Amsacrine_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Amsacrine perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Amsacrine_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0865189
AHNAK AHNAK nucleoprotein 0.0708543
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0696233
EEF2 eukaryotic translation elongation factor 2 0.0615169
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.061015
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0606026
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0575383
TMSB4X thymosin beta 4, X-linked 0.0545643
ADAM10 ADAM metallopeptidase domain 10 0.0489987
GOLGA4 golgin A4 0.04856
ZFAND3 zinc finger, AN1-type domain 3 0.0479069
EIF4A2 eukaryotic translation initiation factor 4A2 0.0459276
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0435964
KMT2E lysine (K)-specific methyltransferase 2E 0.0416915
ZNF292 zinc finger protein 292 0.0403705
KDM3A lysine (K)-specific demethylase 3A 0.0391911
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0343301
DSCAM Down syndrome cell adhesion molecule 0.0339737
LOC112694756 uncharaterized LOC112694756 0.0335107
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0331452
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0331084
EML4 echinoderm microtubule associated protein like 4 0.0318701
RNF145 ring finger protein 145 0.0316864
PGK1 phosphoglycerate kinase 1 0.0307714
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0306025
ELOVL5 ELOVL fatty acid elongase 5 0.0292946
PYGB phosphorylase, glycogen; brain 0.0286347
PTBP2 polypyrimidine tract binding protein 2 0.0280288
EZR ezrin 0.0279054
BIRC6 baculoviral IAP repeat containing 6 0.0273933
QKI QKI, KH domain containing, RNA binding 0.0271659
SETD5 SET domain containing 5 0.0270083
JMJD1C jumonji domain containing 1C 0.0265524
ANK2 ankyrin 2, neuronal 0.0265047
RLF rearranged L-myc fusion 0.0261568
USP3 ubiquitin specific peptidase 3 0.0254876
RBM39 RNA binding motif protein 39 0.0254358
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0253313
CAMTA1 calmodulin binding transcription activator 1 0.0253084
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0246355
ZCCHC7 zinc finger, CCHC domain containing 7 0.0244802
NAMPT nicotinamide phosphoribosyltransferase 0.0240681
COG5 component of oligomeric golgi complex 5 0.0240408
CDC73 cell division cycle 73 0.0238715
BRWD1 bromodomain and WD repeat domain containing 1 0.0236122
EXT1 exostosin glycosyltransferase 1 0.0235609
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0235219
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0233008
SMYD3 SET and MYND domain containing 3 0.022977
RAB6A RAB6A, member RAS oncogene family 0.0228754
ZEB1 zinc finger E-box binding homeobox 1 0.0226294
SPAG9 sperm associated antigen 9 0.022496
LPP LIM domain containing preferred translocation partner in lipoma 0.0224793
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0224586
XPO1 exportin 1 0.0224536
MSI2 musashi RNA-binding protein 2 0.0224267
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0220956
NUP58 nucleoporin 58 0.021912
NCOR1 nuclear receptor corepressor 1 0.0217494
NBAS neuroblastoma amplified sequence 0.0217222
FBXO11 F-box protein 11 0.0216779
ADAM9 ADAM metallopeptidase domain 9 0.0216738
IQGAP1 IQ motif containing GTPase activating protein 1 0.0216048
OGA O-GlcNAcase 0.0215663
TMEM41B transmembrane protein 41B 0.0212869
NFIA nuclear factor I/A 0.0211867
TXNIP thioredoxin interacting protein 0.0210452
KMT2C lysine (K)-specific methyltransferase 2C 0.0210018
SREBF2 sterol regulatory element binding transcription factor 2 0.0209134
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0207759
USP47 ubiquitin specific peptidase 47 0.0206832
TFG TRK-fused gene 0.0203883
HDLBP high density lipoprotein binding protein 0.0203776
HELZ helicase with zinc finger 0.0203571
NCKAP1 NCK-associated protein 1 0.0202059
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0199052
SBF2 SET binding factor 2 0.0198315
PNISR PNN-interacting serine/arginine-rich protein 0.0197543
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0196254
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.019586
LDHA lactate dehydrogenase A 0.0192206
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0191719
HOOK2 hook microtubule-tethering protein 2 0.0191528
EVI5 ecotropic viral integration site 5 0.0189652
PARD3 par-3 family cell polarity regulator 0.0189605
SMNDC1 survival motor neuron domain containing 1 0.0188316
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.018634
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0186068
KDM4C lysine (K)-specific demethylase 4C 0.0185226
SRP54 signal recognition particle 54kDa 0.0185188
VMP1 vacuole membrane protein 1 0.0184269
SLMAP sarcolemma associated protein 0.0184084
ANXA1 annexin A1 0.0183589
GARS1 glycyl-tRNA synthetase 1 0.0183391
