| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A 1,5-dihydroimidazo[2,1-]quinazoline having an oxo substituent at the 2-position and chloro substituents at the 6- and 7-positions. (Chemical Entities of Biological Interest Ontology, CHEBI_142290) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/135409400 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Anagrelide relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NEB | nebulin | 1.45 |
| PARP3 | poly (ADP-ribose) polymerase family, member 3 | 1.19 |
| LARP6 | La ribonucleoprotein domain family, member 6 | 1.08 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 1.0 |
| DOCK11 | dedicator of cytokinesis 11 | 0.9 |
| ATXN7L3 | ataxin 7-like 3 | 0.87 |
| TEN1 | TEN1 CST complex subunit | 0.77 |
| USP31 | ubiquitin specific peptidase 31 | 0.75 |
| ATF3 | activating transcription factor 3 | 0.67 |
| BRSK2 | BR serine/threonine kinase 2 | 0.66 |
| GCH1 | GTP cyclohydrolase 1 | 0.65 |
| ARID3A | AT rich interactive domain 3A (BRIGHT-like) | 0.65 |
| PFKFB1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | 0.6 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 0.6 |
| CHSY3 | chondroitin sulfate synthase 3 | 0.53 |
| OTUB2 | OTU deubiquitinase, ubiquitin aldehyde binding 2 | 0.53 |
| CNTRL | centriolin | 0.51 |
| TMEM39B | transmembrane protein 39B | 0.51 |
| ICOSLG | inducible T-cell co-stimulator ligand | 0.49 |
| MYNN | myoneurin | 0.47 |
| ZNF267 | zinc finger protein 267 | 0.46 |
| TIGD5 | tigger transposable element derived 5 | 0.46 |
| CDX2 | caudal type homeobox 2 | 0.44 |
| AASDH | aminoadipate-semialdehyde dehydrogenase | 0.43 |
| DDN | dendrin | 0.43 |
| MT-ND4 | NADH dehydrogenase, subunit 4 (complex I) | 0.43 |
| HES1 | hes family bHLH transcription factor 1 | 0.43 |
| RUNDC1 | RUN domain containing 1 | 0.42 |
| FGF2 | fibroblast growth factor 2 (basic) | 0.39 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | 0.38 |
| DFFB | DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) | 0.38 |
| FLYWCH1 | FLYWCH-type zinc finger 1 | 0.38 |
| ALG6 | ALG6, alpha-1,3-glucosyltransferase | 0.38 |
| AUNIP | aurora kinase A and ninein interacting protein | 0.37 |
| RHBDD2 | rhomboid domain containing 2 | 0.37 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | 0.37 |
| MMACHC | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria | 0.36 |
| UPF3A | UPF3 regulator of nonsense transcripts homolog A (yeast) | 0.36 |
| LRIG3 | leucine-rich repeats and immunoglobulin-like domains 3 | 0.36 |
| ZNF799 | zinc finger protein 799 | 0.36 |
| RAD52 | RAD52 homolog (S. cerevisiae) | 0.35 |
| DNA2 | DNA replication helicase/nuclease 2 | 0.35 |
| RPGR | retinitis pigmentosa GTPase regulator | 0.35 |
| TMEM208 | transmembrane protein 208 | 0.34 |
| ZNF564 | zinc finger protein 564 | 0.33 |
| FNIP1 | folliculin interacting protein 1 | 0.33 |
| ZBTB24 | zinc finger and BTB domain containing 24 | 0.32 |
| RETREG3 | reticulophagy regulator family member 3 | 0.32 |
| RBL2 | retinoblastoma-like 2 | 0.32 |
| DONSON | downstream neighbor of SON | 0.32 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.3 |
| CEP128 | centrosomal protein 128kDa | 0.3 |
| KSR2 | kinase suppressor of ras 2 | 0.3 |
| MUS81 | MUS81 structure-specific endonuclease subunit | 0.29 |
| DES | desmin | 0.29 |
| NMU | neuromedin U | 0.29 |
| HAL | histidine ammonia-lyase | 0.28 |
| DENND5A | DENN/MADD domain containing 5A | 0.28 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.28 |
| COX10 | COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor | 0.28 |
| RELT | RELT tumor necrosis factor receptor | 0.28 |
| KLHDC2 | kelch domain containing 2 | 0.28 |
| DPY19L4 | dpy-19-like 4 (C. elegans) | 0.28 |
| ATP7B | ATPase, Cu++ transporting, beta polypeptide | 0.28 |
