| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Amsacrine perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Amsacrine_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.107099 |
| MED13L | mediator complex subunit 13-like | 0.0685639 |
| PHIP | pleckstrin homology domain interacting protein | 0.0676428 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.0560967 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0559407 |
| TSC22D2 | TSC22 domain family, member 2 | 0.055747 |
| XPO1 | exportin 1 | 0.0512514 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0493816 |
| USP34 | ubiquitin specific peptidase 34 | 0.048709 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0478216 |
| NTM | neurotrimin | 0.0443945 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0441734 |
| JMJD1C | jumonji domain containing 1C | 0.0421669 |
| POTEF | POTE ankyrin domain family, member F | 0.0410143 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0403998 |
| ERBIN | erbb2 interacting protein | 0.0401109 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0398525 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0397609 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0396766 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0394515 |
| HECTD4 | HECT domain containing E3 ubiquitin protein ligase 4 | 0.0392526 |
| TARS1 | threonyl-tRNA synthetase 1 | 0.0375372 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.0373673 |
| SNX6 | sorting nexin 6 | 0.0362244 |
| GOLPH3 | golgi phosphoprotein 3 (coat-protein) | 0.0358039 |
| FNDC3B | fibronectin type III domain containing 3B | 0.035723 |
| GSE1 | Gse1 coiled-coil protein | 0.035574 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0355682 |
| NOP58 | NOP58 ribonucleoprotein | 0.0346907 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0346874 |
| FSCN1 | fascin actin-bundling protein 1 | 0.0346286 |
| SETD5 | SET domain containing 5 | 0.0344503 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0344016 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.033885 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0335597 |
| NDUFS1 | NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) | 0.033378 |
| ITSN2 | intersectin 2 | 0.0332367 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.033223 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0328114 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0326774 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.032559 |
| NOTCH2 | notch 2 | 0.0325067 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0325033 |
| UBE2K | ubiquitin-conjugating enzyme E2K | 0.0324744 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0323468 |
| TOX | thymocyte selection-associated high mobility group box | 0.0321991 |
| VRK2 | vaccinia related kinase 2 | 0.032035 |
| NHSL1 | NHS-like 1 | 0.0317564 |
| PCM1 | pericentriolar material 1 | 0.0315447 |
| MDN1 | MDN1, midasin homolog (yeast) | 0.0315078 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0310029 |
| DENND1A | DENN/MADD domain containing 1A | 0.0309379 |
| GPHN | gephyrin | 0.0304318 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0303551 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0303416 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.030295 |
| LSM14A | LSM14A, SCD6 homolog A (S. cerevisiae) | 0.030242 |
| FNBP1L | formin binding protein 1-like | 0.0302048 |
| FBL | fibrillarin | 0.0295798 |
| SETD2 | SET domain containing 2 | 0.0295069 |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | 0.0294453 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0292837 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0291692 |
| UBE2G1 | ubiquitin-conjugating enzyme E2G 1 | 0.0290835 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0287699 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0287613 |
| DOK6 | docking protein 6 | 0.0287422 |
| TLN1 | talin 1 | 0.028688 |
| NFIA | nuclear factor I/A | 0.0286227 |
| SFTPA2 | surfactant protein A2 | 0.0284872 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0284544 |
| FMNL2 | formin-like 2 | 0.0284122 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0283839 |
| TUT4 | terminal uridylyl transferase 4 | 0.0281733 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0280689 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0280128 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0278641 |
| NCOA2 | nuclear receptor coactivator 2 | 0.0277169 |
| PDE8A | phosphodiesterase 8A | 0.0275036 |
| KMT2A | lysine (K)-specific methyltransferase 2A | 0.027351 |
| DENND4C | DENN/MADD domain containing 4C | 0.0272535 |
| SQSTM1 | sequestosome 1 | 0.0272101 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0269582 |
| PRTG | protogenin | 0.0268982 |
| GOLGA4 | golgin A4 | 0.0267978 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0265826 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.026517 |
| TJP1 | tight junction protein 1 | 0.0264441 |
| SKIL | SKI-like proto-oncogene | 0.0263595 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.026218 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | 0.0260792 |
| BRD2 | bromodomain containing 2 | 0.0260197 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0259918 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.0259004 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0258449 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | 0.0258286 |
| SRP54 | signal recognition particle 54kDa | 0.0258027 |
| ZNF609 | zinc finger protein 609 | 0.0257722 |
| FAM168B | family with sequence similarity 168, member B | 0.0257501 |
