| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Amsacrine perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Amsacrine_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL6A3 | collagen, type VI, alpha 3 | 0.0981593 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0757139 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0731354 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0714561 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0675235 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0630725 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0622797 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0590161 |
| EGFR | epidermal growth factor receptor | 0.0582432 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0573187 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0534658 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0523582 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0511946 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0509299 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0507206 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0501201 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.049089 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0475868 |
| AHNAK | AHNAK nucleoprotein | 0.0475325 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0467342 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0464685 |
| FAM13A | family with sequence similarity 13, member A | 0.0443641 |
| GLIS3 | GLIS family zinc finger 3 | 0.0437187 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0426739 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0407912 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0388725 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0364873 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0334605 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0328346 |
| MEF2A | myocyte enhancer factor 2A | 0.0324082 |
| HIP1 | huntingtin interacting protein 1 | 0.0322285 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0318098 |
| RUNX1 | runt-related transcription factor 1 | 0.0314003 |
| GSE1 | Gse1 coiled-coil protein | 0.0302348 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0302275 |
| SMAD3 | SMAD family member 3 | 0.0301709 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0295594 |
| ARRDC3 | arrestin domain containing 3 | 0.0293531 |
| RRBP1 | ribosome binding protein 1 | 0.0290038 |
| VEGFA | vascular endothelial growth factor A | 0.0289036 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0286465 |
| STC2 | stanniocalcin 2 | 0.028643 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0285543 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0285526 |
| ZNF638 | zinc finger protein 638 | 0.0283869 |
| MED13L | mediator complex subunit 13-like | 0.0281598 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0281166 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0276152 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0270346 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0269103 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.0268095 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.026257 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0260292 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0259378 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0259188 |
| CLMP | CXADR-like membrane protein | 0.0259153 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0258857 |
| SEPTIN9 | septin 9 | 0.0258767 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0258626 |
| CAB39 | calcium binding protein 39 | 0.0258006 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0257705 |
| ADM | adrenomedullin | 0.0254998 |
| CDK6 | cyclin-dependent kinase 6 | 0.0250363 |
| CD44 | CD44 molecule (Indian blood group) | 0.0244307 |
| WWOX | WW domain containing oxidoreductase | 0.0243043 |
| VEGFC | vascular endothelial growth factor C | 0.0242925 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0242176 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0240238 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0234379 |
| CANX | calnexin | 0.0230259 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0227514 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.02266 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0225907 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0225839 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0224156 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0221504 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0220931 |
| RSRP1 | arginine/serine-rich protein 1 | 0.0219704 |
| TGFB1 | transforming growth factor, beta 1 | 0.021719 |
| KYNU | kynureninase | 0.021627 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0214916 |
| PIAS1 | protein inhibitor of activated STAT, 1 | 0.021359 |
| RNF24 | ring finger protein 24 | 0.0213165 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0212946 |
| EP300 | E1A binding protein p300 | 0.0212804 |
| APP | amyloid beta (A4) precursor protein | 0.0212433 |
| ANXA5 | annexin A5 | 0.0212294 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0212093 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0209221 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0209126 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0208577 |
| OGA | O-GlcNAcase | 0.0208467 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0206302 |
| LNPK | lunapark, ER junction formation factor | 0.0205843 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0205588 |
| RIN2 | Ras and Rab interactor 2 | 0.0205372 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0203835 |
