member 2 | 0.046022 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0458329 |
| SQSTM1 | sequestosome 1 | 0.0455512 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0451131 |
| SLTM | SAFB-like, transcription modulator | 0.0443388 |
| FMNL2 | formin-like 2 | 0.0431851 |
| FNBP4 | formin binding protein 4 | 0.0429456 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0425489 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0424202 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0423229 |
| JAK1 | Janus kinase 1 | 0.0418024 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0412251 |
| RPS6 | ribosomal protein S6 | 0.0410304 |
| PHF21A | PHD finger protein 21A | 0.0408666 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0406687 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0404869 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0392359 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0392121 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0390858 |
| LOC112694756 | uncharaterized LOC112694756 | 0.038582 |
| PAPOLA | poly(A) polymerase alpha | 0.0385676 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0382533 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0380379 |
| KRT18 | keratin 18, type I | 0.0380002 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0379015 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0375692 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | 0.0372026 |
| MSI2 | musashi RNA-binding protein 2 | 0.0359584 |
| ATP13A3 | ATPase type 13A3 | 0.0359322 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0354664 |
| SKP1 | S-phase kinase-associated protein 1 | 0.0354287 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0352181 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0352117 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0350316 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0345851 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0344669 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0343973 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0343456 |
| VGF | VGF nerve growth factor inducible | 0.0341276 |
| RBM5 | RNA binding motif protein 5 | 0.033926 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0337718 |
| CANX | calnexin | 0.0333186 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0332872 |
| TOP1 | topoisomerase (DNA) I | 0.0332304 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.033213 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.0327757 |
| SPPL2A | signal peptide peptidase like 2A | 0.0327726 |
| MYO10 | myosin X | 0.0319427 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0317963 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0317921 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0315465 |
| PITPNB | phosphatidylinositol transfer protein, beta | 0.0314774 |
| LAMA4 | laminin, alpha 4 | 0.0314737 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0314727 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0313387 |
| PTK2 | protein tyrosine kinase 2 | 0.0313141 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0311934 |
| WDR26 | WD repeat domain 26 | 0.0311413 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0308744 |
| BCL2L11 | BCL2-like 11 (apoptosis facilitator) | 0.0308682 |
| LRP12 | low density lipoprotein receptor-related protein 12 | 0.0306338 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0303337 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.0300309 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0299546 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0299125 |
| SEPTIN9 | septin 9 | 0.0298025 |
| CMIP | c-Maf inducing protein | 0.0298006 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0296097 |
| PTPN9 | protein tyrosine phosphatase, non-receptor type 9 | 0.029527 |
| RND3 | Rho family GTPase 3 | 0.0294863 |
| TPD52 | tumor protein D52 | 0.0293557 |
| GPHN | gephyrin | 0.0292438 |
| PDIA5 | protein disulfide isomerase family A, member 5 | 0.0291904 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | 0.029185 |
| NCKAP1 | NCK-associated protein 1 | 0.0289712 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0281635 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.119393 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.114832 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0971012 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0960669 |
| MYO1E | myosin IE | -0.0880569 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0846074 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0842175 |
| S100A10 | S100 calcium binding protein A10 | -0.0769621 |
| S100A9 | S100 calcium binding protein A9 | -0.0755788 |
| TMCC3 | transmembrane and coiled-coil domain family 3 | -0.075361 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0730996 |
| POTEF | POTE ankyrin domain family, member F | -0.072945 |
| TMSB10 | thymosin beta 10 | -0.0725399 |
| VCAN | versican | -0.0708756 |
| ANTXR2 | anthrax toxin receptor 2 | -0.070819 |
| B2M | beta-2-microglobulin | -0.0667202 |
| RBM47 | RNA binding motif protein 47 | -0.0663874 |
| VCL | vinculin | -0.0656867 |
| LMO7 | LIM domain 7 | -0.064573 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0642303 |
| SMYD3 | SET and MYND domain containing 3 | -0.06355 |
| ZNF217 | zinc finger protein 217 | -0.0635032 |
| OSMR | oncostatin M receptor | -0.0634942 |
| PTMA | prothymosin, alpha | -0.063322 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0630237 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0629 |
| TXNIP | thioredoxin interacting protein | -0.0614836 |
| GLIS3 | GLIS family zinc finger 3 | -0.0606228 |
| KATNBL1 | katanin p80 subunit B-like 1 | -0.0600751 |
| CP | ceruloplasmin (ferroxidase) | -0.0586826 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0581957 |
| ERBIN | erbb2 interacting protein | -0.0574745 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0561915 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0560831 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0555386 |
| SLC38A1 | solute carrier family 38, member 1 | -0.053015 |
| GRAMD2B | GRAM domain containing 2B | -0.0529851 |
| PRSS23 | protease, serine, 23 | -0.0525955 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0522724 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0517076 |
| ATOSA | atos homolog A | -0.0513205 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0500788 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0500543 |
| FNDC3B | fibronectin type III domain containing 3B | -0.049775 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0486811 |
| ANXA2 | annexin A2 | -0.0485227 |
| HLA-A | major histocompatibility complex, class I, A | -0.0479091 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0478045 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0463787 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.04625 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0462184 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0458599 |
| RNF213 | ring finger protein 213 | -0.0458329 |
| TXNRD1 | thioredoxin reductase 1 | -0.0452745 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0448451 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0447391 |
| FMN1 | formin 1 | -0.0445363 |
| BPTF | bromodomain PHD finger transcription factor | -0.0440508 |
| TMEM87A | transmembrane protein 87A | -0.0439882 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | -0.0434401 |
| INHBA | inhibin, beta A | -0.0433908 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0433058 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0431658 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0431313 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0430581 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0429313 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0424881 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0422798 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0420144 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -0.0419179 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0418202 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.041474 |
| CLDN4 | claudin 4 | -0.0411726 |
| GRAMD1B | GRAM domain containing 1B | -0.0410906 |
| CD2AP | CD2-associated protein | -0.0410221 |
| F11R | F11 receptor | -0.0407871 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0403979 |
| NCOA2 | nuclear receptor coactivator 2 | -0.039912 |
| RAB22A | RAB22A, member RAS oncogene family | -0.0397531 |
| SERINC1 | serine incorporator 1 | -0.0394225 |
| ANXA11 | annexin A11 | -0.0392082 |
| S100A11 | S100 calcium binding protein A11 | -0.0386297 |
| H3-3B | H3.3 histone B | -0.0386098 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0385524 |
| HLA-B | major histocompatibility complex, class I, B | -0.0382917 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0379227 |
| VIM | vimentin | -0.0377626 |
| CCNI | cyclin I | -0.0367706 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0366609 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0365833 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0365689 |
| POU2F1 | POU class 2 homeobox 1 | -0.0364699 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.036027 |
| MYO5C | myosin VC | -0.0358783 |
| PARD3 | par-3 family cell polarity regulator | -0.0355267 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.03545 |
| RPL35A | ribosomal protein L35a | -0.0353757 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.0351871 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0350771 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0349196 |
