Amsacrine_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Amsacrine perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Amsacrine_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial 0.11128
HMGA2 high mobility group AT-hook 2 0.080211
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0708627
COL6A3 collagen, type VI, alpha 3 0.0651112
TRIO trio Rho guanine nucleotide exchange factor 0.0566807
FN1 fibronectin 1 0.0555621
FRMD4A FERM domain containing 4A 0.0549214
ZSWIM6 zinc finger, SWIM-type containing 6 0.0531959
AHNAK AHNAK nucleoprotein 0.052283
HDAC9 histone deacetylase 9 0.0511465
DST dystonin 0.0493613
COL5A1 collagen, type V, alpha 1 0.0472573
GLIS3 GLIS family zinc finger 3 0.0469132
MACF1 microtubule-actin crosslinking factor 1 0.0466438
AKAP12 A kinase (PRKA) anchor protein 12 0.046175
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0456705
INTS6 integrator complex subunit 6 0.044376
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0437685
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0434827
ZBTB38 zinc finger and BTB domain containing 38 0.0433767
KYNU kynureninase 0.0426798
MYH9 myosin, heavy chain 9, non-muscle 0.0402694
EEF2 eukaryotic translation elongation factor 2 0.0398657
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0382239
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0382002
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0381117
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0380188
ASPH aspartate beta-hydroxylase 0.0372243
EPAS1 endothelial PAS domain protein 1 0.0359396
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.035631
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0348312
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0346347
SMAD3 SMAD family member 3 0.033923
ATXN1 ataxin 1 0.033909
EGFR epidermal growth factor receptor 0.0338864
FLNA filamin A, alpha 0.033856
RNF213 ring finger protein 213 0.0335225
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0306821
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0303336
EFNA5 ephrin-A5 0.0303195
BICC1 BicC family RNA binding protein 1 0.0302762
MYOF myoferlin 0.0299626
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0292831
INHBA inhibin, beta A 0.028867
STC1 stanniocalcin 1 0.0282788
SQSTM1 sequestosome 1 0.0281197
FMNL2 formin-like 2 0.0277481
USP9X ubiquitin specific peptidase 9, X-linked 0.0267315
VEGFA vascular endothelial growth factor A 0.0260459
SEPTIN9 septin 9 0.0260132
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0257321
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0255094
PRKCA protein kinase C, alpha 0.0253693
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0252124
DUSP10 dual specificity phosphatase 10 0.024917
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0248525
TNS3 tensin 3 0.0247437
PRELID2 PRELI domain containing 2 0.0245975
EXT1 exostosin glycosyltransferase 1 0.0235301
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0225733
MLPH melanophilin 0.0224777
RAD51B RAD51 paralog B 0.0224017
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0223981
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0222836
NABP1 nucleic acid binding protein 1 0.0222096
RND3 Rho family GTPase 3 0.0220365
SVIL supervillin 0.0218164
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0216453
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0216068
NAV1 neuron navigator 1 0.0212693
FLNB filamin B, beta 0.021196
TUT7 terminal uridylyl transferase 7 0.0207848
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0206468
FNIP1 folliculin interacting protein 1 0.0206343
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0204225
FAM20C family with sequence similarity 20, member C 0.0203864
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0203279
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0201786
TRIP12 thyroid hormone receptor interactor 12 0.0201305
ZMIZ1 zinc finger, MIZ-type containing 1 0.0199441
PLEC plectin 0.0198232
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0197794
VCL vinculin 0.0196027
FER fer (fps/fes related) tyrosine kinase 0.0193848
SMYD3 SET and MYND domain containing 3 0.0193076
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0191256
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0189324
KLF12 Kruppel-like factor 12 0.0188729
SFTPA2 surfactant protein A2 0.0187644
DCBLD1 discoidin, CUB and LCCL domain containing 1 0.0187424
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0187233
FNDC3B fibronectin type III domain containing 3B 0.0186778
PSD3 pleckstrin and Sec7 domain containing 3 0.0185977
TLE4 transducin-like enhancer of split 4 0.018276