| ANXA2 | annexin A2 | 0.0203488 |
| PUM2 | pumilio RNA-binding family member 2 | 0.020281 |
| JUN | jun proto-oncogene | 0.020234 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.123304 |
| HLA-B | major histocompatibility complex, class I, B | -0.112445 |
| VIM | vimentin | -0.102822 |
| TMSB10 | thymosin beta 10 | -0.101801 |
| MT2A | metallothionein 2A | -0.0902366 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0785815 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0688324 |
| B2M | beta-2-microglobulin | -0.0604192 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.056655 |
| POTEF | POTE ankyrin domain family, member F | -0.0559139 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0528424 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0442345 |
| MT1X | metallothionein 1X | -0.0428222 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0422882 |
| COL1A2 | collagen, type I, alpha 2 | -0.0415087 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0414707 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0394373 |
| CDH13 | cadherin 13 | -0.0394228 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0380962 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0346955 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0330974 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0326519 |
| CENPE | centromere protein E, 312kDa | -0.0296097 |
| VCL | vinculin | -0.0295173 |
| PRSS23 | protease, serine, 23 | -0.0293685 |
| CENPF | centromere protein F, 350/400kDa | -0.0285811 |
| HLA-A | major histocompatibility complex, class I, A | -0.0285387 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0282097 |
| HLA-C | major histocompatibility complex, class I, C | -0.027307 |
| SDC4 | syndecan 4 | -0.0270202 |
| ANLN | anillin, actin binding protein | -0.0260803 |
| IGFBP7 | insulin-like growth factor binding protein 7 | -0.0260248 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.0259142 |
| TUBA1B | tubulin, alpha 1b | -0.0252402 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0252315 |
| ACTG1 | actin gamma 1 | -0.0251837 |
| PRELID2 | PRELI domain containing 2 | -0.025181 |
| TPX2 | TPX2, microtubule-associated | -0.0235172 |
| S100A6 | S100 calcium binding protein A6 | -0.0233646 |
| DIAPH3 | diaphanous-related formin 3 | -0.0232466 |
| UBE2C | ubiquitin-conjugating enzyme E2C | -0.0225398 |
| PLOD1 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 | -0.0224548 |
| PTN | pleiotrophin | -0.0224024 |
| HDLBP | high density lipoprotein binding protein | -0.0223327 |
| BSG | basigin (Ok blood group) | -0.0223105 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | -0.0221251 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0217866 |
| PDIA5 | protein disulfide isomerase family A, member 5 | -0.0217322 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.0214657 |
| GNB2 | guanine nucleotide binding protein (G protein), beta polypeptide 2 | -0.0213212 |
| NUCB2 | nucleobindin 2 | -0.0204235 |
| USP48 | ubiquitin specific peptidase 48 | -0.020378 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0202609 |
| NSD3 | nuclear receptor binding SET domain protein 3 | -0.0202365 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0202111 |
| HJURP | Holliday junction recognition protein | -0.020006 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | -0.0198303 |
| S100A9 | S100 calcium binding protein A9 | -0.0196608 |
| LOXL2 | lysyl oxidase-like 2 | -0.019416 |
| FNIP1 | folliculin interacting protein 1 | -0.0193068 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0192915 |
| EGR1 | early growth response 1 | -0.0192575 |
| SGO2 | shugoshin 2 | -0.0192249 |
| ZNF644 | zinc finger protein 644 | -0.0192183 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0191368 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0188561 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0188148 |
| CALU | calumenin | -0.0186359 |
| PRR11 | proline rich 11 | -0.0185831 |
| PALLD | palladin, cytoskeletal associated protein | -0.0185697 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0181941 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0180195 |
| PTGES2 | prostaglandin E synthase 2 | -0.0178629 |
| UBE3C | ubiquitin protein ligase E3C | -0.0173004 |
| KIF4A | kinesin family member 4A | -0.0172831 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0170668 |
| TPM2 | tropomyosin 2 (beta) | -0.0169897 |
| WASF2 | WAS protein family, member 2 | -0.0169057 |
| SEM1 | SEM1 26S proteasome subunit | -0.0168356 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.016829 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0168141 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0165617 |
| CTSA | cathepsin A | -0.016524 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0165118 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.016295 |
| RPS3 | ribosomal protein S3 | -0.0161704 |
| UMAD1 | UBAP1-MVB12-associated (UMA) domain containing 1 | -0.0160266 |
| KIF20B | kinesin family member 20B | -0.0159983 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0159882 |
| NDUFA4 | NDUFA4, mitochondrial complex associated | -0.0159519 |
| BCL9L | B-cell CLL/lymphoma 9-like | -0.0156063 |
| TPM4 | tropomyosin 4 | -0.0155231 |
| SUCLG2 | succinate-CoA ligase, GDP-forming, beta subunit | -0.015308 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | -0.0152486 |
| TUBB | tubulin, beta class I | -0.0152112 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0151507 |
| RTN3 | reticulon 3 | -0.0150039 |
| FAM177A1 | family with sequence similarity 177, member A1 | -0.014993 |
| NOP58 | NOP58 ribonucleoprotein | -0.0148021 |
| ATG7 | autophagy related 7 | -0.0147625 |