| PTPRU | protein tyrosine phosphatase, receptor type, U | 0.28 |
| ZBTB6 | zinc finger and BTB domain containing 6 | 0.27 |
| PLCD1 | phospholipase C, delta 1 | 0.27 |
| PSMB9 | proteasome (prosome, macropain) subunit, beta type, 9 | 0.27 |
| TTC7A | tetratricopeptide repeat domain 7A | 0.27 |
| MAP3K6 | mitogen-activated protein kinase kinase kinase 6 | 0.27 |
| MCM9 | minichromosome maintenance complex component 9 | 0.27 |
| FAM222B | family with sequence similarity 222, member B | 0.27 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | 0.27 |
| KLHL25 | kelch-like family member 25 | 0.27 |
| EME1 | essential meiotic structure-specific endonuclease 1 | 0.27 |
| DPF1 | D4, zinc and double PHD fingers family 1 | 0.26 |
| ZNF276 | zinc finger protein 276 | 0.26 |
| GATAD1 | GATA zinc finger domain containing 1 | 0.26 |
| HSPBAP1 | HSPB (heat shock 27kDa) associated protein 1 | 0.26 |
| ZNF304 | zinc finger protein 304 | 0.26 |
| UBE2J1 | ubiquitin-conjugating enzyme E2, J1 | 0.26 |
| GRTP1 | growth hormone regulated TBC protein 1 | 0.26 |
| KLHL15 | kelch-like family member 15 | 0.26 |
| RXRG | retinoid X receptor, gamma | 0.26 |
| ATP9B | ATPase, class II, type 9B | 0.25 |
| KRT222 | keratin 222, type II | 0.25 |
| NIN | ninein (GSK3B interacting protein) | 0.25 |
| ATPSCKMT | ATP synthase c subunit lysine N-methyltransferase | 0.25 |
| GALNT5 | polypeptide N-acetylgalactosaminyltransferase 5 | 0.25 |
| ATP23 | ATP23 metallopeptidase and ATP synthase assembly factor homolog | 0.25 |
| SLC6A17 | solute carrier family 6 (neutral amino acid transporter), member 17 | 0.25 |
| KLHL8 | kelch-like family member 8 | 0.25 |
| UNKL | unkempt family zinc finger-like | 0.25 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 0.25 |
| SH3RF2 | SH3 domain containing ring finger 2 | 0.25 |
| PRMT7 | protein arginine methyltransferase 7 | 0.25 |
| ELK1 | ELK1, member of ETS oncogene family | 0.25 |
| LRRC8B | leucine rich repeat containing 8 family, member B | 0.24 |
| F2 | coagulation factor II (thrombin) | 0.24 |
| C15ORF40 | chromosome 15 open reading frame 40 | 0.24 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMEM59 | transmembrane protein 59 | -1.34 |
| BLOC1S5 | biogenesis of lysosomal organelles complex-1, subunit 5, muted | -0.92 |
| SLX4IP | SLX4 interacting protein | -0.71 |
| ATL1 | atlastin GTPase 1 | -0.7 |
| GPN2 | GPN-loop GTPase 2 | -0.56 |
| USP27X | ubiquitin specific peptidase 27, X-linked | -0.53 |
| LENG9 | leukocyte receptor cluster (LRC) member 9 | -0.53 |
| TC2N | tandem C2 domains, nuclear | -0.5 |
| MYORG | myogenesis regulating glycosidase (putative) | -0.49 |
| DEPTOR | DEP domain containing MTOR-interacting protein | -0.49 |
| TEP1 | telomerase-associated protein 1 | -0.48 |
| C9ORF72 | chromosome 9 open reading frame 72 | -0.46 |
| DOCK3 | dedicator of cytokinesis 3 | -0.45 |
| ESAM | endothelial cell adhesion molecule | -0.44 |
| CRTC1 | CREB regulated transcription coactivator 1 | -0.43 |
| UBE2J2 | ubiquitin-conjugating enzyme E2, J2 | -0.42 |
| ANGPTL4 | angiopoietin-like 4 | -0.41 |
| CNTNAP3 | contactin associated protein-like 3 | -0.41 |
| SH3BGRL2 | SH3 domain binding glutamate-rich protein like 2 | -0.4 |
| DAP | death-associated protein | -0.4 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.39 |
| SRD5A3 | steroid 5 alpha-reductase 3 | -0.39 |
| IRF7 | interferon regulatory factor 7 | -0.39 |
| AFF3 | AF4/FMR2 family, member 3 | -0.39 |
| TM7SF3 | transmembrane 7 superfamily member 3 | -0.38 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.36 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | -0.36 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -0.36 |
| ZFYVE28 | zinc finger, FYVE domain containing 28 | -0.35 |
| SHC4 | SHC (Src homology 2 domain containing) family, member 4 | -0.35 |
