| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Amsacrine perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Amsacrine_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.178235 |
| PM20D1 | peptidase M20 domain containing 1 | 0.123704 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.122175 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.113409 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0946643 |
| KYNU | kynureninase | 0.089235 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0852429 |
| MCL1 | myeloid cell leukemia 1 | 0.0848678 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0759017 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0650882 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0648672 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0644583 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0622093 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0602029 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0565346 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0560019 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0559764 |
| SMAD2 | SMAD family member 2 | 0.0539746 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0532454 |
| RAB3B | RAB3B, member RAS oncogene family | 0.0515505 |
| GRAMD1B | GRAM domain containing 1B | 0.0505684 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0505606 |
| PKM | pyruvate kinase, muscle | 0.0486052 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0481173 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0479264 |
| FMNL2 | formin-like 2 | 0.0476806 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0466157 |
| FLNB | filamin B, beta | 0.0443819 |
| FLNA | filamin A, alpha | 0.0439413 |
| VIM | vimentin | 0.043734 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0436755 |
| DST | dystonin | 0.0430977 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0428791 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0411528 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0393072 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0392448 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0389319 |
| LDHA | lactate dehydrogenase A | 0.038785 |
| TBXT | T-box transcription factor T | 0.0387092 |
| SQSTM1 | sequestosome 1 | 0.0381821 |
| ENO1 | enolase 1, (alpha) | 0.037998 |
| POTEF | POTE ankyrin domain family, member F | 0.0376852 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.037618 |
| HDAC4 | histone deacetylase 4 | 0.0370429 |
| SFTPA2 | surfactant protein A2 | 0.0368895 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0368742 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0362654 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0360602 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0354333 |
| INTS6 | integrator complex subunit 6 | 0.0336658 |
| MSN | moesin | 0.0334554 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0329519 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0328652 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0327483 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.032225 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0321261 |
| MAP7 | microtubule-associated protein 7 | 0.0317946 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0315496 |
| ASPH | aspartate beta-hydroxylase | 0.0314257 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0311739 |
| FAT1 | FAT atypical cadherin 1 | 0.0308288 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0307893 |
| COL5A2 | collagen, type V, alpha 2 | 0.0306053 |
| STC1 | stanniocalcin 1 | 0.0305916 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.0302509 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0299273 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.029539 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0295228 |
| DOCK4 | dedicator of cytokinesis 4 | 0.029311 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0292543 |
| EZR | ezrin | 0.0291931 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0290464 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0279072 |
| CSRP1 | cysteine and glycine-rich protein 1 | 0.0273221 |
| IL6 | interleukin 6 | 0.0268631 |
| AUTS2 | autism susceptibility candidate 2 | 0.0268102 |
| NCAM1 | neural cell adhesion molecule 1 | 0.0265787 |
| ITPK1 | inositol-tetrakisphosphate 1-kinase | 0.0264251 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | 0.0261666 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0260837 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0259991 |
| TPM3 | tropomyosin 3 | 0.0258581 |
| BMP6 | bone morphogenetic protein 6 | 0.0252912 |
| CENPF | centromere protein F, 350/400kDa | 0.0252304 |
| CHL1 | cell adhesion molecule L1-like | 0.0248587 |
| CD44 | CD44 molecule (Indian blood group) | 0.0246406 |
| EGR1 | early growth response 1 | 0.0244754 |
| FAM107B | family with sequence similarity 107, member B | 0.0239607 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.023477 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0234601 |
| PLEC | plectin | 0.0234474 |
| HSPA8 | heat shock 70kDa protein 8 | 0.023432 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0233492 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0232925 |
| RAD51B | RAD51 paralog B | 0.0232211 |
| OXSR1 | oxidative stress responsive 1 | 0.0229483 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0229283 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.022793 |
