| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Amsacrine perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Amsacrine_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.141673 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0746075 |
| OSMR | oncostatin M receptor | 0.0611075 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.057084 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0512615 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0466218 |
| PDE10A | phosphodiesterase 10A | 0.0391764 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0371911 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0361993 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0358476 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | 0.0354633 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0354406 |
| PRKCE | protein kinase C, epsilon | 0.0325383 |
| HMGA2 | high mobility group AT-hook 2 | 0.0324635 |
| RNF213 | ring finger protein 213 | 0.0315298 |
| DENND5B | DENN/MADD domain containing 5B | 0.0312531 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.03049 |
| CUX1 | cut-like homeobox 1 | 0.0298025 |
| H1-0 | H1.0 linker histone | 0.0297945 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0297877 |
| R3HDM2 | R3H domain containing 2 | 0.0287467 |
| PYGL | phosphorylase, glycogen, liver | 0.0287147 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0277269 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0271112 |
| KRT18 | keratin 18, type I | 0.0269718 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0266012 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0257331 |
| DSPP | dentin sialophosphoprotein | 0.0255308 |
| ZBTB1 | zinc finger and BTB domain containing 1 | 0.0254593 |
| PATJ | PATJ crumbs cell polarity complex component | 0.0251514 |
| MKI67 | marker of proliferation Ki-67 | 0.0249073 |
| EGFR | epidermal growth factor receptor | 0.0238602 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0236463 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0235472 |
| EHBP1 | EH domain binding protein 1 | 0.0233703 |
| IGF2 | insulin-like growth factor 2 | 0.0233472 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 0.0228821 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0228369 |
| LOXL2 | lysyl oxidase-like 2 | 0.0223351 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0222802 |
| DFFA | DNA fragmentation factor, 45kDa, alpha polypeptide | 0.0219727 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0217755 |
| FMNL2 | formin-like 2 | 0.0217407 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0216463 |
| PLEC | plectin | 0.0211357 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0209059 |
| HLA-C | major histocompatibility complex, class I, C | 0.0207087 |
| HLA-E | major histocompatibility complex, class I, E | 0.0197777 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0194236 |
| MMP12 | matrix metallopeptidase 12 | 0.0193834 |
| NCOA7 | nuclear receptor coactivator 7 | 0.0193414 |
| ETV6 | ets variant 6 | 0.0188914 |
| FAM168A | family with sequence similarity 168, member A | 0.0188012 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.0186851 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0186415 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.0184976 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0184617 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0183759 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0181363 |
| PTK2 | protein tyrosine kinase 2 | 0.0177294 |
| SIK3 | SIK family kinase 3 | 0.0176327 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0175624 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0175493 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | 0.0173909 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0173396 |
| RYR3 | ryanodine receptor 3 | 0.0173227 |
| ATG7 | autophagy related 7 | 0.0168576 |
| CDCP1 | CUB domain containing protein 1 | 0.0167349 |
| YARS1 | tyrosyl-tRNA synthetase 1 | 0.0162808 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0162133 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0161923 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | 0.0161597 |
| SCMH1 | sex comb on midleg homolog 1 (Drosophila) | 0.0160735 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0160659 |
| BRCA1 | breast cancer 1, early onset | 0.0160229 |
| FCHSD2 | FCH and double SH3 domains 2 | 0.0159403 |
| PRRC2B | proline-rich coiled-coil 2B | 0.015923 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0158342 |
| EXOC4 | exocyst complex component 4 | 0.0158337 |
| TPM2 | tropomyosin 2 (beta) | 0.0157968 |
| DHFR | dihydrofolate reductase | 0.015614 |
| GRAMD1B | GRAM domain containing 1B | 0.0155431 |
| WDR70 | WD repeat domain 70 | 0.015542 |
| DTNB | dystrobrevin, beta | 0.0154457 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.01541 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0153187 |
| PHF21A | PHD finger protein 21A | 0.0152743 |
| FAM13A | family with sequence similarity 13, member A | 0.0152274 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0150832 |
| STC1 | stanniocalcin 1 | 0.0150382 |
| RPS6 | ribosomal protein S6 | 0.0150247 |
| MEMO1 | mediator of cell motility 1 | 0.014987 |
| SAMHD1 | SAM domain and HD domain 1 | 0.0149857 |
| ATP9B | ATPase, class II, type 9B | 0.0147377 |
| CEP250 | centrosomal protein 250kDa | 0.014611 |
| AOPEP | aminopeptidase O (putative) | 0.0146101 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 0.0145801 |