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0183201
SEC31A SEC31 homolog A (S. cerevisiae) 0.0182798
TNRC6B trinucleotide repeat containing 6B 0.0181506
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0181235
HDAC9 histone deacetylase 9 0.0181217
TRERF1 transcriptional regulating factor 1 0.0181051

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.10975
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0907715
TPT1 tumor protein, translationally-controlled 1 -0.0651668
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.057916
RPS8 ribosomal protein S8 -0.0566166
RPL35A ribosomal protein L35a -0.0545136
RPS6 ribosomal protein S6 -0.052364
VCL vinculin -0.0518137
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.042665
RPL9 ribosomal protein L9 -0.0392112
RPL34 ribosomal protein L34 -0.0379635
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0358902
CPED1 cadherin-like and PC-esterase domain containing 1 -0.035476
RPL31 ribosomal protein L31 -0.0340905
BMP10 bone morphogenetic protein 10 -0.0340417
S100A4 S100 calcium binding protein A4 -0.0337308
HSPB1 heat shock 27kDa protein 1 -0.0320851
RPL23 ribosomal protein L23 -0.0317632
FOXP1 forkhead box P1 -0.0315099
PKM pyruvate kinase, muscle -0.0313722
RPS23 ribosomal protein S23 -0.0301533
RPLP2 ribosomal protein, large, P2 -0.0293143
RPS19 ribosomal protein S19 -0.0289266
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0287497
RPLP1 ribosomal protein, large, P1 -0.0285099
RPL37A ribosomal protein L37a -0.027739
RPL26 ribosomal protein L26 -0.0272153
SMC4 structural maintenance of chromosomes 4 -0.0270311
DIAPH3 diaphanous-related formin 3 -0.0269013
RPS13 ribosomal protein S13 -0.0268532
RPL19 ribosomal protein L19 -0.0266847
POTEF POTE ankyrin domain family, member F -0.0257262
PDE4B phosphodiesterase 4B, cAMP-specific -0.0254211
LOC102724023 ES1 protein homolog, mitochondrial -0.0248812
NAV2 neuron navigator 2 -0.024663
RPS25 ribosomal protein S25 -0.024258
TUBB4B tubulin, beta 4B class IVb -0.0236219
IGF2 insulin-like growth factor 2 -0.0233506
MKI67 marker of proliferation Ki-67 -0.0229379
RPL36 ribosomal protein L36 -0.0229035
RPS3 ribosomal protein S3 -0.0222211
RPS24 ribosomal protein S24 -0.0221839
RPL12 ribosomal protein L12 -0.021754
S100A9 S100 calcium binding protein A9 -0.0214247
TMSB10 thymosin beta 10 -0.0209706
EBNA1BP2 EBNA1 binding protein 2 -0.0204748
RFC3 replication factor C (activator 1) 3, 38kDa -0.0202186
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0200402
RPLP0 ribosomal protein, large, P0 -0.0199611
RPS21 ribosomal protein S21 -0.0199486
RPL32 ribosomal protein L32 -0.0199317
RPL7A ribosomal protein L7a -0.0195642
PFN1 profilin 1 -0.0193509
PDE4D phosphodiesterase 4D, cAMP-specific -0.0192645
ACTG1 actin gamma 1 -0.0192523
CENPF centromere protein F, 350/400kDa -0.0191917
RPS12 ribosomal protein S12 -0.0188946
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0187738
MYL12B myosin, light chain 12B, regulatory -0.0187715
TUBA1B tubulin, alpha 1b -0.0187595
RPS15 ribosomal protein S15 -0.0186018
RPS14 ribosomal protein S14 -0.0182464
HEG1 heart development protein with EGF-like domains 1 -0.0182352
RPL30 ribosomal protein L30 -0.0181348
RPL36A ribosomal protein L36a -0.0174801
PRDX2 peroxiredoxin 2 -0.0174051
CRPPA CDP-L-ribitol pyrophosphorylase A -0.0173957
RPL11 ribosomal protein L11 -0.0173502
TPI1 triosephosphate isomerase 1 -0.0171395
PTMS parathymosin -0.0169851
TBCA tubulin folding cofactor A -0.0167609
S100A10 S100 calcium binding protein A10 -0.0167264
IFI16 interferon, gamma-inducible protein 16 -0.0166853
RPL28 ribosomal protein L28 -0.01657
GSE1 Gse1 coiled-coil protein -0.0165205
PDE7B phosphodiesterase 7B -0.0163669
CCND1 cyclin D1 -0.0162277
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0159086
RPS17 ribosomal protein S17 -0.0158895
RPS27 ribosomal protein S27 -0.0155625
FER1L6 fer-1-like family member 6 -0.0154722
RPS10 ribosomal protein S10 -0.0154053
CENPE centromere protein E, 312kDa -0.0152985
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0152301
RPS16 ribosomal protein S16 -0.0150383
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0148884
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0146297
ARL4C ADP-ribosylation factor-like 4C -0.0146083
RPL27 ribosomal protein L27 -0.0145718
RPL18 ribosomal protein L18 -0.0144312
PRUNE2 prune homolog 2 (Drosophila) -0.0142361
EMP3 epithelial membrane protein 3 -0.0140343
HMGB1 high mobility group box 1 -0.0139624
RACK1 receptor for activated C kinase 1 -0.0139123
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0138089
RPS27A ribosomal protein S27a -0.0137554
RPL37 ribosomal protein L37 -0.0136576
RPS11 ribosomal protein S11 -0.0136089
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0135726
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0135432