Anaphylaxis Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description anomaly in a reaction manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks (Mammalian Phenotype Ontology, MP_0002531)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D000707
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Genes

306 genes/proteins associated with the disease Anaphylaxis from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
ASPG asparaginase 2.88009
KNG1 kininogen 1 2.88009
LTB4R leukotriene B4 receptor 2.88009
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 2.88009
NLRP3 NLR family, pyrin domain containing 3 2.88009
TNF tumor necrosis factor 2.42222
IL1B interleukin 1, beta 2.41259
IL6 interleukin 6 2.36438
CXCL8 chemokine (C-X-C motif) ligand 8 2.3036
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.29513
IL4 interleukin 4 2.25624
BCL2 B-cell CLL/lymphoma 2 2.23792
BAX BCL2-associated X protein 2.22649
CAT catalase 2.20629
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 2.18262
HMOX1 heme oxygenase 1 2.14843
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.10719
CCL2 chemokine (C-C motif) ligand 2 2.10067
VEGFA vascular endothelial growth factor A 2.09499
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 2.08918
MAPK1 mitogen-activated protein kinase 1 2.06319
IL10 interleukin 10 2.05991
IFNG interferon, gamma 2.0542
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.04605
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 2.03794
MAPK3 mitogen-activated protein kinase 3 2.03676
FOS FBJ murine osteosarcoma viral oncogene homolog 2.03025
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 2.02293
MPO myeloperoxidase 2.008
ICAM1 intercellular adhesion molecule 1 2.00564
NOS2 nitric oxide synthase 2, inducible 1.98367
FAS Fas cell surface death receptor 1.97757
TP53 tumor protein p53 1.95721
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.94296
BCL2L1 BCL2-like 1 1.92705
MMP9 matrix metallopeptidase 9 1.92579
JUN jun proto-oncogene 1.91797
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.91619
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.90754
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.90672
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 1.89011
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.88917
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.88901
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.86637
GSTP1 glutathione S-transferase pi 1 1.86236
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.83396
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.82604
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.81811
EGFR epidermal growth factor receptor 1.81756
CCND1 cyclin D1 1.8068
GADD45A growth arrest and DNA-damage-inducible, alpha 1.80057
SOD2 superoxide dismutase 2, mitochondrial 1.80057
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 1.79713
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.79369
VCAM1 vascular cell adhesion molecule 1 1.77686
DDIT3 DNA-damage-inducible transcript 3 1.77316
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.7568
EGF epidermal growth factor 1.756
CCL3 chemokine (C-C motif) ligand 3 1.7546
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.74681
TGFB1 transforming growth factor, beta 1 1.73557
IL2 interleukin 2 1.73292
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 1.73231
CFLAR CASP8 and FADD-like apoptosis regulator 1.72633
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.72322
COL1A1 collagen, type I, alpha 1 1.71111
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.70761
BAK1 BCL2-antagonist/killer 1 1.70719
PPARA peroxisome proliferator-activated receptor alpha 1.7045
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 1.70347
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.69721
ALB albumin 1.6934
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.6789
IL1A interleukin 1, alpha 1.66835
FGF2 fibroblast growth factor 2 (basic) 1.65886
EDN1 endothelin 1 1.65687
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1.65555
SELL selectin L 1.64438
REN renin 1.63855
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 1.63451
POMC proopiomelanocortin 1.63161
RB1 retinoblastoma 1 1.63116
CDK4 cyclin-dependent kinase 4 1.62915
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.62601
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 1.61851
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.61529
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 1.60664
TIMP1 TIMP metallopeptidase inhibitor 1 1.60454
EGR1 early growth response 1 1.60198
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.60082
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 1.58936
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.58232
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 1.56044
CCL5 chemokine (C-C motif) ligand 5 1.55206
PARP1 poly (ADP-ribose) polymerase 1 1.54499
MMP2 matrix metallopeptidase 2 1.54306
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9 1.54086