| TOB1 | transducer of ERBB2, 1 | 0.0227818 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0226796 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.189941 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.189195 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.123211 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.119818 |
| TMSB10 | thymosin beta 10 | -0.118765 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.114505 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.106252 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.100234 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0978587 |
| PCBP3 | poly(rC) binding protein 3 | -0.079969 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0769379 |
| RPS24 | ribosomal protein S24 | -0.0756375 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0710979 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0674265 |
| RPLP1 | ribosomal protein, large, P1 | -0.0662416 |
| RPS6 | ribosomal protein S6 | -0.0636911 |
| RPL35A | ribosomal protein L35a | -0.0611864 |
| RBM39 | RNA binding motif protein 39 | -0.0608069 |
| RPL26 | ribosomal protein L26 | -0.0604129 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0590939 |
| RPS19 | ribosomal protein S19 | -0.0586394 |
| EFNA5 | ephrin-A5 | -0.0584055 |
| PTMA | prothymosin, alpha | -0.0581542 |
| SMYD3 | SET and MYND domain containing 3 | -0.0566089 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0548115 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0529354 |
| RPL12 | ribosomal protein L12 | -0.0528014 |
| RPL36A | ribosomal protein L36a | -0.0504761 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0498412 |
| NCKAP5 | NCK-associated protein 5 | -0.0497171 |
| NRCAM | neuronal cell adhesion molecule | -0.0495519 |
| RPL34 | ribosomal protein L34 | -0.0494837 |
| RPS21 | ribosomal protein S21 | -0.0482049 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0473712 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.0468196 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.0437051 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0425886 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0419563 |
| S100A6 | S100 calcium binding protein A6 | -0.0417257 |
| SRPK2 | SRSF protein kinase 2 | -0.0413789 |
| RPL36 | ribosomal protein L36 | -0.0408992 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0397602 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0390252 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0389228 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0378172 |
| GOLGA4 | golgin A4 | -0.0367321 |
| RPL23 | ribosomal protein L23 | -0.0360113 |
| RPL38 | ribosomal protein L38 | -0.0355875 |
| RTN4 | reticulon 4 | -0.0355713 |
| CDH13 | cadherin 13 | -0.0354965 |
| RPL31 | ribosomal protein L31 | -0.0351925 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0348973 |
| KIAA0825 | KIAA0825 | -0.0341642 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0337923 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | -0.0336803 |
| FTL | ferritin, light polypeptide | -0.0331219 |
| RPL9 | ribosomal protein L9 | -0.0323491 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0320937 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0315541 |
| OGA | O-GlcNAcase | -0.0312436 |
| SCN3A | sodium channel, voltage gated, type III alpha subunit | -0.0306502 |
| TXNRD1 | thioredoxin reductase 1 | -0.0306011 |
| RPS12 | ribosomal protein S12 | -0.0303879 |
| RPS3 | ribosomal protein S3 | -0.0300776 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0299939 |
| RPL19 | ribosomal protein L19 | -0.0298376 |
| NCAM2 | neural cell adhesion molecule 2 | -0.0297329 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0287397 |
| RPL37A | ribosomal protein L37a | -0.0286443 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0285538 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0280453 |
| RPS13 | ribosomal protein S13 | -0.0278489 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0277185 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0270847 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | -0.0268912 |
| RPL37 | ribosomal protein L37 | -0.0267306 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.026236 |
| USP3 | ubiquitin specific peptidase 3 | -0.0262021 |
| PRKD3 | protein kinase D3 | -0.0261502 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0259214 |
| RPLP2 | ribosomal protein, large, P2 | -0.025839 |
| PTGR1 | prostaglandin reductase 1 | -0.0257359 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0257 |
| GNAS | GNAS complex locus | -0.0256332 |
| RPL35 | ribosomal protein L35 | -0.0255587 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.025551 |
| RPL13A | ribosomal protein L13a | -0.025314 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0250544 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0249322 |
| LSAMP | limbic system-associated membrane protein | -0.0248407 |
| SAR1A | secretion associated, Ras related GTPase 1A | -0.0245362 |
| SPAG9 | sperm associated antigen 9 | -0.0245254 |
| RPS27 | ribosomal protein S27 | -0.0244457 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.02399 |
| BMERB1 | bMERB domain containing 1 | -0.0239859 |
| POU2F1 | POU class 2 homeobox 1 | -0.0238301 |
| RPS16 | ribosomal protein S16 | -0.0234545 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.0232917 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0232546 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0231136 |
