| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Amsacrine perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Amsacrine_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.197824 |
| FN1 | fibronectin 1 | 0.155872 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.098852 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0862051 |
| PLEC | plectin | 0.0829999 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0823143 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0811423 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0697111 |
| CANX | calnexin | 0.06889 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.062417 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0459527 |
| HLA-E | major histocompatibility complex, class I, E | 0.0434116 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0401956 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.039073 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0387184 |
| PLAU | plasminogen activator, urokinase | 0.0382209 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0381529 |
| TMSB4X | thymosin beta 4, X-linked | 0.0357909 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0347782 |
| F11R | F11 receptor | 0.0341183 |
| KRT18 | keratin 18, type I | 0.0340838 |
| RPL4 | ribosomal protein L4 | 0.0340636 |
| SFTPA2 | surfactant protein A2 | 0.0335897 |
| HLA-A | major histocompatibility complex, class I, A | 0.0331585 |
| RPS12 | ribosomal protein S12 | 0.0328395 |
| VEGFA | vascular endothelial growth factor A | 0.0313252 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0312165 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0294819 |
| TPM3 | tropomyosin 3 | 0.0293078 |
| AHNAK | AHNAK nucleoprotein | 0.0292922 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0290348 |
| LAMC2 | laminin, gamma 2 | 0.0290253 |
| CALR | calreticulin | 0.0289614 |
| RPS6 | ribosomal protein S6 | 0.0288439 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0273108 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0267237 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0262418 |
| FAM13A | family with sequence similarity 13, member A | 0.0261037 |
| CTSS | cathepsin S | 0.0257466 |
| RPL3 | ribosomal protein L3 | 0.0256851 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0255799 |
| RPS2 | ribosomal protein S2 | 0.02554 |
| YBX1 | Y box binding protein 1 | 0.025382 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0252195 |
| CD109 | CD109 molecule | 0.024648 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0243091 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0240486 |
| RPS17 | ribosomal protein S17 | 0.0232889 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 0.0231692 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0227729 |
| SQSTM1 | sequestosome 1 | 0.0226816 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0219336 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0212828 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0211991 |
| G0S2 | G0/G1 switch 2 | 0.0211556 |
| H1-0 | H1.0 linker histone | 0.0211513 |
| CERT1 | ceramide transporter 1 | 0.0211216 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.020487 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0202864 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0202149 |
| MCL1 | myeloid cell leukemia 1 | 0.0200371 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.020007 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0196953 |
| MSI2 | musashi RNA-binding protein 2 | 0.0196508 |
| DSPP | dentin sialophosphoprotein | 0.019574 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0194508 |
| RPL14 | ribosomal protein L14 | 0.0192279 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0191208 |
| RPS27A | ribosomal protein S27a | 0.0190389 |
| DSG2 | desmoglein 2 | 0.018968 |
| RPS18 | ribosomal protein S18 | 0.0185629 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0184522 |
| CRABP2 | cellular retinoic acid binding protein 2 | 0.0183987 |
| UPP1 | uridine phosphorylase 1 | 0.0178908 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0178407 |
| ANXA1 | annexin A1 | 0.0176287 |
| CCND1 | cyclin D1 | 0.0175882 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.017511 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0173773 |
| COL6A1 | collagen, type VI, alpha 1 | 0.017225 |
| IRF6 | interferon regulatory factor 6 | 0.0171194 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 0.0170625 |
| DHFR | dihydrofolate reductase | 0.0170492 |
| YEATS2 | YEATS domain containing 2 | 0.0170228 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0169927 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0167265 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0166417 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | 0.0165633 |
| MX1 | MX dynamin-like GTPase 1 | 0.0164835 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0161575 |
| SET | SET nuclear proto-oncogene | 0.0160055 |
| APP | amyloid beta (A4) precursor protein | 0.0159042 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0159013 |
| ZFR | zinc finger RNA binding protein | 0.01585 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0158421 |
| OGFRL1 | opioid growth factor receptor-like 1 | 0.015829 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | 0.0157286 |
| TKT | transketolase | 0.0156774 |
| PAPOLA | poly(A) polymerase alpha | 0.0156443 |