COL3A1 collagen, type III, alpha 1 1.53675
GSK3B glycogen synthase kinase 3 beta 1.53627
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.53209
CALCA calcitonin-related polypeptide alpha 1.52816
SPP1 secreted phosphoprotein 1 1.52616
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.51886
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 1.51734
MMP1 matrix metallopeptidase 1 1.51055
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 1.51004
CDK2 cyclin-dependent kinase 2 1.50298
MAPK14 mitogen-activated protein kinase 14 1.49609
CLU clusterin 1.49045
FASLG Fas ligand (TNF superfamily, member 6) 1.4871
CCNB1 cyclin B1 1.48531
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 1.48093
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 1.47582
NQO1 NAD(P)H dehydrogenase, quinone 1 1.4753
PPARG peroxisome proliferator-activated receptor gamma 1.47452
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.47115
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.47115
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 1.46935
CHUK conserved helix-loop-helix ubiquitous kinase 1.46436
PCNA proliferating cell nuclear antigen 1.45643
HSPA1A heat shock 70kDa protein 1A 1.45537
GCLC glutamate-cysteine ligase, catalytic subunit 1.45299
NFE2L2 nuclear factor, erythroid 2-like 2 1.43727
IL12B interleukin 12B 1.41091
PLAT plasminogen activator, tissue 1.4098
IL5 interleukin 5 1.4098
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.40925
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.40925
TLR4 toll-like receptor 4 1.40457
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 1.4012
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.4012
CPT1A carnitine palmitoyltransferase 1A (liver) 1.4012
MCL1 myeloid cell leukemia 1 1.38974
NOS3 nitric oxide synthase 3 (endothelial cell) 1.38724
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.38213
CYCS cytochrome c, somatic 1.37987
CASP6 caspase 6, apoptosis-related cysteine peptidase 1.37733
DUSP1 dual specificity phosphatase 1 1.37504
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.3736
IL13 interleukin 13 1.36933
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 1.36562
ARNT aryl hydrocarbon receptor nuclear translocator 1.36533
MAPK8 mitogen-activated protein kinase 8 1.3639
TAC1 tachykinin, precursor 1 1.36247
CCNG1 cyclin G1 1.35589
CXCL10 chemokine (C-X-C motif) ligand 10 1.35473
ACTA2 actin, alpha 2, smooth muscle, aorta 1.34723
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 1.34372
GSTT1 glutathione S-transferase theta 1 1.33434
NPY neuropeptide Y 1.33346
NGF nerve growth factor (beta polypeptide) 1.32726
CD36 CD36 molecule (thrombospondin receptor) 1.31506
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.31476
F3 coagulation factor III (thromboplastin, tissue factor) 1.31387
LTA lymphotoxin alpha 1.31208
H2AFX H2A histone family, member X 1.31178
E2F1 E2F transcription factor 1 1.30971
IGFBP1 insulin-like growth factor binding protein 1 1.30543
VIM vimentin 1.29996
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 1.29936
INS insulin 1.29379
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.2898
G6PC glucose-6-phosphatase, catalytic subunit 1.28889
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 1.28734
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 1.28703
JUND jun D proto-oncogene 1.28364
PPARD peroxisome proliferator-activated receptor delta 1.28364
AHR aryl hydrocarbon receptor 1.27966
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 1.27689
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7 1.27132
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.27039
PRKCE protein kinase C, epsilon 1.26638
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.26421
F2 coagulation factor II (thrombin) 1.26175
APAF1 apoptotic peptidase activating factor 1 1.25929
NOS1 nitric oxide synthase 1 (neuronal) 1.25588
BIRC5 baculoviral IAP repeat containing 5 1.25152
MAP2K2 mitogen-activated protein kinase kinase 2 1.24307
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 1.24307
ASNS asparagine synthetase (glutamine-hydrolyzing) 1.24087
HSF1 heat shock transcription factor 1 1.2368
GSTA2 glutathione S-transferase alpha 2 1.23584
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.23233
GCLM glutamate-cysteine ligase, modifier subunit 1.22979
CRP C-reactive protein, pentraxin-related 1.22534
MAP2K1 mitogen-activated protein kinase kinase 1 1.22371
BRCA1 breast cancer 1, early onset 1.2208
FN1 fibronectin 1 1.21823
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) 1.21663
HRH1 histamine receptor H1 1.2137
NUPR1 nuclear protein, transcriptional regulator, 1 1.20784
BAD BCL2-associated agonist of cell death 1.20622
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.2046
INSR insulin receptor 1.19999
IL12A interleukin 12A 1.19933
XDH xanthine dehydrogenase 1.19639
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 1.19509
GPX1 glutathione peroxidase 1 1.19312
LBP lipopolysaccharide binding protein 1.19113
