Amsacrine_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Amsacrine perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

104 genes differentially expressed following the Amsacrine_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A 0.164545
PDE4D phosphodiesterase 4D, cAMP-specific 0.153845
EXT1 exostosin glycosyltransferase 1 0.152158
GPC6 glypican 6 0.145791
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.125295
NDRG1 N-myc downstream regulated 1 0.113185
NALF1 NALCN channel auxiliary factor 1 0.108075
EIF1 eukaryotic translation initiation factor 1 0.106442
VIM vimentin 0.10077
PTK2 protein tyrosine kinase 2 0.091067
TPT1 tumor protein, translationally-controlled 1 0.086643
RIMS2 regulating synaptic membrane exocytosis 2 0.0857713
OGA O-GlcNAcase 0.0813758
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0804659
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0767995
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0680163
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0672586
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0649265
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0619963
MAML3 mastermind-like 3 (Drosophila) 0.06064
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0595475
PDLIM5 PDZ and LIM domain 5 0.05869
GOLGA4 golgin A4 0.0584792
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0577955
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0510935
MON2 MON2 homolog (S. cerevisiae) 0.0486982
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0459284
MYOF myoferlin 0.045629
TRIO trio Rho guanine nucleotide exchange factor 0.0435668
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0434309
MYO1E myosin IE 0.0409657
IGFBP5 insulin-like growth factor binding protein 5 0.0391037
PSD3 pleckstrin and Sec7 domain containing 3 0.0381886
DOCK5 dedicator of cytokinesis 5 0.037088
EFNA5 ephrin-A5 0.0365652
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0356361
KYNU kynureninase 0.0352769
ACTG1 actin gamma 1 0.0347349
ZBTB20 zinc finger and BTB domain containing 20 0.0321059
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0318202
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0313305
JMJD1C jumonji domain containing 1C 0.0293954
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0291091
EEF2 eukaryotic translation elongation factor 2 0.0243742
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0235692
ASPH aspartate beta-hydroxylase 0.0179433
SPAG9 sperm associated antigen 9 0.0147992
MCL1 myeloid cell leukemia 1 0.0131152
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0130246
NCOA3 nuclear receptor coactivator 3 0.0125802
KMT2E lysine (K)-specific methyltransferase 2E 0.0102606
COL19A1 collagen, type XIX, alpha 1 0.0101718
DST dystonin 0.00926822
PARD3 par-3 family cell polarity regulator 0.00651243
NPAS2 neuronal PAS domain protein 2 0.00630497
NF1 neurofibromin 1 0.00599289
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.00469631
CCNI cyclin I 0.00274167

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.233767
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.19165
PTMA prothymosin, alpha -0.184518
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.1636
ANXA2 annexin A2 -0.152535
UBC ubiquitin C -0.148955
PRKCA protein kinase C, alpha -0.14076
LPP LIM domain containing preferred translocation partner in lipoma -0.119699
TMSB10 thymosin beta 10 -0.112863
LMO7 LIM domain 7 -0.11266
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.111535
RLF rearranged L-myc fusion -0.0920582
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0811288
RPS6 ribosomal protein S6 -0.0738142
RTN4 reticulon 4 -0.0724031
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0634511
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0595773
PKM pyruvate kinase, muscle -0.0574133
MYO10 myosin X -0.0558478
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.055241
COL6A3 collagen, type VI, alpha 3 -0.0538898
EGFR epidermal growth factor receptor -0.0505125
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0494664
ZFAND3 zinc finger, AN1-type domain 3 -0.0480743
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0470309
FNDC3B fibronectin type III domain containing 3B -0.046794
NUP58 nucleoporin 58 -0.0455439
RPL23 ribosomal protein L23 -0.0430795
RPS27A ribosomal protein S27a -0.0417697
RPS3 ribosomal protein S3 -0.0402134
FTH1 ferritin, heavy polypeptide 1 -0.0379058
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.027189
AKAP12 A kinase (PRKA) anchor protein 12 -0.0264681
NAMPT nicotinamide phosphoribosyltransferase -0.0228531
ESYT2 extended synaptotagmin-like protein 2 -0.0198743
SBF2 SET binding factor 2 -0.0187574
DSCAM Down syndrome cell adhesion molecule -0.01386
WAC WW domain containing adaptor with coiled-coil -0.0105848
PGK1 phosphoglycerate kinase 1 -0.00981609
NKD1 naked cuticle homolog 1 (Drosophila) -0.00968901
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.00938116
FN1 fibronectin 1 -0.00923791
IGF2 insulin-like growth factor 2 -0.0077637
ZNF292 zinc finger protein 292 -0.00633428
LDHA lactate dehydrogenase A -0.00580558
ACTN4 actinin, alpha 4 -0.00276303