| MALSU1 | mitochondrial assembly of ribosomal large subunit 1 | -0.34 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.34 |
| FAM126A | family with sequence similarity 126, member A | -0.34 |
| CDKN1C | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | -0.33 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.33 |
| CCDC102A | coiled-coil domain containing 102A | -0.33 |
| ZNF362 | zinc finger protein 362 | -0.33 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.33 |
| CSNK1G2 | casein kinase 1, gamma 2 | -0.32 |
| ZNF888 | zinc finger protein 888 | -0.32 |
| SLC49A4 | solute carrier family 49 member 4 | -0.32 |
| TSPAN4 | tetraspanin 4 | -0.32 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.31 |
| ABTB1 | ankyrin repeat and BTB (POZ) domain containing 1 | -0.31 |
| CYP4F22 | cytochrome P450, family 4, subfamily F, polypeptide 22 | -0.31 |
| STMN1 | stathmin 1 | -0.3 |
| TPBG | trophoblast glycoprotein | -0.3 |
| MAPKBP1 | mitogen-activated protein kinase binding protein 1 | -0.3 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.3 |
| GATA6 | GATA binding protein 6 | -0.29 |
| VWA5A | von Willebrand factor A domain containing 5A | -0.29 |
| GVINP1 | GTPase, very large interferon inducible pseudogene 1 | -0.29 |
| SLC26A2 | solute carrier family 26 (anion exchanger), member 2 | -0.29 |
| MSRB2 | methionine sulfoxide reductase B2 | -0.29 |
| TMEM242 | transmembrane protein 242 | -0.29 |
| ZNF341 | zinc finger protein 341 | -0.29 |
| SMIM12 | small integral membrane protein 12 | -0.29 |
| MPV17L2 | MPV17 mitochondrial membrane protein-like 2 | -0.29 |
| MAP3K11 | mitogen-activated protein kinase kinase kinase 11 | -0.28 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.28 |
| RNFT2 | ring finger protein, transmembrane 2 | -0.28 |
| TANK | TRAF family member-associated NFKB activator | -0.28 |
| CERK | ceramide kinase | -0.28 |
| MT1F | metallothionein 1F | -0.28 |
| NRP1 | neuropilin 1 | -0.28 |
| PRUNE2 | prune homolog 2 (Drosophila) | -0.28 |
| NCOA1 | nuclear receptor coactivator 1 | -0.28 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.28 |
| HELB | helicase (DNA) B | -0.27 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.27 |
| CAPN5 | calpain 5 | -0.27 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.26 |
| ANTKMT | adenine nucleotide translocase lysine methyltransferase | -0.26 |
| S100A2 | S100 calcium binding protein A2 | -0.26 |
| WTAP | Wilms tumor 1 associated protein | -0.26 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.26 |
| TIMM10 | translocase of inner mitochondrial membrane 10 homolog (yeast) | -0.26 |
| NIPA1 | non imprinted in Prader-Willi/Angelman syndrome 1 | -0.26 |
| TSPAN3 | tetraspanin 3 | -0.25 |
| SLC66A2 | solute carrier family 66 member 2 | -0.25 |
| SGTA | small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha | -0.25 |
| CETN1 | centrin, EF-hand protein, 1 | -0.25 |
| AMD1 | adenosylmethionine decarboxylase 1 | -0.25 |
| ADCY10 | adenylate cyclase 10 (soluble) | -0.25 |
| UBAP1 | ubiquitin associated protein 1 | -0.25 |
| RAB5IF | RAB5 interacting factor | -0.25 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.25 |
| LRP1 | low density lipoprotein receptor-related protein 1 | -0.25 |
| PSMB10 | proteasome (prosome, macropain) subunit, beta type, 10 | -0.25 |
| CCNDBP1 | cyclin D-type binding-protein 1 | -0.25 |
| ISL2 | ISL LIM homeobox 2 | -0.25 |
| GAS2L1 | growth arrest-specific 2 like 1 | -0.24 |
| C12ORF66 | chromosome 12 open reading frame 66 | -0.24 |
| NUCB1 | nucleobindin 1 | -0.24 |
| LDB1 | LIM domain binding 1 | -0.24 |
| CD63 | CD63 molecule | -0.24 |
| DDAH2 | dimethylarginine dimethylaminohydrolase 2 | -0.24 |
| NDFIP2 | Nedd4 family interacting protein 2 | -0.24 |
| NDRG1 | N-myc downstream regulated 1 | -0.24 |