| GARRE1 | granule associated Rac and RHOG effector 1 | 0.025704 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.190516 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.170178 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.159893 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.10832 |
| COL5A2 | collagen, type V, alpha 2 | -0.092126 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.087647 |
| PCDH9 | protocadherin 9 | -0.082525 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0796185 |
| TMSB10 | thymosin beta 10 | -0.0793021 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0662651 |
| GPC3 | glypican 3 | -0.0642262 |
| PTMA | prothymosin, alpha | -0.0640136 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0629226 |
| CADM2 | cell adhesion molecule 2 | -0.0626192 |
| ACTG1 | actin gamma 1 | -0.0604817 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0593663 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0583635 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0573993 |
| COL3A1 | collagen, type III, alpha 1 | -0.0557311 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0550818 |
| PDGFC | platelet derived growth factor C | -0.0548522 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0545733 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0541154 |
| ZNF385D | zinc finger protein 385D | -0.0520018 |
| CENPE | centromere protein E, 312kDa | -0.0503185 |
| TENM3 | teneurin transmembrane protein 3 | -0.049594 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0463692 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.045836 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0447509 |
| METAP2 | methionyl aminopeptidase 2 | -0.0438801 |
| THBS1 | thrombospondin 1 | -0.0429984 |
| RPS21 | ribosomal protein S21 | -0.0429214 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0423242 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0414403 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | -0.0400525 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.0398116 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0394426 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0393932 |
| DST | dystonin | -0.0387426 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.038665 |
| COL11A1 | collagen, type XI, alpha 1 | -0.0383211 |
| ITGAV | integrin, alpha V | -0.0376981 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0358991 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0348023 |
| WDR43 | WD repeat domain 43 | -0.0343049 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0342988 |
| RTN4 | reticulon 4 | -0.0342699 |
| NCAM2 | neural cell adhesion molecule 2 | -0.0341215 |
| COLGALT2 | collagen beta(1-O)galactosyltransferase 2 | -0.0331604 |
| SYT1 | synaptotagmin I | -0.0329918 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0328918 |
| ZNF292 | zinc finger protein 292 | -0.0328819 |
| TPX2 | TPX2, microtubule-associated | -0.0328256 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0325499 |
| SMYD3 | SET and MYND domain containing 3 | -0.03251 |
| RPL37 | ribosomal protein L37 | -0.0323804 |
| CDC50A | cell division cycle 50 P4-ATPase accessory subunit A | -0.0322268 |
| SAMD4B | sterile alpha motif domain containing 4B | -0.0321391 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0319991 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.0313391 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0311871 |
| COL1A2 | collagen, type I, alpha 2 | -0.0311659 |
| RIGI | RNA sensor RIG-I | -0.0310877 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0307803 |
| TXNRD1 | thioredoxin reductase 1 | -0.0305508 |
| TTK | TTK protein kinase | -0.0304079 |
| KIF4A | kinesin family member 4A | -0.0301693 |
| EMP1 | epithelial membrane protein 1 | -0.0301495 |
| RAI1 | retinoic acid induced 1 | -0.029988 |
| SHROOM3 | shroom family member 3 | -0.0297705 |
| NPAS3 | neuronal PAS domain protein 3 | -0.0295217 |
| ANKRD50 | ankyrin repeat domain 50 | -0.0291759 |
| VCL | vinculin | -0.0289731 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0286763 |
| FIGN | fidgetin | -0.0286022 |
| PLEKHG1 | pleckstrin homology domain containing, family G (with RhoGef domain) member 1 | -0.0284989 |
| HMGA2 | high mobility group AT-hook 2 | -0.028369 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0282931 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.0282807 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.027802 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | -0.0274942 |
| DMD | dystrophin | -0.027304 |
| SEMA3E | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E | -0.027139 |
| CALM3 | calmodulin 3 (phosphorylase kinase, delta) | -0.0268228 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | -0.0267734 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | -0.0267417 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0267284 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0264526 |
| CALU | calumenin | -0.0264485 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0262758 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0262163 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0261835 |
| TPM4 | tropomyosin 4 | -0.0261815 |
| USP3 | ubiquitin specific peptidase 3 | -0.0257373 |
| ZNF608 | zinc finger protein 608 | -0.0256632 |
| MRPS30 | mitochondrial ribosomal protein S30 | -0.0255155 |
| FOXP2 | forkhead box P2 | -0.0254693 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0252251 |
| PEG10 | paternally expressed 10 | -0.0249984 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | -0.0248678 |