SDK1 sidekick cell adhesion molecule 1 0.0182299
RUNX1 runt-related transcription factor 1 0.0181995
GOLGB1 golgin B1 0.0181391
NAV2 neuron navigator 2 0.0181012
TMEM132D transmembrane protein 132D 0.0180576
TGM2 transglutaminase 2 0.017966

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.225574
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.121085
HLA-B major histocompatibility complex, class I, B -0.096117
NAMPT nicotinamide phosphoribosyltransferase -0.0732623
MT2A metallothionein 2A -0.0703532
TMSB10 thymosin beta 10 -0.0703392
FTL ferritin, light polypeptide -0.0678368
TPT1 tumor protein, translationally-controlled 1 -0.0654853
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.057114
RPS12 ribosomal protein S12 -0.0557269
B2M beta-2-microglobulin -0.0539383
PTMA prothymosin, alpha -0.0528679
RPS6 ribosomal protein S6 -0.049025
FTH1 ferritin, heavy polypeptide 1 -0.0460441
RPL35A ribosomal protein L35a -0.0438696
UGCG UDP-glucose ceramide glucosyltransferase -0.0436166
EIF1 eukaryotic translation initiation factor 1 -0.0424152
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0423473
RPS8 ribosomal protein S8 -0.0415293
CENPF centromere protein F, 350/400kDa -0.0406997
RPL23 ribosomal protein L23 -0.0382558
TPM4 tropomyosin 4 -0.0364072
RPLP1 ribosomal protein, large, P1 -0.0360507
RPL36A ribosomal protein L36a -0.0359
RPS24 ribosomal protein S24 -0.0355806
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0353497
RPS13 ribosomal protein S13 -0.0349629
RPLP2 ribosomal protein, large, P2 -0.034385
ADM adrenomedullin -0.0335901
RPL26 ribosomal protein L26 -0.0327072
RPL37A ribosomal protein L37a -0.0326597
RPS3 ribosomal protein S3 -0.0318289
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0295416
MKI67 marker of proliferation Ki-67 -0.028673
IER3 immediate early response 3 -0.028522
GOLGA4 golgin A4 -0.0276732
HLA-A major histocompatibility complex, class I, A -0.0274318
RPS19 ribosomal protein S19 -0.0271737
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.027124
RPL12 ribosomal protein L12 -0.0268564
IFI6 interferon, alpha-inducible protein 6 -0.0260577
RPL31 ribosomal protein L31 -0.02603
RPS23 ribosomal protein S23 -0.0260255
RPLP0 ribosomal protein, large, P0 -0.0258774
RPL11 ribosomal protein L11 -0.0255989
RPS21 ribosomal protein S21 -0.0255463
EGR1 early growth response 1 -0.0250711
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0250465
IFITM3 interferon induced transmembrane protein 3 -0.0248765
NDRG1 N-myc downstream regulated 1 -0.0247227
SLC38A1 solute carrier family 38, member 1 -0.0245637
RPL37 ribosomal protein L37 -0.0244735
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0242597
KPNB1 karyopherin (importin) beta 1 -0.0239887
RPL19 ribosomal protein L19 -0.0236525
RACK1 receptor for activated C kinase 1 -0.0236432
BTG1 B-cell translocation gene 1, anti-proliferative -0.0229756
RTN4 reticulon 4 -0.0225922
RPS25 ribosomal protein S25 -0.022424
RPL9 ribosomal protein L9 -0.0222972
RPL34 ribosomal protein L34 -0.0222677
DEK DEK proto-oncogene -0.022178
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0218988
ANLN anillin, actin binding protein -0.021771
ENO1 enolase 1, (alpha) -0.0217043
KIF4A kinesin family member 4A -0.0213137
RPL36 ribosomal protein L36 -0.0211162
RPL32 ribosomal protein L32 -0.0206717
SMC4 structural maintenance of chromosomes 4 -0.020449
WSB1 WD repeat and SOCS box containing 1 -0.0203774
MXI1 MAX interactor 1, dimerization protein -0.0201937
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0194098
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0190651
ACTG1 actin gamma 1 -0.0188411
PRR11 proline rich 11 -0.0187568
RPL7A ribosomal protein L7a -0.0186704
TMEM41B transmembrane protein 41B -0.0184357
TPX2 TPX2, microtubule-associated -0.0183912
CDCP1 CUB domain containing protein 1 -0.0182888
RPS10 ribosomal protein S10 -0.0182358
GNAS GNAS complex locus -0.0181932
RPL15 ribosomal protein L15 -0.0180716
RPL5 ribosomal protein L5 -0.0178517
CD63 CD63 molecule -0.0177535
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0176824
PGK1 phosphoglycerate kinase 1 -0.0175634
RPS14 ribosomal protein S14 -0.0174659
MATR3 matrin 3 -0.0173945
DIAPH3 diaphanous-related formin 3 -0.0170833
CALR calreticulin -0.0168814
RPL28 ribosomal protein L28 -0.016843
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0167537
IFITM1 interferon induced transmembrane protein 1 -0.0167257
RPL38 ribosomal protein L38 -0.0166321
RB1CC1 RB1-inducible coiled-coil 1 -0.0164843
RPL27A ribosomal protein L27a -0.0164804
RPS27 ribosomal protein S27 -0.0164765
RPL35 ribosomal protein L35 -0.0164144
KLF6 Kruppel-like factor 6 -0.0163765
TUBB tubulin, beta class I -0.0162816