TYMP thymidine phosphorylase 1.18751
COL18A1 collagen, type XVIII, alpha 1 1.18424
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.18126
CD44 CD44 molecule (Indian blood group) 1.18093
ADIPOQ adiponectin, C1Q and collagen domain containing 1.17695
TIMP2 TIMP metallopeptidase inhibitor 2 1.17695
MMP3 matrix metallopeptidase 3 1.17497
GAST gastrin 1.17366
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 1.17333
CTSD cathepsin D 1.173
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 1.166
PECAM1 platelet/endothelial cell adhesion molecule 1 1.16335
FASN fatty acid synthase 1.16269
PRKCD protein kinase C, delta 1.1617
HSPB1 heat shock 27kDa protein 1 1.15967
PDPK1 3-phosphoinositide dependent protein kinase 1 1.15661
PDGFB platelet-derived growth factor beta polypeptide 1.15627
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 1.15391
LHB luteinizing hormone beta polypeptide 1.15357
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 1.15357
CCNE1 cyclin E1 1.14747
HAVCR1 hepatitis A virus cellular receptor 1 1.14713
SOD1 superoxide dismutase 1, soluble 1.14336
BID BH3 interacting domain death agonist 1.14302
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 1.142
RAF1 Raf-1 proto-oncogene, serine/threonine kinase 1.14098
BBC3 BCL2 binding component 3 1.13963
PTK2 protein tyrosine kinase 2 1.13963
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.13484
CYBB cytochrome b-245, beta polypeptide 1.13484
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.13381
BIRC3 baculoviral IAP repeat containing 3 1.13347
TGFA transforming growth factor, alpha 1.13279
CX3CL1 chemokine (C-X3-C motif) ligand 1 1.13143
TRAF2 TNF receptor-associated factor 2 1.12906
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4 1.12838
BIRC2 baculoviral IAP repeat containing 2 1.12599
BCL2L11 BCL2-like 11 (apoptosis facilitator) 1.12599
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.12151
FADD Fas (TNFRSF6)-associated via death domain 1.11911
ATF3 activating transcription factor 3 1.11571
UNG uracil-DNA glycosylase 1.11325
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 1.11325
TRIM28 tripartite motif containing 28 1.11046
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3 1.11046
CTGF connective tissue growth factor 1.10769
CHEK2 checkpoint kinase 2 1.10596
GSTM1 glutathione S-transferase mu 1 1.10211
BDNF brain-derived neurotrophic factor 1.10033
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 1.09998
GDF15 growth differentiation factor 15 1.09927
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 1.09892
IL2RA interleukin 2 receptor, alpha 1.09611
SELE selectin E 1.09541
APP amyloid beta (A4) precursor protein 1.09401
CNR1 cannabinoid receptor 1 (brain) 1.09332
STAT1 signal transducer and activator of transcription 1, 91kDa 1.09083
CDK1 cyclin-dependent kinase 1 1.08833
NOX4 NADPH oxidase 4 1.08797
FGA fibrinogen alpha chain 1.08513
ERBB2 erb-b2 receptor tyrosine kinase 2 1.08301
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 1.08231
DPYD dihydropyrimidine dehydrogenase 1.08231
LCN2 lipocalin 2 1.07911
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) 1.07696
CCL11 chemokine (C-C motif) ligand 11 1.07696
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 1.07376
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1.06987
HMGB1 high mobility group box 1 1.06917
C3 complement component 3 1.06917
LEP leptin 1.06734
ODC1 ornithine decarboxylase 1 1.06698
PGD phosphogluconate dehydrogenase 1.06406
CXCL2 chemokine (C-X-C motif) ligand 2 1.06333
CTSL cathepsin L 1.06152
OAT ornithine aminotransferase 1.06152
FDFT1 farnesyl-diphosphate farnesyltransferase 1 1.05648
DHFR dihydrofolate reductase 1.05386
LPL lipoprotein lipase 1.05274
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 1.05126
POR P450 (cytochrome) oxidoreductase 1.04684
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 1.04611
S100A9 S100 calcium binding protein A9 1.04611
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 1.04051
PLAU plasminogen activator, urokinase 1.03976
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 1.03567
SYK spleen tyrosine kinase 1.03567
TYMS thymidylate synthetase 1.03235
MAPK9 mitogen-activated protein kinase 9 1.03159
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 1.02896
CCNA2 cyclin A2 1.02746
MT1A metallothionein 1A 1.02708
PRL prolactin 1.02596
MAP3K7 mitogen-activated protein kinase kinase kinase 7 1.02559
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 1.0241
MMP7 matrix metallopeptidase 7 1.02373
IGFBP3 insulin-like growth factor binding protein 3 1.02336
MAOB monoamine oxidase B 1.02188
PRKCB protein kinase C, beta 1.02188
NR1I3 nuclear receptor subfamily 1, group I, member 3 1.02151
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) 1.01776
PLCG1 phospholipase C, gamma 1 1.01739
THBS1 thrombospondin 1 1.01512
FOSL2 FOS-like antigen 2 1.01437
ACHE acetylcholinesterase (Yt blood group) 1.01324
CYBA cytochrome b-245, alpha polypeptide 1.01286
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 1.01099