| KMT5B | lysine methyltransferase 5B | 0.0142911 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0142887 |
| ATP13A3 | ATPase type 13A3 | 0.0142502 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.246659 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.190268 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.16238 |
| UBC | ubiquitin C | -0.14528 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.110685 |
| TMSB10 | thymosin beta 10 | -0.10906 |
| VIM | vimentin | -0.10374 |
| PTMA | prothymosin, alpha | -0.0855727 |
| TXNRD1 | thioredoxin reductase 1 | -0.0854332 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0852845 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0837208 |
| PCBP2 | poly(rC) binding protein 2 | -0.0786832 |
| RPS27A | ribosomal protein S27a | -0.0735408 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0665271 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0650106 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0618904 |
| ENO1 | enolase 1, (alpha) | -0.0603291 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.056777 |
| RPL23 | ribosomal protein L23 | -0.0566111 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0521552 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0498916 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0490783 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0475737 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0474115 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0433393 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0433338 |
| PGK1 | phosphoglycerate kinase 1 | -0.0386522 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0385602 |
| RPL5 | ribosomal protein L5 | -0.0373679 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0369351 |
| ACTG1 | actin gamma 1 | -0.0356451 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.0353583 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0345068 |
| RPL37A | ribosomal protein L37a | -0.0343948 |
| PKM | pyruvate kinase, muscle | -0.033795 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0335715 |
| RPS8 | ribosomal protein S8 | -0.0326839 |
| TPI1 | triosephosphate isomerase 1 | -0.0318574 |
| RPS3 | ribosomal protein S3 | -0.0313982 |
| SEPTIN7 | septin 7 | -0.0304242 |
| RBM39 | RNA binding motif protein 39 | -0.0300259 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0299869 |
| USP34 | ubiquitin specific peptidase 34 | -0.0298078 |
| LDHB | lactate dehydrogenase B | -0.0296882 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0285377 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0280777 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0273974 |
| RACK1 | receptor for activated C kinase 1 | -0.0271876 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0269965 |
| POTEF | POTE ankyrin domain family, member F | -0.0269412 |
| OGA | O-GlcNAcase | -0.0268101 |
| PLCB4 | phospholipase C, beta 4 | -0.0264614 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.026423 |
| IPO7 | importin 7 | -0.026321 |
| MCL1 | myeloid cell leukemia 1 | -0.0262379 |
| LDHA | lactate dehydrogenase A | -0.0262287 |
| RTN4 | reticulon 4 | -0.026025 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0259413 |
| TPX2 | TPX2, microtubule-associated | -0.0256717 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0254321 |
| CALU | calumenin | -0.025387 |
| XPO1 | exportin 1 | -0.0251562 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0248234 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0247294 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0247183 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0245288 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0242849 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0240958 |
| RPL31 | ribosomal protein L31 | -0.0239323 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0237155 |
| RBM25 | RNA binding motif protein 25 | -0.0236527 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0231917 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0231669 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0229817 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0228988 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0228179 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0225327 |
| TNPO1 | transportin 1 | -0.0223846 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.0221666 |
| RPS29 | ribosomal protein S29 | -0.0221648 |
| BRD2 | bromodomain containing 2 | -0.0221104 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0219876 |
| YBX1 | Y box binding protein 1 | -0.021953 |
| WDR45B | WD repeat domain 45B | -0.021842 |
| MATR3 | matrin 3 | -0.0217933 |
| FTL | ferritin, light polypeptide | -0.021285 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | -0.0212649 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0211311 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0210989 |
| SPAG9 | sperm associated antigen 9 | -0.0207781 |
| RPL9 | ribosomal protein L9 | -0.0206857 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0206593 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0205313 |
| RPS12 | ribosomal protein S12 | -0.0201374 |
| PFN1 | profilin 1 | -0.0200785 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0199055 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0198412 |
| GOLGA4 | golgin A4 | -0.0196726 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | -0.0196462 |
| TUBA1B | tubulin, alpha 1b | -0.0196298 |