| RPL12 | ribosomal protein L12 | 0.0155673 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.165695 |
| FTL | ferritin, light polypeptide | -0.157133 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.152012 |
| NDRG1 | N-myc downstream regulated 1 | -0.124084 |
| MT2A | metallothionein 2A | -0.0889334 |
| ACTG1 | actin gamma 1 | -0.088513 |
| PTMA | prothymosin, alpha | -0.0672497 |
| HMGA1 | high mobility group AT-hook 1 | -0.0602418 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0584676 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0529044 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0449673 |
| RPL35A | ribosomal protein L35a | -0.0436919 |
| ASPH | aspartate beta-hydroxylase | -0.042956 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0427993 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0417017 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0413469 |
| POTEF | POTE ankyrin domain family, member F | -0.0388935 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0378115 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0372575 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0354899 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0353467 |
| LMNA | lamin A/C | -0.0351572 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0344536 |
| MYO6 | myosin VI | -0.0332082 |
| FAM3C | family with sequence similarity 3, member C | -0.0325954 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0325174 |
| RBM25 | RNA binding motif protein 25 | -0.0315563 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0307623 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0307266 |
| ERBIN | erbb2 interacting protein | -0.0305732 |
| AREG | amphiregulin | -0.0305222 |
| SDC4 | syndecan 4 | -0.0297352 |
| RPS19 | ribosomal protein S19 | -0.0288247 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0285909 |
| S100A10 | S100 calcium binding protein A10 | -0.0283413 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0279159 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0277111 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0270745 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0267221 |
| S100A6 | S100 calcium binding protein A6 | -0.0260017 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0249015 |
| RPLP2 | ribosomal protein, large, P2 | -0.0247285 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0245022 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0244023 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0241612 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0240396 |
| RRBP1 | ribosome binding protein 1 | -0.023025 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.0230171 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0227922 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0226449 |
| CLDN4 | claudin 4 | -0.0221575 |
| S100A4 | S100 calcium binding protein A4 | -0.0218661 |
| TJP1 | tight junction protein 1 | -0.0216913 |
| NPC2 | Niemann-Pick disease, type C2 | -0.0208582 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0208062 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0207492 |
| LMO7 | LIM domain 7 | -0.0206703 |
| RPS21 | ribosomal protein S21 | -0.0205974 |
| SH3RF1 | SH3 domain containing ring finger 1 | -0.0205872 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0205718 |
| LDHA | lactate dehydrogenase A | -0.0201983 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.02005 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0199792 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.0199466 |
| CD2AP | CD2-associated protein | -0.0199297 |
| RAB7A | RAB7A, member RAS oncogene family | -0.01972 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0196425 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0190656 |
| RTN4 | reticulon 4 | -0.0188269 |
| GRAMD2B | GRAM domain containing 2B | -0.0187101 |
| TPI1 | triosephosphate isomerase 1 | -0.0186406 |
| EFNA5 | ephrin-A5 | -0.0182564 |
| FAM162A | family with sequence similarity 162, member A | -0.0180462 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.0179245 |
| RPL36 | ribosomal protein L36 | -0.0178356 |
| ACTN4 | actinin, alpha 4 | -0.0176367 |
| RPL9 | ribosomal protein L9 | -0.0176304 |
| RPL23 | ribosomal protein L23 | -0.0175114 |
| HMGB1 | high mobility group box 1 | -0.0174813 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0173174 |
| ARHGAP20 | Rho GTPase activating protein 20 | -0.0172802 |
| RPL32 | ribosomal protein L32 | -0.0171906 |
| CENPE | centromere protein E, 312kDa | -0.0171715 |
| VCL | vinculin | -0.0171075 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0170155 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0170063 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0167862 |
| GPX4 | glutathione peroxidase 4 | -0.0161881 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0160209 |
| WASF2 | WAS protein family, member 2 | -0.0159822 |
| PFN1 | profilin 1 | -0.0159196 |
| SEC61G | Sec61 gamma subunit | -0.0156926 |
| S100A11 | S100 calcium binding protein A11 | -0.0156462 |
| GNAI2 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | -0.0156334 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0154916 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0153981 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0152145 |
| MT1X | metallothionein 1X | -0.0152112 |
| OSMR | oncostatin M receptor | -0.0151612 |
| MAP4 | microtubule-associated protein 4 | -0.015148 |
